{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:58:19Z","timestamp":1773712699153,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ijid.2022.01.022","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T10:21:01Z","timestamp":1642155661000},"page":"344-347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Positive association between the use of macrolides in food-producing animals and pneumococcal macrolide resistance: a global ecological analysis"],"prefix":"10.1016","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-8998","authenticated-orcid":false,"given":"Chris","family":"Kenyon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"S2","key":"10.1016\/j.ijid.2022.01.022_bib0001","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/jac\/dkf504","article-title":"Antibiotic consumption and resistance selection in Streptococcus pneumoniae","volume":"50","author":"Baquero","year":"2002","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"10.1016\/j.ijid.2022.01.022_bib0002","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1128\/AAC.00234-06","article-title":"Macrolide and azithromycin use are linked to increased macrolide resistance in Streptococcus pneumoniae","volume":"50","author":"Bergman","year":"2006","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"4","key":"10.1016\/j.ijid.2022.01.022_bib0003","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/jac\/dku525","article-title":"Exploring the association between resistance and outpatient antibiotic use expressed as DDDs or packages","volume":"70","author":"Bruyndonckx","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijid.2022.01.022_bib0004","first-page":"358","article-title":"Risk assessment for antibiotic resistance in South East Asia","author":"Chereau","year":"2017","journal-title":"Bmj"},{"issue":"3","key":"10.1016\/j.ijid.2022.01.022_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116746","article-title":"Antimicrobial resistance: the major contribution of poor governance and corruption to this growing problem","volume":"10","author":"Collignon","year":"2015","journal-title":"PloS one"},{"issue":"9","key":"10.1016\/j.ijid.2022.01.022_bib0006","doi-asserted-by":"crossref","first-page":"e398","DOI":"10.1016\/S2542-5196(18)30186-4","article-title":"Anthropological and socioeconomic factors contributing to global antimicrobial resistance: a univariate and multivariable analysis","volume":"2","author":"Collignon","year":"2018","journal-title":"The Lancet Planetary Health"},{"issue":"7","key":"10.1016\/j.ijid.2022.01.022_bib0007","volume":"15","year":"2017","journal-title":"Efsa J"},{"issue":"4","key":"10.1016\/j.ijid.2022.01.022_bib0008","article-title":"The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2018\/2019","volume":"19","year":"2021","journal-title":"Efsa J"},{"issue":"1","key":"10.1016\/j.ijid.2022.01.022_bib0009","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1128\/JCM.40.1.159-164.2002","article-title":"Importance of local variations in antibiotic consumption and geographical differences of erythromycin and penicillin resistance in Streptococcus pneumoniae","volume":"40","author":"Garcia-Rey","year":"2002","journal-title":"J Clin Microbiol"},{"issue":"9459","key":"10.1016\/j.ijid.2022.01.022_bib0010","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(05)17907-0","article-title":"Outpatient antibiotic use in Europe and association with resistance: a cross-national database study","volume":"365","author":"Goossens","year":"2005","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ijid.2022.01.022_bib0011","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01918-14","article-title":"Selection of a multidrug resistance plasmid by sublethal levels of antibiotics and heavy metals","volume":"5","author":"Gullberg","year":"2014","journal-title":"MBio"},{"issue":"7","key":"10.1016\/j.ijid.2022.01.022_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002158","article-title":"Selection of resistant bacteria at very low antibiotic concentrations","volume":"7","author":"Gullberg","year":"2011","journal-title":"PLoS Pathog"},{"issue":"7","key":"10.1016\/j.ijid.2022.01.022_bib0013","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/cid\/cir443","article-title":"Active Bacterial Core Surveillance T. Outpatient antibiotic prescribing and nonsusceptible Streptococcus pneumoniae in the United States, 1996-2003","volume":"53","author":"Hicks","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2022.01.022_bib0014","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jgar.2016.08.010","article-title":"Alarming regional differences in prevalence and antimicrobial susceptibility of group B streptococci in pregnant women: A systematic review and meta-analysis","volume":"7","author":"Huang","year":"2016","journal-title":"Journal of global antimicrobial resistance"},{"issue":"1","key":"10.1016\/j.ijid.2022.01.022_bib0015","doi-asserted-by":"crossref","first-page":"15777","DOI":"10.1038\/s41598-020-72324-9","article-title":"Occurrence, distribution, and health risk assessment of quinolone antibiotics in water, sediment, and fish species of Qingshitan reservoir, South China","volume":"10","author":"Huang","year":"2020","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.ijid.2022.01.022_bib0016","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1099\/jmm.0.000885","article-title":"Prevalence of macrolide resistance in Treponema pallidum is associated with macrolide consumption","volume":"68","author":"Kenyon","year":"2019","journal-title":"J Med Microbiol"},{"issue":"10","key":"10.1016\/j.ijid.2022.01.022_bib0017","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3390\/antibiotics10101193","article-title":"Positive Association between the Use of Quinolones in Food Animals and the Prevalence of Fluoroquinolone Resistance in E. coli and K. pneumoniae, A. baumannii and P. aeruginosa: A Global Ecological