{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:58:11Z","timestamp":1784350691064,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/27265-5"],"award-info":[{"award-number":["2017\/27265-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/21460-3"],"award-info":[{"award-number":["2018\/21460-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["433276\/2018-5"],"award-info":[{"award-number":["433276\/2018-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["429594\/2018-6"],"award-info":[{"award-number":["429594\/2018-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005286","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Mato Grosso","doi-asserted-by":"publisher","award":["FAPEMAT\/0505753\/2017"],"award-info":[{"award-number":["FAPEMAT\/0505753\/2017"]}],"id":[{"id":"10.13039\/501100005286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.177846\/2018-00"],"award-info":[{"award-number":["88887.177846\/2018-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ijid.2021.05.002","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T22:35:24Z","timestamp":1620772524000},"page":"284-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Puzzling paracoccidioidomycosis: Factors associated with the severity of Paracoccidioides lutzii infections"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-3335","authenticated-orcid":false,"given":"Andreia Ferreira","family":"Nery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-7983","authenticated-orcid":false,"given":"Zoilo Pires","family":"de Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-4563","authenticated-orcid":false,"given":"Anderson Messias","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6222-5550","authenticated-orcid":false,"given":"Tiago Ferreira","family":"Portela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-9164","authenticated-orcid":false,"given":"Hugo Dias","family":"Hoffmann-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9134-0657","authenticated-orcid":false,"given":"Breno Gon\u00e7alves","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-1860","authenticated-orcid":false,"given":"Ana Paula","family":"Possa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-2324","authenticated-orcid":false,"given":"Let\u00edcia Rossetto da Silva","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-1916","authenticated-orcid":false,"given":"Ferry","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2686-8193","authenticated-orcid":false,"given":"Rosane Christine","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2021.05.002_bib0005","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s10753-014-9978-y","article-title":"The relationship between inflammatory marker levels and pulmonary tuberculosis severity","volume":"38","author":"Abakay","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.ijid.2021.05.002_bib0010","article-title":"Environmental mapping of Paracoccidioides spp. in Brazil reveals new clues into genetic diversity, biogeography and wild host association","volume":"10","author":"Arantes","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2021.05.002_bib0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.amjcard.2014.10.008","article-title":"Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure","volume":"115","author":"Benites-Zapata","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijid.2021.05.002_bib0020","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.21037\/jtd.2019.12.63","article-title":"The complete blood count to diagnose septic shock","volume":"12","author":"Farkas","year":"2020","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.ijid.2021.05.002_bib0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.prrv.2009.08.001","article-title":"Paracoccidioidomycosis","volume":"10","author":"Ferreira","year":"2009","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.ijid.2021.05.002_bib0030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/myc.12427","article-title":"The burden of serious human fungal infections in Brazil","volume":"59","author":"Giacomazzi","year":"2016","journal-title":"Mycoses"},{"key":"10.1016\/j.ijid.2021.05.002_bib0035","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/s41372-020-0649-6","article-title":"Can we improve early identification of neonatal late-onset sepsis? A validated prediction model","volume":"40","author":"Goldberg","year":"2020","journal-title":"J Perinatol"},{"key":"10.1016\/j.ijid.2021.05.002_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03369","article-title":"Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions","volume":"6","author":"Gomes","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.ijid.2021.05.002_bib0045","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1128\/JCM.41.7.2849-2854.2003","article-title":"Randomly amplified polymorphic DNA as a valuable tool for epidemiological studies of Paracoccidioides brasiliensis","volume":"41","author":"Hahn","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijid.2021.05.002_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007437","article-title":"Clinical and epidemiological features of paracoccidioidomycosis due to Paracoccidioides lutzii","volume":"13","author":"Hahn","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2021.05.002_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046561","article-title":"The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia","volume":"7","author":"Jager","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2021.05.002_bib0060","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/oxfordjournals.molbev.a004056","article-title":"Estimation of nucleotide substitution rates in Eurotiomycete fungi","volume":"19","author":"Kasuga","year":"2002","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.ijid.2021.05.002_bib0065","doi-asserted-by":"crossref","first-page":"556","DOI":"10.4269\/ajtmh.16-0255","article-title":"Therapeutic response in adult patients with nonsevere chronic paracoccidioidomycosis treated with sulfamethoxazole\u2013trimethoprim: a retrospective study","volume":"97","author":"Nery","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijid.2021.05.002_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008485","article-title":"Comparison of clinico-epidemiological and radiological features in paracoccidioidomycosis patients regarding serological classification using antigens from Paracoccidioides brasiliensis complex and Paracoccidioides lutzii","volume":"14","author":"Pereira","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2021.05.002_bib0075","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S0074-02762009000300019","article-title":"Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006","volume":"104","author":"Prado","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.ijid.2021.05.002_bib0080","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/mmy\/myv083","article-title":"Identifying Paracoccidioides phylogenetic species by PCR-RFLP of the alpha-tubulin gene","volume":"54","author":"Roberto","year":"2016","journal-title":"Med Mycol"},{"key":"10.1016\/j.ijid.2021.05.002_bib0085","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1590\/S0102-311X2003000100027","article-title":"Association between smoking and paracoccidioidomycosis: a case-control study in the State of Esp\u00edrito Santo, Brazil","volume":"19","author":"Santos","year":"2003","journal-title":"Cad Saude Publica"},{"key":"10.1016\/j.ijid.2021.05.002_bib0090","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1080\/21505594.2015.1085277","article-title":"Comparison of virulence between Paracoccidioides brasiliensis and Paracoccidioides lutzii using Galleria mellonella as a host model","volume":"6","author":"Scorzoni","year":"2015","journal-title":"Virulence"},{"key":"10.1016\/j.ijid.2021.05.002_bib0095","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1590\/0037-8682-0230-2017","article-title":"Brazilian guidelines for the clinical management of paracoccidioidomycosis","volume":"50","author":"Shikanai-Yasuda","year":"2017","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.ijid.2021.05.002_bib0100","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ympev.2009.04.005","article-title":"Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus","volume":"52","author":"Teixeira","year":"2009","journal-title":"Mol Phylogenet Evol"},{"key":"10.1016\/j.ijid.2021.05.002_bib0105","first-page":"19","article-title":"Paracoccidioides lutzii sp. nov.: biological and clinical implications","volume":"52","author":"Teixeira","year":"2014","journal-title":"Med Mycol"},{"key":"10.1016\/j.ijid.2021.05.002_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037694","article-title":"Genus Paracoccidioides: species recognition and biogeographic aspects","volume":"7","author":"Theodoro","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2021.05.002_bib0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.fgb.2017.05.007","article-title":"Species boundaries in the human pathogen Paracoccidioides","volume":"106","author":"Turissini","year":"2017","journal-title":"Fungal Genet Biol"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971221004033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971221004033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:54:02Z","timestamp":1778799242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971221004033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":23,"alternative-id":["S1201971221004033"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2021.05.002","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Puzzling paracoccidioidomycosis: Factors associated with the severity of Paracoccidioides lutzii infections","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2021.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}