{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:24Z","timestamp":1789609224231,"version":"build-2803163510"},"reference-count":89,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ijmm.2018.08.007","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T15:53:36Z","timestamp":1535558016000},"page":"1096-1104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Complement depletion and Coombs positivity in pneumococcal hemolytic uremic syndrome (pnHUS). Case series and plea to revisit an old pathogenetic concept"],"prefix":"10.1016","volume":"308","author":[{"given":"Martin","family":"Bitzan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"AlKandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Whittemore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-ling","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2018.08.007_bib0005","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1615\/CritRevImmunol.2015012177","article-title":"Roles of complement C1q in pneumococcus-host interactions","volume":"35","author":"Agarwal","year":"2015","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0010","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.4049\/jimmunol.1102934","article-title":"Enolase of Streptococcus pneumoniae binds human complement inhibitor C4b-binding protein and contributes to complement evasion","volume":"189","author":"Agarwal","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0015","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.4049\/jimmunol.1300279","article-title":"An alternative role of C1q in bacterial infections: facilitating Streptococcus pneumoniae adherence and invasion of host cells","volume":"191","author":"Agarwal","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0020","doi-asserted-by":"crossref","first-page":"18333","DOI":"10.1074\/jbc.M114.619494","article-title":"A novel interaction between complement inhibitor C4b-binding protein and plasminogen that enhances plasminogen activation","volume":"290","author":"Agarwal","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00467-010-1690-z","article-title":"Pandemic H1N1 influenza A infection and (atypical) HUS--more than just another trigger?","volume":"26","author":"Allen","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0030","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1001\/archpedi.1984.02140430072019","article-title":"Hemolytic-uremic syndrome associated with Streptococcus pneumoniae. Report of a case and review of the literature","volume":"138","author":"Alon","year":"1984","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0035","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00467-008-0964-1","article-title":"Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome","volume":"24","author":"Ariceta","year":"2009","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0040","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1021\/bi00218a016","article-title":"Secondary structure of a complement control protein module by two-dimensional 1H NMR","volume":"30","author":"Barlow","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0045","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ajcp\/84.2.244","article-title":"Detection of circulating T-activating enzyme in the serum of a patient having hemolytic-uremic syndrome and disseminated intravascular coagulation","volume":"84","author":"Beattie","year":"1985","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0050","series-title":"Pediatric Kidney Disease","first-page":"653","article-title":"Postinfectious hemolytic uremic syndrome","author":"Bitzan","year":"2016"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0055","article-title":"Influenza-associated thrombotic microangiopathies","author":"Bitzan","year":"2017","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0060","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1542\/peds.110.2.371","article-title":"Invasive pneumococcal disease and hemolytic uremic syndrome","volume":"110","author":"Brandt","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0065","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/trf.12981","article-title":"Red blood cell Thomsen-Friedenreich antigen expression and galectin-3 plasma concentrations in Streptococcus pneumoniae-associated hemolytic uremic syndrome and hemolytic anemia","volume":"55","author":"Burin des Roziers","year":"2015","journal-title":"Transfusion"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0070","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1542\/peds.101.4.699","article-title":"Hemolytic uremic syndrome associated with invasive Streptococcus pneumoniae infection","volume":"101","author":"Cabrera","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0075","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pedneo.2011.02.002","article-title":"Nonenteropathic hemolytic uremic syndrome: the experience of a medical center","volume":"52","author":"Chen","year":"2011","journal-title":"Pediatr. Neonatol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0080","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.micpath.2011.02.010","article-title":"Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae infection is dependent on pneumococcal neuraminidase A","volume":"50","author":"Coats","year":"2011","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0085","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1053\/j.ajkd.2004.02.010","article-title":"Non-enteropathic hemolytic uremic syndrome: causes and short-term course","volume":"43","author":"Constantinescu","year":"2004","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0090","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.1542\/peds.2007-2017","article-title":"Streptococcus pneumoniae-associated hemolytic uremic syndrome: classification and the emergence of serotype 19A","volume":"125","author":"Copelovitch","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0095","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1046\/j.1537-2995.2000.40070801.x","article-title":"RBC T activation and hemolysis: implications for pediatric transfusion management","volume":"40","author":"Crookston","year":"2000","journal-title":"Transfusion"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0100","first-page":"219","article-title":"Hemolytic-uremic syndrome in pneumococcal meningitis and infection. Importance of T-transformation","volume":"141","author":"Eber","year":"1993","journal-title":"Monatsschr Kinderheilkd"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1365-2141.2001.02886.x","article-title":"Does red-cell T activation