{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:41:19Z","timestamp":1790462479717,"version":"4.1.0"},"reference-count":116,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ijmm.2019.03.002","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T03:20:19Z","timestamp":1553224819000},"page":"159-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Secreted proteases: A new insight in the pathogenesis of extraintestinal pathogenic Escherichia coli"],"prefix":"10.1016","volume":"309","author":[{"given":"Rima","family":"Tapader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulagna","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2019.03.002_bib0005","first-page":"90","article-title":"Prevalence of Escherichia coli sequence type 131 (ST131) among extraintestinal clinical isolates in different phylogenetic groups","volume":"5","author":"Abdullah","year":"2016","journal-title":"Int. J. Med. Res. Health Sci."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0010","first-page":"17","article-title":"Autotransporter protein-encoding genes of diarrheagenic Escherichia coli are found in both typical and atypical enteropathogenic E. coli","author":"Abreu","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0015","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1128\/iai.64.10.4035-4041.1996","article-title":"Purification and characterization of novel hemagglutinins from Vibrio mimicus: a 39-kilodalton major outer membrane protein and lipopolysaccharide","volume":"64","author":"Alam","year":"1996","journal-title":"Infect. Immun."},{"issue":"10","key":"10.1016\/j.ijmm.2019.03.002_bib0020","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.3390\/ijerph10126235","article-title":"Escherichia coli in Europe: an overview","volume":"2013","author":"Allocati","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.meegid.2017.02.018","article-title":"Distribution of serine protease autotransporters of Enterobacteriaceae in typical and atypical enteroaggregative Escherichia coli","volume":"50","author":"Andrade","year":"2017","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0030","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1128\/IAI.06160-11","article-title":"The type II secretion system and its ubiquitous lipoprotein substrate, SslE, are required for biofilm formation and virulence of Enteropathogenic Escherichia coli","volume":"80","author":"Baldi","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0035","first-page":"486","article-title":"Extraintestinal infections due to Escherichia coli: an emerging issue","volume":"5","author":"Banu","year":"2011","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0040","first-page":"1","article-title":"Proteolytic enzymes: serine and cysteine peptidases","volume":"244","author":"Barett","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0045","series-title":"Handbook of Proteolytic Enzymes","author":"Barrett","year":"2004"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0050","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/S0929-693X(12)71279-4","article-title":"Virulence factors and pathophysiology of extraintestinal pathogenic Escherichia coli","volume":"19","author":"Bidet","year":"2012","journal-title":"Arch. P\u00e9diatr."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0055","first-page":"15","article-title":"Role of uropathogenic Escherichia coli virulence factors in development of urinary tract infection and kidney damage","author":"Bien","year":"2012","journal-title":"Int. J. Nephrol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0060","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1086\/514217","article-title":"Phylogenetic analysis of Escherichia coli strains causing neonatal meningitis suggests horizontal gene transfer from a predominant pool of highly virulent B2 group strains","volume":"177","author":"Bingen","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0065","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1128\/iai.35.2.654-659.1982","article-title":"Further characterization of complement resistance conferred on Escherichia coli by the plasmid genes traT of R100 and iss of ColV, I-K94","volume":"35","author":"Binns","year":"1982","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4269\/ajtmh.2009.80.294","article-title":"Short Report: High prevalence of serine protease autotransporter cytotoxins among strains of enteroaggregative Escherichia coli","volume":"80","author":"Boisen","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0075","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1128\/AEM.00920-07","article-title":"Subtypes of the plasmid-encoded serine protease EspP in Shiga toxin-producing Escherichia coli: distribution, secretion, and proteolytic activity","volume":"73","author":"Brockmeyer","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0080","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1046\/j.1365-2958.1997.3871751.x","article-title":"EspP, a novel extracellular serine protease of enterohaemorrhagic Escherichia coli O157:H7 cleaves human coagulation factor V","volume":"24","author":"Brunder","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/1758-2229.12019","article-title":"The Clermont Escherichia coli phylo-typing method revisited: improvement of specificity and detection of new phylo-groups","volume":"5","author":"Clermont","year":"2013","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0090","series-title":"Mucosal Immunology","first-page":"49","article-title":"Mucus","author":"Cone","year":"2005"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0095","first-page":"759","article-title":"Host defence mechanisms in the bladder. II. Disruption of the layer of mucus","volume":"69","author":"Cornish","year":"1988","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0100","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3390\/toxins2061179","article-title":"Serine protease autotransporters of Enterobacteriaceae (SPATEs): biogenesis and function","volume":"2","author":"Dautin","year":"2010","journal-title":"Toxins"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.micro.61.080706.093233","article-title":"Protein secretion in Gram-negative bacteria via the autotransporter pathway","volume":"61","author":"Dautin","year":"2007","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0110","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/BF01964239","article-title":"Aerobactin production as a virulence factor: a reevaluation","volume":"7","author":"De Lorenzo","year":"1988","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0115","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1365-2958.1997.5141874.x","article-title":"Characterization of an