{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:47:35Z","timestamp":1784213255117,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.ijmm.2014.02.010","type":"journal-article","created":{"date-parts":[[2014,3,2]],"date-time":"2014-03-02T20:46:45Z","timestamp":1393793205000},"page":"490-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Characterization of lactate utilization and its implication on the physiology of Haemophilus influenzae"],"prefix":"10.1016","volume":"304","author":[{"given":"Sabine","family":"Lichtenegger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Roier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stilla","family":"Bauernfeind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Keidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Anthony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Reidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2014.02.010_bib0005","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1128\/IAI.55.4.882-887.1987","article-title":"Antigenic diversity of lipooligosaccharides of nontypable Haemophilus influenzae","volume":"55","author":"Campagnari","year":"1987","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0010","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0022-2836(76)90119-4","article-title":"Transposition and fusion of the lac genes to select promoters in Escherichia coli using bacteriophage lambda and Mu","volume":"104","author":"Casadaban","year":"1976","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0015","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/mmi.12214","article-title":"Evasion of killing by human antibody and complement through multiple variations in the surface oligosaccharide of Haemophilus influenzae","volume":"88","author":"Clark","year":"2013","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0020","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/IAI.71.1.163-172.2003","article-title":"Two-component systems in Haemophilus influenzae: a regulatory role for ArcA in serum resistance","volume":"71","author":"De Souza-Hart","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0025","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/S0021-9258(19)39649-8","article-title":"Purification and characterization of Haemophilus influenzae d-lactate dehydrogenase","volume":"265","author":"Denicola-Seoane","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0030","doi-asserted-by":"crossref","first-page":"6671","DOI":"10.1128\/jb.175.20.6671-6678.1993","article-title":"Three overlapping lct genes involved in l-lactate utilization by Escherichia coli","volume":"175","author":"Dong","year":"1993","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0035","doi-asserted-by":"crossref","first-page":"17410","DOI":"10.1074\/jbc.274.25.17410","article-title":"Systems properties of the Haemophilus influenzae Rd metabolic genotype","volume":"274","author":"Edwards","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0040","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1128\/IAI.73.9.5762-5766.2005","article-title":"Neisseria meningitidis lactate permease is required for nasopharyngeal colonization","volume":"73","author":"Exley","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0045","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1084\/jem.20041548","article-title":"Available carbon source influences the resistance of Neisseria meningitidis against complement","volume":"201","author":"Exley","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0050","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1128\/IAI.01530-06","article-title":"Lactate acquisition promotes successful colonization of the murine genital tract by Neisseria gonorrhoeae","volume":"75","author":"Exley","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0055","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1126\/science.7542800","article-title":"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd","volume":"269","author":"Fleischmann","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0060","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1126\/science.1059361","article-title":"Quinones as the redox signal for the arc two-component system of bacteria","volume":"292","author":"Georgellis","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0065","doi-asserted-by":"crossref","first-page":"7206","DOI":"10.1128\/JB.183.24.7206-7212.2001","article-title":"Redox signal transduction by the ArcB sensor kinase of Haemophilus influenzae lacking the PAS domain","volume":"183","author":"Georgellis","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0070","doi-asserted-by":"crossref","first-page":"8893","DOI":"10.1093\/nar\/17.21.8893","article-title":"A simple method for the preparation of plasmid and chromosomal E. coli DNA","volume":"17","author":"Grimberg","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0075","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.tim.2010.03.007","article-title":"Haemophilus influenzae and the complement system","volume":"18","author":"Hallstr\u00f6m","year":"2010","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0080","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0022-2836(83)80284-8","article-title":"Studies on transformation of Escherichia coli with plasmids","volume":"166","author":"Hanahan","year":"1983","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0085","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1042\/bj0261406","article-title":"Studies on plant amylases: the effect of starch concentration upon the velocity of hydrolysis by the amylase of germinated barley","volume":"26","author":"Hanes","year":"1932","journal-title":"Biochem. J"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0090","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/mpat.2002.0530","article-title":"Signature tagged mutagenesis of Haemophilus influenzae identifies genes required for in vivo survival","volume":"33","author":"Herbert","year":"2002","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0095","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1128\/JB.101.2.513-516.1970","article-title":"Defined medium for growth of Haemophilus influenzae","volume":"101","author":"Herriott","year":"1970","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0100","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF00410174","article-title":"Energy metabolism fo some representatives of the Haemophilus group","volume":"42","author":"Hollander","year":"1976","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"2","key":"10.1016\/j.ijmm.2014.02.010_bib0105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-2958.2001.02204.x","article-title":"Identification of a lipopolysaccharide \u03b1-2,3-sialyltransferase from Haemophilus influenzae","volume":"39","author":"Hood","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-1119(89)90359-4","article-title":"Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension","volume":"77","author":"Horton","year":"1989","journal-title":"Gene"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0115","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1128\/jb.176.6.1695-1701.1994","article-title":"Effects of nitrate respiration on expression of the Arc-controlled operons encoding succinate dehydrogenase and flavin-linked l-lactate dehydrogenase","volume":"176","author":"Iuchi","year":"1994","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0120","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1128\/IAI.62.5.1755-1760.1994","article-title":"Analysis of C3 deposition and degradation on Neisseria meningitidis and Neisseria gonorrhoeae","volume":"62","author":"Jarvis","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0125","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1128\/AEM.64.12.4697-4702.1998","article-title":"In