{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T23:24:31Z","timestamp":1772061871103,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais","award":["PPM-00117-14"],"award-info":[{"award-number":["PPM-00117-14"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["472438\/2013-1"],"award-info":[{"award-number":["472438\/2013-1"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["305154\/2014-1"],"award-info":[{"award-number":["305154\/2014-1"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ijmm.2016.03.010","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T15:50:55Z","timestamp":1460130655000},"page":"187-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["The absence of microbiota delays the inflammatory response to Cryptococcus gattii"],"prefix":"10.1016","volume":"306","author":[{"given":"Marliete Carvalho","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julliana Ribeiro Alves","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maira Juliana Andrade","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Jos\u00e9 Cota de","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Wesley","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella Freitas","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Silva","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Duque Nascimento","family":"Arifa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Campi","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviano dos Santos","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane Alves","family":"Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio L\u00facio","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle G.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Assis","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2016.03.010_bib0005","doi-asserted-by":"crossref","first-page":"e73562","DOI":"10.1371\/journal.pone.0073562","article-title":"Paraquat poisoning induces TNF-\u03b1-dependent iNOS\/NO mediated hyporesponsiveness of the aorta to vasoconstrictors in rats","volume":"8","author":"Aires","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0010","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.1016\/j.jinf.2006.10.002","article-title":"Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis","volume":"54","author":"Brouwer","year":"2007","journal-title":"J. Infect."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0015","doi-asserted-by":"crossref","first-page":"e1950","DOI":"10.1371\/journal.pone.0001950","article-title":"Cryptococcal neuroradiological lesions correlate with severity during cryptococcal meningoencephalitis in HIV-positive patients in the HAART era","volume":"3","author":"Charlier","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0020","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.01065-08","article-title":"Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans","volume":"77","author":"Charlier","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0025","first-page":"1","article-title":"Bifidobacterium longum subsp. infantis BB-02 attenuates acute murine experimental model of inflammatory bowel disease","volume":"1","author":"Elian","year":"2015","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0030","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.4049\/jimmunol.1101682","article-title":"Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice","volume":"188","author":"Fagundes","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0035","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/jac\/dkt114","article-title":"The role of oxidative and nitrosative bursts caused by azoles and amphotericin B against the fungal pathogen Cryptococcus gattii","volume":"68","author":"Ferreira","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0040","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1128\/AAC.00466-15","article-title":"Heteroresistance to itraconazole alters the morphology and increases the virulence of Cryptococcus gattii","volume":"59","author":"Ferreira","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0045","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/SHK.0b013e31826e47e8","article-title":"The endogenous bacteria alter gut epithelial apoptosis and decrease mortality following Pseudomonas aeruginosa pneumonia","volume":"38","author":"Fox","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0050","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1473-3099(14)70945-4","article-title":"Management of Cryptococcus gattii meningoencephalitis","volume":"15","author":"Franco-Paredes","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0055","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1073\/pnas.1019378108","article-title":"Microbiota regulates immune defense against respiratory tract influenza A virus infection","volume":"108","author":"Ichinohe","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0060","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1128\/IAI.64.8.3280-3287.1996","article-title":"Increased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin+ CD44+ T cells in sites of inflammation","volume":"64","author":"Inagaki","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0065","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0070","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/imm.12159","article-title":"Microbiota signalling through MyD88 is necessary for a systemic neutrophilic inflammatory response","volume":"140","author":"Karmarkar","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0075","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","article-title":"Gut microbiota promote hematopoiesis to control bacterial infection","volume":"15","author":"Khosravi","year":"2014","journal-title":"Cell Host Microbe."