{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:45:16Z","timestamp":1789148716751,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001652","name":"FAU Erlangen Nuremberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1181_A02"],"award-info":[{"award-number":["CRC1181_A02"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["VO944\/11-1"],"award-info":[{"award-number":["VO944\/11-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2599_P03"],"award-info":[{"award-number":["FOR2599_P03"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR2294\/10-1"],"award-info":[{"award-number":["KR2294\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2740\/1"],"award-info":[{"award-number":["GRK2740\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ijmm.2024.151641","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T12:49:57Z","timestamp":1734612597000},"page":"151641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Signaling events driving Aspergillus fumigatus-induced eosinophil activation"],"prefix":"10.1016","volume":"318","author":[{"given":"Jasmin","family":"Adam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa-Marie","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Voehringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Krappmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2024.151641_bib1","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.4049\/jimmunol.165.4.2198","article-title":"The differential role of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase in eosinophil functions","volume":"165","author":"Adachi","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature08264","article-title":"Surface hydrophobin prevents immune recognition of airborne fungal spores","volume":"460","author":"Aimanianda","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ijmm.2024.151641_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-9822(06)00122-9","article-title":"Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B\u03b1","volume":"7","author":"Alessi","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ijmm.2024.151641_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0891-5849(90)90034-G","article-title":"Reactive oxygen species and airway inflammation","volume":"9","author":"Barnes","year":"1990","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijmm.2024.151641_bib5","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1124\/pr.116.012518","article-title":"Kinases as novel therapeutic targets in asthma and chronic obstructive pulmonary disease","volume":"68","author":"Barnes","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ijmm.2024.151641_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.633696","article-title":"Structural and signaling events driving Aspergillus fumigatus-induced human eosinophil extracellular trap release","volume":"12","author":"Barroso","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijmm.2024.151641_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0732-8893(00)00236-4","article-title":"The interaction of human monocytes, monocyte-derived macrophages, and polymorphonuclear neutrophils with caspofungin (MK-0991), an echinocandin, for antifungal activity against Aspergillus fumigatus","volume":"39","author":"Chiller","year":"2001","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ijmm.2024.151641_bib8","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/cvr\/cvp359","article-title":"Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells","volume":"85","author":"Choi","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijmm.2024.151641_bib9","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1002\/eji.202170126","article-title":"Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)","volume":"51","author":"Cossarizza","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib10","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/bph.13430","article-title":"The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma","volume":"173","author":"da Silva","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijmm.2024.151641_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3109\/13693786.2012.738312","article-title":"Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults","volume":"51","author":"Denning","year":"2013","journal-title":"Med. Mycol."},{"key":"10.1016\/j.ijmm.2024.151641_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/jof3040055","article-title":"The multifaceted role of T-helper responses in host defense against Aspergillus fumigatus","volume":"3","author":"Dewi","year":"2017","journal-title":"J. Fungi (Basel"},{"key":"10.1016\/j.ijmm.2024.151641_bib13","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/eji.201948411","article-title":"Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis","volume":"50","author":"Dietschmann","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01239-22","article-title":"Phosphatidylinositol 3-Kinase (PI3K) orchestrates Aspergillus fumigatus-induced eosinophil activation independently of canonical toll-like receptor (TLR)\/C-type-lectin receptor (CLR) signaling","volume":"13","author":"Dietschmann","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.ijmm.2024.151641_bib15","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.4049\/jimmunol.181.6.4004","article-title":"Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow","volume":"181","author":"Dyer","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1165\/rcmb.2014-0300OC","article-title":"Chloride channel 3 channels in the activation and migration of human blood eosinophils in allergic asthma","volume":"53","author":"Gaurav","year":"2015","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.ijmm.2024.151641_bib17","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.4049\/jimmunol.1501811","article-title":"Human neutrophils use different mechanisms to kill Aspergillus fumigatus conidia and hyphae: evidence from phagocyte defects","volume":"196","author":"Gazendam","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1501257","article-title":"Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response","volume":"2","author":"Ghari","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ijmm.2024.151641_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006175","article-title":"Central role of IL-23 and IL-17 producing eosinophils as immunomodulatory effector cells in acute pulmonary aspergillosis and allergic asthma","volume":"13","author":"Guerra","year":"2017","journal-title":"PloS Pathog."},{"key":"10.1016\/j.ijmm.2024.151641_bib20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/JLB.3RU0719-241R","article-title":"Calcium signaling and regulation of neutrophil functions: Still a long way to go","volume":"107","author":"Hann","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ijmm.2024.151641_bib21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1439-0507.1980.tb02557.x","article-title":"Mycelial antigens from two strains of Aspergillus fumigatus: an analysis by two-dimensional immunoelectrophoresis","volume":"23","author":"Hearn","year":"1980","journal-title":"Mykosen"},{"key":"10.1016\/j.ijmm.2024.151641_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.immuni.2006.05.014","article-title":"Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy","volume":"25","author":"Hirahashi","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.ijmm.2024.151641_bib23","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.4049\/jimmunol.175.8.5439","article-title":"Nonpathogenic, environmental fungi induce activation and degranulation of human eosinophils","volume":"175","author":"Inoue","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0091-6749(72)90049-8","article-title":"Electron microscopic demonstration of phagocytosis of Candida albicans by human eosinophilic leukocytes","volume":"50","author":"Ishikawa","year":"1972","journal-title":"J. Allergy Clin. Immunol. Pr."