{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:36:46Z","timestamp":1792859806386,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijidonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Infectious Diseases"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ijid.2026.109203","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:43:09Z","timestamp":1792770189000},"page":"109203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Features and Real-World Management of Enterococcus faecium Infective Endocarditis: A Nationwide Multicenter Cohort Study"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1497-8770","authenticated-orcid":false,"given":"Eduardo","family":"Aparicio-Minguij\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Machado-Vilchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Valerio-Minero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane Josune","family":"Goikoetxea-Agirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Blanco-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Rodr\u00edguez","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Hidalgo-Tenorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Ojeda-Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Maria","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Parra-Fari\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria Andrea Hortig\u00fcela","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar Diego","family":"Yag\u00fce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Asunci\u00f3n P\u00e9rez-Jacoiste","family":"As\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"L\u00f3pez-Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"43","key":"10.1016\/j.ijid.2026.109203_bib0001","article-title":"Current epidemiology and outcome of infective endocarditis: A multicenter, prospective, cohort study","volume":"94","author":"Mu\u00f1oz","year":"2015","journal-title":"Medicine (United States)"},{"issue":"12","key":"10.1016\/j.ijid.2026.109203_bib0002","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/1469-0691.12166","article-title":"Enterococcal endocarditis in the beginning of the 21st century: Analysis from the international collaboration on endocarditis-prospective cohort study","volume":"19","author":"Chirouze","year":"2013","journal-title":"Clinical Microbiology and Infection"},{"issue":"1","key":"10.1016\/j.ijid.2026.109203_bib0003","article-title":"The Changing Epidemiology of Infective Endocarditis in the Twenty-First Century","author":"Ambrosioni","year":"2017","journal-title":"Current Infectious Disease Reports. Current Medicine Group LLC"},{"issue":"2","key":"10.1016\/j.ijid.2026.109203_bib0004","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/1469-0691.12236","article-title":"Incidence, clinical characteristics and 30-day mortality of enterococcal bacteraemia in Denmark 2006-2009: A population-based cohort study","volume":"20","author":"Pinholt","year":"2014","journal-title":"Clinical Microbiology and Infection"},{"issue":"5","key":"10.1016\/j.ijid.2026.109203_bib0005","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jacc.2019.11.047","article-title":"A Contemporary Picture of Enterococcal Endocarditis","volume":"75","author":"Peric\u00e0s","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.ijid.2026.109203_bib0006","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2019.04.059","article-title":"Prevalence of Infective Endocarditis in Enterococcus faecalis Bacteremia","volume":"74","author":"Dahl","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.ijid.2026.109203_bib0007","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1080\/22221751.2020.1769500","article-title":"The ongoing challenge of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis in Europe: an epidemiological analysis of bloodstream infections","volume":"9","author":"Ayobami","year":"2020","journal-title":"Emerg Microbes Infect"},{"issue":"4","key":"10.1016\/j.ijid.2026.109203_bib0008","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/cid\/ciad271","article-title":"The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria","volume":"77","author":"Fowler","year":"2023","journal-title":"Clinical Infectious Diseases."},{"key":"10.1016\/j.ijid.2026.109203_bib0009","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 16.0, 2026. https:\/\/www.eucast.org."},{"key":"10.1016\/j.ijid.2026.109203_bib0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejim.2020.10.006","article-title":"Enterococcal infective endocarditis is a marker of current occult or future incident colorectal neoplasia","volume":"83","author":"Ursi","year":"2021","journal-title":"Eur J Intern Med"},{"issue":"10","key":"10.1016\/j.ijid.2026.109203_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12101932","article-title":"Trends in Enterococcus faecium Bacteremia: Exploring Risk Factors with Emphasis on Prior Antibiotic Exposure","volume":"12","author":"S\u00f6rstedt","year":"2024","journal-title":"Microorganisms"},{"issue":"2","key":"10.1016\/j.ijid.2026.109203_bib0012","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/cid\/ciac777","article-title":"Impact of Enterococcus faecalis Endocarditis Treatment on Risk of Relapse","volume":"76","author":"Danneels","year":"2023","journal-title":"Clinical Infectious Diseases"},{"issue":"1","key":"10.1016\/j.ijid.2026.109203_bib0013","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jac\/dkw366","article-title":"Long-term clonal dynamics of Enterococcus faecium strains causing bloodstream infections (1995-2015) in Spain","volume":"72","author":"Tedim","year":"2017","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"7","key":"10.1016\/j.ijid.2026.109203_bib0014","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1128\/AAC.49.7.2693-2700.2005","article-title":"Population structure of Enterococcus faecium causing bacteremia in a Spanish University Hospital: Setting the scene for a future increase in vancomycin