{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:28:13Z","timestamp":1793953693042,"version":"4.8.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/16087-0"],"award-info":[{"award-number":["2023\/16087-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ijid.2026.108568","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:27:28Z","timestamp":1773854848000},"page":"108568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Intralesional meglumine antimoniate for cutaneous leishmaniasis: Evidence from a prospective real-world study in the Brazilian Amazon"],"prefix":"10.1016","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0551-6554","authenticated-orcid":false,"given":"Jo\u00e3o Guilherme Pontes Lima","family":"Assy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ol\u00edvia Campos Pinheiro","family":"Berretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara Karyne Delducke","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila Vieira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e9zia Maciel","family":"Lubacheveski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1dia Vic\u00eancia do Nascimento","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Oscar de Siqueira","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia Maria Almeida","family":"Braz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayane Miranda","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 \u00c2ngelo Lauletta","family":"Lindoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijid.2026.108568_bib0001","series-title":"Control of the leishmaniases: report of a meeting of the WHO Expert Committee on the Control of Leishmaniases","first-page":"22","year":"2010"},{"key":"10.1016\/j.ijid.2026.108568_bib0002","first-page":"653","article-title":"Global leishmaniasis surveillance updates, 2023: three years of the NTD road map","volume":"99","author":"Jain","year":"2024","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1016\/j.ijid.2026.108568_bib0003","doi-asserted-by":"crossref","DOI":"10.1051\/parasite\/2014039","article-title":"Phenotypic characterization of Leishmania spp. causing cutaneous leishmaniasis in the lower Amazon region, western Par\u00e1 state, Brazil, reveals a putative hybrid parasite, Leishmania (Viannia) guyanensis \u00d7 Leishmania (Viannia) shawi shawi","volume":"21","author":"Jennings","year":"2014","journal-title":"Parasite"},{"key":"10.1016\/j.ijid.2026.108568_bib0004","series-title":"Secretaria de vigil\u00e2ncia em sa\u00fade. Departamento de vigil\u00e2ncia das doen\u00e7as transmiss\u00edveis. Manual de vigil\u00e2ncia da leishmaniose tegumentar","year":"2017"},{"key":"10.1016\/j.ijid.2026.108568_bib0005","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade e Ambiente (SVSA). Painel Epidemiol\u00f3gico de Leishmaniose Tegumentar. n.d. http:\/\/leishmanioses.aids.gov.br\/(accessed October 23, 2025)."},{"key":"10.1016\/j.ijid.2026.108568_bib0006","first-page":"69","article-title":"Review of the current treatments for leishmaniases","volume":"3","author":"Lindoso","year":"2012","journal-title":"Res Rep Trop Med"},{"key":"10.1016\/j.ijid.2026.108568_bib0007","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184777","article-title":"Efficacy of pentavalent antimoniate intralesional infiltration therapy for cutaneous leishmaniasis: a systematic review","volume":"12","author":"Brito","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijid.2026.108568_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007856","article-title":"Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: a cost-effectiveness analysis","volume":"13","author":"Brito","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2026.108568_bib0009","article-title":"Interventions for American cutaneous and mucocutaneous leishmaniasis","volume":"8","author":"Pinart","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl 1","key":"10.1016\/j.ijid.2026.108568_bib0010","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1016\/S0035-9203(02)90061-1","article-title":"Genetic variation in populations of Leishmania species in Brazil","volume":"96","author":"Ishikawa","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.ijid.2026.108568_bib0011","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4269\/ajtmh.2001.65.456","article-title":"Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate","volume":"65","author":"Romero","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijid.2026.108568_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002130","article-title":"Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis","volume":"7","author":"Olliaro","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2026.108568_bib0013","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/cid\/cit049","article-title":"Intralesional antimony for single lesions of Bolivian cutaneous leishmaniasis","volume":"56","author":"Soto","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2026.108568_bib0014","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1590\/0037-8682-0213-2016","article-title":"Standardization of intralesional meglumine antimoniate treatment for cutaneous leishmaniasis","volume":"49","author":"Duque","year":"2016","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.ijid.2026.108568_bib0015","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1590\/S0074-02762012000500014","article-title":"Development and validation of PCR-based assays for diagnosis of American cutaneous leishmaniasis and identification of the parasite species","volume":"107","author":"Gra\u00e7a","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.ijid.2026.108568_bib0016","unstructured":"National Cancer Institute. Common terminology criteria for adverse events (CTCAE) version 5.0. Bethesda (MD): National Cancer Institute; 2017. https:\/\/dctd.cancer.gov\/research\/ctep-trials\/for-sites\/adverse-events\/ctcae-v5-5x7.pdf (Accessed October 25, 2025)."