{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:22:54Z","timestamp":1791595374284,"version":"4.3.4"},"reference-count":91,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Innovative Medicines Initiative Joint Undertaking","award":["115523"],"award-info":[{"award-number":["115523"]}]},{"name":"Innovative Medicines Initiative Joint Undertaking","award":["30340"],"award-info":[{"award-number":["30340"]}]},{"name":"COMBACTE"},{"name":"INFECT"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.ijmm.2015.06.002","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T02:06:30Z","timestamp":1435111590000},"page":"532-543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparative Genomics of Streptococcus pyogenes M1 isolates differing in virulence and propensity to cause systemic infection in mice"],"prefix":"10.1016","volume":"305","author":[{"given":"Anne","family":"Fiebig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten G.","family":"Loof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshu","family":"Babbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Itzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper J.","family":"Koehorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Schaap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Patric","family":"Nitsche-Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2015.06.002_bib0005","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0161-5890(90)90071-7","article-title":"Protein H-a novel IgG binding bacterial protein","volume":"27","author":"\u00c5kesson","year":"1990","journal-title":"Mol. Immunol."},{"issue":"Pt 3","key":"10.1016\/j.ijmm.2015.06.002_bib0010","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1042\/bj3000877","article-title":"M1 protein and protein H: IgGFc- and albumin-binding streptococcal surface proteins encoded by adjacent genes","volume":"300","author":"\u00c5kesson","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0015","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1074\/jbc.271.2.1081","article-title":"Protein SIC, a novel extracellular protein of Streptococcus pyogenes interfering with complement function","volume":"271","author":"\u00c5kesson","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0020","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/1471-2164-12-402","article-title":"BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons","volume":"12","author":"Alikhan","year":"2011","journal-title":"BMC Genom."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/1875036201307010001","article-title":"Comparison of Sequencing Utility Programs","volume":"7","author":"Aronesty","year":"2013","journal-title":"Open Bioinform. J."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0030","series-title":"Current Protocols in Molecular Biology","author":"Ausubel","year":"1987"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0035","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1128\/JB.187.10.3311-3318.2005","article-title":"Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes","volume":"187","author":"Aziz","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0040","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1365-2958.2003.03797.x","article-title":"Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB","volume":"51","author":"Aziz","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0045","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1365-2958.2004.04255.x","article-title":"Post-proteomic identification of a novel phage-encoded streptodornase Sda1, in invasive M1T1 Streptococcus pyogenes","volume":"54","author":"Aziz","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0050","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1042\/bj20020149","article-title":"The hyaluronan lyase of Streptococcus pyogenes bacteriophage H4489A","volume":"365","author":"Baker","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0055","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1128\/IAI.66.7.3449-3453.1998","article-title":"Identification of an insertion sequence located in a region encoding virulence factors of Streptococcus pyogenes","volume":"66","author":"Berge","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0060","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ijmm.2013.12.001","article-title":"Distribution of small native plasmids in Streptococcus pyogenes in India","volume":"304","author":"Bergmann","year":"2014","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev-genet-110410-132430","article-title":"CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation","volume":"45","author":"Bhaya","year":"2011","journal-title":"Ann. Rev. Genet."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1741-7007-7-3","article-title":"Assigning strains to bacterial species via the Internet","volume":"7","author":"Bishop","year":"2009","journal-title":"BMC Biol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0075","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1471-2105-8-209","article-title":"CRISPR recognition tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats","volume":"8","author":"Bland","year":"2007","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0080","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1128\/IAI.69.3.1440-1443.2001","article-title":"Induction of lysogenic bacteriophage and phage-associated toxin from group a streptococci during coculture with human pharyngeal cells","volume":"69","author":"Broudy","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0085","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cub.2005.12.039","article-title":"DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps","volume":"16","author":"Buchanan","year":"2006","journal-title":"Curr. Biol.: CB"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0090","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/IAI.68.6.3523-3534.2000","article-title":"Genetic relatedness and superantigen expression in group A streptococcus serotype M1 isolates from patients with severe and nonsevere invasive diseases","volume":"68","author":"Chatellier","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0095","series-title":"Streptococcal Diseases, Encyclopedia of Public Health 2008","first-page":"231","author":"Chhatwal","year":"2008"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0100","doi-asserted-by":"crossref","first-page":"e00387","DOI":"10.1128\/mBio.00387-12","article-title":"Targeted amino acid substitutions impair streptolysin