matter?","volume":"114","author":"Eder","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/00365549509018989","article-title":"Complement analysis in adult patients with a history of bacteremic pneumococcal infections or recurrent pneumonia","volume":"27","author":"Ekdahl","year":"1995","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF00865481","article-title":"Streptococcus pneumoniae-induced hemolytic uremic syndrome: a case for early diagnosis","volume":"8","author":"Erickson","year":"1994","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0120","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1046\/j.1537-2995.1986.26286152912.x","article-title":"Uneventful administration of plasma products in a recipient with T-activated red cells","volume":"26","author":"Eversole","year":"1986","journal-title":"Transfusion"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0125","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0140-6736(17)30062-4","article-title":"Haemolytic uraemic syndrome","volume":"390","author":"Fakhouri","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0130","first-page":"2","article-title":"Severe pneumonia with hemolysis caused by neuraminidase. Detection of cryptantigens by indirect immunofluorescent technic","volume":"119","author":"Fischer","year":"1971","journal-title":"Monatsschr Kinderheilkd"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0463.1928.tb05311.x","article-title":"Investigations into the Thomsen hemagglutination phenomena","volume":"5","author":"Friedenreich","year":"1928","journal-title":"Acta. Path Microbiol. Scand."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0140","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/cid\/ciu274","article-title":"Invasive pneumococcal disease in children can reveal a primary immunodeficiency","volume":"59","author":"Gaschignard","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0145","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1056\/NEJMra1312353","article-title":"Syndromes of thrombotic microangiopathy","volume":"371","author":"George","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0150","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.mehy.2013.05.030","article-title":"Does dysregulated complement activation contribute to haemolytic uraemic syndrome secondary to Streptococcus pneumoniae?","volume":"81","author":"Gilbert","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0155","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s10096-016-2885-4","article-title":"Polymicrobial pneumococcal bacteraemia: a case-control study","volume":"36","author":"Grau","year":"2017","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0160","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.4049\/jimmunol.1501388","article-title":"Complement evasion mediated by enhancement of captured factor H: implications for protection of self-surfaces from complement","volume":"195","author":"Herbert","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0165","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1111\/j.1537-2995.2008.01871.x","article-title":"A severe case of atypical hemolytic uremic syndrome associated with pneumococcal infection and T activation treated successfully with plasma exchange","volume":"48","author":"Hopkins","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0170","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/01.inf.0000223494.83542.ad","article-title":"T-antigen activation for prediction of pneumococcus-induced hemolytic uremic syndrome and hemolytic anemia","volume":"25","author":"Huang","year":"2006","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0175","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s00431-005-0041-8","article-title":"Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan","volume":"165","author":"Huang","year":"2006","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0180","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/INF.0000000000000701","article-title":"Immunodeficiency among children with recurrent invasive pneumococcal disease","volume":"34","author":"Ingels","year":"2015","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0185","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.imbio.2011.07.022","article-title":"Is complement a culprit in infection-induced forms of haemolytic uraemic syndrome?","volume":"217","author":"Johnson","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0190","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4049\/jimmunol.122.1.75","article-title":"Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b","volume":"122","author":"Kazatchkine","year":"1979","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0195","doi-asserted-by":"crossref","first-page":"13345","DOI":"10.1074\/jbc.M117.795088","article-title":"Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation","volume":"292","author":"Kerr","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0200","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/08820137909050053","article-title":"Nature of human serum blood group T antibodies","volume":"8","author":"Kim","year":"1979","journal-title":"Immunol. Commun."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0205","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0140-6736(77)92915-4","article-title":"Thomsen-Friedenreich antigen in haemolytic-uraemic syndrome","volume":"2","author":"Klein","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0210","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/BF01476765","article-title":"Histochemical methods for the demonstration of Thomsen-Friedenreich antigen in cell suspensions and tissue sections","volume":"56","author":"Klein","year":"1978","journal-title":"Klin. Wochenschr."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0215","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/23744235.2015.1131329","article-title":"Early deaths in bloodstream infections: a population-based case series","volume":"48","author":"Kontula","year":"2016","journal-title":"Infect. Dis. (Lond.)"