{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:13:11Z","timestamp":1794010391762,"version":"4.8.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["0315830B"],"award-info":[{"award-number":["0315830B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANPCyY","award":["2010-01039"],"award-info":[{"award-number":["2010-01039"]}]},{"DOI":"10.13039\/501100010253","name":"UBACyT","doi-asserted-by":"crossref","award":["20020100100347"],"award-info":[{"award-number":["20020100100347"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.ijmm.2014.07.013","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T23:01:32Z","timestamp":1406415692000},"page":"1038-1049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Staphylococcus aureus isolates from chronic osteomyelitis are characterized by high host cell invasion and intracellular adaptation, but still induce inflammation"],"prefix":"10.1016","volume":"304","author":[{"given":"Julia","family":"Kalinka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Hachmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Geraci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sordelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Niemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Oetermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"L\u00f6ffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Tuchscherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2014.07.013_bib0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/viru.2.5.17724","article-title":"Staphylococcus aureus biofilms: properties, regulation, and roles in human disease","volume":"2","author":"Archer","year":"2011","journal-title":"Virulence"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0010","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1182\/blood-2005-08-3140","article-title":"The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms","volume":"107","author":"Athanasopoulos","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0015","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/infdis\/170.4.1033","article-title":"Gentamicin-resistant menadione and hemin auxotrophic Staphylococcus aureus persist within cultured endothelial cells","volume":"170","author":"Balwit","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0020","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1128\/IAI.71.1.516-523.2003","article-title":"Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection","volume":"71","author":"Blevins","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1574-695X.2007.00357.x","article-title":"Osteomyelitis and the role of biofilms in chronic infection","volume":"52","author":"Brady","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0030","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1128\/JCM.01822-07","article-title":"Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections","volume":"46","author":"Campbell","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0035","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1016\/j.biomaterials.2009.08.032","article-title":"The presence of both bone sialoprotein-binding protein gene and collagen adhesin gene as a typical virulence trait of the major epidemic cluster in isolates from orthopedic implant infections","volume":"30","author":"Campoccia","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0040","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1160\/TH05-05-0306","article-title":"Staphylococcus aureus interactions with the endothelium: the role of bacterial secretable expanded repertoire adhesive molecules (SERAM) in disturbing host defense systems","volume":"94","author":"Chavakis","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0928-8244(03)00309-2","article-title":"Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus","volume":"40","author":"Cheung","year":"2004","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0065-2911(06)51004-5","article-title":"Surface adhesins of Staphylococcus aureus","volume":"51","author":"Clarke","year":"2006","journal-title":"Adv Microb Physiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.ki.5002035","article-title":"Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells","volume":"71","author":"Disthabanchong","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0060","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1002\/pmic.201000062","article-title":"Profiling the surfacome of Staphylococcus aureus","volume":"10","author":"Dreisbach","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1099\/00221287-6-1-2-95","article-title":"Staphylococcal coagulase; mode of action and antigenicity","volume":"6","author":"Duthie","year":"1952","journal-title":"J Gen Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S8756-3282(01)00632-9","article-title":"Staphylococcus aureus collagen adhesin contributes to the pathogenesis of osteomyelitis","volume":"30","author":"Elasri","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0075","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/mpat.1999.0272","article-title":"Mechanisms of Staphylococcus aureus invasion of cultured osteoblasts","volume":"26","author":"Ellington","year":"1999","journal-title":"Microb Pathog"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0080","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0966-842X(98)01400-0","article-title":"Surface protein adhesins of Staphylococcus aureus","volume":"6","author":"Foster","year":"1998","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0085","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/1471-2164-8-171","article-title":"A global view of Staphylococcus aureus whole genome expression upon internalization in human epithelial cells","volume":"8","author":"Garzoni","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0090","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tim.2008.11.005","article-title":"Staphylococcus aureus: new evidence for intracellular persistence","volume":"17","author":"Garzoni","year":"2009","journal-title":"Trends Microbiol"},{"issue":"Suppl 5","key":"10.1016\/j.ijmm.2014.07.013_bib0095","first-page":"S350L S359","article-title":"Pathogenesis of methicillin-resistant Staphylococcus aureus infection","volume":"46","author":"Gordon","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0100","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/cmi.12233","article-title":"Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin alpha","volume":"16","author":"Grosz","year":"2014","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0105","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1086\/651023","article-title":"Staphylococcal strains vary greatly in their ability to induce an inflammatory response in endothelial cells","volume":"201","author":"Grundmeier","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1574-6968.2008.01198.x","article-title":"Maximal transcription of aur (aureolysin) and sspA (serine protease) in Staphylococcus aureus requires staphylococcal accessory regulator R (sarR) activity","volume":"284","author":"Gustafson","year":"2008","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0115","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1128\/IAI.72.10.6164-6167.2004","article-title":"The extracellular adherence protein from Staphylococcus aureus inhibits neutrophil binding to endothelial cells","volume":"72","author":"Haggar","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0120","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1128\/IAI.71.5.2310-2317.2003","article-title":"Extracellular