O toxicity and group A Streptococcus virulence","volume":"4","author":"Chiarot","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0105","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.1093\/nar\/gku241","article-title":"Classification and evolution of type II CRISPR-Cas systems","volume":"42","author":"Chylinski","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0110","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1096\/fj.06-5804fje","article-title":"Trigger for group A streptococcal M1T1 invasive disease","volume":"20","author":"Cole","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0115","doi-asserted-by":"crossref","first-page":"e00191","DOI":"10.1128\/mBio.00191-10","article-title":"M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus","volume":"1","author":"Cole","year":"2010","journal-title":"mBio"},{"issue":"6","key":"10.1016\/j.ijmm.2015.06.002_bib0120","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1046\/j.1365-2958.2000.01942.x","article-title":"Generation of a mature streptococcal cysteine proteinase is dependent on cell wall-anchored M1 protein","volume":"36","author":"Collin","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0125","doi-asserted-by":"crossref","first-page":"e4166","DOI":"10.1371\/journal.pone.0004166","article-title":"Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes","volume":"4","author":"Courtney","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0130","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/CMR.13.3.470-511.2000","article-title":"Pathogenesis of group A streptococcal infections","volume":"13","author":"Cunningham","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1128\/JB.188.1.77-85.2006","article-title":"RscA, a member of the MDR1 family of transporters, is repressed by CovR and required for growth of Streptococcus pyogenes under heat stress","volume":"188","author":"Dalton","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2105-8-18","article-title":"PILER-CR: fast and accurate identification of CRISPR repeats","volume":"8","author":"Edgar","year":"2007","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0145","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.071559398","article-title":"Complete genome sequence of an M1 strain of Streptococcus pyogenes","volume":"98","author":"Ferretti","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0150","doi-asserted-by":"crossref","first-page":"W29","DOI":"10.1093\/nar\/gkr367","article-title":"HMMER web server: interactive sequence similarity searching","volume":"39","author":"Finn","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0155","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1089\/cmb.2011.0170","article-title":"Opera: reconstructing optimal genomic scaffolds with high-throughput paired-end sequences","volume":"18","author":"Gao","year":"2011","journal-title":"J. Comput. Biol.: J. Comput. Mol. Cell Biol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0160","doi-asserted-by":"crossref","first-page":"128102","DOI":"10.1103\/PhysRevLett.105.128102","article-title":"Heterogeneous diversity of spacers within CRISPR (clustered regularly interspaced short palindromic repeats)","volume":"105","author":"He","year":"2010","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(04)00057-1","article-title":"M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage","volume":"116","author":"Herwald","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0170","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1128\/JB.01415-07","article-title":"Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus","volume":"190","author":"Horvath","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0175","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0180","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0378-1097(03)00842-5","article-title":"Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans","volume":"229","author":"Igwe","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0185","doi-asserted-by":"crossref","first-page":"e1000832","DOI":"10.1371\/journal.ppat.1000832","article-title":"Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates","volume":"6","author":"Ikebe","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0190","doi-asserted-by":"crossref","first-page":"a003657","DOI":"10.1101\/cshperspect.a003657","article-title":"RNA in defense: CRISPRs protect prokaryotes against mobile genetic elements","volume":"4","author":"Jore","year":"2012","journal-title":"Cold Spring Harb.Perspect. Biol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0195","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1086\/651019","article-title":"Dissection of the molecular basis for hypervirulence of an in vivo-selected phenotype of the widely disseminated M1T1 strain of group A Streptococcus bacteria","volume":"201","author":"Kansal","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0200","doi-asserted-by":"crossref","first-page":"R116","DOI":"10.1186\/gb-2010-11-11-r116","article-title":"Quake: quality-aware detection and correction of sequencing errors","volume":"11","author":"Kelley","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0205","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1128\/IAI.67.4.1708-1714.1999","article-title":"Protein H, an antiphagocytic surface protein in Streptococcus pyogenes","volume":"67","author":"Kihlberg","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0210","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1099\/jmm.0.013581-0","article-title":"Typing of the pilus-protein-encoding FCT region and biofilm formation as novel parameters in epidemiological investigations of Streptococcus pyogenes isolates from various infection sites","volume":"59","author":"K\u00f6ller","year":"2010","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0215","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-1119(99)00210-3","article-title":"Initiation of translation in prokaryotes and eukaryotes","volume":"234","author":"Kozak","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0220","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1099\/00221287-148-5-1501","article-title":"Group A streptococcal RofA-type global regulators exhibit a strain-specific genomic presence and regulation