},{"key":"10.1016\/j.ijid.2026.108568_bib0017","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1590\/s1678-9946202567039","article-title":"Can archived lesion smears be used to identify Leishmania species in regions with high species diversity?","volume":"67","author":"Assy","year":"2025","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"10.1016\/j.ijid.2026.108568_bib0018","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.trstmh.2010.11.010","article-title":"Leishmania (Viannia) braziliensis identification by PCR in the state of Para, Brazil","volume":"105","author":"Bacha","year":"2011","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.ijid.2026.108568_bib0019","doi-asserted-by":"crossref","DOI":"10.1590\/1678-4685-gmb-2020-0123","article-title":"Molecular tools confirm natural Leishmania (Viannia) guyanensis\/L. (v.) shawi hybrids causing cutaneous leishmaniasis in the amazon region of Brazil","volume":"44","author":"Lima","year":"2021","journal-title":"Genet Mol Biol"},{"key":"10.1016\/j.ijid.2026.108568_bib0020","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/cid\/ciad253","article-title":"A randomized, controlled, noninferiority, multicenter trial of systemic vs intralesional treatment with meglumine antimoniate for cutaneous leishmaniasis in Brazil","volume":"77","author":"Lyra","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijid.2026.108568_bib0021","first-page":"201","article-title":"Tratamento da leishmaniose tegumentar americana com inje\u00e7\u00f5es intralesionadas de n-metil-glucamina","volume":"65","author":"Gadelha","year":"1990","journal-title":"An Bras Dermatol"},{"issue":"Suppl 1","key":"10.1016\/j.ijid.2026.108568_bib0022","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1590\/0037-8682-0268-2013","article-title":"Tegumentary leishmaniasis in the State of Amazonas: what have we learned and what do we need?","volume":"48","author":"Guerra","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.ijid.2026.108568_bib0023","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ijpddr.2020.11.002","article-title":"A retrospective cohort study of the effectiveness and adverse events of intralesional pentavalent antimonials in the treatment of cutaneous leishmaniasis","volume":"14","author":"Rodrigues","year":"2020","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.ijid.2026.108568_bib0024","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-4362.1997.00188.x","article-title":"Intralesional therapy of American cutaneous leishmaniasis with pentavalent antimony in Rio de Janeiro, Brazil\u2014an area of Leishmania (V.) braziliensis transmission","volume":"36","author":"Oliveira-Neto","year":"1997","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ijid.2026.108568_bib0025","series-title":"Diretrizes para o tratamento das leishmanioses na regi\u00e3o das am\u00e9ricas. Segunda edi\u00e7\u00e3o","year":"2022"},{"key":"10.1016\/j.ijid.2026.108568_bib0026","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.actatropica.2019.03.007","article-title":"Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit","volume":"193","author":"Duque","year":"2019","journal-title":"Acta Trop"},{"key":"10.1016\/j.ijid.2026.108568_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009734","article-title":"An old drug and different ways to treat cutaneous leishmaniasis: intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil","volume":"15","author":"Oliveira-Ribeiro","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2026.108568_bib0028","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760180200","article-title":"Meglumine antimoniate intralesional infiltration for localised cutaneous leishmaniasis: a single arm, open label, phase II clinical trial","volume":"113","author":"Ramalho","year":"2018","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.ijid.2026.108568_bib0029","first-page":"63","article-title":"La infiltraci\u00f3n perilesional de Glucantime y Lidoca\u00edna en el tratamiento de la Leishmaniasis","volume":"28","author":"Torres","year":"2000","journal-title":"Kasmera"},{"key":"10.1016\/j.ijid.2026.108568_bib0030","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.4269\/ajtmh.17-0340","article-title":"Intralesional infiltration with meglumine antimoniate for the treatment of leishmaniasis recidiva cutis in Ecuador","volume":"97","author":"Calvopi\u00f1a","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijid.2026.108568_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010578","article-title":"Effectiveness of intralesional sodium stibogluconate for the treatment of localized cutaneous leishmaniasis at Boru Meda general hospital, Amhara, Ethiopia: pragmatic trial","volume":"16","author":"Tilahun Zewdu","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijid.2026.108568_bib0032","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.abd.2024.08.003","article-title":"Telemedicine (mobile-health) as an alternative in the follow-up of patients in a randomized clinical trial for the treatment of cutaneous leishmaniasis in the state of Amazonas, Brazil","volume":"100","author":"Pennini","year":"2025","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.ijid.2026.108568_bib0033","doi-asserted-by":"crossref","first-page":"662","DOI":"10.4269\/ajtmh.22-0164","article-title":"Sensitivity and specificity of the remote evaluation of therapeutic response in cutaneous leishmaniasis using photographs from a mobile application","volume":"107","author":"Del Castillo","year":"2022","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijid.2026.108568_bib0034","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/14787210.2020.1731305","article-title":"Safety profile of meglumine antimoniate intralesional infiltration for cutaneous leishmaniasis","volume":"18","author":"Fernandes","year":"2020","journal-title":"Expert Rev Anti Infect Ther"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971226002031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971226002031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:05:23Z","timestamp":1793952323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971226002031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":34,"alternative-id":["S1201971226002031"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2026.108568","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intralesional meglumine antimoniate for cutaneous leishmaniasis: Evidence from a prospective real-world study in the Brazilian Amazon","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2026.108568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"108568"}}