adherence protein from Staphylococcus aureus enhances internalization into eukaryotic cells","volume":"71","author":"Haggar","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0125","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1099\/mic.0.26465-0","article-title":"The adhesive and immunomodulating properties of the multifunctional Staphylococcus aureus protein Eap","volume":"149","author":"Harraghy","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.mib.2005.12.002","article-title":"Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus","volume":"9","author":"Hauck","year":"2006","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0135","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.ajpath.2012.07.005","article-title":"A novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection: an integrated view of disease pathogenesis","volume":"181","author":"Horst","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0140","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1006\/mpat.1995.0075","article-title":"Internalization of Staphylococcus aureus by cultured osteoblasts","volume":"19","author":"Hudson","year":"1995","journal-title":"Microb Pathog"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0145","doi-asserted-by":"crossref","first-page":"6778","DOI":"10.1128\/JB.183.23.6778-6786.2001","article-title":"Identification and characterization of a novel 38.5-kilodalton cell surface protein of Staphylococcus aureus with extended-spectrum binding activity for extracellular matrix and plasma proteins","volume":"183","author":"Hussain","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0150","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1128\/IAI.67.5.2677-2681.1999","article-title":"Mechanisms of internalization of Staphylococcus aureus by cultured human osteoblasts","volume":"67","author":"Jevon","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0155","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00003086-200101000-00032","article-title":"Collagen and fibronectin binding in experimental staphylococcal osteomyelitis","author":"Johansson","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0160","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1302\/0301-620X.93B8.25951","article-title":"Chronic haematogenous osteomyelitis in children: an unsolved problem","volume":"93","author":"Jones","year":"2011","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0165","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1086\/598484","article-title":"Transcription Analysis of the Extracellular Adherence Protein from Staphylococcus aureus in Authentic Human Infection and in vitro","volume":"199","author":"Joost","year":"2009","journal-title":"J Infect Dis."},{"key":"10.1016\/j.ijmm.2014.07.013_bib0170","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1086\/383348","article-title":"Reduced adherence and host cell invasion by methicillin-resistant Staphylococcus aureus expressing the surface protein Pls","volume":"189","author":"Juuti","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0175","series-title":"Molecular Biology of the Staohylococci","first-page":"373","article-title":"Agr: a polycistronic locus regulating exoprotein synthesis in Staphylococcus aureus","author":"Kornblum","year":"1990"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0180","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s10096-012-1596-8","article-title":"Molecular fingerprinting of Staphylococcus aureus isolated from patients with osteomyelitis in Argentina and clonal distribution of the cap5(8) genes and of other selected virulence genes","volume":"31","author":"Lattar","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"10.1016\/j.ijmm.2014.07.013_bib0185","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(04)16727-5","article-title":"Osteomyelitis","volume":"364","author":"Lew","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0190","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1086\/657419","article-title":"Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains","volume":"202","author":"Li","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0195","doi-asserted-by":"crossref","first-page":"e1000715","DOI":"10.1371\/journal.ppat.1000715","article-title":"Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils","volume":"6","author":"L\u00f6ffler","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0200","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0205","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1365-2958.1995.tb02316.x","article-title":"Identification of the ligand-binding domain of the surface-located fibrinogen receptor (clumping factor) of Staphylococcus aureus","volume":"16","author":"McDevitt","year":"1995","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0210","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1128\/JCM.00071-08","article-title":"Characterization of clonal relatedness among the natural population of Staphylococcus aureus strains by using spa sequence typing and the BURP (based upon repeat patterns) algorithm","volume":"46","author":"Mellmann","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0215","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2958.1998.00797.x","article-title":"Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis","volume":"28","author":"O\u2019Toole","year":"1998","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0220","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.micro.112408.134309","article-title":"Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus","volume":"64","author":"Otto","year":"2010","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0225","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1128\/JB.181.9.2840-2845.1999","article-title":"Adherence of Staphylococcus aureus is enhanced by an endogenous secreted protein with broad binding activity","volume":"181","author":"Palma","year":"1999","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0230","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/IAI.62.1.152-161.1994","article-title":"The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis","volume":"62","author":"Patti","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0235","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1053\/jinf.2000.0657","article-title":"Clinical isolates of Staphylococcus aureus exhibit diversity in fnb genes and adhesion to human fibronectin","volume":"41","author":"Peacock","year":"2000","journal-title":"J Infect"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0240","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrmicro1384","article-title":"Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections","volume":"4","author":"Proctor","year":"2006","journal-title":"Nat Rev Microbiol"},{"issue":"Suppl 1","key":"10.1016\/j.ijmm.2014.07.013_bib0245","first-page":"177SL 187S","article-title":"Treating osteomyelitis: antibiotics and surgery","volume":"127","author":"Rao","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0250","doi-asserted-by":"crossref","first-page":"e63176","DOI":"10.1371\/journal.pone.0063176","article-title":"PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts","volume":"8","author":"Rasigade","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0255","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1128\/AAC.48.8.2958-2965.2004","article-title":"Modulation of fibronectin adhesins and other virulence factors in a teicoplanin-resistant derivative of