{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T15:04:47Z","timestamp":1760799887541,"version":"3.41.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.ijmm.2016.02.006","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T20:09:46Z","timestamp":1455998986000},"page":"141-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inflammatory response of TLR4 deficient spleen macrophages (CRL 2471) to Brucella abortus S19 and an isogenic \u0394mglA deletion mutant"],"prefix":"10.1016","volume":"306","author":[{"given":"Jens","family":"Jacob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Makou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Finke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Mielke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2016.02.006_bib0005","first-page":"3458","article-title":"Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection","volume":"40","author":"Archambaud","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0010","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1128\/IAI.01017-08","article-title":"The Brucella abortus S19 \u0394vjR live vaccine candidate is safer then S19 and confers protection against wild-type challenge in BALB\/c mice when delivered in a sustained-release vehicle","volume":"7","author":"Arenas-Gamboa","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0966-842X(93)90115-8","article-title":"Macrophage control of Brucella abortus: influence of cytokines and iron","volume":"103","author":"Baldwin","year":"1993","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0020","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0378-1135(02)00222-5","article-title":"Fundamentals of host immune response against Brucella abortus: what the mouse model has revealed about control of infection","volume":"90","author":"Baldwin","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0025","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.imbio.2011.08.006","article-title":"Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages","volume":"216","author":"Bradford","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1099\/00222615-42-2-133","article-title":"Brucella abortus causes an accelerated repopulation of the spleen and liver of mice by macrophages after their liposome-mediated depletion","volume":"42","author":"Buiting","year":"1995","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1135(02)00016-0","article-title":"Brucella abortus INTA2, a novel strain 19 (\u0394)bp26::luc (\u0394)bmp18 double mutant lacking drug resistance markers","volume":"87","author":"Campos","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0040","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/IAI.72.1.176-186.2004","article-title":"Role of toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice","volume":"72","author":"Campos","year":"2004","journal-title":"Infet. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0045","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2859-5-13","article-title":"Brucella spp. noncanonical LPS: structure, biosynthesis and interaction with host immune system","volume":"5","author":"Cardoso","year":"2006","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0050","first-page":"983","article-title":"Regulation of cytokine expression during Brucella abortus infection","volume":"8","author":"Cervantes-Flores","year":"2013","journal-title":"Sci. Res."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0055","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1186\/1471-2164-14-426","article-title":"Early transcriptional responses of internalization defective Brucella abortus mutants in professional phagocytes, RAW 264.7","volume":"14","author":"Cha","year":"2013","journal-title":"BMC Genomics"},{"issue":"5","key":"10.1016\/j.ijmm.2016.02.006_bib0060","doi-asserted-by":"crossref","first-page":"e1002675","DOI":"10.1371\/journal.ppat.1002675","article-title":"The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition","volume":"8","author":"Conde-Alvarez","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0065","doi-asserted-by":"crossref","first-page":"e1002575","DOI":"10.1371\/journal.ppat.1002575","article-title":"In situ microscopy analysis reveals local inate immune response developed around Brucella infected cells in resistent and susceptibel mice","volume":"8","author":"Copin","year":"2012","journal-title":"Plos Pathog."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0070","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.3181\/0904-RM-124","article-title":"Brucella melitensis, B. neotomae and B. ovis elicit common and distinctive macrophage defense transcriptional responses","volume":"234","author":"Covert","year":"2009","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0075","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1128\/IAI.01259-08","article-title":"Proinflammatory response of human osteoblastic cell lines and osteoblast-monocyte interaction upon infection with Brucella spp","volume":"77","author":"Delpino","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0080","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0378-1135(02)00223-7","article-title":"The innate immune response against Brucella in humans","volume":"90","author":"Dornand","year":"2002","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0085","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1128\/IAI.71.3.1125-1133.2003","article-title":"Microarray analysis of mRNA levels from RAW264.7 macrophages infected with Brucella abortus","volume":"71","author":"Eskra","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/imm.12030","article-title":"HLA-DM: arbiter conformations","volume":"138","author":"Ferrante","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0095","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.4049\/jimmunol.173.7.4635","article-title":"Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus","volume":"173","author":"Giambartolomei","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0100","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4049\/jimmunol.116.2.454","article-title":"Cellular mechanism of endotoxin unresponsiveness in C3H\/HeJ mice","volume":"116","author":"Glode","year":"1976","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0105","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1128\/IAI.60.4.1385-1389.1992","article-title":"Lipopolysaccharide (LPS) from Brucella abortus is less toxic than that from E. coli, suggesting the possible use of B. abortus or LPS from B. abortus as a carrier in vaccines","volume":"60","author":"Goldstein","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2012.00130","article-title":"The role of innate immune signals in immunity to Brucella abortus","volume":"2","author":"Gomes","year":"2012","journal-title":"Front. Cell. Inf. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0115","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1297-9716-43-29","article-title":"What have we learned from brucellosis in the mouse model?","volume":"43","author":"Grillo","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0120","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.2460\/ajvr.1988.49.07.1092","article-title":"Survival of rough and smooth strains of Brucella abortus in bovine mammary gland macrophages","volume":"49","author":"Harmon","year":"1988","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0125","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.vetimm.2012.07.006","article-title":"Characterization of Brucella abortus infection of bovine monocyte-derived dendritic cells","volume":"149","author":"Heller","year":"2012","journal-title":"Vet. Immunol. Immunpathol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1084\/jem.108.3.343","article-title":"A cellular basis of immunity in experimental Brucella infection","volume":"108","author":"Holland","year":"1958","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1286-4579(02)00076-X","article-title":"Delayed type hypersensitivity-associated disruption of splenic periarteriolar lymphatic sheaths coincides with temporary loss of IFN\u03b3 production and impaired eradication of bacteria in Brucella abortus-infected mice","volume":"5","author":"Hort","year":"2003","journal-title":"Microbes Inf."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0140","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.micinf.2005.07.003","article-title":"In vitro and in vivo characterization of smooth small colony variants of Brucella abortus S19","volume":"8","author":"Jacob","year":"2006","journal-title":"Microbes Inf."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0145","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijmm.2012.02.001","article-title":"The mglA gene and its flanking regions in Brucella. The role of mglA in tolerance to hostile environments, Fe-metabolism and in vivo persistence","volume":"302","author":"Jacob","year":"2012","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0150","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0022-5193(64)90049-9","article-title":"The role of iron in macrophages","volume":"7","author":"Janoff","year":"1964","journal-title":"J. Theor. Biol."},{"issue":"8","key":"10.1016\/j.ijmm.2016.02.006_bib0155","doi-asserted-by":"crossref","first-page":"e70852","DOI":"10.1371\/journal.pone.0070852","article-title":"Comparative genomic analysis of Brucella melitensis vaccine strain M5 provides insights into virulence attenuation","volume":"8","author":"Jiang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0160","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/cimm.1993.1121","article-title":"Iron augments macrophage-mediated killing of Brucella abortus alone and in conjunction with Interferon-\u03b3","volume":"148","author":"Jiang","year":"1993","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0165","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/cimm.1993.1241","article-title":"Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxides","volume":"151","author":"Jiang","year":"1993","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0390","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.micinf.2011.10.001","article-title":"Iron metabolism and the innate response to infection","volume":"14","author":"Johnson","year":"2012","journal-title":"Microbes Inf."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0170","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1128\/IAI.60.7.3011-3014.1992","article-title":"Survival of virulent and attenuated strains of Brucella abortus in normal and IFN-\u03b3 treated murine peritoneal macrophages","volume":"60","author":"Jones","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0175","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1128\/IAI.01787-05","article-title":"Evaluation of protection afforded by Brucella abortus and Brucella melitensis unmarked deletion mutants exhibiting different rates of clearance in BALB\/c mice","volume":"74","author":"Kahl-McDonagh","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0180","doi-asserted-by":"crossref","first-page":"15711","DOI":"10.1073\/pnas.232454299","article-title":"The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell","volume":"99","author":"K\u00f6hler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0185","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1128\/IAI.68.6.3680-3688.2000","article-title":"Listeria monocytogenes-infected human dendritic cells: uptake and host cell response","volume":"68","author":"Kolb-M\u00e4urer","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0190","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.tiv.2011.06.017","article-title":"Evaluation and validation of multiple cell lines and primary mouse macrophages to predict phospholipidosis potential","volume":"25","author":"LeCureux","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0195","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.vetmic.2012.05.039","article-title":"Inhibition of mCD14 inhibits TNF\u03b1 secretion and NO production in RAW264.7 cells stimulated by Brucella melitensis infection","volume":"160","author":"Lei","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0200","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1046\/j.1365-2958.2000.02150.x","article-title":"Identification and characterization of in vivo attenuated mutants of Brucella melitensis","volume":"38","author":"Lestrate","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0205","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.180.2.1080","article-title":"Central