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0220","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00213-18","article-title":"Desialylation of platelets by pneumococcal neuraminidase A induces ADP-dependent platelet hyper-reactivity","author":"Kullaya","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0225","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1440-1797.2011.01500.x","article-title":"Invasive pneumococcal pneumonia is the major cause of paediatric haemolytic-uraemic syndrome in Taiwan","volume":"17","author":"Lee","year":"2012","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0230","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/j.lpm.2011.11.013","article-title":"Management of hemolytic uremic syndrome","volume":"41","author":"Loirat","year":"2012","journal-title":"Presse Med"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0235","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00467-015-3076-8","article-title":"An international consensus approach to the management of atypical hemolytic uremic syndrome in children","volume":"31","author":"Loirat","year":"2016","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0240","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/INF.0b013e31829ee872","article-title":"Diagnosis of Streptococcus pneumoniae-associated hemolytic uremic syndrome","volume":"32","author":"Loupiac","year":"2013","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0245","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/CCM.0b013e3181b4a76b","article-title":"Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses","volume":"38","author":"McConnell","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0250","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/infdis\/jix305","article-title":"Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells","volume":"217","author":"Meinel","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0255","first-page":"535","article-title":"Clinical analysis of hemolytic-uremic syndrome associated with Streptococcus pneumoniae serotype 3 infection in a child","volume":"51","author":"Meng","year":"2013","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0260","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1537-2995.1975.15476034552.x","article-title":"Severe hemolytic anemia in an adult associated with anti-T","volume":"15","author":"Moores","year":"1975","journal-title":"Transfusion"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0265","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0022-3476(79)80765-9","article-title":"Hemolytic-uremic syndrome associated with pneumococcal sepsis","volume":"95","author":"Moorthy","year":"1979","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0270","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s004670100564","article-title":"Prognosis of Streptococcus pneumoniae-induced hemolytic uremic syndrome","volume":"16","author":"Nathanson","year":"2001","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0275","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/cid\/cix685","article-title":"Comparison of the impact of pneumococcal conjugate vaccine 10 or pneumococcal conjugate vaccine 13 on invasive pneumococcal disease in equivalent populations","volume":"65","author":"Naucler","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0280","first-page":"183","article-title":"Bacterial-induced RBC alterations complicating necrotizing enterocolitis","volume":"138","author":"Novak","year":"1984","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0285","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3109\/15513819009064722","article-title":"The pathobiology of red cell cryptantigen exposure","volume":"10","author":"Novak","year":"1990","journal-title":"Pediatr. Pathol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0290","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/15513818309025872","article-title":"Hemolytic-uremic syndrome and T-cryptantigen exposure by neuraminidase-producing pneumococci: an emerging problem?","volume":"1","author":"Novak","year":"1983","journal-title":"Pediatr. Pathol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0295","first-page":"368","article-title":"T-cryptantigen determination affects mortality in necrotizing enterocolitis","volume":"176","author":"Novak","year":"1993","journal-title":"Surg. Gynecol. Obstet."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0300","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1172\/JCI106591","article-title":"Neuraminidase activity in bacterial meningitis","volume":"50","author":"O\u2019Toole","year":"1971","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0305","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4137\/CPath.S670","article-title":"Pneumococcal induced T-activation with resultant thrombotic microangiopathy","volume":"3","author":"Oliver","year":"2010","journal-title":"Clin. Med. Insights Pathol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0310","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.4049\/jimmunol.164.9.4742","article-title":"Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement","volume":"164","author":"Pangburn","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0315","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0008-6215(00)84040-9","article-title":"Immunochemical studies on the specificity of the peanut (Arachis hypogaea) agglutinin","volume":"51","author":"Pereira","year":"1976","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0320","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0140-6736(79)91343-6","article-title":"Exchange transfusion with heparinised fresh blood in necrotising enterocolitis","volume":"1","author":"Poschmann","year":"1979","journal-title":"Lancet"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0325","first-page":"15","article-title":"Neuraminidase induced hemolytic anemia. Experimental and clinical observations (author's transl)","volume":"124","author":"Poschmann","year":"1976","journal-title":"Monatsschr Kinderheilkd"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0330","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1440-1754.2009.01603.x","article-title":"Ten years of pneumococcal-associated haemolytic uraemic syndrome in New Zealand children","volume":"45","author":"Prestidge","year":"2009","journal-title":"J. Paediatr. Child Health"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0335","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s00467-005-1843-7","article-title":"Prospective surveillance of Canadian children with the haemolytic uraemic syndrome","volume":"20","author":"Proulx","year":"2005","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0340","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1365-2141.2001.02301.x","article-title":"T activation","volume":"112","author":"Ramasethu","year":"2001","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0345","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/infdis\/jix306","article-title":"Hemolytic uremic syndrome associated with pneumococci in children-an elusive mystery now