{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:13:55Z","timestamp":1792844035422,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ijid.2022.03.034","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T01:29:15Z","timestamp":1648085355000},"page":"130-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"119","author":[{"given":"Ah Young","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-4470","authenticated-orcid":false,"given":"Wongi","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-9948","authenticated-orcid":false,"given":"Dong Keon","family":"Yon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-5208","authenticated-orcid":false,"given":"Seung Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Won","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0964-1467","authenticated-orcid":false,"given":"Seoyeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-5004","authenticated-orcid":false,"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2115-7835","authenticated-orcid":false,"given":"Min Seo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-9510","authenticated-orcid":false,"given":"Sungsoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Il","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-9833","authenticated-orcid":false,"given":"Lee","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2022.03.034_bib0001","doi-asserted-by":"crossref","DOI":"10.1111\/jth.15493","article-title":"Comparison of adverse drug reactions among four COVID-19 vaccines in Europe using the EudraVigilance database: Thrombosis at unusual sites","author":"Abbattista","year":"2021","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ijid.2022.03.034_bib0002","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejim.2021.05.026","article-title":"SARS-CoV-2 vaccine-induced cerebral venous thrombosis","volume":"89","author":"Ciccone","year":"2021","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ijid.2022.03.034_bib0003","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1056\/NEJMe2106315","article-title":"SARS-CoV-2 Vaccine\u2013Induced Immune Thrombotic Thrombocytopenia","volume":"384","author":"Cines","year":"2021","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ijid.2022.03.034_bib0004","unstructured":"COVID-19 Map. Johns Hopkins Coronavirus Resource Center 2021. https:\/\/coronavirus.jhu.edu\/map.html (accessed October 1, 2021)."},{"key":"10.1016\/j.ijid.2022.03.034_bib0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-Analysis in Clinical Trials Revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.ijid.2022.03.034_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2021.102663","article-title":"Perspectives on vaccine induced thrombotic thrombocytopenia","volume":"121","author":"Dotan","year":"2021","journal-title":"J Autoimmun"},{"key":"10.1016\/j.ijid.2022.03.034_bib0007","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.therap.2021.05.007","article-title":"Atypical thrombosis associated with VaxZevria\u00ae (AstraZeneca) vaccine: Data from the French Network of Regional Pharmacovigilance Centres","volume":"76","author":"Gras-Champel","year":"2021","journal-title":"Therapie"},{"key":"10.1016\/j.ijid.2022.03.034_bib0008","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1056\/NEJMoa2104840","article-title":"Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination","volume":"384","author":"Greinacher","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2022.03.034_bib0009","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.ijid.2022.03.034_bib0010","doi-asserted-by":"crossref","first-page":"n1931","DOI":"10.1136\/bmj.n1931","article-title":"Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study","author":"Hippisley-Cox","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ijid.2022.03.034_bib0011","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2021.36.e197","article-title":"Predicted and Observed Incidence of Thromboembolic Events among Koreans Vaccinated with ChAdOx1 nCoV-19 Vaccine","volume":"36","author":"Huh","year":"2021","journal-title":"Journal of Korean Medical Science"},{"key":"10.1016\/j.ijid.2022.03.034_bib0012","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1309\/AJCPG0MNR5NGKNFX","article-title":"Platelet factor 4\/heparin antibodies in blood bank donors","volume":"134","author":"Hursting","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ijid.2022.03.034_bib0013","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-021-03744-4","article-title":"Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia","volume":"596","author":"Huynh","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ijid.2022.03.034_bib0014","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehab592","article-title":"Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score","author":"Hwang","year":"2021","journal-title":"European Heart Journal"},{"key":"10.1016\/j.ijid.2022.03.034_bib0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1159\/000509802","article-title":"Cerebral Venous Thrombosis: A Comprehensive Review","volume":"83","author":"Idiculla","year":"2020","journal-title":"Eur Neurol"},{"key":"10.1016\/j.ijid.2022.03.034_bib0016","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/EDE.0b013e31821b506e","article-title":"The false-positive to false-negative ratio in epidemiologic studies","volume":"22","author":"Ioannidis","year":"2011","journal-title":"Epidemiology"},{"key":"10.1016\/j.ijid.2022.03.034_bib0017","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1182\/blood-2013-01-478966","article-title":"Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4","volume":"122","author":"Jaax","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.ijid.2022.03.034_bib0018","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/S0002-9149(00)00766-9","article-title":"Risk of pulmonary embolism and\/or deep venous thrombosis in Asian-Americans","volume":"85","author":"Klatsky","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijid.2022.03.034_bib0019","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1111\/ene.15029","article-title":"Post-SARS-CoV-2-vaccination cerebral venous sinus thrombosis: an analysis of cases notified to the European Medicines Agency","volume":"28","author":"Krzywicka","year":"2021","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.ijid.2022.03.034_bib0020","doi-asserted-by":"crossref","first-page":"820","DOI":"10.7326\/0003-4819-127-9-199711010-00008","article-title":"Quantitative