resistance?","volume":"49","author":"Coque","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"issue":"16","key":"10.1016\/j.ijid.2026.109203_bib0015","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1017\/S0950268818002479","article-title":"Enterococcal bacteraemia: Predictive and prognostic risk factors for ampicillin resistance","volume":"146","author":"Matsumura","year":"2018","journal-title":"Epidemiol Infect"},{"issue":"4","key":"10.1016\/j.ijid.2026.109203_bib0016","doi-asserted-by":"crossref","first-page":"859","DOI":"10.18388\/abp.2015_1147","article-title":"Comparison of antibiotic resistance and virulence between biofilm-producing and non-producing clinical isolates of Enterococcus faecium","volume":"62","author":"Sie\u0144ko","year":"2015","journal-title":"Acta Biochim Pol"},{"issue":"2","key":"10.1016\/j.ijid.2026.109203_bib0017","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/jac\/dkx387","article-title":"Distribution of putative virulence markers in Enterococcus faecium: Towards a safety profile review","volume":"73","author":"Freitas","year":"2018","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"39","key":"10.1016\/j.ijid.2026.109203_bib0018","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC Guidelines for the management of endocarditis","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.ijid.2026.109203_bib0019","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s10096-022-04437-0","article-title":"Antimicrobial activity of dalbavancin against Gram-positive bacteria isolated from patients hospitalized with bloodstream infection in United States and European medical centers (2018\u20132020)","volume":"41","author":"Sader","year":"2022","journal-title":"European Journal of Clinical Microbiology and Infectious Diseases"},{"key":"10.1016\/j.ijid.2026.109203_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.779885","article-title":"Pharmacodynamics of Linezolid Plus Fosfomycin Against Vancomycin\u2013Resistant Enterococcus faecium in a Hollow Fiber Infection Model","volume":"12","author":"Wang","year":"2021","journal-title":"Front Microbiol"},{"issue":"5","key":"10.1016\/j.ijid.2026.109203_bib0021","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/jac\/dkad079","article-title":"Teicoplanin and vancomycin as treatment for glycopeptide-susceptible Enterococcus faecium bacteraemia: a propensity score-adjusted non-inferior comparative study","volume":"78","author":"Yamaguchi","year":"2023","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"11","key":"10.1016\/j.ijid.2026.109203_bib0022","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1093\/jac\/dkae291","article-title":"Use of teicoplanin monotherapy for the treatment of enterococcal infective endocarditis: A retrospective and comparative study at a referral centre","volume":"79","author":"Villamar\u00edn","year":"2024","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"3","key":"10.1016\/j.ijid.2026.109203_bib0023","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/AAC.06067-11","article-title":"Oritavancin activity against vancomycin-susceptible and vancomycin-resistant enterococci with molecularly characterized glycopeptide resistance genes recovered from bacteremic patients, 2009-2010","volume":"56","author":"Mendes","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"10.1016\/j.ijid.2026.109203_bib0024","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1093\/jac\/dkw319","article-title":"Longitudinal (2001-14) analysis of enterococci and VRE causing invasive infections in European and US hospitals, including a contemporary (2010-13) analysis of oritavancin in vitro potency","volume":"71","author":"Mendes","year":"2016","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.ijid.2026.109203_bib0025","series-title":"How do I manage a patient with enterococcal bacteraemia? Clinical Microbiology and Infection","first-page":"364","author":"Rosselli Del Turco","year":"2021"},{"key":"10.1016\/j.ijid.2026.109203_bib0026","series-title":"Future Microbiology","first-page":"1215","article-title":"Enterococcal endocarditis revisited","author":"Peric\u00e1s","year":"2015"},{"issue":"1","key":"10.1016\/j.ijid.2026.109203_bib0027","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-024-09824-w","article-title":"Clinical outcome of ampicillin or ampicillin\/sulbactam versus glycopeptides in ampicillin-susceptible Enterococcus faecalis\/faecium bacteremia: a 10-year retrospective cohort study","volume":"24","author":"Seong","year":"2024","journal-title":"BMC Infect Dis"},{"issue":"10","key":"10.1016\/j.ijid.2026.109203_bib0028","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1093\/jac\/dkaf226","article-title":"Is ampicillin plus cephalosporins a therapeutic option for Ampicillin-Susceptible Enterococcus faecium?","volume":"80","author":"Bierge","year":"2025","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"8","key":"10.1016\/j.ijid.2026.109203_bib0029","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1093\/jac\/dkz173","article-title":"In vitro activity of ampicillin and ceftriaxone against ampicillin-susceptible Enterococcus faecium","volume":"74","author":"Lorenzo","year":"2019","journal-title":"Journal of Antimicrobial Chemotherapy"}],"container-title":["International Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971226008386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1201971226008386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:54:25Z","timestamp":1792857265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1201971226008386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S1201971226008386"],"URL":"https:\/\/doi.org\/10.1016\/j.ijid.2026.109203","relation":{},"ISSN":["1201-9712"],"issn-type":[{"value":"1201-9712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Features and Real-World Management of Enterococcus faecium Infective Endocarditis: A Nationwide Multicenter Cohort Study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Infectious Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijid.2026.109203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"109203"}}