{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:10:52Z","timestamp":1784549452318,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM25\/00065"],"award-info":[{"award-number":["CM25\/00065"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM23\/00277"],"award-info":[{"award-number":["CM23\/00277"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FIS PI24\/01776"],"award-info":[{"award-number":["FIS PI24\/01776"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ijid.2026.108384","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:14:03Z","timestamp":1768324443000},"page":"108384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of novel \u03b2-lactams on Gut Decolonization in Haematological Patients with Multidrug-Resistant Gram-Negative Infections"],"prefix":"10.1016","volume":"164","author":[{"given":"Antonio","family":"Gallardo-Pizarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Rafael","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso Francesco","family":"Aiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Monz\u00f3-Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Martinez-Urrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Teijon-Lumbreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Del R\u00edo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Morata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Hernandez-Meneses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Cuervo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rivero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pitart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Mensa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8915-0683","authenticated-orcid":false,"given":"Carolina","family":"Garcia-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2026.108384_bib0001","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1473-3099(22)00811-8","article-title":"Incidence of infection with multidrug-resistant gram-negative bacteria and vancomycin-resistant enterococci in carriers: a systematic review and meta-regression analysis","volume":"23","author":"Willems","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijid.2026.108384_bib0002","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10096-023-04548-2","article-title":"Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers","volume":"42","author":"Campos-Madueno","year":"2023","journal-title":"Eur J Clin Microbiol Infect Dis: Off Publ Eur Soc Clin Microbiol"},{"key":"10.1016\/j.ijid.2026.108384_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.107043","article-title":"Prevalence of and risk factors for intestinal colonisation by multidrug-resistant gram-negative bacteria in patients with haematological malignancies: a systematic review and meta-analysis","volume":"63","author":"Luo","year":"2024","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijid.2026.108384_bib0004","doi-asserted-by":"crossref","first-page":"e4627","DOI":"10.1093\/cid\/ciaa068","article-title":"Compositional flux within the intestinal microbiota and risk for bloodstream infection with gram-negative bacteria","volume":"73","author":"Stoma","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2026.108384_bib0005","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/cis580","article-title":"Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation","volume":"55","author":"Taur","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2026.108384_bib0006","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.cmi.2025.05.033","article-title":"Rectal colonisation by multidrug-resistant gram-negative bacteria and subsequent bacteraemia in haematological patients","volume":"31","author":"Gallardo-Pizarro","year":"2025","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijid.2026.108384_bib0007","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10096-023-04581-1","article-title":"Carriage of multidrug-resistant gram-negative bacilli: duration and risk factors","volume":"42","author":"Herrera","year":"2023","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijid.2026.108384_bib0008","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jgar.2018.11.014","article-title":"KPC-producing Klebsiella pneumoniae gut decolonisation following ceftazidime\/avibactam-based combination therapy: a retrospective observational study","volume":"17","author":"Bassetti","year":"2019","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.ijid.2026.108384_bib0009","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/1120009X.2018.1424504","article-title":"Treatment of a Klebsiella pneumoniae KPC cellulitis and gut decolonization with ceftazidime\/avibactam in a migrant from Libya","volume":"30","author":"Carannante","year":"2018","journal-title":"J Chemother Florence Italy"},{"key":"10.1016\/j.ijid.2026.108384_bib0010","first-page":"424","article-title":"Successful treatment of Klebsiella pneumoniae NDM sepsis and intestinal decolonization with ceftazidime\/avibactam plus aztreonam combination in a patient with TTP complicated by SARSCoV-2 nosocomial infection","volume":"57","author":"Perrotta","year":"2021","journal-title":"Med Kaunas Lith"},{"key":"10.1016\/j.ijid.2026.108384_bib0011","doi-asserted-by":"crossref","first-page":"ciae403","DOI":"10.1093\/cid\/ciae403","article-title":"Infectious Diseases Society of America 2024 guidance on the treatment of antimicrobial-resistant gram-negative infections","author":"Tamma","year":"2024","journal-title":"Clin Infect Dis: Off Publ Infect Dis Soc Am"},{"key":"10.1016\/j.ijid.2026.108384_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210991","article-title":"Colonization with multidrug resistant organisms determines the clinical course of patients with acute myeloid leukemia undergoing intensive induction chemotherapy","volume":"14","author":"Ballo","year":"2019","journal-title":"PLOS ONE"},{"key":"10.1016\/j.ijid.2026.108384_bib0013","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/cncr.31045","article-title":"Clinical impact of colonization with multidrug-resistant organisms on outcome after allogeneic stem cell transplantation in patients with acute myeloid leukemia","volume":"124","author":"Scheich","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.ijid.2026.108384_bib0014","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.bbmt.2017.05.016","article-title":"Clinical impact of colonization with multidrug-resistant organisms on outcome after autologous stem cell transplantation: a retrospective single-center study","volume":"23","author":"Scheich","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.ijid.2026.108384_bib0016","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1017\/ice.2021.492","article-title":"Effectiveness of selective digestive decolonization therapy using oral gentamicin for eradication of carbapenem-resistant Enterobacteriaceae carriage","volume":"43","author":"Park","year":"2022","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.ijid.2026.108384_bib0017","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2018.030","article-title":"Decolonization of intestinal carriage of MDR\/XDR gram-negative