{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T04:14:59Z","timestamp":1742098499305,"version":"3.38.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000968","name":"Department of Communities, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001731","name":"Danida Fellowship Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005369","name":"Ministry of Foreign Affairs of Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005369","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ijid.2025.107804","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T21:42:16Z","timestamp":1738186936000},"page":"107804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Wider antibody breadth against multiple Plasmodium falciparum antigens is associated with reduced risk of malaria in a transmission hotspot in southern Ghana"],"prefix":"10.1016","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-1885","authenticated-orcid":false,"given":"Eric","family":"Kyei-Baafour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-9985","authenticated-orcid":false,"given":"Kwadwo Asamoah","family":"Kusi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice","family":"Owusu-Yeboa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quratul-Ain","family":"Issahaque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selassie","family":"Kumordjie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fareed K.N.","family":"Authur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duah","family":"Dwomoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susheel Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dodoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Theisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-2137","authenticated-orcid":false,"given":"Bright","family":"Adu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2025.107804_bib0001","doi-asserted-by":"crossref","DOI":"10.1080\/16549716.2017.1381471","article-title":"Towards malaria control and elimination in Ghana: challenges and decision making tools to guide planning","volume":"10","author":"Awine","year":"2017","journal-title":"Glob Health Action"},{"article-title":"National malaria control programme-NMCP, national public health reference laboratory-NPHRL","year":"2020","series-title":"ICF: Ghana malaria indicator survey 2019","key":"10.1016\/j.ijid.2025.107804_bib0002"},{"key":"10.1016\/j.ijid.2025.107804_bib0003","doi-asserted-by":"crossref","first-page":"12006","DOI":"10.3390\/ijerph191912006","article-title":"Distribution and risk factors of malaria in the greater Accra region in Ghana","volume":"19","author":"Kawaguchi","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.ijid.2025.107804_bib0004","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1128\/CMR.00025-08","article-title":"Acquired immunity to malaria","volume":"22","author":"Doolan","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijid.2025.107804_bib0005","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1084\/jem.172.6.1633","article-title":"Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes","volume":"172","author":"Bouharoun-Tayoun","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.ijid.2025.107804_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000218","article-title":"The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: a systematic review and meta-analysis","volume":"7","author":"Fowkes","year":"2010","journal-title":"PLoS Med"},{"key":"10.1016\/j.ijid.2025.107804_bib0007","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1128\/IAI.01585-07","article-title":"Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria","volume":"76","author":"Osier","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2025.107804_bib0008","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4049\/jimmunol.1300778","article-title":"Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development","volume":"191","author":"Richards","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.ijid.2025.107804_bib0009","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.immuni.2015.02.012","article-title":"Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria","volume":"42","author":"Boyle","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.ijid.2025.107804_bib0010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1741-7015-12-108","article-title":"Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria","volume":"12","author":"Osier","year":"2014","journal-title":"BMC Med"},{"key":"10.1016\/j.ijid.2025.107804_bib0011","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/infdis\/jiw617","article-title":"Naturally acquired antibodies target the glutamate-rich protein on intact merozoites and predict protection against febrile malaria","volume":"215","author":"Kana","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2025.107804_bib0012","doi-asserted-by":"crossref","first-page":"e9871","DOI":"10.1371\/journal.pone.0009871","article-title":"Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies","volume":"5","author":"Joos","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2025.107804_bib0013","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/cid\/cit556","article-title":"Breadth of anti-merozoite antibody responses is associated with the genetic diversity of asymptomatic Plasmodium falciparum infections and protection against clinical malaria","volume":"57","author":"Rono","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2025.107804_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249936","article-title":"Suitability of IgG responses to multiple Plasmodium falciparum antigens as markers of transmission intensity and pattern","volume":"16","author":"Kyei-Baafour","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.ijid.2025.107804_bib0015","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1189\/jlb.5MA0716-294R","article-title":"Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance","volume":"101","author":"McCallum","year":"2017","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ijid.2025.107804_bib0016","doi-asserted-by":"crossref","first-page":"e00125","DOI":"10.1128\/IAI.00125-20","article-title":"Microscopic and submicroscopic asymptomatic Plasmodium falciparum infections in Ghanaian children and protection against febrile