explained?","volume":"217","author":"Riesbeck","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0350","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.4049\/jimmunol.178.3.1861","article-title":"Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system","volume":"178","author":"Rupprecht","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0355","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1351\/pac198456070907","article-title":"The anti-recognition function of sialic acids: studies with erythocytes and macrophages","volume":"56","author":"Schauer","year":"1984","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0360","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2008030287","article-title":"New equations to estimate GFR in children with CKD","volume":"20","author":"Schwartz","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0365","first-page":"359","article-title":"Hemolytic-uremic syndrome associated with neuraminidase-producing microorganisms: treatment by exchange transfusion","volume":"35","author":"Seger","year":"1980","journal-title":"Helv. Paediatr. Acta"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0370","first-page":"121","article-title":"Necrotising enterocolitis and neuraminidase-producing bacteria","volume":"35","author":"Seger","year":"1980","journal-title":"Helv. Paediatr. Acta"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0375","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0022-3468(81)80844-5","article-title":"Pediatric surgical patients with severe anaerobic infection: report of 16 T-antigen positive cases and possible hazards of blood transfusion","volume":"16","author":"Seges","year":"1981","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0380","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1023\/A:1018565316310","article-title":"Monoclonal antibodies for the detection of desialylation of erythrocyte membranes during haemolytic disease and haemolytic uraemic syndrome caused by the in vivo action of microbial neuraminidase","volume":"14","author":"Seitz","year":"1997","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0385","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1128\/CVI.00257-06","article-title":"Serum antibodies to pneumococcal neuraminidase NanA in relation to pneumococcal carriage and acute otitis media","volume":"13","author":"Simell","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0390","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1099\/jmm.0.000322","article-title":"Defining the role of pneumococcal neuraminidases and O-glycosidase in pneumococcal haemolytic uraemic syndrome","volume":"65","author":"Singh","year":"2016","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0395","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1099\/jmm.0.063479-0","article-title":"Investigating the role of pneumococcal neuraminidase A activity in isolates from pneumococcal haemolytic uraemic syndrome","volume":"62","author":"Smith","year":"2013","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0400","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/MOP.0b013e32835d7f2c","article-title":"Update on Streptococcus pneumoniae associated hemolytic uremic syndrome","volume":"25","author":"Spinale","year":"2013","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0405","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2141.1981.tb02813.x","article-title":"Origin of anti-Thomsen-Friedenreich (T) and Tn agglutinins in man and in White Leghorn chicks","volume":"47","author":"Springer","year":"1981","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0410","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2215\/CJN.01900214","article-title":"AKI in hospitalized children: comparing the pRIFLE, AKIN, and KDIGO definitions","volume":"10","author":"Sutherland","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0415","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1093\/ndt\/gft198","article-title":"The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome","volume":"28","author":"Szilagyi","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0420","first-page":"85","article-title":"Ein vermehrungsf\u00e4higes Agens als Ver\u00e4nderer des isoagglutinatorischen Verhaltens der roten Blutk\u00f6rperchen, eine bisher unbekannte Quelle der Fehlbestimmungen","volume":"52","author":"Thomsen","year":"1927","journal-title":"Z Immunitaetsforsch Immunobiol"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0340-904X(78)80054-2","article-title":"The Thomsen agglutination phenomenon: a discovery revisited 50 years later","volume":"154","author":"Vaith","year":"1978","journal-title":"Z. Immunitatsforsch. Immunobiol."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0430","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000045396","article-title":"Positive Coombs test in pneumococcus-associated hemolytic uremic syndrome. A review of the literature","volume":"82","author":"von Vigier","year":"1999","journal-title":"Nephron"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0435","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jpeds.2007.03.055","article-title":"Hemolytic uremic syndrome associated with invasive pneumococcal disease: the United kingdom experience","volume":"151","author":"Waters","year":"2007","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ijmm.2018.08.007_bib0440","first-page":"9","article-title":"Management of streptococcal pneumoniae-induced hemolytic uremic syndrome: a case report","volume":"2","author":"Weintraub","year":"2014","journal-title":"Clin Nephrol Case Stud"},{"key":"10.1016\/j.ijmm.2018.08.007_bib0445","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0022-3476(89)80748-6","article-title":"Transfusion of infants with activation of erythrocyte T antigen","volume":"115","author":"Williams","year":"1989","journal-title":"J. Pediatr."}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422118302820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422118302820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T13:46:41Z","timestamp":1693835201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422118302820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":89,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S1438422118302820"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2018.08.007","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement depletion and Coombs positivity in pneumococcal hemolytic uremic syndrome (pnHUS). Case series and plea to revisit an old pathogenetic concept","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2018.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}