exported protease from Shiga toxin-producing Escherichia coli","volume":"25","author":"Djafari","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0120","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1128\/IAI.68.7.4145-4154.2000","article-title":"Relationship between the Tsh autotransporter and pathogenicity of avian Escherichia coli and localization and analysis of the Tsh genetic region","volume":"68","author":"Dozois","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0125","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1099\/00221287-147-6-1671","article-title":"Commensal Escherichia coli isolates are phylogenetically distributed among geographically distinct human populations","volume":"147","author":"Duriez","year":"2001","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0130","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1128\/IAI.70.12.7105-7113.2002","article-title":"Functional comparison of serine protease autotransporters of Enterobacteriaceae","volume":"70","author":"Dutta","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0135","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1128\/IAI.66.7.3155-3163.1998","article-title":"Pet, an autotransporter enterotoxin from enteroaggregative Escherichia coli","volume":"66","author":"Eslava","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0140","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1084\/jem.180.4.1243","article-title":"Defective inflammatory response in interleukin 6-deficient mice","volume":"180","author":"Fattori","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0145","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-94-007-5940-4_7","article-title":"Bacterial proteases and virulence","volume":"66","author":"Frees","year":"2013","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0150","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1574-6968.2001.tb10540.x","article-title":"Yersinia HPI in septicemic Escherichia coli strains isolated from diverse hosts","volume":"196","author":"Gophna","year":"2001","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2958.2000.02110.x","article-title":"Identification of Sat, an autotransporter toxin produced by uropathogenic Escherichia coli","volume":"38","author":"Guyer","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0160","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1128\/IAI.70.8.4539-4546.2002","article-title":"Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells","volume":"70","author":"Guyer","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0165","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1128\/mr.57.4.823-837.1993","article-title":"Bacterial extracellular zinc-containing metalloproteases","volume":"57","author":"Hase","year":"1993","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0170","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/IAI.72.1.593-597.2004","article-title":"Autotransporter genes pic and tsh are associated with Escherichia coli strains that cause acute pyelonephritis and are expressed during urinary tract infection","volume":"72","author":"Heimer","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0175","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1128\/IAI.69.3.1231-1243.2001","article-title":"Virulence functions of autotransporter proteins","volume":"69","author":"Henderson","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0180","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0966-842X(98)01318-3","article-title":"The great escape: structure and function of the autotransporter proteins","volume":"6","author":"Henderson","year":"1998","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0185","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1128\/IAI.67.11.5587-5596.1999","article-title":"Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli","volume":"67","author":"Henderson","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0190","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1574-6968.2009.01664.x","article-title":"An overview of atypical enteropathogenic Escherichia coli","volume":"297","author":"Hernandes","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(94)01079-X","article-title":"Families of zinc metalloproteases","volume":"354","author":"Hooper","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0200","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/JB.01238-08","article-title":"Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348\/69","volume":"191","author":"Iguchi","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0205","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4236\/aer.2013.13005","article-title":"Versatility of microbial proteases","volume":"1","author":"Jisha","year":"2013","journal-title":"Adv. Enz. Res."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0210","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.4.1.80","article-title":"Virulence factors in Escherichia coli urinary tract infection","volume":"4","author":"Johnson","year":"1991","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0215","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1067\/mlc.2002.121550","article-title":"Extraintestinal pathogenic Escherichia coli: \u201cThe other bad E. coli\u201d","volume":"139","author":"Johnson","year":"2002","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0220","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1086\/317656","article-title":"Phylogenetic distribution of extraintestinal virulence-associated traits in Escherichia coli","volume":"183","author":"Johnson","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0225","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Pathogenic Escherichia coli","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0230","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1462-5822.2003.t01-1-00271.x","article-title":"The K1 capsule modulates trafficking of E. coli-containing vacuoles and enhances intracellular bacterial survival in human brain microvascular endothelial cells","volume":"5","author":"Kim","year":"2003","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0235","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nrmicro2762","article-title":"The type II secretion system: biogenesis, molecular, architecture and mechanism","volume":"10","author":"Korotkov","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0240","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1128\/IAI.72.10.5548-5554.2004","article-title":"Functional analysis of the Tsh autotransporter from an avian pathogenic Escherichia coli strain","volume":"72","author":"Kostakioti","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0245","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1128\/iai.56.3.640-648.1988","article-title":"Distribution