{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:02:43Z","timestamp":1783702963810,"version":"3.55.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ijid.2025.108291","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T15:19:37Z","timestamp":1765120777000},"page":"108291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Nonthyroidal illness syndrome and diagnostic utility of CSF mNGS: insights from a case series of neurological scrub typhus"],"prefix":"10.1016","volume":"163","author":[{"given":"Jinhao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingru","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyuan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2025.108291_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005838","article-title":"Estimating the burden of scrub typhus: a systematic review","volume":"11","author":"Bonell","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2025.108291_bib0002","article-title":"Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review","volume":"15","author":"Panesar","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.ijid.2025.108291_bib0003","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4103\/aian.aian_739_21","article-title":"Neurological facets of scrub typhus: a comprehensive narrative review","volume":"24","author":"Garg","year":"2021","journal-title":"Ann Indian Acad Neurol"},{"key":"10.1016\/j.ijid.2025.108291_bib0004","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11910-022-01215-5","article-title":"Neurological manifestations of scrub typhus","volume":"22","author":"Basu","year":"2022","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.ijid.2025.108291_bib0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/QCO.0000000000001135","article-title":"Neurological complications of scrub typhus","volume":"38","author":"Reba","year":"2025","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.ijid.2025.108291_bib0006","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2147\/IDR.S450693","article-title":"Case report: encephalitis with initial manifestation of Orientia Tsutsugamushi infection detected by metagenomic next-generation sequencing","volume":"17","author":"Han","year":"2024","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.ijid.2025.108291_bib0007","article-title":"An update on the laboratory diagnosis of Rickettsia spp","volume":"10","author":"Stewart","year":"2021","journal-title":"Infection. Pathogens"},{"key":"10.1016\/j.ijid.2025.108291_bib0008","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s13205-023-03628-6","article-title":"Isothermal nucleic acid amplification and its uses in modern diagnostic technologies","volume":"13","author":"Srivastava","year":"2023","journal-title":"3 Biotech"},{"key":"10.1016\/j.ijid.2025.108291_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115387","article-title":"Emerging threat of scrub typhus: a call for greater awareness and research","volume":"164","author":"Bhuvaneshwari","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.ijid.2025.108291_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.diagmicrobio.2023.116046","article-title":"Isothermal amplification technology (IAT) for rapid diagnosis of Rickettsioses: scope, overview, existing evidence, and the way forward","volume":"107","author":"Dixit","year":"2023","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.ijid.2025.108291_bib0011","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s13312-018-1224-5","article-title":"Comparison of scrub typhus meningitis with acute bacterial meningitis and tuberculous meningitis","volume":"55","author":"Kakarlapudi","year":"2018","journal-title":"Indian Pediatr"},{"key":"10.1016\/j.ijid.2025.108291_bib0012","doi-asserted-by":"crossref","DOI":"10.1590\/1516-3180.2023.0142.r1.08122023","article-title":"Case report of scrub typhus complicated by hypokalemia and multiple organ dysfunction syndrome","volume":"142","author":"Chen","year":"2024","journal-title":"Sao Paulo Med J"},{"key":"10.1016\/j.ijid.2025.108291_bib0013","doi-asserted-by":"crossref","first-page":"58","DOI":"10.17925\/EE.2022.18.1.58","article-title":"Thyroid function during and after COVID-19 infection: a review","volume":"18","author":"\u00c7abuk","year":"2022","journal-title":"TouchREV Endocrinol"},{"key":"10.1016\/j.ijid.2025.108291_bib0014","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2147\/JIR.S442598","article-title":"Association between nonthyroidal illness syndrome and disseminated intravascular coagulation in sepsis","volume":"17","author":"Yao","year":"2024","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.ijid.2025.108291_bib0015","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1080\/14787210.2021.1941869","article-title":"Scrub typhus and antibiotic-resistant Orientia tsutsugamushi","volume":"19","author":"Lu","year":"2021","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.ijid.2025.108291_bib0016","doi-asserted-by":"crossref","DOI":"10.1029\/2024GH001203","article-title":"Current and future projection of scrub typhus risk related to land use change in China","volume":"9","author":"Han","year":"2025","journal-title":"Geohealth"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971225005132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971225005132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:54:10Z","timestamp":1783018450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971225005132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":16,"alternative-id":["S1201971225005132"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2025.108291","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonthyroidal illness syndrome and diagnostic utility of CSF mNGS: insights from a case series of neurological scrub typhus","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2025.108291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"108291"}}