vivo transposon mutagenesis in Haemophilus influenzae","volume":"64","author":"Krai\u00df","year":"1998","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0130","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/IAI.58.4.914-919.1990","article-title":"Multiple mechanisms in serum factor-induced resistance of Haemophilus influenzae type b to antibody","volume":"58","author":"Kuratana","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0135","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/infdis\/163.5.1073","article-title":"Host metabolites that phenotypically increase the resistance of Haemophilus influenzae type b to clearance mechanisms","volume":"163","author":"Kuratana","year":"1991","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0140","series-title":"Units of Measurements, Body Fluids, Composition of the Body, Nutrition","author":"Lentner","year":"1981"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0145","doi-asserted-by":"crossref","first-page":"13318","DOI":"10.1073\/pnas.0403064101","article-title":"Identification of a quinone-sensitive redox switch in the ArcB sensor kinase","volume":"101","author":"Malpica","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0150","series-title":"Molecular Cloning, A Laboratory Manual","author":"Maniatis","year":"1989"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0155","doi-asserted-by":"crossref","first-page":"e5854","DOI":"10.1371\/journal.pone.0005854","article-title":"Tracing the evolution of competence in Haemophilus influenzae","volume":"4","author":"Maughan","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0160","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1128\/JB.187.13.4410-4420.2005","article-title":"Coupling of NAD+ biosynthesis and nicotinamide ribosyl transport: characterization of NadR ribonucleotide kinase mutants of Haemophilus influenzae","volume":"187","author":"Merdanovic","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0165","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1128\/JB.109.2.560-564.1972","article-title":"Identification of competence-repressing factors during log-phase growth of Haemophilus influenzae","volume":"109","author":"Miller","year":"1972","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0170","doi-asserted-by":"crossref","first-page":"e1001247","DOI":"10.1371\/journal.ppat.1001247","article-title":"Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemophilus influenzae","volume":"7","author":"Nakamura","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0175","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1099\/00221287-147-4-1069","article-title":"The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to l-lactate permease","volume":"147","author":"N\u00fa\u00f1ez","year":"2001","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0180","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1099\/00222615-37-2-133","article-title":"Effect of haemin limitation on the cytochrome complement and glucose metabolism of non-typable Haemophilus influenzae","volume":"37","author":"O\u2018Reilly","year":"1992","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0185","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1128\/jb.173.18.5612-5618.1991","article-title":"sxy-1, a Haemophilus influenzae mutation causing greatly enhanced spontaneous competence","volume":"173","author":"Redfield","year":"1991","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0190","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1471-2148-6-82","article-title":"Evolution of competence and DNA uptake specificity in the Pasteurellaceae","volume":"6","author":"Redfield","year":"2006","journal-title":"BMC Evol Biol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0195","doi-asserted-by":"crossref","first-page":"e42664","DOI":"10.1371\/journal.pone.0042664","article-title":"Intranasal immunization with nontypeable Haemophilus influenzae outer membrane vesicles induces cross-protective immunity in mice","volume":"7","author":"Roier","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0200","article-title":"Outer membrane protein P5 is required for resistance of nontypeable Haemophilus influenzae to both the classical and alternative complement pathways","author":"Rosadini","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0205","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/nar\/16.1.356","article-title":"The nucleotide sequence of pACYC177","volume":"16","author":"Rose","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0210","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/nar\/16.1.355","article-title":"The nucleotide sequence of pACYC184","volume":"16","author":"Rose","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0215","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI108525","article-title":"The paradox of Hemophilus influenzae type B bacteremia in the presence of serum bactericidal activity","volume":"58","author":"Shaw","year":"1976","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1438-4221(00)80117-4","article-title":"Host factors that influence the behaviour of bacterial pathogens in vivo","volume":"290","author":"Smith","year":"2000","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0225","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1128\/IAI.00117-07","article-title":"Effect of host lactate on gonococci and meningococci: new concepts on the role of metabolites in pathogenicity","volume":"75","author":"Smith","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0230","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0378-1119(82)90015-4","article-title":"The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers","volume":"19","author":"Vieira","year":"1982","journal-title":"Gene"},{"key":"10.1016\/j.ijmm.2014.02.010_bib0235","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1128\/MMBR.68.1.132-153.2004","article-title":"Diversity of microbial sialic acid metabolism","volume":"68","author":"Vimr","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0240","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1365-2958.2007.05747.x","article-title":"The ArcA regulon and oxidative stress resistance in Haemophilus influenzae","volume":"64","author":"Wong","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0245","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1128\/IAI.01269-10","article-title":"ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae","volume":"79","author":"Wong","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0250","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1128\/jb.178.16.4773-4777.1996","article-title":"High-affinity maltose\/trehalose transport system in the hyperthermophilic archaeon Thermococcus litoralis","volume":"178","author":"Xavier","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2014.02.010_bib0255","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-1119(85)90120-9","article-title":"Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors","volume":"33","author":"Yanisch-Perron","year":"1985","journal-title":"Gene"}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422114000204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422114000204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T04:07:43Z","timestamp":1648440463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422114000204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":51,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1438422114000204"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2014.02.010","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of lactate utilization and its implication on the physiology of Haemophilus influenzae","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2014.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}