synthesis in systematic reviews","volume":"127","author":"Lau","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijid.2022.03.034_bib0021","doi-asserted-by":"crossref","first-page":"e12529","DOI":"10.1002\/rth2.12529","article-title":"Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)","volume":"5","author":"Makris","year":"2021","journal-title":"Research and Practice in Thrombosis and Haemostasis"},{"key":"10.1016\/j.ijid.2022.03.034_bib0022","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/STROKEAHA.110.602672","article-title":"Genes associated with adult cerebral venous thrombosis","volume":"42","author":"Marjot","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.ijid.2022.03.034_bib0023","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1056\/NEJMoa2109908","article-title":"Clinical Features of Vaccine-Induced Immune Thrombocytopenia and Thrombosis","volume":"385","author":"Pavord","year":"2021","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ijid.2022.03.034_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(21)01608-1","article-title":"Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study","author":"Perry","year":"2021","journal-title":"The Lancet"},{"key":"10.1016\/j.ijid.2022.03.034_bib0025","doi-asserted-by":"crossref","first-page":"n1114","DOI":"10.1136\/bmj.n1114","article-title":"Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study","volume":"373","author":"Potteg\u00e5rd","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ijid.2022.03.034_bib0026","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.15585\/mmwr.mm7032e4","article-title":"Use of COVID-19 Vaccines After Reports of Adverse Events Among Adult Recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 Vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices \u2014 United States, July 2021","volume":"70","author":"Rosenblum","year":"2021","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.ijid.2022.03.034_bib0027","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1001\/jamaneurol.2021.3619","article-title":"Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia","volume":"78","author":"S\u00e1nchez van Kammen","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.ijid.2022.03.034_bib0028","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1001\/jama.2021.9889","article-title":"Frequency of Thrombocytopenia and Platelet Factor 4\/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic","volume":"326","author":"S\u00e1nchez van Kammen","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.ijid.2022.03.034_bib0029","doi-asserted-by":"crossref","unstructured":"Schultz NH, S\u00f8rvoll IH, Michelsen AE, Munthe LA, Lund-Johansen F, Ahlen MT, et\u00a0al. Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination. N Engl J Med 2021;384:2124\u201330. doi:10.1056\/NEJMoa2104882.","DOI":"10.1056\/NEJMoa2104882"},{"key":"10.1016\/j.ijid.2022.03.034_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/ana.26172","article-title":"COVID-19 Vaccine-Associated Cerebral Venous Thrombosis in Germany","author":"Schulz","year":"2021","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ijid.2022.03.034_bib0031","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1056\/NEJMoa2105385","article-title":"Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination","volume":"384","author":"Scully","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2022.03.034_bib0032","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1001\/jama.2021.7517","article-title":"US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021","volume":"325","author":"See","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.ijid.2022.03.034_bib0033","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/cmi.2017.151","article-title":"Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction","volume":"15","author":"Segal","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.ijid.2022.03.034_bib0034","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1093\/ehjcvp\/pvab036","article-title":"Incidence of cerebral venous thrombosis and COVID-19 vaccination: possible causal effect or just chance?","volume":"7","author":"de Simone","year":"2021","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1016\/j.ijid.2022.03.034_bib0035","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s41591-021-01408-4","article-title":"First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland","volume":"27","author":"Simpson","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.ijid.2022.03.034_bib0036","doi-asserted-by":"crossref","DOI":"10.1002\/ajh.25829","article-title":"Hematological findings and complications of COVID-19","author":"Terpos","year":"2020","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ijid.2022.03.034_bib0037","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1182\/blood.2021011958","article-title":"Prothrombotic immune thrombocytopenia after COVID-19 vaccination","volume":"138","author":"Tiede","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.ijid.2022.03.034_bib0038","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1055\/s-0040-1717078","article-title":"Characterization of New Monoclonal PF4-Specific Antibodies as Useful Tools for Studies on Typical and Autoimmune Heparin-Induced Thrombocytopenia","volume":"121","author":"Vayne","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ijid.2022.03.034_bib0039","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0140-6736(20)32661-1","article-title":"Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomized controlled trials in Brazil, South Africa, and the UK","volume":"397","author":"Voysey","year":"2021","journal-title":"Lancet"}],"updated-by":[{"DOI":"10.1016\/j.ijid.2022.08.025","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000}}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971222001710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971222001710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T14:30:46Z","timestamp":1715437846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971222001710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":39,"alternative-id":["S1201971222001710"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2022.03.034","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ijid.2022.08.025","asserted-by":"object"}]},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2022.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}