{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:28:11Z","timestamp":1793953691704,"version":"4.8.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003996","name":"Kunming Medical University","doi-asserted-by":"publisher","award":["202101AY070001\\u2014217"],"award-info":[{"award-number":["202101AY070001\\u2014217"]}],"id":[{"id":"10.13039\/501100003996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ijid.2026.108523","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:17:04Z","timestamp":1772900224000},"page":"108523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["How to differentiate pediatric enteroviral meningoencephalitis from scrub typhus meningoencephalitis: A single-center retrospective study from Yunnan Province, China"],"prefix":"10.1016","volume":"167","author":[{"given":"Yonghan","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ijid.2026.108523_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006062","article-title":"A review of the global epidemiology of scrub typhus","volume":"11","author":"Xu","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2026.108523_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115387","article-title":"Emerging threat of scrub typhus: a call for greater awareness and research","volume":"164","author":"Bhuvaneshwari","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"10.1016\/j.ijid.2026.108523_bib0003","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/QCO.0000000000001135","article-title":"Neurological complications of scrub typhus","volume":"38","author":"Reba","year":"2025","journal-title":"Curr Opin Infect Dis"},{"issue":"1","key":"10.1016\/j.ijid.2026.108523_bib0004","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2469651","article-title":"Construction and validation of a predictive model for meningoencephalitis in pediatric scrub typhus based on machine learning algorithms","volume":"14","author":"Luo","year":"2025","journal-title":"Emerg Microbes Infect"},{"issue":"2","key":"10.1016\/j.ijid.2026.108523_bib0005","article-title":"Clinical profile and long-term outcomes of scrub typhus meningoencephalitis in children","volume":"17","author":"Mishra","year":"2025","journal-title":"Cureus"},{"issue":"11","key":"10.1016\/j.ijid.2026.108523_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010952","article-title":"Neurological manifestations of scrub typhus infection: a systematic review and meta-analysis of clinical features and case fatality","volume":"16","author":"Alam","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"issue":"20","key":"10.1016\/j.ijid.2026.108523_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205201","article-title":"Enterovirus-associated hand-foot and mouth disease and neurological complications in Japan and the rest of the world","volume":"20","author":"Gonzalez","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ijid.2026.108523_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2020.104516","article-title":"Non-polio enterovirus infections in children with central nervous system disorders in Shanghai, 2016-2018: serotypes and clinical characteristics","volume":"129","author":"Li","year":"2020","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ijid.2026.108523_bib0009","doi-asserted-by":"crossref","first-page":"6167","DOI":"10.1038\/srep06167","article-title":"Non-polio enteroviruses from acute flaccid paralysis surveillance in Shandong Province, China, 1988-2013","volume":"4","author":"Tao","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijid.2026.108523_bib0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijid.2023.11.020","article-title":"Non-polio enteroviruses circulation in acute flaccid paralysis cases and sewage in Senegal from 2013 to 2021","volume":"138","author":"Ndiaye","year":"2024","journal-title":"Int J Infect Dis"},{"issue":"6","key":"10.1016\/j.ijid.2026.108523_bib0011","doi-asserted-by":"crossref","first-page":"e2361","DOI":"10.1002\/rmv.2361","article-title":"Insight into the enterovirus A71: a review","volume":"32","author":"Kinobe","year":"2022","journal-title":"Rev Med Virol"},{"issue":"5","key":"10.1016\/j.ijid.2026.108523_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0013090","article-title":"Development and validation of a simple-to-use nomogram for predicting severe scrub typhus in children","volume":"19","author":"Luo","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"10.1016\/j.ijid.2026.108523_bib0013","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1186\/s12879-021-06462-4","article-title":"Epidemiological characteristics of hand, foot, and mouth disease in Yunnan Province, China, 2008-2019","volume":"21","author":"Jiang","year":"2021","journal-title":"BMC Infect Dis"},{"issue":"4","key":"10.1016\/j.ijid.2026.108523_bib0014","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s10096-025-05050-7","article-title":"Eschar is not the sole clue for scrub typhus: a retrospective analysis of pediatric scrub typhus without eschars","volume":"44","author":"Luo","year":"2025","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijid.2026.108523_bib0015","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciae104","article-title":"Guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2024 