{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:37:45Z","timestamp":1787981865048,"version":"build-2784847793"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.ijid.2020.11.202","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T07:50:26Z","timestamp":1606895426000},"page":"423-430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study"],"prefix":"10.1016","volume":"103","author":[{"given":"Yalda","family":"Lucero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Lagomarcino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Roessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Mamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"O\u2019Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2020.11.202_bib0005","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.gtc.2015.05.008","article-title":"Screening to identify and eradicate Helicobacter pylori infection in teenagers in Japan","volume":"44","author":"Akamatsu","year":"2015","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.ijid.2020.11.202_bib0010","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/j.1365-2222.2011.03831.x","article-title":"Effects of Helicobacter pylori, geohelminth infection and selected commensal bacteria on the risk of allergic disease and sensitization in 3-year-old Ethiopian children","volume":"41","author":"Amberbir","year":"2011","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"10.1016\/j.ijid.2020.11.202_bib0015","doi-asserted-by":"crossref","first-page":"e93943","DOI":"10.1371\/journal.pone.0093943","article-title":"Th1 and Th17 responses to Helicobacter pylori in Bangladeshi infants, children and adults","volume":"9","author":"Bhuiyan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2020.11.202_bib0020","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/MPG.0b013e3181bab2ee","article-title":"Exposure to Helicobacter pylori-positive siblings and persistence of Helicobacter pylori infection in early childhood","volume":"50","author":"Cervantes","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.ijid.2020.11.202_bib0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000103886","article-title":"Usefulness of a serological panel test in the assessment of gastritis in symptomatic children","volume":"25","author":"de Angelis","year":"2007","journal-title":"Dig Dis"},{"key":"10.1016\/j.ijid.2020.11.202_bib0030","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1097\/MPG.0000000000001045","article-title":"Helicobacter pylori Infection and children\u2019s growth: an overview","volume":"62","author":"Dror","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.ijid.2020.11.202_bib0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fmicb.2020.00090","article-title":"Gastric damage and Cancer-associated biomarkers in Helicobacter pylori-infected children","volume":"11","author":"George","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0040","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1128\/jcm.35.2.468-470.1997","article-title":"Seroepidemiology of Helicobacter pylori infection in a cohort of children monitored from 6 months to 11 years of age","volume":"35","author":"Granstrom","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0045","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cca.2008.12.014","article-title":"GastroPanel: evaluation of the usefulness in the diagnosis of gastro-duodenal mucosal alterations in children","volume":"402","author":"Guariso","year":"2009","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ijid.2020.11.202_bib0050","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/MPG.0000000000000500","article-title":"Peptic ulcer disease in Helicobacter pylori-infected children: clinical findings and mucosal immune response","volume":"59","author":"Hern\u00e1ndez","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.ijid.2020.11.202_bib0055","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/MPG.0000000000001594","article-title":"Joint ESPGHAN\/NASPGHAN guidelines for the management of Helicobacter pylori in children and adolescents (update 2016)","volume":"64","author":"Jones","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.ijid.2020.11.202_bib0060","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00431-017-2955-3","article-title":"Helicobacter pylori infection, serum pepsinogens, and pediatric abdominal pain: a pilot study","volume":"176","author":"Kassem","year":"2017","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ijid.2020.11.202_bib0065","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/MPG.0b013e3182227e90","article-title":"Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children","volume":"53","author":"Koletzko","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.ijid.2020.11.202_bib0070","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1086\/515376","article-title":"Acquisition versus loss of Helicobacter pylori infection in Japan: results from an 8-year birth cohort study","volume":"178","author":"Kumagai","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2020.11.202_bib0075","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.3748\/wjg.v11.i43.6751","article-title":"Concentrations of gastric mucosal cytokines in children with food allergy and Helicobacter pylori infection","volume":"11","author":"Maciorkowska","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0080","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0140-6736(02)08025-X","article-title":"Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood","volume":"359","author":"Malaty","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ijid.2020.11.202_bib0085","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/515105","article-title":"Natural history of Helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community","volume":"28","author":"Malaty","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2020.11.202_bib0090","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1128\/JCM.38.5.1971-1973.2000","article-title":"Evidence from a nine-year birth cohort study in Japan of transmission pathways of Helicobacter pylori infection","volume":"38","author":"Malaty","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0095","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1086\/378276","article-title":"Seroepidemiology of Helicobacter pylori and hepatitis A virus and the mode of transmission of infection: a 9-year cohort study in rural Japan","volume":"37","author":"Malaty","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2020.11.202_bib0100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.annepidem.2005.08.002","article-title":"Effects of a new Helicobacter pylori infection on height