{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:55:33Z","timestamp":1790661333941,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Transregional Collaborative Research Center 34 (C7)"},{"name":"Interdisciplinary Center for Clinical Research"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ijmm.2018.02.003","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T17:58:14Z","timestamp":1519495094000},"page":"631-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Staphylococcus aureus in the airways of cystic fibrosis patients - A retrospective long-term study"],"prefix":"10.1016","volume":"308","author":[{"given":"Mathias","family":"Schwerdt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Schwartbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Kampmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-9419","authenticated-orcid":false,"given":"Dennis","family":"G\u00f6rlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"D\u00fcbbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2053-4379","authenticated-orcid":false,"given":"J\u00f6rg","family":"Gro\u00dfe-Onnebrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"K\u00fcster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Sch\u00fcltingkemper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Treffon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C.","family":"Kahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2018.02.003_bib0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/1469-0691.12406","article-title":"Two-week intravenous antibiotics do not eradicate persistent Staphylococcus aureus clones in cystic fibrosis patients","volume":"20","author":"Andersen","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/JCM.01510-06","article-title":"Prevalence and clinical significance of Staphylococcus aureus small-colony variants in cystic fibrosis lung disease","volume":"45","author":"Besier","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0015","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1128\/JB.00912-07","article-title":"In vivo mutations of thymidylate synthase (thyA) are responsible for thymidine-dependency in clinical small colony variants (TD-SCVs) of Staphylococcus aureus","volume":"190","author":"Chatterjee","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0020","series-title":"2014 Annual Data Report","author":"Cystic Fibrosis Foundation Patient Registry","year":"2015"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0025","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1164\/rccm.200802-327OC","article-title":"Persistent methicillin-resistant Staphylococcus aureus and rate of FEV1 decline in cystic fibrosis","volume":"178","author":"Dasenbrook","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0030","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1001\/jama.2010.791","article-title":"Association between respiratory tract methicillin-resistant Staphylococcus aureus and survival in cystic fibrosis","volume":"303","author":"Dasenbrook","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0035","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/MCP.0b013e32834b95ed","article-title":"Update on methicillin-resistant Staphylococcus aureus in cystic fibrosis","volume":"17","author":"Dasenbrook","year":"2011","journal-title":"Curr. Opin. Pulm. Med"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0040","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/cid\/cir399","article-title":"Inflammatory responses to individual microorganisms in the lungs of children with cystic fibrosis","volume":"53","author":"Gangell","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0045","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/IAI.68.3.1304-1311.2000","article-title":"Direct quantitative transcript analysis of the agr regulon of Staphylococcus aureus during human infection in comparison to the expression profile in vitro","volume":"68","author":"Goerke","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0050","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1086\/381502","article-title":"Increased frequency of genomic alterations in Staphylococcus aureus during chronic infection is in part due to phage mobilization","volume":"189","author":"Goerke","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0055","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ijmm.2013.09.012","article-title":"Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation","volume":"303","author":"Hirschhausen","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0060","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1365-2958.2003.03482.x","article-title":"Identification of a 5-nucleotide sequence that controls expression of the ica locus in Staphylococcus aureus and characterization of the DNA-binding properties of IcaR","volume":"48","author":"Jefferson","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0065","doi-asserted-by":"crossref","first-page":"e0166220","DOI":"10.1371\/journal.pone.0166220","article-title":"Factors associated with worse lung function in cystic fibrosis patients with persistent Staphylococcus aureus","volume":"11","author":"Junge","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0070","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1086\/515238","article-title":"Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis","volume":"177","author":"Kahl","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0075","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1128\/JCM.41.1.410-413.2003","article-title":"Thymidine-dependent small-colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separation","volume":"41","author":"Kahl","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0080","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1128\/JCM.41.9.4424-4427.2003","article-title":"Population dynamics of persistent Staphylococcus aureus isolated from the airways of cystic fibrosis patients during a 6-year prospective study","volume":"41","author":"Kahl","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0085","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1128\/CMR.00069-15","article-title":"Clinical significance and pathogenesis of staphylococcal small colony variants in persistent infections","volume":"29","author":"Kahl","year":"2016","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0090","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1128\/AAC.00742-15","article-title":"Thymidine-dependent Staphylococcus aureus small colony variants (SCVs) are induced by trimethoprim-sulfamethoxazole (SXT) and have an increased fitness during SXT challenge","volume":"59","author":"Kriegeskorte","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0095","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1128\/CMR.15.2.194-222.2002","article-title":"Lung infections associated with cystic fibrosis","volume":"15","author":"Lyczak","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0100","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/S0140-6736(09)60327-5","article-title":"Cystic fibrosis","volume":"373","author":"O'Sullivan","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0105","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/INF.0000000000000714","article-title":"Increased prevalence and resistance of important pathogens recovered from respiratory specimens of cystic fibrosis patients during a decade","volume":"34","author":"Raidt","year":"2015","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jpeds.2008.08.001","article-title":"Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis","volume":"154","author":"Sagel","year":"2009","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0115","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jama.290.13.1749","article-title":"Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial","volume":"290","author":"Saiman","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0120","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1001\/jama.2010.563","article-title":"Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial","volume":"303","author":"Saiman","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0125","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1128\/JCM.00361-08","article-title":"Clinical characteristics associated with isolation of small-colony variants of Staphylococcus aureus and Pseudomonas aeruginosa from respiratory secretions of patients with cystic fibrosis","volume":"46","author":"Schneider","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0130","doi-asserted-by":"crossref","first-page":"e1006024","DOI":"10.1371\/journal.ppat.1006024","article-title":"Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients","volume":"12","author":"Schwartbeck","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0135","first-page":"CD001912","article-title":"Prophylactic anti-staphylococcal antibiotics for cystic fibrosis","volume":"12","author":"Smyth","year":"2012","journal-title":"Cochrane. Database Syst. Rev."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0140","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ppul.20305","article-title":"Prophylactic antibiotics in cystic fibrosis: a conviction without evidence?","volume":"40","author":"Smyth","year":"2005","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0145","series-title":"UK Cystic Fibrosis Registry 2014 Annual Data Report","author":"Trust","year":"2015"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0150","series-title":"Standard for the Clinical Care of Children and Adults with Cystic Fibrosis in the UK","author":"Trust","year":"2016"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0155","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/cid\/cit270","article-title":"Staphylococcus aureus small-colony variants are independently associated with worse lung disease in children with cystic fibrosis","volume":"57","author":"Wolter","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.02.003_bib0160","first-page":"8","article-title":"A novel repressor of the ica locus discovered in clinically isolated super-biofilm-elaborating staphylococcus aureus","volume":"31","author":"Yu","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.ijmm.2018.02.003_bib0165","series-title":"ECFSPR Annual Report","author":"Zolin","year":"2013"}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422117304484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422117304484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T21:30:01Z","timestamp":1660512601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422117304484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1438422117304484"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2018.02.003","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Staphylococcus aureus in the airways of cystic fibrosis patients - A retrospective long-term study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2018.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}