pattern","volume":"148","author":"Kreikemeyer","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0225","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0966-842X(03)00098-2","article-title":"Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions","volume":"11","author":"Kreikemeyer","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0230","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1128\/IAI.01218-12","article-title":"Regulation of inhibition of neutrophil infiltration by the two-component regulatory system CovRS in subcutaneous murine infection with group A streptococcus","volume":"81","author":"Li","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0235","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10096-013-2005-7","article-title":"Association between polymorphisms in the csrRS two-component regulatory system and invasive group A streptococcal infection","volume":"33","author":"Lin","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0240","doi-asserted-by":"crossref","first-page":"e3450","DOI":"10.1371\/journal.pone.0003450","article-title":"Impact of orthologous gene replacement on the circuitry governing pilus gene transcription in streptococci","volume":"3","author":"Lizano","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0245","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1182\/blood-2011-02-337568","article-title":"Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense","volume":"118","author":"Loof","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0250","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1128\/MMBR.00039-13","article-title":"The role of CRISPR-Cas systems in virulence of pathogenic bacteria","volume":"78","author":"Louwen","year":"2014","journal-title":"Microbiol. Mol. Biol. Rev.: MMBR"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0255","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/nar\/25.5.0955","article-title":"tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence","volume":"25","author":"Lowe","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0260","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2047-217X-1-18","article-title":"SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler","volume":"1","author":"Luo","year":"2012","journal-title":"GigaScience"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0265","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1096\/fj.12-212142","article-title":"Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone","volume":"26","author":"Maamary","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0270","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1159\/000317640","article-title":"Parameters governing invasive disease propensity of non-M1 serotype group A streptococci","volume":"2","author":"Maamary","year":"2010","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0275","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrmicro2577","article-title":"Evolution and classification of the CRISPR-Cas systems","volume":"9","author":"Makarova","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0280","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1093\/bioinformatics\/btp393","article-title":"IMG ER: a system for microbial genome annotation expert review and curation","volume":"25","author":"Markowitz","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0285","doi-asserted-by":"crossref","first-page":"15641","DOI":"10.1073\/pnas.0507808102","article-title":"Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens","volume":"102","author":"Mora","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0290","doi-asserted-by":"crossref","first-page":"E1768","DOI":"10.1073\/pnas.1403138111","article-title":"Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences","volume":"111","author":"Nasser","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0295","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-1-62703-709-9_9","article-title":"Annotating functional RNAs in genomes using Infernal","volume":"1097","author":"Nawrocki","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0300","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/bioinformatics\/btp157","article-title":"Infernal 1.0: inference of RNA alignments","volume":"25","author":"Nawrocki","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0305","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1084\/jem.20120325","article-title":"Antibody orientation at bacterial surfaces is related to invasive infection","volume":"209","author":"Nordenfelt","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0310","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1182\/blood-2008-10-182527","article-title":"Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen","volume":"114","author":"Oehmcke","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0315","doi-asserted-by":"crossref","first-page":"e1003529","DOI":"10.1371\/journal.ppat.1003529","article-title":"A novel role for pro-coagulant microvesicles in the early host defense against Streptococcus pyogenes","volume":"9","author":"Oehmcke","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0320","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1365-2958.1995.tb02360.x","article-title":"Role of the conserved C-repeat region of the M protein of Streptococcus pyogenes","volume":"15","author":"Perez-Casal","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0325","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-2958.2006.05381.x","article-title":"Defining the Mga regulon: comparative transcriptome analysis reveals both direct and indirect regulation by Mga in the group A streptococcus","volume":"62","author":"Ribardo","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0330","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/bioinformatics\/btp356","article-title":"Reordering contigs of draft genomes using the Mauve aligner","volume":"25","author":"Rissman","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0335","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fcimb.2014.00037","article-title":"CRISPR-Cas systems: new players in gene regulation and bacterial physiology","volume":"4","author":"Sampson","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0340","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/infdis\/jiu260","article-title":"A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development","volume":"210","author":"Sanderson-Smith","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0345","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1182\/blood-2010-02-271858","article-title":"Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis","volume":"116","author":"Shannon","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0350","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0355","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.biochi.2014.03.012","article-title":"Characterization