and degree of heterogeneity of the afimbrial-adhesin-encoding operon (afa) among uropathogenic Escherichia coli isolates","volume":"56","author":"Labigne-Roussel","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0250","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1128\/IAI.73.5.2818-2827.2005","article-title":"Identification of genes required for avian Escherichia coli septicemia by signature-tagged mutagenesis","volume":"73","author":"Li","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0255","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/IAI.01106-13","article-title":"Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells","volume":"82","author":"Luo","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003446","article-title":"Conservation and immunogenicity of novel antigens in diverse isolates of enterotoxigenic Escherichia coli","volume":"9","author":"Luo","year":"2015","journal-title":"Plos Neg. Trop. Dis."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0265","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1073\/pnas.95.6.3140","article-title":"Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms","volume":"95","author":"Maiden","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0270","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/cid\/cis502","article-title":"Food-borne origins of Escherichia coli causing extraintestinal infections","volume":"55","author":"Manges","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0275","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijpara.2005.10.007","article-title":"Genomic and proteomic approaches highlight phagocytosis of living and apoptotic human cells by the parasite Entamoeba histolytica","volume":"36","author":"Marion","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0280","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1128\/IAI.01086-06","article-title":"Protease activity, secretion, cell entry, cytotoxicity, and cellular targets of secreted autotransporter toxin of uropathogenic Escherichia coli","volume":"74","author":"Maroncle","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0285","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1128\/iai.58.10.3434-3437.1990","article-title":"Genetically engineered S and F1C fimbriae differ in their contribution to adherence of Escherichia coli to cultured renal tubular cells","volume":"58","author":"Marre","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0290","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1128\/AEM.01567-10","article-title":"proteolytic enzyme production by strains of the insect pathogen Xenorhabdus and characterization of an early-log-phase-secreted protease as a potential virulence factor","volume":"76","author":"Massaoud","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0295","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.aambs.2014.09.002","article-title":"Escherichia coli ST131: the quintessential example of an international multiresistant high-risk clone","volume":"90","author":"Mathers","year":"2015","journal-title":"Adv. Appl. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0300","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1089\/fpd.2013.1533","article-title":"Human and avian extraintestinal pathogenic Escherichia coli: infections, zoonotic risks, and antibiotic resistance trends","volume":"10","author":"Mellata","year":"2013","journal-title":"Foodborne Pathog. Dis."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0305","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1128\/IAI.69.1.315-324.2001","article-title":"EspC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin","volume":"69","author":"Mellies","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0310","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/IAI.00800-13","article-title":"Response of extraintestinal pathogenic Escherichia coli to human serum reveals a protective role for Rcs-regulated exopolysaccharide colanic acid","volume":"82","author":"Miajlovic","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0315","doi-asserted-by":"crossref","first-page":"9072","DOI":"10.1073\/pnas.0915077107","article-title":"Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli","volume":"107","author":"Moriel","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0320","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00118-12","article-title":"Escherichia coli: great diversity around a common core","volume":"3","author":"Moriel","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0325","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1462-5822.2002.00193.x","article-title":"Adhesion and entry of uropathogenic Escherichia coli","volume":"4","author":"Mulvey","year":"2002","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030287","article-title":"A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes","volume":"7","author":"Nakjang","year":"2012","journal-title":"PLoS One"},{"issue":"66","key":"10.1016\/j.ijmm.2019.03.002_bib0335","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1128\/IAI.66.7.3149-3154.1998","article-title":"In vitro effects of a high-molecular-weight heat-labile enterotoxin from enteroaggregative Escherichia coli","volume":"1998","author":"Navarro-Garcia","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004124","article-title":"SslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains","volume":"10","author":"Nesta","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0345","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1471-4906(03)00079-6","article-title":"Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing?","volume":"24","author":"Netea","year":"2003","journal-title":"Trends Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0350","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1128\/JB.00791-15","article-title":"Molecular characterization of the vacuolating autotransporter toxin in uropathogenic Escherichia coli","volume":"198","author":"Nichols","year":"2016","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0355","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1128\/JCM.00346-13","article-title":"Prevalence and characteristics of the epidemic multiresistant Escherichia coli ST131 clonal group among extended-spectrum beta- lactamase-producing E. coli isolates in Copenhagen, Denmark","volume":"51","author":"Olesen","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0360","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0014-5793(95)00927-2","article-title":"Interaction of the bacterial protein toxin alpha-haemolysin with model membranes: protein