{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:06:06Z","timestamp":1787162766193,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T00:00:00Z","timestamp":1630195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["804744"],"award-info":[{"award-number":["804744"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["804744"],"award-info":[{"award-number":["804744"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ijid.2021.08.066","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T10:48:16Z","timestamp":1630752496000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Arthralgia resolution rate following chikungunya virus infection"],"prefix":"10.1016","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-5703","authenticated-orcid":false,"given":"Megan","family":"O'Driscoll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-4254","authenticated-orcid":false,"given":"Henrik","family":"Salje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen Y.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-3158","authenticated-orcid":false,"given":"Hugh","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2021.08.066_bib0001","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tmaid.2017.01.004","article-title":"Long-term sequelae of chikungunya virus disease: A systematic review","volume":"15","author":"van Aalst","year":"2017","journal-title":"Travel Med Infect Dis [Internet]"},{"issue":"2","key":"10.1016\/j.ijid.2021.08.066_bib0002","article-title":"Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings","volume":"14","author":"Anwar","year":"2020","journal-title":"PLoS Negl Trop Dis [Internet]"},{"issue":"3","key":"10.1016\/j.ijid.2021.08.066_bib0003","article-title":"Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique): A prospective cohort study","volume":"14","author":"Bertolotti","year":"2020","journal-title":"PLoS Negl Trop Dis [Internet]"},{"issue":"4","key":"10.1016\/j.ijid.2021.08.066_bib0004","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/art.40384","article-title":"Frequency of Chronic Joint Pain Following Chikungunya Virus Infection: A Colombian Cohort Study","volume":"70","author":"Chang","year":"2018","journal-title":"Arthritis Rheumatol [Internet]"},{"issue":"5","key":"10.1016\/j.ijid.2021.08.066_bib0005","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1017\/S0950268811001300","article-title":"Acute Chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study","volume":"140","author":"Chopra","year":"2012","journal-title":"Epidemiol Infect [Internet]"},{"issue":"5","key":"10.1016\/j.ijid.2021.08.066_bib0006","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/infdis\/jix312","article-title":"Long-term Chikungunya Sequelae in Cura\u00e7ao: Burden, Determinants, and a Novel Classification Tool","volume":"216","author":"Elsinga","year":"2017","journal-title":"J Infect Dis [Internet]"},{"issue":"1054","key":"10.1016\/j.ijid.2021.08.066_bib0007","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1136\/postgradmedj-2012-131477","article-title":"Prevalence of and risk factors for chronic arthralgia and rheumatoid-like polyarthritis more than 2 years after infection with chikungunya virus","volume":"89","author":"Essackjee","year":"2013","journal-title":"Postgrad Med"},{"issue":"4","key":"10.1016\/j.ijid.2021.08.066_bib0008","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3201\/eid2304.161562","article-title":"Persistent Arthralgia Associated with Chikungunya Virus Outbreak, US Virgin Islands, December 2014-February 2016","volume":"23","author":"Feldstein","year":"2017","journal-title":"Emerg Infect Dis [Internet]"},{"issue":"4","key":"10.1016\/j.ijid.2021.08.066_bib0009","article-title":"First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features","volume":"10","author":"van Genderen","year":"2016","journal-title":"PLoS Negl Trop Dis [Internet]"},{"issue":"4","key":"10.1016\/j.ijid.2021.08.066_bib0010","article-title":"Chikungunya virus infection in Aruba: Diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia","volume":"13","author":"Huits","year":"2018","journal-title":"PLoS One [Internet]"},{"issue":"8","key":"10.1016\/j.ijid.2021.08.066_bib0011","doi-asserted-by":"crossref","first-page":"e1279","DOI":"10.1371\/journal.pntd.0001279","article-title":"Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severity","volume":"5","author":"Kelvin","year":"2011","journal-title":"PLoS Negl Trop Dis [Internet]"},{"key":"10.1016\/j.ijid.2021.08.066_bib0012","article-title":"Epidemiology, clinical manifestations, and long-term outcomes of a major outbreak of chikungunya in a hamlet in sri lanka, in 2007: a longitudinal cohort study","volume":"2012","author":"Kularatne","year":"2012","journal-title":"J Trop Med [Internet]"},{"issue":"6","key":"10.1016\/j.ijid.2021.08.066_bib0013","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.trstmh.2010.01.011","article-title":"Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging","volume":"104","author":"Manimunda","year":"2010","journal-title":"Trans R Soc Trop Med Hyg [Internet]"},{"issue":"2","key":"10.1016\/j.ijid.2021.08.066_bib0014","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jcv.2012.10.019","article-title":"Chikungunya infection in Malaysia: comparison with dengue infection in adults and predictors of persistent arthralgia","volume":"56","author":"Mohd Zim","year":"2013","journal-title":"J Clin Virol [Internet]"},{"issue":"7","key":"10.1016\/j.ijid.2021.08.066_bib0015","article-title":"A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A cohort study","volume":"14","author":"de Moraes","year":"2020","journal-title":"PLoS Negl Trop Dis [Internet]"},{"issue":"2","key":"10.1016\/j.ijid.2021.08.066_bib0016","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jinf.2012.04.005","article-title":"Long-term chikungunya infection clinical manifestations after an outbreak in Italy: a prognostic cohort study","volume":"65","author":"Moro","year":"2012","journal-title":"J