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1126\/science.1211057","article-title":"Intestinal microbiota promote enteric virus replication and systemic pathogenesis","volume":"334","author":"Kuss","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2990.2006.00706.x","article-title":"Behavioural and histopathological alterations in mice with cerebral malaria","volume":"32","author":"Lackner","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/mi.2009.124","article-title":"The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis","volume":"3","author":"Lavelle","year":"2010","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0095","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.prp.2014.04.022","article-title":"Thalidomide alleviates acute pancreatitis-associated lung injury via down-regulation of NF\u03baB induced TNF-\u03b1","volume":"210","author":"Lv","year":"2014","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0100","doi-asserted-by":"crossref","first-page":"12980","DOI":"10.1073\/pnas.0902963106","article-title":"The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation","volume":"106","author":"Ma","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nprot.2007.8","article-title":"A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators","volume":"2","author":"Maxeiner","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0110","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/eji.201343927","article-title":"Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection","volume":"44","author":"Mittr\u00fccker","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0115","first-page":"1389","article-title":"Intragastric infection of germfree and conventional mice with Salmonella typhimurium","volume":"22","author":"Nardi","year":"1989","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0120","doi-asserted-by":"crossref","first-page":"e1000953","DOI":"10.1371\/journal.ppat.1000953","article-title":"Cryptococcal cell morphology affects host cell interactions and pathogenicity","volume":"6","author":"Okagaki","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0125","doi-asserted-by":"crossref","first-page":"e1000953","DOI":"10.1371\/journal.ppat.1000953","article-title":"Cryptococcal cell morphology affects host cell interactions and pathogenicity","volume":"17","author":"Okagaki","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0130","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7883\/yoken.66.216","article-title":"Histopathological study of murine pulmonary cryptococcosis induced by Cryptococcus gattii and Cryptococcus neoformans","volume":"66","author":"Okubo","year":"2013","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4303\/jnp\/N100402","article-title":"Development of a murine model of neuroparacoccidioidomycosis","author":"Pedroso","year":"2010","journal-title":"J. Neuropararasitol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11046-013-9679-3","article-title":"Traffic of leukocytes and cytokine up-regulation in the central nervous system in a murine model of neuroparacoccidioidomycosis","volume":"176","author":"Pedroso","year":"2013","journal-title":"Mycopathologia"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0145","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1099\/mic.0.000149","article-title":"Evaluation of mucositis induced by irinotecan after microbial colonization in germ-free mice","volume":"161","author":"Pedroso","year":"2015","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0150","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america","volume":"50","author":"Perfect","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0155","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/infdis\/jit435","article-title":"Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis","volume":"209","author":"Robertson","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0160","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s003359900551","article-title":"Behavioral and functional analysis of mouse phenotype SHIRPA, a proposed protocol for comprehensive phenotype assessment","volume":"8","author":"Rogers","year":"1997","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3940(01)01885-7","article-title":"SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice","volume":"306","author":"Rogers","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0170","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0175","doi-asserted-by":"crossref","first-page":"e112669","DOI":"10.1371\/journal.pone.0112669","article-title":"Fluconazole alters the polysaccharide capsule of Cryptococcus gattii and leads to distinct behaviors in murine Cryptococcosis","volume":"9","author":"Santos","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2016.03.010_bib0180","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1172\/JCI41963","article-title":"Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain","volume":"120","author":"Shi","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0185","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrmicro2974","article-title":"The gut microbiota\u2013masters of host development and physiology","volume":"11","author":"Sommer","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0190","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.4049\/jimmunol.173.6.4137","article-title":"The essential role of the intestinal microbiota in facilitating acute inflammatory responses","volume":"173","author":"Souza","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0195","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/imr.12097","article-title":"Dual role of commensal bacteria in viral infections","volume":"255","author":"Wilks","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2011.10.024","article-title":"The germfree murine animal: an important animal model for research on the relationship between gut microbiota and the host","volume":"157","author":"Yi","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0205","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1128\/MMBR.00001-06","article-title":"The selective value of bacterial shape","volume":"70","author":"Young","year":"2006","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ijmm.2016.03.010_bib0210","doi-asserted-by":"crossref","first-page":"e1000945","DOI":"10.1371\/journal.ppat.1000945","article-title":"Fungal cell gigantism during mammalian infection","volume":"6","author":"Zaragoza","year":"2010","journal-title":"PLoS Pathog."}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422116300303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422116300303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T09:29:35Z","timestamp":1600421375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422116300303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S1438422116300303"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2016.03.010","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The absence of microbiota delays the inflammatory response to Cryptococcus gattii","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2016.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}