{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:53:00Z","timestamp":1790049180665,"version":"4.0.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ijid.2021.04.081","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T12:33:45Z","timestamp":1619786025000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Targeted deep amplicon sequencing of antimalarial resistance markers in Plasmodium falciparum isolates from Cameroon"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-8832","authenticated-orcid":false,"given":"Mariangela","family":"L\u2019Episcopia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7810-9095","authenticated-orcid":false,"given":"Bruna G.","family":"Djeunang Dongho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruviben","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schmedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashidhar","family":"Ravishankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edvige","family":"Perrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Modiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi W.","family":"Lucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-7389","authenticated-orcid":false,"given":"Gianluca","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldin","family":"Talundzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Severini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0005","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1186\/s13071-019-3753-8","article-title":"Review of malaria situation in Cameroon: technical viewpoint on challenges and prospects for disease elimination","volume":"12","author":"Antonio-Nkondjio","year":"2019","journal-title":"Parasit Vectors"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0010","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s40249-017-0350-y","article-title":"Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon: cross-sectional study","volume":"6","author":"Apinjoh","year":"2017","journal-title":"Infect Dis Poverty"},{"issue":"7481","key":"10.1016\/j.ijid.2021.04.081_bib0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ijid.2021.04.081_bib0020","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ijid.2021.04.081_bib0025","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/infdis\/jiaa687","article-title":"Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda","volume":"223","author":"Asua","year":"2021","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0030","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12936-020-03157-0","article-title":"Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in northern Uganda","volume":"19","author":"Balikagala","year":"2020","journal-title":"Malar J"},{"issue":"4","key":"10.1016\/j.ijid.2021.04.081_bib0035","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1080\/20477724.2019.1639018","article-title":"Molecular surveillance of putative drug resistance markers of antifolate and artemisinin among imported Plasmodium falciparum in Qatar","volume":"113","author":"Bansal","year":"2019","journal-title":"Pathog Glob Health"},{"issue":"3","key":"10.1016\/j.ijid.2021.04.081_bib0040","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4269\/ajtmh.2006.75.388","article-title":"Molecular epidemiology of malaria in Cameroon. XXI. Baseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change","volume":"75","author":"Basco","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0045","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1038\/s41598-020-60549-7","article-title":"Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in southeast of Tanzania","volume":"10","author":"Bwire","year":"2020","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.ijid.2021.04.081_bib0050","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02093-20","article-title":"Expansion of a specific Plasmodium falciparum PfMDR1 haplotype in Southeast Asia with increased substrate transport","volume":"11","author":"Cal\u00e7ada","year":"2020","journal-title":"mBio"},{"issue":"9","key":"10.1016\/j.ijid.2021.04.081_bib0055","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1093\/jac\/dkv160","article-title":"Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine\/pyrimethamine in pregnant women in Yaound\u00e9, Cameroon: emergence of highly resistant pfdhfr\/pfdhps alleles","volume":"70","author":"Chauvin","year":"2015","journal-title":"J Antimicrob Chemother"},{"issue":"12","key":"10.1016\/j.ijid.2021.04.081_bib0060","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/tmi.12595","article-title":"Influence of malaria transmission intensity and the 581G mutation on the efficacy of intermittent preventive treatment in pregnancy: systematic review and meta-analysis","volume":"20","author":"Chico","year":"2015","journal-title":"Trop Med Int Health"},{"issue":"8","key":"10.1016\/j.ijid.2021.04.081_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105690","article-title":"Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children","volume":"9","author":"Conrad","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2021.04.081_bib0070","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/1475-2875-12-399","article-title":"Atovaquone-proguanil