{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:04:14Z","timestamp":1782551054066,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ijmm.2015.10.002","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T15:26:23Z","timestamp":1445786783000},"page":"925-936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Distinct inflammatory and cytopathic characteristics of Escherichia coli isolates from inflammatory bowel disease patients"],"prefix":"10.1016","volume":"305","author":[{"given":"Stina Rikke","family":"Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengameh Chlo\u00e9","family":"Mirsepasi-Lauridsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Hammerich","family":"Thysen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Brynskov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Krogfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Munk","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Elm","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Brix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2015.10.002_bib0005","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1083\/jcb.201108081","article-title":"Cell death and infection: a double-edged sword for host and pathogen survival","volume":"195","author":"Ashida","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0010","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI30504","article-title":"CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease","volume":"117","author":"Barnich","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0015","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/JCM.37.7.2312-2316.1999","article-title":"Evaluation of Statens Serum Institut enteric medium for detection of enteric pathogens","volume":"37","author":"Blom","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-2036.2003.01638.x","article-title":"Inhibitory effect of probiotic Escherichia coli strain Nissle 1917 on adhesion to and invasion of intestinal epithelial cells by adherent-invasive E-coli strains isolated from patients with Crohn's disease","volume":"18","author":"Boudeau","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0025","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1128\/IAI.67.9.4499-4509.1999","article-title":"Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease","volume":"67","author":"Boudeau","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0030","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1128\/AEM.66.10.4555-4558.2000","article-title":"Rapid and simple determination of the Escherichia coli phylogenetic group","volume":"66","author":"Clermont","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0035","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1136\/gut.2005.078824","article-title":"Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease","volume":"55","author":"Conte","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0040","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.gastro.2004.04.061","article-title":"High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease","volume":"127","author":"Darfeuille-Michaud","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0091-6749(99)70518-X","article-title":"IL-18: a T-H1-inducing, proinflammatory cytokine and new member of the IL-1 family","volume":"103","author":"Dinarello","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0050","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1172\/JCI19836","article-title":"Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis","volume":"113","author":"Fuss","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0055","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4049\/jimmunol.157.3.1261","article-title":"Disparate CD4(+) lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease \u2013 Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5","volume":"157","author":"Fuss","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0060","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1128\/IAI.69.9.5529-5537.2001","article-title":"Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death","volume":"69","author":"Glasser","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0065","doi-asserted-by":"crossref","first-page":"5432","DOI":"10.1128\/JB.186.16.5432-5441.2004","article-title":"Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917","volume":"186","author":"Grozdanov","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0070","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.gastro.2005.05.002","article-title":"Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution","volume":"129","author":"Heller","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0075","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1128\/AEM.01601-10","article-title":"The probiotic Escherichia coli Nissle 1917 reduces pathogen invasion and modulates cytokine expression in Caco-2 cells infected with Crohn's disease-associated E. coli LF82","volume":"77","author":"Huebner","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0080","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.micpath.2011.08.006","article-title":"Ex vivo intestinal adhesion of Escherichia coli LF82 in Crohn's disease","volume":"51","author":"Jensen","year":"2011","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0085","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2165\/11632710-000000000-00000","article-title":"Probiotics in the management of inflammatory bowel disease a systematic review of intervention studies in adult patients","volume":"72","author":"Jonkers","year":"2012","journal-title":"Drugs"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0090","first-page":"57","article-title":"Evaluation of minibact, a new system for rapid identification of enterobacteriaceae \u2013 comparison of minibact, micro-Id and Api-20e with a conventional method as reference","volume":"94","author":"Kjaeldgaard","year":"1986","journal-title":"Acta Pathol. Microbiol. Immunol. Scand. B"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0095","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/gut.2006.099796","article-title":"High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease","volume":"56","author":"Kotlowski","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0100","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1189\/jlb.0708452","article-title":"IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88-and p38 alpha-dependent pathway","volume":"86","author":"Kroeger","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0105","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/gut.2003.037747","article-title":"Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine","volume":"53","author":"Kruis","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0016-5085(94)90054-X","article-title":"Course of ulcerative-colitis \u2013 analysis of changes in disease-activity over years","volume":"107","author":"Langholz","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0115","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/ibd.20272","article-title":"Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease","volume":"14","author":"Leach","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0120","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/gut.2009.199679","article-title":"New IBD genetics: common pathways with other diseases","volume":"60","author":"Lees","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0125","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/01.mib.0000235828.09305.0c","article-title":"Abnormal microbiota composition in the ileocolonic mucosa of Crohn's disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis","volume":"12","author":"Martinez-Medina","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0130","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","article-title":"Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria","volume":"11","author":"Miao","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0135","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ibd.21436","article-title":"Highlighting new phylogenetic specificities of Crohn's disease microbiota","volume":"17","author":"Mondot","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0140","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3109\/00365529209000127","article-title":"Incidence and prevalence of Crohn's-disease in the county of Copenhagen, 1962\u201387 \u2013 a sixfold increase in incidence","volume":"27","author":"Munkholm","year":"1992","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1359-6101(00)00015-0","article-title":"Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu","volume":"12","author":"Nakanishi","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0150","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1128\/JCM.43.8.3636-3641.2005","article-title":"Etiology of diarrhea in young children in Denmark: a case\u2013control study","volume":"43","author":"Olesen","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/1471-2180-9-171","article-title":"A phylogenetic group of Escherichia coli associated with active left-sided Inflammatory Bowel Disease","volume":"9","author":"Petersen","year":"2009","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0160","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/IAI.67.2.546-553.1999","article-title":"The link between phylogeny and virulence in Escherichia coli extraintestinal infection","volume":"67","author":"Picard","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0165","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.4049\/jimmunol.162.11.6829","article-title":"IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells","volume":"162","author":"Pizarro","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0170","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.4049\/jimmunol.180.2.1139","article-title":"Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling","volume":"180","author":"Rallabhandi","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0175","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.4049\/jimmunol.181.7.5120","article-title":"Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists","volume":"181","author":"Roses","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0180","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1053\/j.gastro.2009.07.049","article-title":"Th1\/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease","volume":"137","author":"Sakuraba","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0185","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1136\/gut.50.6.812","article-title":"Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage","volume":"50","author":"Sivakumar","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0190","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1128\/JCM.02600-05","article-title":"Temperature gradient gel electrophoresis of fecal 16S rRNA reveals active Escherichia coli in the microbiota of patients with ulcerative colitis","volume":"44","author":"Sokol","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0195","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jim.2012.09.005","article-title":"Isolation of IL-12p70-competent human monocyte-derived dendritic cells","volume":"386","author":"Sondergaard","year":"2012","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ijmm.2015.10.002_bib0200","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/infdis\/jis244","article-title":"Staphylococcus aureus activation of caspase 1\/calpain signaling mediates invasion through human keratinocytes","volume":"205","author":"Soong","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2015.10.002_bib0205","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/1471-2164-12-316","article-title":"Comparative genomics of Escherichia coli isolated from patients with inflammatory bowel disease","volume":"12","author":"Vejborg","year":"2011","journal-title":"BMC Genomics"}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422115300126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422115300126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:27:50Z","timestamp":1718152070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422115300126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1438422115300126"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2015.10.002","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct inflammatory and cytopathic characteristics of Escherichia coli isolates from inflammatory bowel disease patients","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2015.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}