of hyaluronic acid specific hyaluronate lyase (HylP) from Streptococcus pyogenes","volume":"102","author":"Singh","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0360","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-1097(02)01184-9","article-title":"Regulation of protein H expression in M1serotype isolates of Streptococcus pyogenes","volume":"219","author":"Smith","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0365","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2105-8-64","article-title":"Minimus: a fast, lightweight genome assembler","volume":"8","author":"Sommer","year":"2007","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0370","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1097\/00003246-200011000-00025","article-title":"Contact activation in shock caused by invasive group A Streptococcus pyogenes","volume":"28","author":"Sriskandan","year":"2000","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0375","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1086\/322018","article-title":"Enhanced susceptibility to superantigen-associated streptococcal sepsis in human leukocyte antigen-DQ transgenic mice","volume":"184","author":"Sriskandan","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0380","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/IAI.74.1.40-48.2006","article-title":"Role of hyaluronidase in subcutaneous spread and growth of group A streptococcus","volume":"74","author":"Starr","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0385","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1473-3099(09)70178-1","article-title":"Global emm type distribution of group A streptococci: systematic review and implications for vaccine development","volume":"9","author":"Steer","year":"2009","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0390","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1086\/432514","article-title":"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events","volume":"192","author":"Sumby","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0395","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1371\/journal.ppat.0020005","article-title":"Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity","volume":"2","author":"Sumby","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0400","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1128\/IAI.61.8.3369-3374.1993","article-title":"Association of phenotypic and genotypic characteristic of invasive Streptococcus pyogenes isolates with clinical components of toxic shock syndrome","volume":"61","author":"Talkington","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0405","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1756-0500-6-126","article-title":"Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease","volume":"6","author":"Tatsuno","year":"2013","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0410","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tim.2004.03.004","article-title":"Assembly of pili in Gram-positive bacteria","volume":"12","author":"Ton-That","year":"2004","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0415","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1462-2920.2007.01444.x","article-title":"Rapidly evolving CRISPRs implicated in acquired resistance of microorganisms to viruses","volume":"10","author":"Tyson","year":"2008","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0420","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/mpat.2001.0453","article-title":"Complementation of a speA negative Streptococcus pyogenes with speA: effects on virulence and production of streptococcal pyrogenic exotoxin A","volume":"31","author":"Unnikrishnan","year":"2001","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0425","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1128\/IAI.00192-13","article-title":"Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370","volume":"81","author":"Venturini","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0430","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1128\/IAI.01695-06","article-title":"Dynamics in prophage content of invasive and noninvasive M1 and M28 Streptococcus pyogenes isolates in The Netherlands from 1959 to 1996","volume":"75","author":"Vlaminckx","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0435","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/nm1612","article-title":"DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection","volume":"13","author":"Walker","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0440","first-page":"317","article-title":"CRISPR-Cas systems: beyond adaptive immunity Nature reviews","volume":"12","author":"Westra","year":"2014","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2015.06.002_bib0445","doi-asserted-by":"crossref","first-page":"W347","DOI":"10.1093\/nar\/gkr485","article-title":"PHAST: a fast phage search tool","volume":"39","author":"Zhou","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0450","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000329550","article-title":"Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections","volume":"4","author":"Zinkernagel","year":"2012","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.ijmm.2015.06.002_bib0455","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.chom.2008.07.002","article-title":"The IL-8 protease SpyCEP\/ScpC of group A Streptococcus promotes resistance to neutrophil killing","volume":"4","author":"Zinkernagel","year":"2008","journal-title":"Cell Host Microbe"}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422115000545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422115000545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T20:51:09Z","timestamp":1748465469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422115000545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":91,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1438422115000545"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2015.06.002","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative Genomics of Streptococcus pyogenes M1 isolates differing in virulence and propensity to cause systemic infection in mice","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2015.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}