{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:07:36Z","timestamp":1785182856035,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.ijmm.2013.03.004","type":"journal-article","created":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T04:15:32Z","timestamp":1364530532000},"page":"190-200","source":"Crossref","is-referenced-by-count":27,"title":["Methylthioadenosine\/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS\/AI-2 system"],"prefix":"10.1016","volume":"303","author":[{"given":"Yan","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2013.03.004_bib0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2011.02.022","article-title":"Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism","volume":"145","author":"Adams","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ijmm.2013.03.004_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2958.2011.07808.x","article-title":"The evolution of a superbug: how Staphylococcus aureus overcomes its unique susceptibility to polyamines","volume":"82","author":"Anzaldi","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0015","doi-asserted-by":"crossref","first-page":"e10790","DOI":"10.1371\/journal.pone.0010790","article-title":"Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation","volume":"5","author":"Beenken","year":"2010","journal-title":"PLoS One"},{"issue":"Suppl. 5","key":"10.1016\/j.ijmm.2013.03.004_bib0020","doi-asserted-by":"crossref","first-page":"S344","DOI":"10.1086\/533590","article-title":"Epidemiology of methicillin-resistant Staphylococcus aureus","volume":"46","author":"Boucher","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0025","doi-asserted-by":"crossref","first-page":"e16084","DOI":"10.1371\/journal.pone.0016084","article-title":"Structure\u2013activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp.","volume":"6","author":"Brackman","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2013.03.004_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1097(97)00116-X","article-title":"Gene replacement in Staphylococcus carnosus and Staphylococcus xylosus","volume":"151","author":"Br\u00fcckner","year":"1997","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0035","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/nm1207-1405","article-title":"Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia","volume":"13","author":"Bubeck Wardenburg","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0040","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.chembiol.2005.04.012","article-title":"A nucleosidase required for in vivo function of the S-adenosyl-l-methionine radical enzyme, biotin synthase","volume":"12","author":"Choi-Rhee","year":"2005","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0045","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/jac\/dkp129","article-title":"Assessment of methylthioadenosine\/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as targets for novel antimicrobials using a novel high-throughput method","volume":"63","author":"Cornell","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0050","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1365-2958.1998.01075.x","article-title":"Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments","volume":"30","author":"Coulter","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0055","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1128\/CMR.00081-09","article-title":"Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic","volume":"23","author":"David","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0060","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/bj2320335","article-title":"Escherichia coli S-adenosylhomocysteine\/5\u2032-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action","volume":"232","author":"Della Ragione","year":"1985","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0065","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1128\/JB.188.8.2885-2897.2006","article-title":"Functional analysis of luxS in Staphylococcus aureus reveals a role in metabolism but not quorum sensing","volume":"188","author":"Doherty","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0070","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1515\/BC.2002.116","article-title":"Extracellular proteases of Staphylococcus spp.","volume":"383","author":"Dubin","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0075","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi","volume":"390","author":"Fraser","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ijmm.2013.03.004_bib0080","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa043252","article-title":"Methicillin-resistant Staphylococcus aureus disease in three communities","volume":"352","author":"Fridkin","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0085","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/infdis\/jir713","article-title":"Formylated peptides are important virulence factors in Staphylococcus aureus arthritis in mice","volume":"205","author":"Gjertsson","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0090","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nchembio.153","article-title":"Transition state analogs of 5\u2032-methylthioadenosine nucleosidase disrupt quorum sensing","volume":"5","author":"Gutierrez","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0095","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1128\/JB.01170-08","article-title":"Growth deficiencies of Neisseria meningitidis pfs and luxS mutants are not due to inactivation of quorum sensing","volume":"191","author":"Heurlier","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0100","doi-asserted-by":"crossref","first-page":"12873","DOI":"10.1073\/pnas.0904958106","article-title":"NOD2 contributes to cutaneous defense against Staphylococcus aureus through {alpha}-toxin-dependent innate immune activation","volume":"106","author":"Hruz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0105","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa1007474","article-title":"Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections","volume":"364","author":"Jain","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0110","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1084\/jem.20050846","article-title":"Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity","volume":"202","author":"Liu","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0115","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1124\/pr.107.07110","article-title":"Sortase as a target of anti-infective therapy","volume":"60","author":"Maresso","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0120","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1128\/IAI.65.7.2621-2628.1997","article-title":"Modification of the Staphylococcus aureus fibronectin binding phenotype by V8 