role of MYD-88- dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection","volume":"180","author":"Macedo","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.120.1.105","article-title":"The Immunological basis of acquired cellular resistance","volume":"120","author":"Mackaness","year":"1964","journal-title":"JEM"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0215","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/oxfordjournals.bmb.a070516","article-title":"The relationship of delayed hypersensitivity to acquired cellular resistance","volume":"23","author":"Mackaness","year":"1967","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0220","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3324\/haematol.2009.020123","article-title":"Heme controls ferroportin 1 (FPN1) transcription involving Bach1, Nrf2 and MARE\/ARE sequence motif at position-7007 of the FPN1 promotor","volume":"95","author":"Marre","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0225","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-065X.2010.00982.x","article-title":"An evolutionary strategy for a stealthy intracellular Brucella pathogen","volume":"240","author":"Martirosyan","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0230","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0008-8749(92)90338-P","article-title":"Mouse splenic macrophage cell lines with different antigen-presenting activities for CD4+ helper T cell subsets and allogeneic CD8+ T cells","volume":"145","author":"McCormack","year":"1992","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0395","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0531-5131(03)00112-2","article-title":"Nonheme ferric and ferrous iron accumulation in macrophages of rats and cats","volume":"1251","author":"Meguro","year":"2003","journal-title":"Int. Congr. Ser."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0400","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1679\/aohc.68.171","article-title":"The presence of ferric and ferrous iron in the nonheme iron storage of resident macrophages in different tissues and organs: histochemical demonstrations by the perfusion-perls and - turnbull methods in the rat","volume":"68","author":"Meguro","year":"2005","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0235","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1128\/jb.172.7.3569-3576.1990","article-title":"Brucella abortus 16S rRNA and lipid A reveal a phylogenetic relationship with members of the \u03ac-2 subdivision of the class Proteobacteria","volume":"172","author":"Moreno","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0240","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1111\/j.1462-5822.2007.00942.x","article-title":"Th co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium","volume":"9","author":"Nairz","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0245","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.20121946","article-title":"Nitric-oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection","volume":"210","author":"Nairz","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0255","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.micinf.2008.07.005","article-title":"The role of innate immune receptors in the control of Brucella abortus infection: toll-like receptors and beyond","volume":"10","author":"Oliveira","year":"2008","journal-title":"Microbes Inf."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0260","doi-asserted-by":"crossref","first-page":"e98913","DOI":"10.1371\/journal.pone.0098913","article-title":"A defective TLR4 Signaling for IFN\u03b3-expression is responsible for the innately lower ability of BALB\/c macrophages to produce NO in response to LPS as compared to C57BL\/6","volume":"9","author":"Oliveira","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0265","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/IAI.00417-09","article-title":"Establishment of systemic Brucella melitensis infection through the digestive tract requires urease, the type IV secretion system and Lipopolysaccharide O-Antigen","volume":"77","author":"Paixao","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0270","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.micinf.2006.10.008","article-title":"Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strain","volume":"9","author":"Parent","year":"2007","journal-title":"Mic. Inf."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2012.00115","article-title":"Toll-like receptors are critical for clearance of Brucella and play different roles in development of adaptive immunity following aerosol challenge in mice","volume":"2","author":"Pei","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0280","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/IAI.72.1.440-450.2004","article-title":"Brucella abortus rough mutants are cytopathic for macrophages in culture","volume":"72","author":"Pei","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0285","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0928-8244(02)00469-8","article-title":"Tailoring host immune responses to Listeria by manipulation of virulence genes-the interface between innate and acquired immunity","volume":"35","author":"Peters","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0290","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2460\/ajvr.1989.50.03.318","article-title":"Duration of strain 2308 infection and immunogenicity of Brucella abortus lipopolysaccharide in five strains of mice","volume":"50","author":"Philips","year":"1989","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0295","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1128\/IAI.66.12.5711-5724.1998","article-title":"Brucella abortus transits through the autophagic pathway and replicates in the endoplasmatic reticulum on non-professional phagocytes","volume":"66","author":"Pizarro-Cerda","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0300","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1128\/IAI.66.5.2387-2392.1998","article-title":"Virulent Brucella abortus prevents lysosome fusions and is distributed within autophagsome-like