Infect [Internet]"},{"key":"10.1016\/j.ijid.2021.08.066_bib0017","first-page":"e72","article-title":"Persistent arthralgia and related risks factors in laboratory-confirmed cases of Chikungunya virus infection in Mexico","volume":"41","author":"Murillo-Zamora","year":"2017","journal-title":"Rev Panam Salud Publica [Internet]"},{"key":"10.1016\/j.ijid.2021.08.066_bib0018","article-title":"Prevalence of and risk factors for long-term disabilities following chikungunya virus disease: A meta-analysis","volume":"35","author":"Noor","year":"2020","journal-title":"Travel Med Infect Dis [Internet]"},{"issue":"7","key":"10.1016\/j.ijid.2021.08.066_bib0019","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/trstmh\/try063","article-title":"Chikungunya chronic disease: a systematic review and meta-analysis","volume":"112","author":"Paix\u00e3o","year":"2018","journal-title":"Trans R Soc Trop Med Hyg [Internet]"},{"issue":"2","key":"10.1016\/j.ijid.2021.08.066_bib0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/0972-9062.242561","article-title":"Chikungunya virus outbreak in Sint Maarten: Long-term arthralgia after a 15-month period","volume":"55","author":"Peters","year":"2018","journal-title":"J Vector Borne Dis [Internet]"},{"issue":"Pt 2","key":"10.1016\/j.ijid.2021.08.066_bib0021","first-page":"471","article-title":"Re-emergence of Chikungunya and O'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships","volume":"81","author":"Powers","year":"2000","journal-title":"J Gen Virol [Internet]"},{"issue":"2","key":"10.1016\/j.ijid.2021.08.066_bib0022","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3899\/jrheum.141609","article-title":"Disability with Persistent Pain Following an Epidemic of Chikungunya in Rural South India","volume":"43","author":"Rahim","year":"2016","journal-title":"J Rheumatol [Internet]"},{"key":"10.1016\/j.ijid.2021.08.066_bib0023","unstructured":"Sanyaolu A, Okorie C, Badaru O. Chikungunya Epidemiology: A Global Perspective [Internet]. [cited 2021 Apr 1] 2021. Available from: https:\/\/smjournals.com\/public-health-epidemiology\/fulltext\/smjphe-v2-1028.php"},{"issue":"3","key":"10.1016\/j.ijid.2021.08.066_bib0024","doi-asserted-by":"crossref","first-page":"e2137","DOI":"10.1371\/journal.pntd.0002137","article-title":"Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study","volume":"7","author":"Schilte","year":"2013","journal-title":"PLoS Negl Trop Dis [Internet]."},{"issue":"7","key":"10.1016\/j.ijid.2021.08.066_bib0025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.medmal.2015.05.007","article-title":"French guidelines for the management of chikungunya (acute and persistent presentations). November 2014","volume":"45","author":"Simon","year":"2015","journal-title":"Med Mal Infect [Internet]"},{"issue":"3","key":"10.1016\/j.ijid.2021.08.066_bib0026","doi-asserted-by":"crossref","first-page":"e389","DOI":"10.1371\/journal.pntd.0000389","article-title":"Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period","volume":"3","author":"Sissoko","year":"2009","journal-title":"PLoS Negl Trop Dis [Internet]."},{"issue":"3","key":"10.1016\/j.ijid.2021.08.066_bib0027","first-page":"239","article-title":"Characterization of chronic clinical manifestations in patients with chikungunya fever","volume":"56","author":"de Sosa-Mart\u00ednez","year":"2018","journal-title":"Rev Med Inst Mex Seguro Soc [Internet]"},{"issue":"6","key":"10.1016\/j.ijid.2021.08.066_bib0028","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1086\/605496","article-title":"Chikungunya fever: an epidemiological review of a re-emerging infectious disease","volume":"49","author":"Staples","year":"2009","journal-title":"Clin Infect Dis [Internet]"},{"issue":"8","key":"10.1016\/j.ijid.2021.08.066_bib0029","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3899\/jrheum.190162","article-title":"Chronic Joint Pain 3 Years after Chikungunya Virus Infection Largely Characterized by Relapsing-remitting Symptoms","volume":"47","author":"Tritsch","year":"2020","journal-title":"J Rheumatol [Internet]"},{"key":"10.1016\/j.ijid.2021.08.066_bib0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijid.2017.03.006","article-title":"Global expansion of chikungunya virus: mapping the 64-year history","volume":"58","author":"Wahid","year":"2017","journal-title":"Int J Infect Dis [Internet]"},{"issue":"5","key":"10.1016\/j.ijid.2021.08.066_bib0031","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s10067-019-04919-1","article-title":"Stiffness, pain, and joint counts in chronic chikungunya disease: relevance to disability and quality of life","volume":"39","author":"Watson","year":"2020","journal-title":"Clin Rheumatol [Internet]"},{"key":"10.1016\/j.ijid.2021.08.066_bib0032","unstructured":"World Health Organization. Chikungunya [Internet]. [cited 2021 Mar 15] 2020. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chikungunya"},{"key":"10.1016\/j.ijid.2021.08.066_bib0033","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/1471-2474-15-249","article-title":"Identification of initial severity determinants to predict arthritis after chikungunya infection in a cohort of French gendarmes","volume":"15","author":"Yaseen","year":"2014","journal-title":"BMC Musculoskelet Disord [Internet]"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971221006998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971221006998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:00:23Z","timestamp":1761120023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971221006998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":33,"alternative-id":["S1201971221006998"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2021.08.066","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arthralgia resolution rate following chikungunya virus infection","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2021.08.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}