binding does not always lead to lytic activity","volume":"371","author":"Ostolaza","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0365","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1084\/jem.188.6.1091","article-title":"Characterization of a hemoglobin protease secreted by the pathogenic Escherichia coli strain EB1","volume":"188","author":"Otto","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0370","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1128\/IAI.70.1.5-10.2002","article-title":"Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis","volume":"70","author":"Otto","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0375","doi-asserted-by":"crossref","first-page":"17339","DOI":"10.1074\/jbc.M412885200","article-title":"Crystal structure of hemoglobin protease, a heme binding autotransporter protein from pathogenic Escherichia coli","volume":"280","author":"Otto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0380","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-1097(03)00862-0","article-title":"PicU, a second serine protease autotransporter of uropathogenic Escherichia coli","volume":"230","author":"Parham","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0385","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1128\/JCM.43.5.2425-2434.2005","article-title":"Prevalence of pathogenicity island IICFT073 genes among extraintestinal clinical isolates of Escherichia coli","volume":"43","author":"Parham","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0390","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0006-291X(83)90328-5","article-title":"Escherichia coli strains binding neuraminyl \u03b12-3 galactosides","volume":"111","author":"Parkkinen","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0395","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1128\/IAI.71.9.5087-5096.2003","article-title":"A novel pathogenicity island integrated adjacent to the thrW tRNA gene of avian pathogenic Escherichia coli encodes a vacuolating autotransporter toxin","volume":"71","author":"Parreira","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0400","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/IAI.67.2.546-553.1999","article-title":"The link between phylogeny and virulence in Escherichia coli extraintestinal infection","volume":"67","author":"Picard","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0405","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fmicb.2012.00009","article-title":"Extraintestinal pathogenic Escherichia coli: a combination of virulence with antibiotic resistance","volume":"3","author":"Pitout","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0410","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0415","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/infdis\/jiv429","article-title":"Extra-intestinal Pathogenic Escherichia coli (ExPEC), a common human pathogen: challenges for vaccine development and progress in the field","volume":"213","author":"Poolman","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0420","doi-asserted-by":"crossref","first-page":"827","DOI":"10.4049\/jimmunol.148.3.827","article-title":"Role of TraT protein, an anticomplementary protein produced in Escherichia coli by R100 factor, in serum resistance","volume":"148","author":"Pramoonjago","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0425","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1128\/iai.62.4.1369-1380.1994","article-title":"Isolation and characterization of a gene involved in hemagglutination by an avian pathogenic Escherichia coli strain","volume":"62","author":"Provence","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0430","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1128\/iai.65.7.2685-2692.1997","article-title":"Evolutionary relationships among pathogenic and nonpathogenic Escherichia coli strains inferred from multilocus enzyme electrophoresis and mdh sequence studies","volume":"65","author":"Pupo","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0435","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/bj2900205","article-title":"Evolutionary families of peptidases","volume":"290","author":"Rawlings","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0440","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1128\/AEM.01542-06","article-title":"Autotransporter-encoding sequences are phylogenetically distributed among Escherichia coli clinical isolates and reference strains","volume":"73","author":"Restieri","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0445","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkq415","article-title":"Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain","volume":"66","author":"Rogers","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0450","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ijmm.2010.04.009","article-title":"Distribution and evolution of virulence factors in septicemic Escherichia coli","volume":"300","author":"Ron","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0455","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1128\/IAI.00264-10","article-title":"Enterotoxigenic Escherichia coli elicits immune responses to multiple surface proteins","volume":"78","author":"Roy","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0460","first-page":"1","article-title":"Insight into neonatal septicaemic Escherichia coli from India with respect to phylogroups, serotypes, virulence, extended-spectrum-\u03b2-lactamases and association of ST131 clonal group","volume":"10","author":"Roy","year":"2014","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0465","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00018-013-1355-8","article-title":"Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence","volume":"71","author":"Ruiz-Perez","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0470","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1286-4579(03)00049-2","article-title":"Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem","volume":"5","author":"Russo","year":"2003","journal-title":"Microb. Infect."