and weight in Colombian children","volume":"16","author":"Mera","year":"2006","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0105","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/adc.2005.089847","article-title":"Psychiatric, somatic, and gastrointestinal disorders, and Helicobacter pylori infection in children with recurrent abdominal pain","volume":"91","author":"Nakayama","year":"2006","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ijid.2020.11.202_bib0110","article-title":"Helicobacter pylori infection and its related factors in junior high school students in Nagano Prefecture","volume":"22","author":"Nakayama","year":"2017","journal-title":"Japan. Helicobacter"},{"key":"10.1016\/j.ijid.2020.11.202_bib0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/cid\/civ256","article-title":"Persistent and transient Helicobacter pylori infections in early childhood","volume":"61","author":"O\u2019Ryan","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2020.11.202_bib0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/INF.0b013e318278b929","article-title":"Dynamics of Helicobacter pylori detection in stools during the first 5 years of life in Chile, a rapidly developing country","volume":"32","author":"O\u2019Ryan","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ijid.2020.11.202_bib0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/ped.13038","article-title":"Nationwide survey of Helicobacter pylori treatment for children and adolescents in Japan","volume":"59","author":"Okuda","year":"2017","journal-title":"Pediatr Int"},{"key":"10.1016\/j.ijid.2020.11.202_bib0130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fcimb.2016.00121","article-title":"Helicobacter pylori infection is associated with decreased expression of SLC5A8, a cancer suppressor gene, in young children","volume":"6","author":"Orellana-Manzano","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0135","doi-asserted-by":"crossref","first-page":"E87","DOI":"10.1542\/peds.108.5.e87","article-title":"Acute Helicobacter pylori infection is followed by an increase in diarrheal disease among Peruvian children","volume":"108","author":"Passaro","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijid.2020.11.202_bib0140","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1128\/JCM.41.6.2401-2407.2003","article-title":"Transient and persistent Helicobacter pylori colonization in Native American children","volume":"41","author":"Perez-Perez","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0145","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM199104113241507","article-title":"Helicobacter pylori and peptic ulcer disease","volume":"324","author":"Peterson","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2020.11.202_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068833","article-title":"Iron status and Helicobacter pylori infection in symptomatic children: an international multi-centered study","volume":"8","author":"Queiroz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2020.11.202_bib0155","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/j.gastro.2005.08.063","article-title":"Childhood functional gastrointestinal disorders: child\/adolescent","volume":"130","author":"Rasquin","year":"2006","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.ijid.2020.11.202_bib0160","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3109\/00365513.2010.520732","article-title":"Assessment of systemic matrix metalloproteinase and their regulator response in children with Helicobacter pylori gastritis","volume":"70","author":"Rautelin","year":"2010","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.ijid.2020.11.202_bib0165","series-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2018"},{"key":"10.1016\/j.ijid.2020.11.202_bib0170","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1086\/605845","article-title":"Cost-effectiveness of a potential prophylactic Helicobacter pylori vaccine in the United States","volume":"200","author":"Rupnow","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2020.11.202_bib0175","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/mi.2012.133","article-title":"Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children","volume":"6","author":"Serrano","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0180","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1651-2227.2004.tb02955.x","article-title":"Cytokines in the gastric mucosa of children with Helicobacter pylori infection","volume":"9","author":"Shimizu","year":"2004","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.ijid.2020.11.202_bib0185","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1203\/00006450-199902000-00010","article-title":"Helicobacter pylori colonization in early life","volume":"45","author":"Thomas","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ijid.2020.11.202_bib0190","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2020.11.202_bib0195","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000079145","article-title":"Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer","volume":"25","author":"Ueno","year":"2004","journal-title":"Tumour Biol"},{"key":"10.1016\/j.ijid.2020.11.202_bib0200","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12399","article-title":"Review: prevalence and dynamics of Helicobacter pylori infection during childhood","volume":"22","author":"Zabala Torrres","year":"2017","journal-title":"Helicobacter"},{"key":"10.1016\/j.ijid.2020.11.202_bib0205","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0140-6736(15)60310-5","article-title":"Efficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"386","author":"Zeng","year":"2015","journal-title":"Lancet"}],"updated-by":[{"DOI":"10.1016\/j.ijid.2021.05.046","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000}}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971220325182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971220325182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T11:27:11Z","timestamp":1723980431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971220325182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":41,"alternative-id":["S1201971220325182"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2020.11.202","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ijid.2021.05.046","asserted-by":"object"}]},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helicobacter pylori, clinical, laboratory, and noninvasive biomarkers suggestive of gastric damage in healthy school-aged children: A case-control study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2020.11.202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}