methicillin-resistant Staphylococcus aureus","volume":"48","author":"Renzoni","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0260","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1128\/JB.05436-11","article-title":"Coordinated regulation by AgrA, SarA, and SarR to control agr expression in Staphylococcus aureus","volume":"193","author":"Reyes","year":"2011","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0265","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1128\/JB.188.7.2593-2603.2006","article-title":"Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives","volume":"188","author":"Roberts","year":"2006","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0270","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02557826","article-title":"Human bone cells in vitro","volume":"37","author":"Robey","year":"1985","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0275","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1086\/516520","article-title":"Expression of collagen-binding protein and types 5 and 8 capsular polysaccharide in clinical isolates of Staphylococcus aureus","volume":"176","author":"Ryding","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0280","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tim.2008.11.004","article-title":"Staphylococcus aureus as an intracellular pathogen: the role of small colony variants","volume":"17","author":"Sendi","year":"2009","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0285","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3892\/etm.2011.423","article-title":"Interaction of Staphylococcus aureus with osteoblasts (Review)","volume":"3","author":"Shi","year":"2012","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0290","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1128\/MMBR.00008-06","article-title":"Mapping the pathways to staphylococcal pathogenesis by comparative secretomics","volume":"70","author":"Sibbald","year":"2006","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0295","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1128\/IAI.68.12.6871-6878.2000","article-title":"Heterologously expressed Staphylococcus aureus fibronectin-binding proteins are sufficient for invasion of host cells","volume":"68","author":"Sinha","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0300","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1462-5822.1999.00011.x","article-title":"Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin alpha5beta1","volume":"1","author":"Sinha","year":"1999","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0305","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijmm.2009.08.019","article-title":"Staphylococcus aureus host cell invasion and post-invasion events","volume":"300","author":"Sinha","year":"2010","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0310","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1160\/TH05-04-0235","article-title":"Mechanism and consequences of invasion of endothelial cells by Staphylococcus aureus","volume":"94","author":"Sinha","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0315","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/314576","article-title":"Adhesion of Staphylococcus aureus to collagen is not a major virulence determinant for septic arthritis, osteomyelitis, or endocarditis","volume":"179","author":"Thomas","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0320","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1099\/mic.0.2007\/011874-0","article-title":"agr function in clinical Staphylococcus aureus isolates","volume":"154","author":"Traber","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0325","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1128\/JCM.41.9.4465-4467.2003","article-title":"Use of multiplex PCR to identify Staphylococcus aureus adhesins involved in human hematogenous infections","volume":"41","author":"Tristan","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0330","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1086\/656047","article-title":"Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence","volume":"202","author":"Tuchscherr","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0335","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/emmm.201000115","article-title":"Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection","volume":"3","author":"Tuchscherr","year":"2011","journal-title":"EMBO Mol Med"},{"issue":"Pt 3","key":"10.1016\/j.ijmm.2014.07.013_bib0340","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/bj3450611","article-title":"A bone sialoprotein-binding protein from Staphylococcus aureus: a member of the staphylococcal Sdr family","volume":"345","author":"Tung","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0345","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1128\/IAI.70.10.5428-5437.2002","article-title":"Increased expression of clumping factor and fibronectin-binding proteins by hemB mutants of Staphylococcus aureus expressing small colony variant phenotypes","volume":"70","author":"Vaudaux","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0350","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10096-010-0888-0","article-title":"Heterogeneity of the humoral immune response following Staphylococcus aureus bacteremia","volume":"29","author":"Verkaik","year":"2010","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0355","doi-asserted-by":"crossref","first-page":"50691","DOI":"10.1074\/jbc.M408713200","article-title":"Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10","volume":"279","author":"Walsh","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0360","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/nm1656","article-title":"Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA","volume":"13","author":"Wang","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0365","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.1128\/IAI.66.11.5238-5243.1998","article-title":"Staphylococcus aureus Agr and Sar global regulators influence internalization and induction of apoptosis","volume":"66","author":"Wesson","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0370","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijmm.2009.10.003","article-title":"Interaction of staphylococci with bone","volume":"300","author":"Wright","year":"2010","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.ijmm.2014.07.013_bib0375","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1128\/IAI.01274-09","article-title":"Natural variability of in vitro adherence to fibrinogen and fibronectin does not correlate with in vivo infectivity of Staphylococcus aureus","volume":"78","author":"Ythier","year":"2010","journal-title":"Infect Immun"}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422114000952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422114000952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T10:18:56Z","timestamp":1689416336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422114000952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":75,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S1438422114000952"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2014.07.013","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Staphylococcus aureus isolates from chronic osteomyelitis are characterized by high host cell invasion and intracellular adaptation, but still induce inflammation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2014.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}