{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:30:54Z","timestamp":1792740654316,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ijid.2024.107371","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T08:19:40Z","timestamp":1734596380000},"page":"107371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Marburg virus reaches Rwanda: how close are we to a vaccine solution?"],"prefix":"10.1016","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-3883","authenticated-orcid":false,"given":"Olivier","family":"Sibomana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6741-5508","authenticated-orcid":false,"given":"Clyde Moono","family":"Hakayuwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1341-1535","authenticated-orcid":false,"given":"Jildas","family":"Munyantore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2024.107371_bib0001","series-title":"StatPearls","article-title":"Marburg Fever","author":"Hunter","year":"2024"},{"issue":"8","key":"10.1016\/j.ijid.2024.107371_bib0002","doi-asserted-by":"crossref","first-page":"e980","DOI":"10.1002\/iid3.980","article-title":"First-ever marburg virus disease outbreak in equatorial guinea and Tanzania: an imminent crisis in West and East Africa","volume":"11","author":"Sibomana","year":"2023","journal-title":"Immun Inflamm Dis"},{"issue":"8034","key":"10.1016\/j.ijid.2024.107371_bib0003","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/d41586-024-03275-8","article-title":"Lethal Marburg virus is on the rise in Rwanda: why scientists are worried","volume":"634","author":"Sidik","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ijid.2024.107371_bib0004","unstructured":"CDC. Fact Sheet: Facts on Marburg. Accessed: Oct. 17, 2024. [Online]. Available: https:\/\/www.cdc.gov\/marburg\/communication-resources\/Facts-on-Marburg.html"},{"issue":"8","key":"10.1016\/j.ijid.2024.107371_bib0005","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.3201\/eid2508.190268","article-title":"Marburgvirus in Egyptian Fruit Bats, Zambia","volume":"25","author":"Kajihara","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ijid.2024.107371_bib0006","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijid.2020.07.042","article-title":"Marburg virus disease: A summary for clinicians","volume":"99","author":"Kortepeter","year":"2020","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2024.107371_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1239079","article-title":"Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges","volume":"14","author":"Srivastava","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijid.2024.107371_bib0008","unstructured":"CDC. Marburg outbreak in Rwanda situation summary. Accessed: Oct. 17, 2024. [Online]. Available: https:\/\/www.cdc.gov\/marburg\/situation-summary\/index.html"},{"key":"10.1016\/j.ijid.2024.107371_bib0009","unstructured":"WHO. Marburg virus disease \u2013Rwanda. Accessed: Oct. 17, 2024. [Online]. Available: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2024-DON539"},{"issue":"8034","key":"10.1016\/j.ijid.2024.107371_bib0010","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/d41586-024-03328-y","article-title":"Rwanda's seven steps in seven days for managing Marburg virus","volume":"634","author":"Rwagasore","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ijid.2024.107371_bib0011","unstructured":"WHO. Weekly operational update on response to Marburg virus disease in Rwanda. Accessed: Oct. 17, 2024. [Online]. Available: https:\/\/www.afro.who.int\/countries\/rwanda\/publication\/weekly-operational-update-response-marburg-virus-disease-rwanda."},{"issue":"10","key":"10.1016\/j.ijid.2024.107371_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010805","article-title":"An introduction to the Marburg virus vaccine consortium, MARVAC","volume":"18","author":"Cross","year":"2022","journal-title":"PLoS Pathogens"},{"issue":"7","key":"10.1016\/j.ijid.2024.107371_bib0013","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.3390\/pharmaceutics15071972","article-title":"Recent advancement in mRNA vaccine development and applications","volume":"15","author":"Fayez","year":"2023","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.ijid.2024.107371_bib0014","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41577-018-0005-7","article-title":"Nonhuman primate models of human viral infections","volume":"18","author":"Estes","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"10.1016\/j.ijid.2024.107371_bib0015","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.3390\/vaccines9121490","article-title":"Vaccine technologies and platforms for infectious diseases: current progress, challenges, and opportunities","volume":"9","author":"Ghattas","year":"2021","journal-title":"Vaccines"},{"issue":"9","key":"10.1016\/j.ijid.2024.107371_bib0016","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1080\/21645515.2021.1911204","article-title":"COVID-19 vaccine platforms: delivering on a promise?","volume":"17","author":"Verdecia","year":"2021","journal-title":"Human Vaccines Immunother"},{"key":"10.1016\/j.ijid.2024.107371_bib0017","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40794-022-00176-4","article-title":"Vaccines platforms and COVID-19: what you need to know","volume":"8","author":"Acosta-Coley","year":"2022","journal-title":"Tropical Dis, Travel Med Vaccines"},{"key":"10.1016\/j.ijid.2024.107371_bib0018","unstructured":"WHO. WHO technical advisory group \u2013candidate vaccine prioritization. Accessed: Oct. 17, 2024. [Online]. Available: https:\/\/cdn.who.int\/media\/docs\/default-source\/blue-print\/who-tag-cvp-report-marburg-trial-for-tag-cvp-review.pdf."