update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)","author":"Miller","year":"2024","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2026.108523_bib0016","first-page":"187","article-title":"CSF in acute and chronic infectious diseases","volume":"146","author":"Benninger","year":"2017","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.ijid.2026.108523_bib0017","article-title":"Nonthyroidal illness syndrome and diagnostic utility of CSF mNGS: insights from a case series of neurological scrub typhus","author":"Xi","year":"2025","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ijid.2026.108523_bib0018","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fmicb.2019.00319","article-title":"Metagenomic approach to characterizing disease epidemiology in a disease-endemic environment in Northern Thailand","volume":"10","author":"Takhampunya","year":"2019","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.ijid.2026.108523_bib0019","doi-asserted-by":"crossref","first-page":"e1466","DOI":"10.1371\/journal.pntd.0001466","article-title":"Orientia tsutsugamushi in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endothelium","volume":"6","author":"Paris","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"10.1016\/j.ijid.2026.108523_bib0020","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00076-17","article-title":"An update on host-pathogen interplay and modulation of immune responses during Orientia tsutsugamushi infection","volume":"31","author":"D\u00edaz","year":"2018","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijid.2026.108523_bib0021","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.3389\/fmicb.2019.02065","article-title":"Scrub typhus pathogenesis: innate immune response and lung injury during Orientia tsutsugamushi infection","volume":"10","author":"Trent","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijid.2026.108523_bib0022","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fmicb.2020.00261","article-title":"Enterovirus and encephalitis","volume":"11","author":"Chen","year":"2020","journal-title":"Front Microbiol"},{"issue":"2","key":"10.1016\/j.ijid.2026.108523_bib0023","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.virol.2010.12.014","article-title":"Enterovirus infections of the central nervous system","volume":"411","author":"Rhoades","year":"2011","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.ijid.2026.108523_bib0024","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/jgid.jgid_98_24","article-title":"A systematic review and meta-analysis of scrub typhus and its association with liver disease","volume":"17","author":"Balamurugan","year":"2025","journal-title":"J Glob Infect Dis"},{"issue":"3","key":"10.1016\/j.ijid.2026.108523_bib0025","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12664-023-01350-y","article-title":"Clinical profile and outcomes of pediatric scrub typhus associated with elevated hepatic transaminases","volume":"42","author":"Narayanasamy","year":"2023","journal-title":"Indian J Gastroenterol"},{"issue":"2","key":"10.1016\/j.ijid.2026.108523_bib0026","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3947\/ic.2019.51.2.161","article-title":"Clinical and laboratory predictors associated with complicated scrub typhus","volume":"51","author":"Kim","year":"2019","journal-title":"Infect Chemother"},{"issue":"3","key":"10.1016\/j.ijid.2026.108523_bib0027","first-page":"334","article-title":"Association between severity of scrub typhus and serum procalcitonin level","volume":"40","author":"Li","year":"2018","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"issue":"1","key":"10.1016\/j.ijid.2026.108523_bib0028","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61555-9","article-title":"Global seroprevalence of scrub typhus: a systematic review and meta-analysis","volume":"14","author":"Dasgupta","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijid.2026.108523_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2024.107151","article-title":"Global and regional seroprevalence, incidence, mortality of, and risk factors for scrub typhus: a systematic review and meta-analysis","volume":"146","author":"Wang","year":"2024","journal-title":"Int J Infect Dis"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S120197122600158X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S120197122600158X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:04:43Z","timestamp":1793952283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S120197122600158X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":29,"alternative-id":["S120197122600158X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2026.108523","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"How to differentiate pediatric enteroviral meningoencephalitis from scrub typhus meningoencephalitis: A single-center retrospective study from Yunnan Province, China","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2026.108523","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"108523"}}