malaria","volume":"88","author":"Adu","year":"2020","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2025.107804_bib0017","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12934-018-0902-2","article-title":"Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum","volume":"17","author":"Singh","year":"2018","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.ijid.2025.107804_bib0018","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12936-016-1146-4","article-title":"Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas","volume":"15","author":"Adu","year":"2016","journal-title":"Malar J"},{"key":"10.1016\/j.ijid.2025.107804_bib0020","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/infdis\/jiv057","article-title":"Antibodies to the Plasmodium falciparum proteins MSPDBL1 and MSPDBL2 opsonize merozoites, inhibit parasite growth, and predict protection from clinical malaria","volume":"212","author":"Chiu","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2025.107804_bib0021","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1086\/315341","article-title":"Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria","volume":"181","author":"Dodoo","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2025.107804_bib0022","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4269\/ajtmh.2006.74.191","article-title":"High titers of IgG antibodies against Plasmodium falciparum serine repeat antigen 5 (SERA5) are associated with protection against severe malaria in Ugandan children","volume":"74","author":"Okech","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijid.2025.107804_bib0023","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1086\/423208","article-title":"Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies to improve vaccine design","volume":"190","author":"Singh","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2025.107804_bib0024","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12936-019-2684-3","article-title":"Association of high Plasmodium falciparum parasite densities with polyclonal microscopic infections in asymptomatic children from Toubacouta, Senegal","volume":"18","author":"Diouf","year":"2019","journal-title":"Malar J"},{"key":"10.1016\/j.ijid.2025.107804_bib0025","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/infdis\/jiv088","article-title":"Asymptomatic multiclonal Plasmodium falciparum infections carried through the dry season predict protection against subsequent clinical malaria","volume":"212","author":"Sond\u00e9n","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2025.107804_bib0026","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/infdis\/172.4.1047","article-title":"Impact of transmission intensity and age on Plasmodium falciparum density and associated fever: implications for malaria vaccine trial design","volume":"172","author":"Beadle","year":"1995","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2025.107804_bib0027","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s13071-017-2338-7","article-title":"Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana","volume":"10","author":"Amoah","year":"2017","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.ijid.2025.107804_bib0028","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/femsre\/fuw001","article-title":"Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria","volume":"40","author":"Beeson","year":"2016","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.ijid.2025.107804_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1161301","article-title":"High opsonic phagocytosis activity and growth inhibition of merozoites are associated with RON4 antibody levels and protect against febrile malaria in Ghanaian children","volume":"14","author":"Kyei-Baafour","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijid.2025.107804_bib0030","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1128\/CVI.00064-11","article-title":"Comparative immunogenicities of full-length Plasmodium falciparum merozoite surface protein 3 and a 24-kgdalton N-terminal fragment","volume":"18","author":"Imam","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.ijid.2025.107804_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.775659","article-title":"Antibody targets and properties for complement-fixation against the circumsporozoite protein in malaria immunity","volume":"12","author":"Kurtovic","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijid.2025.107804_bib0032","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1128\/IAI.02398-14","article-title":"Acquisition of antibodies against Plasmodium falciparum merozoites and malaria immunity in young children and the influence of age, force of infection, and magnitude of response","volume":"83","author":"Stanisic","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijid.2025.107804_bib0033","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.vaccine.2003.09.017","article-title":"A Plasmodium falciparum GLURP\u2013MSP3 chimeric protein; expression in Lactococcus lactis, immunogenicity and induction of biologically active antibodies","volume":"22","author":"Theisen","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2025.107804_bib0034","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1016\/j.vaccine.2013.06.042","article-title":"A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria","volume":"31","author":"Murungi","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.ijid.2025.107804_bib0035","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.pt.2015.11.015","article-title":"Malaria parasites in the asymptomatic: looking for the hay in the haystack","volume":"32","author":"Galatas","year":"2016","journal-title":"Trends Parasitol"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971225000281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971225000281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T11:24:23Z","timestamp":1742037863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971225000281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":34,"alternative-id":["S1201971225000281"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2025.107804","relation":{},"ISSN":["1201-9712"],"issn-type":[{"type":"print","value":"1201-9712"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wider antibody breadth against multiple Plasmodium falciparum antigens is associated with reduced risk of malaria in a transmission hotspot in southern Ghana","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2025.107804","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"107804"}}