},{"issue":"4","key":"10.1016\/j.ijid.2024.107371_bib0019","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s11262-017-1455-x","article-title":"Ebola and Marburg virus vaccines","volume":"53","author":"Reynolds","year":"2019","journal-title":"Virus Genes"},{"key":"10.1016\/j.ijid.2024.107371_bib0020","doi-asserted-by":"crossref","first-page":"703986","DOI":"10.3389\/fimmu.2021.703986","article-title":"Recombinant protein filovirus vaccines protect cynomolgus macaques from Ebola, Sudan, and Marburg viruses","volume":"12","author":"Lehrer","year":"2021","journal-title":"Front. Immunol"},{"issue":"2","key":"10.1016\/j.ijid.2024.107371_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192312","article-title":"A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates","volume":"13","author":"Callendret","year":"2018","journal-title":"PLOS ONE"},{"key":"10.1016\/j.ijid.2024.107371_bib0022","article-title":"Rapid and durable protection against Marburg virus with a single-shot ChAd3-MARV GP vaccine","author":"Hunegnaw","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.ijid.2024.107371_bib0023","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.3389\/fimmu.2018.03071","article-title":"Protection Against Marburg Virus Using a Recombinant VSV-Vaccine Depends on T and B Cell Activation","volume":"9","author":"Marzi","year":"2019","journal-title":"Front. Immunol"},{"issue":"5","key":"10.1016\/j.ijid.2024.107371_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010433","article-title":"A highly attenuated Vesiculovax vaccine rapidly protects nonhuman primates against lethal Marburg virus challenge","volume":"16","author":"Woolsey","year":"2022","journal-title":"PLOS Neglected Tropical Dis"},{"issue":"3","key":"10.1016\/j.ijid.2024.107371_bib0025","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01190-17","article-title":"Single-dose trivalent Vesiculovax vaccine protects macaques from lethal ebolavirus and Marburgvirus challenge","volume":"92","author":"Matassov","year":"2018","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.ijid.2024.107371_bib0026","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI131958","article-title":"Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death","volume":"130","author":"Cross","year":"2020","journal-title":"J Clin Invest"},{"issue":"10373","key":"10.1016\/j.ijid.2024.107371_bib0027","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0140-6736(22)02400-X","article-title":"Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial","volume":"401","author":"Hamer","year":"2023","journal-title":"The Lancet"},{"key":"10.1016\/j.ijid.2024.107371_bib0028","unstructured":"Sabin Vaccine Institute. Sabin vaccine institute delivers Marburg vaccines to combat outbreak in Rwanda, Sabin Vaccine Institute. Accessed: Oct. 17, 2024. [Online]. Available: https:\/\/www.sabin.org\/resources\/sabin-vaccine-institute-delivers-marburg-vaccines-to-combat-outbreak-in-rwanda\/."},{"issue":"19","key":"10.1016\/j.ijid.2024.107371_bib0029","doi-asserted-by":"crossref","first-page":"10386","DOI":"10.1128\/JVI.00594-10","article-title":"Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates","volume":"84","author":"Geisbert","year":"2010","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.ijid.2024.107371_bib0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/viro.1998.9367","article-title":"Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates","volume":"251","author":"Hevey","year":"1998","journal-title":"Virology"},{"issue":"10","key":"10.1016\/j.ijid.2024.107371_bib0031","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1080\/21645515.2019.1651140","article-title":"Vaccines against Ebola virus and Marburg virus: recent advances and promising candidates","volume":"15","author":"Suschak","year":"2019","journal-title":"Human Vaccines Immunother"},{"key":"10.1016\/j.ijid.2024.107371_bib0032","unstructured":"CDC. About Marburg, Marburg Virus Disease. Accessed: Oct. 17, 2024. [Online]. Available: https:\/\/www.cdc.gov\/marburg\/about\/index.html"},{"key":"10.1016\/j.ijid.2024.107371_bib0033","unstructured":"WHO. Marburg virus disease strategic preparedness and response plan for Rwanda. Accessed: Oct. 17, 2024. [Online]. Available: https:\/\/www.who.int\/publications\/m\/item\/marburg-virus-disease-global-strategic-preparedness-and-response-plan-for-rwanda."}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971224004466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971224004466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T11:23:43Z","timestamp":1742037823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971224004466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":33,"alternative-id":["S1201971224004466"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2024.107371","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Marburg virus reaches Rwanda: how close are we to a vaccine solution?","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2024.107371","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"107371"}}