{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:56:11Z","timestamp":1793055371627,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272331"],"award-info":[{"award-number":["82272331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341071"],"award-info":[{"award-number":["82341071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ijid.2025.108280","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:41:15Z","timestamp":1765212075000},"page":"108280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Development and validation of a novel critical risk stratification scale for hemorrhagic fever with renal syndrome patients with Hantaan virus infection"],"prefix":"10.1016","volume":"163","author":[{"given":"Shijia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boquan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-2622","authenticated-orcid":false,"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2025.108280_bib0001","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41598-017-18819-4","article-title":"Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005\u20132016","volume":"8","author":"Liang","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijid.2025.108280_bib0002","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S1473-3099(18)30293-7","article-title":"Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China, 2011\u201317: a prospective observational study","volume":"18","author":"Li","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijid.2025.108280_bib0003","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3109\/1040841X.2013.783555","article-title":"Epidemiology of Hantavirus infections in humans: a comprehensive, global overview","volume":"40","author":"Watson","year":"2014","journal-title":"Crit Rev Microbiol"},{"key":"10.1016\/j.ijid.2025.108280_bib0004","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.tim.2023.05.004","article-title":"A framework for understanding and predicting orthohantavirus functional traits","volume":"31","author":"Mull","year":"2023","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.ijid.2025.108280_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.onehlt.2024.100895","article-title":"Asymmetric association between meteorological factors and human infections with hemorrhagic fever with renal syndrome: a 16-year ecological trend study in Shaanxi, China","volume":"19","author":"Xue","year":"2024","journal-title":"One Health"},{"key":"10.1016\/j.ijid.2025.108280_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jiph.2024.102647","article-title":"Scientometric analysis of research trends in hemorrhagic fever with renal syndrome: a historical review and network visualization","volume":"18","author":"Xu","year":"2025","journal-title":"J Infect Public Health"},{"key":"10.1016\/j.ijid.2025.108280_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cei\/uxac111","article-title":"HTNV infection induces activation and deficiency of CD8+MAIT cells in HFRS patients","volume":"211","author":"Zhang","year":"2023","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ijid.2025.108280_bib0008","first-page":"1","article-title":"Hemorrhagic fever with renal syndrome: pathogenesis and clinical picture","volume":"6","author":"Jiang","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ijid.2025.108280_bib0009","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1016\/S1473-3099(23)00128-7","article-title":"Hantavirus in humans: a review of clinical aspects and management","volume":"23","author":"Vial","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijid.2025.108280_bib0010","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1515\/med-2021-0307","article-title":"Development and validation of a nomogram for predicting severity in patients with hemorrhagic fever with renal syndrome: a retrospective study","volume":"16","author":"Yang","year":"2021","journal-title":"Open Med (Wars)"},{"key":"10.1016\/j.ijid.2025.108280_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.865233","article-title":"Evaluation of serum ferritin, procalcitonin, and C-reactive protein for the prediction of severity and mortality in hemorrhagic fever with renal syndrome","volume":"13","author":"Che","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijid.2025.108280_bib0012","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cmi.2023.11.003","article-title":"Development and validation of a novel death risk stratification scale in patients with hemorrhagic fever with renal syndrome: a 14-year ambispective cohort study","volume":"30","author":"Hu","year":"2024","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijid.2025.108280_bib0013","first-page":"51","article-title":"Clinical characteristics and a novel prediction nomogram (EASTAR) for patients with hemorrhagic fever with renal syndrome: a multicenter retrospective study","volume":"10","author":"Ma","year":"2025","journal-title":"Trop Med Infect Dis"},{"key":"10.1016\/j.ijid.2025.108280_bib0014","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijid.2017.08.003","article-title":"Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus hemorrhagic fever with Renal Syndrome","volume":"63","author":"Yu","year":"2017","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2025.108280_bib0015","article-title":"Clinical and laboratory features and factors predicting disease severity in pediatric patients with hemorrhagic fever with renal syndrome caused by Hantaan virus","volume":"95","author":"Li","year":"2023","journal-title":"J Med Virol"},{"key":"10.1016\/j.ijid.2025.108280_bib0016","volume":"278","year":"2008"},{"key":"10.1016\/j.ijid.2025.108280_bib0017","article-title":"Evaluation of clinical prediction models (part 3): calculating the sample size required for an external validation study","volume":"384","author":"Riley","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.ijid.2025.108280_bib0018","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","article-title":"Serial evaluation of the SOFA score to predict outcome in critically ill patients","volume":"286","author":"Ferreira","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.ijid.2025.108280_bib0019","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00134-022-06914-8","article-title":"ICU scoring systems","volume":"49","author":"Quintairos","year":"2023","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ijid.2025.108280_bib0020","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new Simplified Acute Physiology Score (SAPS II) based on a European\/North American multicenter study","volume":"270","author":"Le Gall","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.ijid.2025.108280_bib0021","article-title":"Hyperamylasemia caused by the Hantaan virus: A retrospective study of 101 patients with hemorrhagic fever with renal syndrome in West China","volume":"2022","author":"Zhang","year":"2022","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.ijid.2025.108280_bib0022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013042","article-title":"IL-6 trans-signaling mediates cytokine secretion and barrier dysfunction in hantavirus-infected cells and correlates to severity in HFRS","volume":"21","author":"Maleki","year":"2025","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ijid.2025.108280_bib0023","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.2147\/IJGM.S480204","article-title":"A comprehensive analysis exploring the vital role of the systemic immune-inflammatory index upon admission in severe hemorrhagic fever with renal syndrome","volume":"17","author":"Yao","year":"2024","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.ijid.2025.108280_bib0024","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12879-023-08777-w","article-title":"Levels of peripheral blood routine, biochemical and coagulation parameters in patients with hemorrhagic fever with renal syndrome and their relationship with prognosis: an observational cohort study","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ijid.2025.108280_bib0025","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.3389\/fimmu.2018.02098","article-title":"Neutrophil activation in acute hemorrhagic fever with renal syndrome is mediated by hantavirus-infected microvascular endothelial cells","volume":"9","author":"Strandin","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijid.2025.108280_bib0026","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.174133","article-title":"Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation","volume":"9","author":"Leborgne","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.ijid.2025.108280_bib0027","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1161\/CIRCULATIONAHA.113.001870","article-title":"Increased risk of acute myocardial infarction and stroke during hemorrhagic fever with renal syndrome: a self-controlled case series study","volume":"129","author":"Connolly-Andersen","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ijid.2025.108280_bib0028","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.jtcvs.2017.12.107","article-title":"Nomogram: an analogue tool to deliver digital knowledge","volume":"155","author":"Park","year":"2018","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971225005028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971225005028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:45:50Z","timestamp":1783017950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971225005028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":28,"alternative-id":["S1201971225005028"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2025.108280","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a novel critical risk stratification scale for hemorrhagic fever with renal syndrome patients with Hantaan virus infection","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2025.108280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"108280"}}