{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:05:10Z","timestamp":1791925510147,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.ijid.2023.04.003","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T21:07:21Z","timestamp":1680815241000},"page":"173-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Determinants of poor clinical outcome in patients with influenza pneumonia: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"131","author":[{"given":"Javier","family":"Arranz-Herrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Presa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-5193","authenticated-orcid":false,"given":"Sergio","family":"Rius-Rocabert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-8410","authenticated-orcid":false,"given":"Alberto","family":"Utrero-Rico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 \u00c1ngel","family":"Arranz-Arija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-3817","authenticated-orcid":false,"given":"Antonio","family":"Lalueza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M","family":"Escribese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Ochando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-5199","authenticated-orcid":false,"given":"Vicente","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-8833","authenticated-orcid":false,"given":"Estanislao","family":"Nistal-Villan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2023.04.003_bib0001","first-page":"1","article-title":"Deaths: final data for 2019","volume":"70","author":"Xu","year":"2021","journal-title":"Natl Vital Stat Rep"},{"key":"10.1016\/j.ijid.2023.04.003_bib0002","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrmicro3231","article-title":"The co-pathogenesis of influenza viruses with bacteria in the lung","volume":"12","author":"McCullers","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ijid.2023.04.003_bib0003","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/infdis\/jis415","article-title":"Mortality attributable to 9 common infections: significant effect of influenza A, respiratory syncytial virus, influenza B, Norovirus, and parainfluenza in elderly persons","volume":"206","author":"van Asten","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2023.04.003_bib0004","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/CMR.00058-05","article-title":"Insights into the interaction between influenza virus and pneumococcus","volume":"19","author":"McCullers","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijid.2023.04.003_bib0005","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1086\/591708","article-title":"Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness","volume":"198","author":"Morens","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2023.04.003_bib0006","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0140-6736(59)92351-7","article-title":"Gas-analytical studies in severe pneumonia; observations during the 1957 influenza epidemic","volume":"1","author":"Herzog","year":"1959","journal-title":"Lancet"},{"key":"10.1016\/j.ijid.2023.04.003_bib0007","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/rmv.689","article-title":"Pandemic influenza: certain uncertainties","volume":"21","author":"Morens","year":"2011","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.ijid.2023.04.003_bib0008","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s13054-019-2539-x","article-title":"Influenza virus-related critical illness: pathophysiology and epidemiology","volume":"23","author":"Kalil","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.ijid.2023.04.003_bib0009","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1097\/01.inf.0000108197.81270.35","article-title":"Respiratory viruses predisposing to bacterial infections: role of neuraminidase","volume":"23","author":"Peltola","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ijid.2023.04.003_bib0010","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1128\/iai.35.1.350-355.1982","article-title":"Depression of monocyte and polymorphonuclear leukocyte oxidative metabolism and bactericidal capacity by influenza A virus","volume":"35","author":"Abramson","year":"1982","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2023.04.003_bib0011","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198902093200606","article-title":"Tissue destruction by neutrophils","volume":"320","author":"Weiss","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2023.04.003_bib0012","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1086\/318536","article-title":"Proinflammatory interactions of pneumolysin with human neutrophils","volume":"183","author":"Cockeran","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2023.04.003_bib0013","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1097\/CCM.0b013e3182416f23","article-title":"Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States","volume":"40","author":"Rice","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ijid.2023.04.003_bib0014","first-page":"327","article-title":"Secondary bacterial infections in influenza virus infection pathogenesis","volume":"385","author":"Smith","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.ijid.2023.04.003_bib0015","doi-asserted-by":"crossref","first-page":"e8540","DOI":"10.1371\/journal.pone.0008540","article-title":"Streptococcus pneumoniae Coinfection is correlated with the severity of H1N1 pandemic influenza","volume":"4","author":"Palacios","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2023.04.003_bib0016","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(09)61203-4","article-title":"Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates","volume":"374","author":"Watt","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ijid.2023.04.003_bib0017","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1056\/NEJMoa0904252","article-title":"Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico","volume":"361","author":"Perez-Padilla","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2023.04.003_bib0018","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1056\/NEJMoa0903810","article-title":"Emergence of a novel swine-origin influenza A (H1N1) virus in humans","volume":"360","author":"Dawood","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2023.04.003_bib0019","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1001\/jama.2009.1583","article-title":"Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California","volume":"302","author":"Louie","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.ijid.2023.04.003_bib0020","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.medcli.2016.02.025","article-title":"The PRISMA statement extension for systematic reviews incorporating network meta-analysis: PRISMA-NMA","volume":"147","author":"Hutton","year":"2016","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.ijid.2023.04.003_bib0021","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/irv.12398","article-title":"The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis","volume":"10","author":"Klein","year":"2016","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.ijid.2023.04.003_bib0022","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s11739-022-02957-3","article-title":"Use of antibiotics in respiratory viral infections","volume":"17","author":"Fern\u00e1ndez-Montero","year":"2022","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.ijid.2023.04.003_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180920","article-title":"Characteristics and outcomes of a cohort hospitalized for pandemic and seasonal influenza in Germany based on nationwide inpatient data","volume":"12","author":"von der Beck","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2023.04.003_bib0024","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1741-7015-10-162","article-title":"The age distribution of mortality due to influenza: pandemic and peri-pandemic","volume":"10","author":"Reichert","year":"2012","journal-title":"BMC Med"},{"key":"10.1016\/j.ijid.2023.04.003_bib0025","first-page":"339","article-title":"Microscopic and baceriologic analysis of expectorated sputum","volume":"50","author":"Murray","year":"1975","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ijid.2023.04.003_bib0026","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11739-021-02824-7","article-title":"Bacterial infections in patients hospitalized with COVID-19","volume":"17","author":"Moreno-Torres","year":"2022","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.ijid.2023.04.003_bib0027","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1086\/338238","article-title":"Polymerase chain reaction is more sensitive than viral culture and antigen testing for the detection of respiratory viruses in adults with hematological cancer and pneumonia","volume":"34","author":"van Elden","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2023.04.003_bib0028","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1038\/s41467-020-16429-9","article-title":"Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection","volume":"11","author":"Kaul","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijid.2023.04.003_bib0029","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40168-017-0386-z","article-title":"Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis","volume":"6","author":"Yildiz","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.ijid.2023.04.003_bib0030","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.eimc.2014.10.019","article-title":"Validity of procalcitonin for the diagnosis of bacterial infection in elderly patients","volume":"33","author":"G\u00f3mez-Cerquera","year":"2015","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.ijid.2023.04.003_bib0031","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.3389\/fimmu.2018.01843","article-title":"Influenza in asthmatics: for better or for worse?","volume":"9","author":"Veerapandian","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijid.2023.04.003_bib0032","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/all.14972","article-title":"Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19","volume":"77","author":"Eggert","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.ijid.2023.04.003_bib0033","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00002093-199809000-00004","article-title":"Mortality associated with an influenza outbreak on a dementia care unit","volume":"12","author":"Brandeis","year":"1998","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.ijid.2023.04.003_bib0034","series-title":"Expert Panel Report 3: Guidelines for the diagnosis and management of asthma","year":"2007"},{"key":"10.1016\/j.ijid.2023.04.003_bib0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41590-019-0568-x","article-title":"Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection","volume":"21","author":"Aegerter","year":"2020","journal-title":"Nat Immunol"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971223001352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971223001352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:11:14Z","timestamp":1761120674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971223001352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":35,"alternative-id":["S1201971223001352"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2023.04.003","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determinants of poor clinical outcome in patients with influenza pneumonia: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2023.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}