{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:06Z","timestamp":1791946026671,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.ijmm.2013.03.005","type":"journal-article","created":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T23:15:56Z","timestamp":1365290156000},"page":"239-246","source":"Crossref","is-referenced-by-count":13,"title":["Host metabolism promotes growth of Chlamydia pneumoniae in a low oxygen environment"],"prefix":"10.1016","volume":"303","author":[{"given":"M\u00e1rta","family":"Szasz\u00e1k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Shima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"K\u00e4ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hannus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Solbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2013.03.005_bib0005","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1582-4934.2011.01258.x","article-title":"Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia","volume":"15","author":"Carreau","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0010","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bbrc.2005.06.017","article-title":"High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines","volume":"333","author":"Chowdhury","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0015","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2006.04.023","article-title":"Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance","volume":"9","author":"Fantin","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijmm.2013.03.005_bib0025","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/excr.1998.4172","article-title":"Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism","volume":"243","author":"Foster","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0079-6107(93)90001-Z","article-title":"Evolution of glycolysis","volume":"59","author":"Fothergill-Gilmore","year":"1993","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0035","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/clind\/15.5.757","article-title":"Infections caused by Chlamydia pneumoniae strain TWAR","volume":"15","author":"Grayston","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0040","doi-asserted-by":"crossref","first-page":"35245","DOI":"10.1074\/jbc.C110.175851","article-title":"FoxOs function synergistically to promote glucose production","volume":"285","author":"Haeusler","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0045","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.2741\/hahn","article-title":"Chlamydia pneumoniae as a respiratory pathogen","volume":"7","author":"Hahn","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1165\/rcmb.2004-0202OC","article-title":"Hypoxia decreases cellular ATP demand and inhibits mitochondrial respiration of a549 cells","volume":"32","author":"Heerlein","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0055","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1046\/j.1462-5822.2003.00319.x","article-title":"More than just innate immunity: comparative analysis of Chlamydophila pneumoniae and Chlamydia trachomatis effects on host\u2013cell gene regulation","volume":"5","author":"Hess","year":"2003","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0060","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrd3010","article-title":"Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application","volume":"9","author":"Jackson","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0065","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1189\/jlb.1210683","article-title":"Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1alpha (HIF1A) and result in differential HIF1A-dependent gene expression","volume":"90","author":"Jantsch","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0070","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1128\/JB.00279-07","article-title":"Characterization of in vitro chlamydial cultures in low-oxygen atmospheres","volume":"189","author":"Juul","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0075","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/sj.cr.7310072","article-title":"Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha","volume":"16","author":"Li","year":"2006","journal-title":"Cell Res."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijmm.2013.03.005_bib0085","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2407-6-26","article-title":"Hypoxia-inducible transcription factor-1alpha promotes hypoxia-induced A549 apoptosis via a mechanism that involves the glycolysis pathway","volume":"6","author":"Luo","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijmm.2013.03.005_bib0090","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1172\/JCI31807","article-title":"Foxo3 is required for the regulation of oxidative stress in erythropoiesis","volume":"117","author":"Marinkovic","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0095","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1371\/journal.ppat.0030083","article-title":"Gene expression profiles of Chlamydophila pneumoniae during the developmental cycle and iron depletion-mediated persistence","volume":"3","author":"Maurer","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0100","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ijmm.2013.03.005_bib0195","first-page":"7052","article-title":"Enhancement of ATP levels and glucose metabolism during an infection by Chlamydia","volume":"273","author":"Ojcius","year":"1998","journal-title":"NMR studies of living cells. J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0105","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/sj.onc.1209597","article-title":"Glycolysis inhibition for anticancer treatment","volume":"25","author":"Pelicano","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.ijmm.2013.03.005_bib0110","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1161\/CIRCRESAHA.107.166744","article-title":"Forkhead transcription factors coordinate expression of myocardial KATP channel subunits and energy metabolism","volume":"102","author":"Philip-Couderc","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0115","doi-asserted-by":"crossref","first-page":"e1000201","DOI":"10.1371\/journal.ppat.1000201","article-title":"Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection","volume":"4","author":"Prudencio","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0120","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/cdd.2008.21","article-title":"The role of hypoxia-inducible factors in tumorigenesis","volume":"15","author":"Rankin","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0125","doi-asserted-by":"crossref","first-page":"19502","DOI":"10.1073\/pnas.1008178107","article-title":"Hypoxia abrogates antichlamydial properties of IFN-gamma in human fallopian tube cells in vitro and ex vivo","volume":"107","author":"Roth","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0130","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1111\/j.1462-5822.2007.00948.x","article-title":"Chlamydia pneumoniae directly interferes with HIF-1alpha stabilization in human host cells","volume":"9","author":"Rupp","year":"2007","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0135","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1073\/pnas.0407759102","article-title":"Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo","volume":"102","author":"Rupp","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0140","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1128\/JB.186.3.683-691.2004","article-title":"ATP\/ADP translocases: a common feature of obligate intracellular amoebal symbionts related to Chlamydiae and Rickettsiae","volume":"186","author":"Schmitz-Esser","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0145","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1182\/blood-2010-10-314427","article-title":"High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq","volume":"117","author":"Schodel","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ijmm.2013.03.005_bib0150","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1462-5822.2011.01642.x","article-title":"HIF-1alpha is involved in mediating apoptosis resistance to Chlamydia trachomatis-infected cells","volume":"13","author":"Sharma","year":"2011","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0155","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1073\/pnas.94.13.6658","article-title":"c-Myc transactivation of LDH-A: implications for tumor metabolism and growth","volume":"94","author":"Shim","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000272066","article-title":"Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells","volume":"25","author":"Signorelli","year":"2010","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0165","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/sj.bjp.0707346","article-title":"The potential of high-content high-throughput microscopy in drug discovery","volume":"152","author":"Starkuviene","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0170","doi-asserted-by":"crossref","first-page":"e1002108","DOI":"10.1371\/journal.ppat.1002108","article-title":"Fluorescence lifetime imaging unravels C. trachomatis metabolism and its crosstalk with the host cell","volume":"7","author":"Szaszak","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0175","doi-asserted-by":"crossref","first-page":"14871","DOI":"10.1074\/jbc.M400461200","article-title":"Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha","volume":"279","author":"Uchida","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2013.03.005_bib0180","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/CS20070298","article-title":"Role of Chlamydia pneumoniae in atherosclerosis","volume":"114","author":"Watson","year":"2008","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ijmm.2013.03.005_bib0185","doi-asserted-by":"crossref","first-page":"e11576","DOI":"10.1371\/journal.pone.0011576","article-title":"Activation of hypoxia inducible factor 1 is a general phenomen in infections with human pathogens","volume":"5","author":"Werth","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2013.03.005_bib0190","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1128\/IAI.71.2.614-620.2003","article-title":"Induction of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection","volume":"71","author":"Yang","year":"2003","journal-title":"Infect. Immun."}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422113000532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422113000532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T23:32:18Z","timestamp":1539732738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422113000532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S1438422113000532"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2013.03.005","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}