{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:44:51Z","timestamp":1791819891578,"version":"4.3.4"},"reference-count":11,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ijid.2026.108915","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:56:47Z","timestamp":1782143807000},"page":"108915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rethinking Chagas disease for 21st-century health systems"],"prefix":"10.1016","volume":"171","author":[{"given":"Vibhu Kanna Rajesh","family":"Kanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-7449","authenticated-orcid":false,"given":"Sangkavi","family":"Kuhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-0720","authenticated-orcid":false,"given":"Faraan O.","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Lombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ijid.2026.108915_bib0001","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S1473-3099(25)00562-6","article-title":"Global, regional, and national burden of Chagas disease, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023","volume":"26","year":"2026","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijid.2026.108915_bib0002","article-title":"The epidemiology of Chagas disease in the Americas","volume":"37","author":"Cucunub\u00e1","year":"2024","journal-title":"Lancet Reg Health Am"},{"issue":"10115","key":"10.1016\/j.ijid.2026.108915_bib0003","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","article-title":"Chagas disease","volume":"391","author":"P\u00e9rez-Molina","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ijid.2026.108915_bib0004","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40249-021-00897-2","article-title":"Community-based screening of Chagas disease among Latin American migrants in a non-endemic country: an observational study","volume":"10","author":"Ramos-Sesma","year":"2021","journal-title":"Infect Dis Poverty"},{"key":"10.1016\/j.ijid.2026.108915_bib0005","article-title":"Clinical features of Chagas disease progression and severity","volume":"37","author":"Nunes","year":"2024","journal-title":"Lancet Reg Health Am"},{"issue":"14","key":"10.1016\/j.ijid.2026.108915_bib0006","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1507574","article-title":"Randomized trial of benznidazole for chronic Chagas' cardiomyopathy","volume":"373","author":"Morillo","year":"2015","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.ijid.2026.108915_bib0007","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1002\/ejhf.3460","article-title":"Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: unmasking a three-headed monster","volume":"26","author":"Echeverr\u00eda","year":"2024","journal-title":"Eur J Heart Fail"},{"issue":"5","key":"10.1016\/j.ijid.2026.108915_bib0008","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jcmg.2023.11.003","article-title":"Myocardial fibrosis by Magnetic resonance and outcomes in Chagas disease: a systematic review and meta-analysis","volume":"17","author":"G\u00f3mez-Ochoa","year":"2024","journal-title":"JACC Cardiovasc Imaging"},{"issue":"21","key":"10.1016\/j.ijid.2026.108915_bib0009","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijid.2026.108915_bib0010","article-title":"Prevalence of Chagas disease among Latin American immigrants in non-endemic countries: an updated systematic review and meta-analysis","volume":"46","author":"Nepomuceno de Andrade","year":"2024","journal-title":"Lancet Reg Health Eur"},{"issue":"5","key":"10.1016\/j.ijid.2026.108915_bib0011","doi-asserted-by":"crossref","DOI":"10.36660\/abc.20240555i","article-title":"Acute heart failure in patients with Chagas cardiomyopathy: results of the I Brazilian heart failure registry (BREATHE)","volume":"122","author":"Silva","year":"2025","journal-title":"Arq Bras Cardiol"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971226005503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971226005503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:46:28Z","timestamp":1791816388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971226005503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":11,"alternative-id":["S1201971226005503"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2026.108915","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rethinking Chagas disease for 21st-century health systems","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2026.108915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"108915"}}