{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:39:21Z","timestamp":1790627961800,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008385","name":"Fondazione per la Ricerca sulla Fibrosi Cistica","doi-asserted-by":"publisher","award":["FFC#9\/2010"],"award-info":[{"award-number":["FFC#9\/2010"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","award":["Kah2\/024\/09"],"award-info":[{"award-number":["Kah2\/024\/09"]}],"id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","award":["SFTR34C7"],"award-info":[{"award-number":["SFTR34C7"]}],"id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["0315829B"],"award-info":[{"award-number":["0315829B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.ijmm.2013.09.012","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T17:19:22Z","timestamp":1381252762000},"page":"685-692","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation"],"prefix":"10.1016","volume":"303","author":[{"given":"Nina","family":"Hirschhausen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Block","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bianconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bragonzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Birtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"D\u00fcbbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"K\u00fcster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Kahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5155-3383","authenticated-orcid":false,"given":"Barbara C.","family":"Kahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2013.09.012_bib0005","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1164\/rccm.200812-1943OC","article-title":"Pseudomonas aeruginosa microevolution during cystic fibrosis lung infection establishes clones with adapted virulence","volume":"180","author":"Bragonzi","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nm.2715","article-title":"Cystic fibrosis: a mucosal immunodeficiency syndrome","volume":"18","author":"Cohen","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0015","unstructured":"Cystic Fibrosis Foundation, 2011. Cystic Fibrosis Foundation Patient Registry \u2013 2010 Annual Data Report. Bethesda, MD."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0025","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/JCM.38.3.1008-1015.2000","article-title":"Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus","volume":"38","author":"Enright","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/infdis\/jis311","article-title":"The length of the Staphylococcus aureus protein A polymorphic region regulates inflammation: impact on acute and chronic infection","volume":"206","author":"Garofalo","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0035","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tim.2008.11.005","article-title":"Staphylococcus aureus: new evidence for intracellular persistence","volume":"17","author":"Garzoni","year":"2009","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijmm.2005.01.004","article-title":"Staphylococcus aureus strain designation by agr and cap polymorphism typing and delineation of agr diversification by sequence analysis","volume":"295","author":"Goerke","year":"2005","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0045","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1111\/j.1462-2920.2007.01423.x","article-title":"High phenotypic diversity in infecting but not in colonizing Staphylococcus aureus populations","volume":"9","author":"Goerke","year":"2007","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijmm.2004.06.013","article-title":"Regulatory and genomic plasticity of Staphylococcus aureus during persistent colonization and infection","volume":"294","author":"Goerke","year":"2004","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0055","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ijmm.2010.08.003","article-title":"Adaptation of Staphylococcus aureus to the cystic fibrosis lung","volume":"300","author":"Goerke","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0060","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1128\/JCM.41.12.5442-5448.2003","article-title":"Typing of methicillin-resistant Staphylococcus aureus in the University hospital setting using a novel software for spa repeat determination and database management","volume":"41","author":"Harmsen","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0065","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1086\/514061","article-title":"Regulation of Staphylococcus aureus capsular polysaccharide type 5: CO2 inhibition in vitro and in vivo","volume":"176","author":"Herbert","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0070","first-page":"91","article-title":"Microevolution of Pseudomonas aeruginosa to a chronic pathogen of the cystic fibrosis lung","volume":"358","author":"Hogardt","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0075","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1086\/515238","article-title":"Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis","volume":"177","author":"Kahl","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0080","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ijmm.2010.08.002","article-title":"Impact of Staphylococcus aureus on the pathogenesis of chronic cystic fibrosis lung disease","volume":"300","author":"Kahl","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0085","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1128\/JCM.41.9.4424-4427.2003","article-title":"Population dynamics of persistent Staphylococcus aureus isolated from the airways of cystic fibrosis patients during a 6-year prospective study","volume":"41","author":"Kahl","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0090","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1128\/JCM.43.1.502-505.2005","article-title":"Variation of the polymorphic region X of the protein A gene during persistent airway infection of cystic fibrosis patients reflects two independent mechanisms of genetic change in Staphylococcus aureus","volume":"43","author":"Kahl","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0095","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/pmic.201000796","article-title":"Small colony variants of Staphylococcus aureus reveal distinct protein profiles","volume":"11","author":"Kriegeskorte","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.ijmm.2013.09.012_bib0100","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0105","first-page":"1931","article-title":"Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A","volume":"119","author":"Martin","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0110","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1126\/science.284.5419.1523","article-title":"Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen","volume":"284","author":"McKenney","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ijmm.2013.09.012_bib0115","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1164\/rccm.201009-1430OC","article-title":"Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections","volume":"183","author":"Mowat","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/CMR.17.1.218-234.2004","article-title":"Staphylococcus aureus capsular polysaccharides","volume":"17","author":"O\u2019Riordan","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0125","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/S0140-6736(09)60327-5","article-title":"Cystic fibrosis","volume":"373","author":"O'Sullivan","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ijmm.2013.09.012_bib0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrmicro1384","article-title":"Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections","volume":"4","author":"Proctor","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0135","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1086\/520932","article-title":"Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets","volume":"196","author":"Risley","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0140","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1073\/pnas.0602138103","article-title":"Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients","volume":"103","author":"Smith","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0145","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/MCP.0b013e3282efbbac","article-title":"Update on the epidemiology and management of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, in patients with cystic fibrosis","volume":"13","author":"Stone","year":"2007","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0150","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/emmm.201000115","article-title":"Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection","volume":"3","author":"Tuchscherr","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0155","doi-asserted-by":"crossref","first-page":"7932","DOI":"10.1128\/IAI.73.12.7932-7937.2005","article-title":"Capsule-negative Staphylococcus aureus induces chronic experimental mastitis in mice","volume":"73","author":"Tuchscherr","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2013.09.012_bib0160","series-title":"European Cystic Fibrosis Foundation Patient Registry \u2013 Annual Data Report 2008\u20132009","author":"Viviani","year":"2012"},{"key":"10.1016\/j.ijmm.2013.09.012_bib0165","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(05)70295-4","article-title":"The role of nasal carriage in Staphylococcus aureus infections","volume":"5","author":"Wertheim","year":"2005","journal-title":"Lancet Infect. Dis."}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422113001501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422113001501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:56:34Z","timestamp":1761411394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422113001501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1438422113001501"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2013.09.012","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2013.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}