compartments","volume":"66","author":"Pizarro-Cerda","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0305","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.162.6.3519","article-title":"Modulation of endocytosis in nuclear factor Il-6 (\u0394,\u0394) macrophages is responsible for a high susceptibility to intracellular bacterial infection","volume":"162","author":"Pizarro-Cerda","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0310","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-065X.2010.00989.x","article-title":"Innate immunity to intracellular pathogens: macrophage receptors and responses to microbial entry","volume":"240","author":"Pl\u00fcddemann","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0315","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0008-8749(80)90065-9","article-title":"Macrophage activation during experimental murine brucellosis: II, Inhibition of in vitro lymphocyte proliferation by Brucella-activated macrophages","volume":"49","author":"Riglar","year":"1980","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0320","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1189\/jlb.0103015","article-title":"Smooth and rough lipopolysaccharide of Brucella induce different intracellular trafficking and cytokine\/chemokine release in human monocytes","volume":"74","author":"Rittig","year":"2003","journal-title":"J. Leukocyt. Biol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0325","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1111\/j.1462-5822.2007.00922.x","article-title":"Brucella requires a functional Type IVsecretion system to elicit innate immune responses in mice","volume":"9","author":"Roux","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0330","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.micpath.2007.11.003","article-title":"SPG\/IND induced septic shock in a LPS-low responder strain, C3H\/HeJ mice","volume":"44","author":"Saito","year":"2008","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0335","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1371\/journal.ppat.0040021","article-title":"Brucella control of dendritic cell maturation is dependent on the TIR-containing protein btp1","volume":"4","author":"Salcedo","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0340","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2353\/ajpath.2010.090503","article-title":"Brucella abortus induces the secretion of proinflmatory mediators from glia cells leading to astrocyte apoptosis","volume":"176","author":"Samartino","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0345","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1046\/j.1365-2249.2000.01295.x","article-title":"Growth of Brucella abortus in macrophages from resistent and susceptible mouse strains","volume":"121","author":"Sathiyaseelan","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0350","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1128\/IAI.01109-10","article-title":"Putative ATP-binding cassette ransporter is essential for Brucella ovis pathogenesis in mice","volume":"79","author":"Silva","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0355","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jcp.1041250307","article-title":"Transformation of mouse bone marrow cells by transfection with a human oncogene related to c-myc is associated with the endogenous production of macrophage colony stimulating factor 1","volume":"125","author":"Sklar","year":"1985","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0360","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jhep.2005.03.030","article-title":"Pathways for the regulation of body iron homeostasis in response to experimental iron overload","volume":"43","author":"Theurl","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0365","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1128\/IAI.25.1.328-336.1979","article-title":"Analysis of the effects of Lipopolysacharides on macrophages: differential phagocytic responses of C3H\/HeN and C3H\/HeJ macrophages in vitro","volume":"25","author":"Vogel","year":"1979","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0370","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.4049\/jimmunol.162.10.5666","article-title":"Cutting edge: Functional characterization of the effect of the C3H\/HeJ defect in mice thet lack an Lpsn gene: in vivo evidence for a dominant negative mutation","volume":"162","author":"Vogel","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2016.02.006_bib0375","doi-asserted-by":"crossref","first-page":"e65934","DOI":"10.1371\/journal.pone.0065934","article-title":"The attenuated Brucella abortus strain S19 invades, persists in, and activates human dendritic cells, and induces the secretion of IL-12p70 but not Il 23","volume":"8","author":"Weinhold","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0380","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0022-1759(91)90389-W","article-title":"Immortalization of growth factor-dependent mouse splenic macrophages derived from cloned progenitors","volume":"137","author":"Wilson","year":"1991","journal-title":"J. Immunnol. Methods"},{"key":"10.1016\/j.ijmm.2016.02.006_bib0385","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1128\/IAI.26.2.680-685.1979","article-title":"Comparison of Brucella abortus and Brucella melitensis infections in mice and their effect on acquired cellular resistance","volume":"26","author":"Young","year":"1979","journal-title":"Infect. Immun."}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S143842211630011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S143842211630011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T13:10:26Z","timestamp":1748783426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S143842211630011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S143842211630011X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2016.02.006","relation":{},"ISSN":["1438-4221"],"issn-type":[{"type":"print","value":"1438-4221"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory response of TLR4 deficient spleen macrophages (CRL 2471) to Brucella abortus S19 and an isogenic \u0394mglA deletion mutant","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2016.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}