in the treatment of imported uncomplicated Plasmodium falciparum malaria: a prospective observational study of 553 cases","volume":"12","author":"Cordel","year":"2013","journal-title":"Malar J"},{"issue":"23","key":"10.1016\/j.ijid.2021.04.081_bib0075","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1073\/pnas.85.23.9109","article-title":"Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum","volume":"85","author":"Cowman","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.ijid.2021.04.081_bib0080","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1371\/journal.pctr.0010014","article-title":"Randomised trial of chloroquine\/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum","volume":"1","author":"Dunyo","year":"2006","journal-title":"PLoS Clin Trials"},{"issue":"9","key":"10.1016\/j.ijid.2021.04.081_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0221895","article-title":"K-13 propeller gene polymorphisms isolated between 2014 and 2017 from Cameroonian Plasmodium falciparum malaria patients","volume":"14","author":"Eboumbou Moukoko","year":"2019","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ijid.2021.04.081_bib0090","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1093\/infdis\/jiu836","article-title":"The A581G mutation in the gene encoding Plasmodium falciparum dihydropteroate synthetase reduces the effectiveness of sulfadoxine-pyrimethamine preventive therapy in Malawian pregnant women","volume":"211","author":"Gutman","year":"2015","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.ijid.2021.04.081_bib0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.meegid.2005.09.001","article-title":"Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y","volume":"6","author":"Holmgren","year":"2006","journal-title":"Infect Genet Evol"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0100","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/s12936-016-1474-4","article-title":"Prevalence of crt and mdr-1 mutations in Plasmodium falciparum isolates from Grande Comore island after withdrawal of chloroquine","volume":"15","author":"Huang","year":"2016","journal-title":"Malar J"},{"issue":"3","key":"10.1016\/j.ijid.2021.04.081_bib0105","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1128\/AAC.00875-06","article-title":"Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria","volume":"51","author":"Humphreys","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"10.1016\/j.ijid.2021.04.081_bib0110","first-page":"1352","article-title":"K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa","volume":"211","author":"Kamau","year":"2015","journal-title":"J Infect Dis"},{"issue":"17","key":"10.1016\/j.ijid.2021.04.081_bib0115","doi-asserted-by":"crossref","first-page":"17142","DOI":"10.1074\/jbc.M500388200","article-title":"Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae","volume":"280","author":"Kessl","year":"2005","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.ijid.2021.04.081_bib0120","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1086\/338566","article-title":"Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria","volume":"185","author":"Kublin","year":"2002","journal-title":"J Infect Dis"},{"issue":"12","key":"10.1016\/j.ijid.2021.04.081_bib0125","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1086\/375419","article-title":"Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi","volume":"187","author":"Kublin","year":"2003","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.ijid.2021.04.081_bib0130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/cid\/cir839","article-title":"Global TravEpiNet: a national consortium of clinics providing care to international travelers--analysis of demographic characteristics, travel destinations, and pretravel healthcare of high-risk US international travelers, 2009-2011","volume":"54","author":"LaRocque","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0135","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13071-020-4005-7","article-title":"Targeted deep amplicon sequencing of kelch 13 and cytochrome b in Plasmodium falciparum isolates from an endemic African country using the Malaria Resistance Surveillance (MaRS) protocol","volume":"13","author":"L\u2019Episcopia","year":"2020","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.ijid.2021.04.081_bib0140","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.meegid.2015.08.039","article-title":"Molecular mutation profile of Pfcrt and Pfmdr1 in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea","volume":"36","author":"Li","year":"2015","journal-title":"Infect Genet Evol"},{"issue":"2","key":"10.1016\/j.ijid.2021.04.081_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056677","article-title":"Molecular diagnosis of malaria by photo-induced electron transfer fluorogenic primers: PET-PCR","volume":"8","author":"Lucchi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2021.04.081_bib0150","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.08714","article-title":"Genomic epidemiology of artemisinin resistant malaria","volume":"5","author":"MalariaGEN Plasmodium falciparum Community