bacteria with oral colistin in patients with hematological malignancies: results of a randomized controlled trial","volume":"10","author":"Stoma","year":"2018","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.1016\/j.ijid.2026.108384_bib0018","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.ajic.2013.04.018","article-title":"Eradication of carbapenem-resistant Enterobacteriaceae gastrointestinal colonization with nonabsorbable oral antibiotic treatment: a prospective controlled trial","volume":"41","author":"Oren","year":"2013","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ijid.2026.108384_bib0036","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/jac\/dkw221","article-title":"Natural history and decolonization strategies for ESBL\/carbapenem-resistant Enterobacteriaceae carriage: systematic review and meta-analysis","volume":"71","author":"Bar-Yoseph","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijid.2026.108384_bib0019","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmi.2019.01.005","article-title":"ESCMID-EUCIC clinical guidelines on decolonization of multidrug-resistant gram-negative bacteria carriers","volume":"25","author":"Tacconelli","year":"2019","journal-title":"Clin Microbiol Infect: Off Publ Eur Soc Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijid.2026.108384_bib0020","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jiph.2023.01.009","article-title":"Decolonization of drug-resistant Enterobacteriaceae carriers: a scoping review of the literature","volume":"16","author":"Mascolo","year":"2023","journal-title":"J Infect Public Health"},{"issue":"12","key":"10.1016\/j.ijid.2026.108384_bib0021","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/jac\/dkae361","article-title":"Concentrations of ceftazidime and avibactam in bile fluid\u2014a prospective phase IIb study","volume":"79","author":"Witowski","year":"2024","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijid.2026.108384_bib0022","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijantimicag.2015.02.027","article-title":"Ecological effect of ceftazidime\/avibactam on the normal human intestinal microbiota","volume":"46","author":"Rashid","year":"2015","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijid.2026.108384_bib0023","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/phar.2431","article-title":"Antibiotics in the biliary tract: a review of the pharmacokinetics and clinical outcomes of antibiotics penetrating the bile and gallbladder wall","volume":"40","author":"Thabit","year":"2020","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ijid.2026.108384_bib0024","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jiac.2023.06.002","article-title":"Efficacy and safety of tazobactam\/ceftolozane in combination with metronidazole for intraabdominal infection in a hepato-biliary-pancreatic field in clinical practice","volume":"29","author":"Kubo","year":"2023","journal-title":"J Infect Chemother: Off J Jpn Soc Chemother"},{"key":"10.1016\/j.ijid.2026.108384_bib0025","doi-asserted-by":"crossref","DOI":"10.1038\/s44259-025-00129-9","article-title":"Absence of gut microbiota restoration following meropenem treatment in a systemic infection model","volume":"3","author":"Ribeiro","year":"2025","journal-title":"Npj Antimicrob Resist"},{"key":"10.1016\/j.ijid.2026.108384_bib0026","doi-asserted-by":"crossref","DOI":"10.4014\/jmb.2025.3512.C01","article-title":"Gut microbiome-based strategies for the control of carbapenem-resistant Enterobacteriaceae","volume":"35","author":"Lee","year":"2025","journal-title":"J Microbiol Biotechnol"},{"key":"10.1016\/j.ijid.2026.108384_bib0027","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/cid\/ciy936","article-title":"Gastrointestinal microbiota disruption and risk of colonization with carbapenem-resistant Pseudomonas aeruginosa in intensive care unit patients","volume":"69","author":"Pettigrew","year":"2019","journal-title":"Clin Infect Dis: Off Publ Infect Dis Soc Am"},{"key":"10.1016\/j.ijid.2026.108384_bib0028","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jhin.2023.03.024","article-title":"Modifiable risk factors associated with later gut decolonization of carbapenem-resistant gram-negative bacteria in children: a prospective cohort study","volume":"136","author":"Darda","year":"2023","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.ijid.2026.108384_bib0029","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/infdis\/jiad033","article-title":"Impact of antibiotic treatment on the gut microbiome and its resistome in hematopoietic stem cell transplant recipients","volume":"228","author":"N\u00f8rgaard","year":"2023","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijid.2026.108384_bib0030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41579-023-00936-9","article-title":"Antibiotic-induced collateral damage to the microbiota and associated infections","volume":"21","author":"de Nies","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ijid.2026.108384_bib0031","first-page":"1113","article-title":"Gut microbiota dysbiosis facilitates susceptibility to bloodstream infection","volume":"62","author":"Lin","year":"2024","journal-title":"J Microbiol Seoul Korea"},{"key":"10.1016\/j.ijid.2026.108384_bib0032","doi-asserted-by":"crossref","DOI":"10.1111\/tid.70049","article-title":"Effect of antibiotics with anaerobic coverage on graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis","volume":"27","author":"Ito","year":"2025","journal-title":"Transpl Infect Dis: Off J Transplant Soc"},{"key":"10.1016\/j.ijid.2026.108384_bib0033","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1182\/blood.2024025366","article-title":"Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy","volume":"145","author":"Prasad","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.ijid.2026.108384_bib0034","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00277-017-3205-5","article-title":"Colonization with multidrug-resistant bacteria increases the risk of complications and a fatal outcome after allogeneic hematopoietic cell transplantation","volume":"97","author":"Sadowska-Klasa","year":"2018","journal-title":"Ann Hematol"},{"key":"10.1016\/j.ijid.2026.108384_bib0035","article-title":"Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis","volume":"34","author":"Sastre-Femenia","year":"2023","journal-title":"Lancet Reg Health Eur"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971226000196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971226000196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:59:10Z","timestamp":1784548750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971226000196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":35,"alternative-id":["S1201971226000196"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2026.108384","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of novel \u03b2-lactams on Gut Decolonization in Haematological Patients with Multidrug-Resistant Gram-Negative Infections","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2026.108384","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"108384"}}