},{"key":"10.1016\/j.ijmm.2024.151641_bib25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.tcb.2007.09.001","article-title":"Immunoreceptor-like signaling by b2 and b3 integrins","volume":"17","author":"Jakus","year":"2007","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.ijmm.2024.151641_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0065-2660(08)60245-X","article-title":"Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations","volume":"19","author":"K\u00e4fer","year":"1977","journal-title":"Adv. Genet."},{"key":"10.1016\/j.ijmm.2024.151641_bib27","doi-asserted-by":"crossref","first-page":"L1179","DOI":"10.1152\/ajplung.00005.2012","article-title":"The p110delta subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.","volume":"302","author":"Kang","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ijmm.2024.151641_bib28","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1038\/s41598-020-64594-0","article-title":"Roles of PI3K pan-inhibitors and PI3K-delta inhibitors in allergic lung inflammation: a systematic review and meta-analysis.","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijmm.2024.151641_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12950-015-0065-4","article-title":"Functional activity of peripheral blood eosinophils in allergen-induced late-phase airway inflammation in asthma patients","volume":"12","author":"Lavinskiene","year":"2015","journal-title":"J. Inflamm. (Lond. )"},{"key":"10.1016\/j.ijmm.2024.151641_bib30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bcp.2012.05.005","article-title":"Role of NADPH oxidase\/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases","volume":"84","author":"Lee","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijmm.2024.151641_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nchembio.1735","article-title":"Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation","volume":"11","author":"Lewis","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ijmm.2024.151641_bib32","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/IAI.01172-13","article-title":"Eosinophil deficiency compromises lung defense against Aspergillus fumigatus","volume":"82","author":"Lilly","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2024.151641_bib33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41577-022-00826-w","article-title":"Immune responses to human fungal pathogens and therapeutic prospects","volume":"23","author":"Lionakis","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib34","article-title":"Inhibition of spleen tyrosine kinase restores glucocorticoid sensitivity to improve steroid-resistant asthma","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijmm.2024.151641_bib35","doi-asserted-by":"crossref","first-page":"L860","DOI":"10.1152\/ajplung.00131.2004","article-title":"Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils","volume":"288","author":"Machida","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ijmm.2024.151641_bib36","doi-asserted-by":"crossref","first-page":"6708","DOI":"10.4049\/jimmunol.0901220","article-title":"Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils","volume":"183","author":"Matsuwaki","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib37","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.4049\/jimmunol.167.11.6615","article-title":"Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2","volume":"167","author":"Miike","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib38","doi-asserted-by":"crossref","first-page":"E83","DOI":"10.1038\/ncb0402-e83","article-title":"Sensing the environment: a historical perspective on integrin signal transduction","volume":"4","author":"Miranti","year":"2002","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.ijmm.2024.151641_bib39","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2017.07.048","article-title":"Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus","volume":"141","author":"Muniz","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib40","article-title":"Targeting of protease activator receptor-2 (PAR-2) antagonist FSLLRY-NH2 as an asthma adjuvant therapy","volume":"99","author":"Ocasio-Rivera","year":"2020","journal-title":"Med. (Baltim. )"},{"key":"10.1016\/j.ijmm.2024.151641_bib41","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/mi.2009.102","article-title":"Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi","volume":"2","author":"Porter","year":"2009","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib42","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.21037\/jtd.2017.01.05","article-title":"Recent developments in the role of reactive oxygen species in allergic asthma","volume":"9","author":"Qu","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.ijmm.2024.151641_bib43","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaci.2015.04.041","article-title":"Eosinophil extracellular trap cell death-derived DNA traps: Their presence in secretions and functional attributes","volume":"137","author":"Ueki","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijmm.2024.151641_bib44","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1182\/blood-2012-05-432088","article-title":"Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans","volume":"121","author":"Ueki","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.ijmm.2024.151641_bib45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ijmm.2024.151641_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163751","article-title":"IL-33-induced cytokine secretion and survival of mouse eosinophils is promoted by autocrine GM-CSF","volume":"11","author":"Willebrand","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmm.2024.151641_bib47","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.4049\/jimmunol.181.4.2907","article-title":"Innate antifungal immunity of human eosinophils mediated by a beta 2 integrin, CD11b","volume":"181","author":"Yoon","year":"2008","journal-title":"J. Immunol."}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422124000456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422124000456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:28:20Z","timestamp":1778614100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422124000456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":47,"alternative-id":["S1438422124000456"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2024.151641","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signaling events driving Aspergillus fumigatus-induced eosinophil activation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2024.151641","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151641"}}