Analysis","volume":"10","author":"Kenyon","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.ijid.2022.01.022_bib0018","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fmed.2018.00329","article-title":"Antimicrobial consumption and susceptibility of Neisseria gonorrhoeae: a global ecological analysis","volume":"5","author":"Kenyon","year":"2018","journal-title":"Frontiers in medicine"},{"issue":"3","key":"10.1016\/j.ijid.2022.01.022_bib0019","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1128\/AAC.05658-11","article-title":"Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study","volume":"56","author":"Kim","year":"2012","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"15","key":"10.1016\/j.ijid.2022.01.022_bib0020","doi-asserted-by":"crossref","first-page":"E3463","DOI":"10.1073\/pnas.1717295115","article-title":"Global increase and geographic convergence in antibiotic consumption between 2000 and 2015","volume":"115","author":"Klein","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"51","key":"10.1016\/j.ijid.2022.01.022_bib0021","doi-asserted-by":"crossref","first-page":"12896","DOI":"10.1073\/pnas.1721095115","article-title":"Impact of existing vaccines in reducing antibiotic resistance: Primary and secondary effects","volume":"115","author":"Klugman","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.ijid.2022.01.022_bib0022","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/cid\/ciz294","article-title":"Mycoplasma genitalium in symptomatic male urethritis: macrolide use is associated with increased resistance","volume":"70","author":"Li","year":"2020","journal-title":"Clinical Infectious Diseases"},{"issue":"7","key":"10.1016\/j.ijid.2022.01.022_bib0023","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/319604","article-title":"Measuring and interpreting associations between antibiotic use and penicillin resistance in Streptococcus pneumoniae","volume":"32","author":"Lipsitch","year":"2001","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.ijid.2022.01.022_bib0024","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.envpol.2017.01.003","article-title":"Usage, residue, and human health risk of antibiotics in Chinese aquaculture: A review","volume":"223","author":"Liu","year":"2017","journal-title":"Environ Pollut"},{"key":"10.1016\/j.ijid.2022.01.022_bib0025","first-page":"358","article-title":"Antibiotic residues in the environment of South East Asia","author":"Lundborg","year":"2017","journal-title":"Bmj"},{"issue":"9560","key":"10.1016\/j.ijid.2022.01.022_bib0026","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0140-6736(07)60235-9","article-title":"Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study","volume":"369","author":"Malhotra-Kumar","year":"2007","journal-title":"The Lancet"},{"key":"10.1016\/j.ijid.2022.01.022_bib0027","unstructured":"McGee L, Klugman P. Resistance in Streptococcus pneumoniae. In: Mayers DL, Sobel JD, Ouellette M, Kaye KS, Marchaim D, editors. Antimicrobial drug resistance: Clinical and epidemiological aspects. 2: Springer; 2017."},{"key":"10.1016\/j.ijid.2022.01.022_bib0028","article-title":"Antibiotic residues and resistance in the environment","author":"Pikkemaat","year":"2016","journal-title":"RIKILT Wageningen UR;"},{"key":"10.1016\/j.ijid.2022.01.022_bib0029","first-page":"41","article-title":"Antimicrobial resistance control in Asia","author":"Song","year":"2015","journal-title":"AMR control"},{"issue":"6","key":"10.1016\/j.ijid.2022.01.022_bib0030","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1128\/AAC.48.6.2101-2107.2004","article-title":"High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)","volume":"48","author":"Song","year":"2004","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"9","key":"10.1016\/j.ijid.2022.01.022_bib0031","article-title":"Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis (vol, pg e316, 017)","volume":"1","author":"Tang","year":"2017","journal-title":"Lancet Planetary Health"},{"key":"10.1016\/j.ijid.2022.01.022_bib0032","series-title":"ResistanceMap: Antibiotic resistance","year":"2021"},{"issue":"6358","key":"10.1016\/j.ijid.2022.01.022_bib0033","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aao1495","article-title":"Reducing antimicrobial use in food animals","volume":"357","author":"Van Boeckel","year":"2017","journal-title":"Science"},{"issue":"4-5","key":"10.1016\/j.ijid.2022.01.022_bib0034","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.drup.2011.07.001","article-title":"Epidemiology and characteristics of antimicrobial resistance in China","volume":"14","author":"Xiao","year":"2011","journal-title":"Drug resistance updates"},{"key":"10.1016\/j.ijid.2022.01.022_bib0035","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13756-019-0654-8","article-title":"Antimicrobial Resistance in the Asia Pacific region: a meeting report","volume":"8","author":"Yam","year":"2019","journal-title":"Antimicrob Resist Infect Control"},{"issue":"2","key":"10.1016\/j.ijid.2022.01.022_bib0036","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1128\/AAC.04308-14","article-title":"Macrolide-resistant Mycoplasma pneumoniae in adults in Zhejiang, China","volume":"59","author":"Zhou","year":"2015","journal-title":"Antimicrobial agents and chemotherapy"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971222000236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971222000236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:08:43Z","timestamp":1761120523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971222000236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":36,"alternative-id":["S1201971222000236"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2022.01.022","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positive association between the use of macrolides in food-producing animals and pneumococcal macrolide resistance: a global ecological analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2022.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}