Project","year":"2016","journal-title":"eLife"},{"issue":"5","key":"10.1016\/j.ijid.2021.04.081_bib0155","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/infdis\/jis747","article-title":"Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms","volume":"207","author":"Malmberg","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2021.04.081_bib0160","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51015","article-title":"Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance","volume":"9","author":"Mathieu","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.ijid.2021.04.081_bib0165","first-page":"337","article-title":"Therapeutic efficacy of sulfadoxine-pyrimethamine (Fansidar\u00ae) and mutation rates to anti-folate genes in different regions of Cameroon","volume":"95S","author":"Mbacham","year":"2005","journal-title":"Acta Trop"},{"key":"10.1016\/j.ijid.2021.04.081_bib0170","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12936-016-1490-4","article-title":"Selection of N86F184D1246 haplotype of Pfmrd1 gene by artemether-lumefantrine drug pressure on Plasmodium falciparum populations in Senegal","volume":"15","author":"Mbaye","year":"2016","journal-title":"Malar J"},{"issue":"11","key":"10.1016\/j.ijid.2021.04.081_bib0175","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1128\/AAC.00623-08","article-title":"2008. Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central Africa","volume":"52","author":"McCollum","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0180","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4269\/ajtmh.2011.10-0523","volume":"85","author":"Menemedengue","year":"2011","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"10.1016\/j.ijid.2021.04.081_bib0185","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng.3189","article-title":"Genetic architecture of artemisinin-resistant Plasmodium falciparum","volume":"47","author":"Miotto","year":"2015","journal-title":"Nat Genet"},{"issue":"12","key":"10.1016\/j.ijid.2021.04.081_bib0190","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AAC.00638-09","article-title":"In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1","volume":"53","author":"Mwai","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"10.1016\/j.ijid.2021.04.081_bib0195","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.pt.2013.08.002","article-title":"Mapping\u2019 partially resistant\u2019,\u2019 fully resistant\u2019, and\u2019 super resistant\u2019 malaria","volume":"29","author":"Naidoo","year":"2013","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.ijid.2021.04.081_bib0200","series-title":"Cameroon National Malaria Control Programme. Annual report of activities 2006, Yaound\u00e9","author":"NMCP","year":"2006"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0205","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12936-020-03264-y","article-title":"Molecular assessment of kelch13 non-synonymous mutations in Plasmodium falciparum isolates from Central African Republic (2017\u20132019)","volume":"19","author":"Nzoumbou-Boko","year":"2020","journal-title":"Malar J"},{"issue":"12","key":"10.1016\/j.ijid.2021.04.081_bib0210","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1093\/infdis\/jiu349","article-title":"Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates","volume":"210","author":"Ocholla","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2021.04.081_bib0215","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1475-2875-8-89","article-title":"A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria","volume":"8","author":"Picot","year":"2009","journal-title":"Malar J"},{"issue":"2","key":"10.1016\/j.ijid.2021.04.081_bib0220","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofu059","article-title":"Novel mutation in cytochrome B of Plasmodium falciparum in one of two atovaquone-proguanil treatment failures in travelers returning from same site in Nigeria","volume":"1","author":"Plucinski","year":"2014","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0225","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40249-020-00712-4","article-title":"High multiple mutations of Plasmodium falciparum-resistant genotypes to sulphadoxine-pyrimethamine in Lagos, Nigeria","volume":"9","author":"Quan","year":"2020","journal-title":"Infect Dis Poverty"},{"issue":"6772","key":"10.1016\/j.ijid.2021.04.081_bib0230","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/35002615","article-title":"Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum","volume":"403","author":"Reed","year":"2000","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ijid.2021.04.081_bib0235","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1046\/j.1365-3156.2000.00614.x","volume":"5","author":"Ringwald","year":"2000","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.ijid.2021.04.081_bib0240","article-title":"Investigation of polymorphisms in the P. falciparum artemisinin resistance marker kelch13 in asymptomatic infections in a rural area of Cameroon","author":"Safeukui","year":"2017","journal-title":"bioRxiv"},{"issue":"4","key":"10.1016\/j.ijid.2021.04.081_bib0245","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1365-2958.2005.04729.x","article-title":"pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum","volume":"57","author":"Sidhu","year":"2005","journal-title":"Mol