{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:09:40Z","timestamp":1782756580046,"version":"3.54.5"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020655","name":"European Health and Digital Executive Agency","doi-asserted-by":"publisher","award":["101113109 RELECOV 2.0"],"award-info":[{"award-number":["101113109 RELECOV 2.0"]}],"id":[{"id":"10.13039\/100020655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017487","name":"Technology and Renewable Energy Institute","doi-asserted-by":"publisher","award":["OA17\/008"],"award-info":[{"award-number":["OA17\/008"]}],"id":[{"id":"10.13039\/100017487","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017487","name":"Technology and Renewable Energy Institute","doi-asserted-by":"publisher","award":["OA23\/043"],"award-info":[{"award-number":["OA23\/043"]}],"id":[{"id":"10.13039\/100017487","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CD22\/00138"],"award-info":[{"award-number":["CD22\/00138"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI20\/00876"],"award-info":[{"award-number":["PI20\/00876"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CB06\/06\/1088"],"award-info":[{"award-number":["CB06\/06\/1088"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019170","name":"Tenerife Council","doi-asserted-by":"publisher","award":["CGIAC0000014697"],"award-info":[{"award-number":["CGIAC0000014697"]}],"id":[{"id":"10.13039\/501100019170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019170","name":"Tenerife Council","doi-asserted-by":"publisher","award":["A0000014697"],"award-info":[{"award-number":["A0000014697"]}],"id":[{"id":"10.13039\/501100019170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019170","name":"Tenerife Council","doi-asserted-by":"publisher","award":["CGIEU0000219140"],"award-info":[{"award-number":["CGIEU0000219140"]}],"id":[{"id":"10.13039\/501100019170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014851","name":"Fundaci\u00f3n DISA","doi-asserted-by":"publisher","award":["OA23\/074"],"award-info":[{"award-number":["OA23\/074"]}],"id":[{"id":"10.13039\/501100014851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023554","name":"Canary Foundation Canary Islands Health Research Institute","doi-asserted-by":"publisher","award":["EMER24\/06"],"award-info":[{"award-number":["EMER24\/06"]}],"id":[{"id":"10.13039\/501100023554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023554","name":"Canary Foundation Canary Islands Health Research Institute","doi-asserted-by":"publisher","award":["PIFIISC21\/37"],"award-info":[{"award-number":["PIFIISC21\/37"]}],"id":[{"id":"10.13039\/501100023554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ijid.2025.108233","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:50:35Z","timestamp":1763657435000},"page":"108233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A prolonged Delta SARS-CoV-2 infection during the Omicron wave in an HIV immunosuppressed patient"],"prefix":"10.1016","volume":"162","author":[{"given":"Diego","family":"Garc\u00eda-Mart\u00ednez de Artola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ciuffreda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Miguel","family":"Lorenzo-Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Mu\u00f1oz-Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"Gonz\u00e1lez-Montelongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Rodr\u00edguez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Alcoba-Florez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Abella-Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Mel\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5352-069X","authenticated-orcid":false,"given":"Carlos","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2025.108233_bib0001","article-title":"Rapid emergence of omicron sublineages expressing spike protein R346T","volume":"24","author":"Groenheit","year":"2023","journal-title":"Lancet Reg Health Eur"},{"issue":"11","key":"10.1016\/j.ijid.2025.108233_bib0002","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.chom.2022.09.015","article-title":"Evasion of neutralizing antibody responses by the SARS-CoV-2 BA.2.75 variant","volume":"30","author":"Qu","year":"2022","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.ijid.2025.108233_bib0003","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41592-023-01769-3","article-title":"Outbreak.info genomic reports: scalable and dynamic surveillance of SARS-CoV-2 variants and mutations","volume":"20","author":"Gangavarapu","year":"2023","journal-title":"Nat Methods"},{"issue":"5","key":"10.1016\/j.ijid.2025.108233_bib0004","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.cell.2021.01.037","article-title":"Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity","volume":"184","author":"Thomson","year":"2021","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.ijid.2025.108233_bib0005","first-page":"345","article-title":"V483A: an emerging mutation hotspot of SARS-CoV-2","volume":"16","author":"Ashwaq","year":"2021","journal-title":"Future Virol"},{"issue":"1","key":"10.1016\/j.ijid.2025.108233_bib0006","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/s41467-021-21118-2","article-title":"SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity","volume":"12","author":"Ozono","year":"2021","journal-title":"Nat Commun"},{"issue":"49","key":"10.1016\/j.ijid.2025.108233_bib0007","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2021.26.49.2101059","article-title":"Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021","volume":"26","author":"Lassauni\u00e8re","year":"2021","journal-title":"Euro Surveill"},{"issue":"5","key":"10.1016\/j.ijid.2025.108233_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(24)00769-2","article-title":"Targeting the SARS-CoV-2 reservoir in long COVID","volume":"25","author":"Proal","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijid.2025.108233_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2024.199392","article-title":"A systematic mutation analysis of 13 major SARS-CoV-2 variants","volume":"345","author":"Bai","year":"2024","journal-title":"Virus Res"},{"key":"10.1016\/j.ijid.2025.108233_bib0010","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41423-023-01087-w","article-title":"The immune response to SARS-CoV-2 in people with HIV","volume":"21","author":"H\u00f6ft","year":"2024","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"10.1016\/j.ijid.2025.108233_bib0011","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.chom.2022.01.005","article-title":"SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape","volume":"30","author":"Cele","year":"2022","journal-title":"Cell Host & Microbe"},{"issue":"1","key":"10.1016\/j.ijid.2025.108233_bib0012","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.1038\/s41467-021-26602-3","article-title":"Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants","volume":"12","author":"Weigang","year":"2021","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ijid.2025.108233_bib0013","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jinf.2021.07.028","article-title":"Longitudinal study of a SARS-CoV-2 infection in an immunocompromised patient with X-linked agammaglobulinemia","volume":"83","author":"Ciuffreda","year":"2021","journal-title":"J Infect"},{"issue":"2","key":"10.1016\/j.ijid.2025.108233_bib0014","doi-asserted-by":"crossref","first-page":"veac050","DOI":"10.1093\/ve\/veac050","article-title":"Recurrent SARS-CoV-2 mutations in immunodeficient patients","volume":"8","author":"Wilkinson","year":"2022","journal-title":"Virus Evol"},{"issue":"3","key":"10.1016\/j.ijid.2025.108233_bib0015","article-title":"Characterisation of a persistent SARS-CoV-2 infection lasting more than 750 days in a person living with HIV: a genomic analysis","volume":"6","author":"Velasquez-Reyes","year":"2025","journal-title":"Lancet Microbe"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971225004552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971225004552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:14:06Z","timestamp":1773875646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971225004552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"alternative-id":["S1201971225004552"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2025.108233","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A prolonged Delta SARS-CoV-2 infection during the Omicron wave in an HIV immunosuppressed patient","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2025.108233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"108233"}}