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0475","first-page":"17","article-title":"Prevalence and evaluation of toxin genes among uropathogenic Escherichia coli clinical isolates by duplex PCR","volume":"1","author":"Saraylu","year":"2012","journal-title":"J. Med. Bacteriol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0480","first-page":"187","article-title":"N-acetyl-D-glucosamine specific hemagglutinin receptor of Vibrio cholerae O1 in chicken erythrocyte membranes","volume":"32","author":"Sasmal","year":"2002","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0485","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1128\/AEM.71.8.4872-4874.2005","article-title":"Escherichia coli K1\u2032s capsule is a barrier to bacteriophage T7","volume":"71","author":"Scholl","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0490","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/IAI.66.2.480-485.1998","article-title":"Prevalence of the \u201chigh-pathogenicity island\u201d of Yersinia species among Escherichia coli strains that are pathogenic to humans","volume":"66","author":"Schubert","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0495","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1155\/2013\/165974","article-title":"Cytokines in sepsis: potent immunoregulators and potential therapeutic targets\u2014An updated view","volume":"2013","author":"Schulte","year":"2013","journal-title":"Mediators Inflam."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0500","first-page":"399","article-title":"Proinflammatory cytokines (IL-6, IL-8), cytokine inhibitors (IL-6sR, sTNFRII) and anti-inflammatory cytokines (IL-10, IL-13) in the pathogenesis of sepsis in newborns and infants","volume":"49","author":"Sikora","year":"2001","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0505","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2007.00778.x","article-title":"A molecular swiss army knife: OmpA structure, function and expression","volume":"273","author":"Smith","year":"2007","journal-title":"FEMS Microbiol. Lett ."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0510","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1128\/IAI.00752-12","article-title":"Escherichia coli isolates that carry vat, fyuA, chuA, and yfcV efficiently colonize the urinary tract","volume":"80","author":"Spurbeck","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0515","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1128\/IAI.06394-11","article-title":"YghG (GspSbeta) is a novel pilot protein required for localization of the GspSbeta type II secretion system secretin of enterotoxicogenic Escherichia coli","volume":"80","author":"Strozen","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0520","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0378-1097(03)00688-8","article-title":"Prevalence of secreted autotransporter toxin gene among diffusely adhering Escherichia coli isolated from stools of children","volume":"227","author":"Taddei","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0525","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s10096-014-2161-4","article-title":"The high prevalence of serine protease autotransporters of Enterobacteriaceae (SPATEs) in Escherichia coli causing neonatal septicemia","volume":"33","author":"Tapader","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmm.2016.06.003","article-title":"Role in proinflammatory response of YghJ, a secreted metalloprotease from neonatal septicemic Escherichia coli","author":"Tapader","year":"2016","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0535","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.micpath.2017.02.020","article-title":"YghJ, the secreted metalloprotease of pathogenic E. coli induces hemorrhagic fluid accumulation in mice ileal loop","volume":"105","author":"Tapader","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0540","doi-asserted-by":"crossref","first-page":"e00399","DOI":"10.1128\/IAI.00399-18","article-title":"SslE (YghJ), a cell-associated and secreted lipoprotein of neonatal septicemic Escherichia coli, induces Toll-like receptor 2-dependent macrophage activation and proinflammation through NF\u03baB and MAP kinase signaling","volume":"86","author":"Tapader","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0545","first-page":"785","article-title":"Targeting proteases: successes, failures and future prospects","volume":"5","author":"Turk","year":"2006","journal-title":"Nat. Rev."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0550","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/35015091","article-title":"\u03b1-Haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells","volume":"405","author":"Uhlen","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0555","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.iy.13.040195.002253","article-title":"Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin","volume":"13","author":"Ulevitch","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0560","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1371\/journal.pone.0117486","article-title":"Pathogenic E. coli exploits SslE mucinase activity to translocate through the mucosal barrier and get access to host cells","volume":"10","author":"Valeri","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2019.03.002_bib0565","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1128\/IAI.73.3.1735-1743.2005","article-title":"Identification of enterohemorrhagic Escherichia coli O26: H-genes required for intestinal colonization in calves","volume":"73","author":"Van Diemen","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0570","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yexmp.2008.03.007","article-title":"Origins and virulence mechanisms of uropathogenic Escherichia coli","volume":"85","author":"Wiles","year":"2008","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0575","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1128\/JB.01115-06","article-title":"Transcriptional regulation of the yghJ-ppA-yghG-gspCDEFGHIJKLM cluster, encoding the type II secretion pathway in enterotoxicogenic Escherichia coli","volume":"189","author":"Yang","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2019.03.002_bib0580","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1139\/m90-051","article-title":"Aerobactin uptake system, ColV production, and drug resistance encoded by a plasmid from an urinary tract infection Escherichia coli strain of human origin","volume":"36","author":"Zgur-Bertok","year":"1990","journal-title":"Can. J. Microbiol."}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S143842211830331X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S143842211830331X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:59:08Z","timestamp":1761411548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S143842211830331X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":116,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S143842211830331X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2019.03.002","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secreted proteases: A new insight in the pathogenesis of extraintestinal pathogenic Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2019.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}