Microbiol"},{"issue":"6","key":"10.1016\/j.ijid.2021.04.081_bib0250","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1365-3156.2007.01843.x","article-title":"The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa","volume":"12","author":"Sisowath","year":"2007","journal-title":"Trop Med Int Health"},{"issue":"2","key":"10.1016\/j.ijid.2021.04.081_bib0255","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0166-6851(93)90050-8","article-title":"Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections","volume":"58","author":"Snounou","year":"1993","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.ijid.2021.04.081_bib0260","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1475-2875-9-247","article-title":"Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations","volume":"9","author":"Sridaran","year":"2010","journal-title":"Malar J"},{"issue":"1","key":"10.1016\/j.ijid.2021.04.081_bib0265","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12936-021-03605-5","article-title":"Low prevalence of highly sulfadoxine-resistant dihydropteroate synthase alleles in Plasmodium falciparum isolates in Benin","volume":"20","author":"Svigel","year":"2021","journal-title":"Malar J"},{"issue":"2","key":"10.1016\/j.ijid.2021.04.081_bib0270","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.actatropica.2007.04.008","article-title":"Molecular epidemiology of malaria in Cameroon. XXVII. Clinical and parasitological response to sulfadoxine-pyrimethamine treatment and Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase alleles in Cameroonian children","volume":"103","author":"Tahar","year":"2007","journal-title":"Acta Trop"},{"issue":"4","key":"10.1016\/j.ijid.2021.04.081_bib0275","doi-asserted-by":"crossref","first-page":"e02474","DOI":"10.1128\/AAC.02474-17","article-title":"Next-generation sequencing and bioinformatics protocol for malaria drug resistance marker surveillance","volume":"62","author":"Talundzic","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijid.2021.04.081_bib0280","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/1475-2875-13-472","article-title":"Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012\u20132013","volume":"13","author":"Torrentino-Madamet","year":"2014","journal-title":"Malar J"},{"issue":"25","key":"10.1016\/j.ijid.2021.04.081_bib0285","doi-asserted-by":"crossref","first-page":"13944","DOI":"10.1073\/pnas.94.25.13944","article-title":"Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum","volume":"94","author":"Triglia","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.ijid.2021.04.081_bib0290","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1038\/s41591-020-1005-2","article-title":"Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda","volume":"26","author":"Uwimana","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.ijid.2021.04.081_bib0295","series-title":"Malaria Operational Plan Cameroon\u2014President\u2019s Malaria Initiative, Yaound\u00e9","author":"USAID","year":"2017"},{"key":"10.1016\/j.ijid.2021.04.081_bib0300","doi-asserted-by":"crossref","first-page":"833","DOI":"10.4269\/ajtmh.14-0031","article-title":"Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine","volume":"91","author":"Venkatesan","year":"2014","journal-title":"Am J Trop Med Hyg"},{"issue":"12","key":"10.1016\/j.ijid.2021.04.081_bib0305","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01067-19","article-title":"No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in coastal Kenya, but a near complete reversion to chloroquine wild type parasites","volume":"63","author":"Wamae","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijid.2021.04.081_bib0310","series-title":"World malaria report, 2020","author":"WHO","year":"2020"},{"issue":"12","key":"10.1016\/j.ijid.2021.04.081_bib0315","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1128\/AAC.03494-14","article-title":"Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin","volume":"58","author":"Wurtz","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.ijid.2021.04.081_bib0320","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jmii.2017.06.009","article-title":"Updates on k13 mutant alleles for artemisinin resistance in Plasmodium falciparum","volume":"51","author":"Zaw","year":"2018","journal-title":"J Microbiol Immunol Infect"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971221003933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971221003933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:59:16Z","timestamp":1761119956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971221003933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":64,"alternative-id":["S1201971221003933"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2021.04.081","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted deep amplicon sequencing of antimalarial resistance markers in Plasmodium falciparum isolates from Cameroon","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2021.04.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}