protease","volume":"65","author":"McGavin","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0125","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0014-5793(79)80988-6","article-title":"Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain","volume":"99","author":"Pajula","year":"1979","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0130","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nm.2423","article-title":"In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation","volume":"17","author":"Panizzi","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0135","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2958.2010.07455.x","article-title":"Methylthioadenosine\/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism","volume":"79","author":"Parveen","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0140","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1128\/IAI.74.5.3016-3020.2006","article-title":"Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice","volume":"74","author":"Parveen","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0145","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1046\/j.1365-2958.2000.01792.x","article-title":"Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi","volume":"35","author":"Parveen","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0150","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/S0021-9258(18)69118-5","article-title":"Degradation of elastin by a cysteine proteinase from Staphylococcus aureus","volume":"263","author":"Potempa","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0155","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/j.1462-5822.2008.01213.x","article-title":"A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens","volume":"10","author":"Prajsnar","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0160","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1128\/IAI.69.1.159-169.2001","article-title":"Description of staphylococcus serine protease (ssp) operon in Staphylococcus aureus and nonpolar inactivation of sspA-encoded serine protease","volume":"69","author":"Rice","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0165","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1099\/mic.0.26634-0","article-title":"The role and regulation of the extracellular proteases of Staphylococcus aureus","volume":"150","author":"Shaw","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2013.03.004_bib0170","doi-asserted-by":"crossref","first-page":"12741","DOI":"10.1016\/S0021-9258(18)98961-1","article-title":"The kinetic mechanism of S-adenosyl-L-methionine: glutamylmethyltransferase from Salmonella typhimurium","volume":"266","author":"Simms","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0175","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1107\/S1744309108009275","article-title":"Structure of Staphylococcus aureus 5\u2032-methylthioadenosine\/S-adenosylhomocysteine nucleosidase","volume":"64","author":"Siu","year":"2008","journal-title":"Acta Crystallogr. F \u2013 Struct. Biol. Cryst. Commun."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0180","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2148-4-36","article-title":"Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways","volume":"4","author":"Sun","year":"2004","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0185","doi-asserted-by":"crossref","first-page":"e1002349","DOI":"10.1371\/journal.ppat.1002349","article-title":"Zebrafish: a see-through host and a fluorescent toolbox to probe host-pathogen interaction","volume":"8","author":"Tobin","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0190","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0966-842X(00)88988-X","article-title":"Are bacterial proteinases pathogenic factors?","volume":"3","author":"Travis","year":"1995","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0195","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1471-4906(01)01939-1","article-title":"Fishing for lymphoid genes","volume":"22","author":"Trede","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0200","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrmicro1146","article-title":"Making \u2018sense\u2019 of metabolism: autoinducer-2, LuxS and pathogenic bacteria","volume":"3","author":"Vendeville","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0205","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1086\/598967","article-title":"The SaeR\/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus","volume":"199","author":"Voyich","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0210","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1099\/00221287-148-4-909","article-title":"LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone","volume":"148","author":"Winzer","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2013.03.004_bib0215","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/IAI.70.6.2758-2762.2002","article-title":"Transcription of clumping factor A in attached and unattached Staphylococcus aureus in vitro and during device-related infection","volume":"70","author":"Wolz","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0220","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1126\/science.1188888","article-title":"Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence","volume":"329","author":"Wyatt","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ijmm.2013.03.004_bib0225","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1086\/342046","article-title":"Activation and transcriptional interaction between agr RNAII and RNAIII in Staphylococcus aureus in vitro and in an experimental endocarditis model","volume":"186","author":"Xiong","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0230","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijantimicag.2012.08.016","article-title":"LuxS\/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325","volume":"41","author":"Xue","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ijmm.2013.03.004_bib0235","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2180-12-288","article-title":"Staphylococcus aureus autoinducer-2 quorum sensing decreases biofilm formation in an icaR-dependent manner","volume":"12","author":"Yu","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0240","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0145-305X(01)00034-9","article-title":"Phylogenetic aspects of the complement system","volume":"25","author":"Zarkadis","year":"2001","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ijmm.2013.03.004_bib0245","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1128\/IAI.00131-10","article-title":"Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence","volume":"78","author":"Zhao","year":"2010","journal-title":"Infect. Immun."}],"updated-by":[{"DOI":"10.1016\/j.ijmm.2026.151731","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000}}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422113000465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422113000465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T17:34:59Z","timestamp":1644687299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422113000465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S1438422113000465"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2013.03.004","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}