{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:27:29Z","timestamp":1793939249225,"version":"4.8.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021J01347"],"award-info":[{"award-number":["2021J01347"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026J0011837"],"award-info":[{"award-number":["2026J0011837"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022J011406"],"award-info":[{"award-number":["2022J011406"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Medical Microbiology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijmm.2026.151727","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:53:49Z","timestamp":1781625229000},"page":"151727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Gain-of-function mutation in the sensor kinase CpxS modulates the antimicrobial resistance and virulence of Pseudomonas aeruginosa"],"prefix":"10.1016","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1435-8049","authenticated-orcid":false,"given":"Xueqin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijmm.2026.151727_bib1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1128\/JB.01957-14","article-title":"The Vibrio cholerae Cpx envelope stress response senses and mediates adaptation to low iron","volume":"197","author":"Acosta","year":"2015","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2026.151727_bib2","article-title":"Culture of small colony variant of Pseudomonas aeruginosa and quantitation of its alginate","volume":"156","author":"Al Ahmar","year":"2020","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ijmm.2026.151727_bib3","doi-asserted-by":"crossref","DOI":"10.1099\/jmm.0.001791","article-title":"Genomic and metabolic versatility of Pseudomonas aeruginosa contributes to its inter-kingdom transmission and survival","volume":"73","author":"Ambreetha","year":"2024","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.991","article-title":"Type VI secretion system of Pseudomonas aeruginosa is associated with biofilm formation but not environmental adaptation","volume":"9","author":"Chen","year":"2020","journal-title":"MicrobiologyOpen"},{"key":"10.1016\/j.ijmm.2026.151727_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1099\/mic.0.26740-0","article-title":"Enteropathogenic Escherichia coli (EPEC) adhesion to intestinal epithelial cells: role of bundle-forming pili (BFP), EspA filaments and intimin","volume":"150","author":"Cleary","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2026.151727_bib6","series-title":"Performance standards for antimicrobial susceptibility testing","year":"2022"},{"key":"10.1016\/j.ijmm.2026.151727_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1099\/mic.0.000789","article-title":"The Type VI secretion system: a versatile bacterial weapon","volume":"165","author":"Coulthurst","year":"2019","journal-title":"Microbiology"},{"key":"10.1016\/j.ijmm.2026.151727_bib8","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00798-17","article-title":"Evaluation of CpxRA as a therapeutic target for uropathogenic Escherichia coli infections","volume":"86","author":"Dbeibo","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2026.151727_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fcimb.2016.00011","article-title":"The two-component system cpxRA negatively regulates the locus of enterocyte effacement of enterohemorrhagic Escherichia coli involving \u03c3(32) and Lon protease","volume":"6","author":"De la Cruz","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3389\/fmicb.2015.00807","article-title":"The two-component system CpxR\/A represses the expression of Salmonella virulence genes by affecting the stability of the transcriptional regulator HilD","volume":"6","author":"De la Cruz","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4161\/cib.1.1.6717","article-title":"A novel two-component system BqsS-BqsR modulates quorum sensing-dependent biofilm decay in Pseudomonas aeruginosa","volume":"1","author":"Dong","year":"2008","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.ijmm.2026.151727_bib12","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1128\/iai.60.8.3072-3078.1992","article-title":"A 66-kilodalton heat shock protein of Salmonella Typhimurium is responsible for binding of the bacteriu of the bacterium to intestinal mucus","volume":"60","author":"Ensgraber","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2026.151727_bib13","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1128\/jb.172.2.884-900.1990","article-title":"Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications","volume":"172","author":"Essar","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2026.151727_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02430-21","article-title":"CpxA phosphatase inhibitor activates cpxRA and is a potential treatment for uropathogenic Escherichia coli in a murine model of infection","volume":"10","author":"Fortney","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.ijmm.2026.151727_bib15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41564-024-01601-4","article-title":"Siderophores promote cooperative interspecies and intraspecies cross-protection against antibiotics in vitro","volume":"9","author":"Galdino","year":"2024","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2217\/fmb-2017-0111","article-title":"Effects of null mutation of the heat-shock gene htpG on the production of virulence factors by Pseudomonas aeruginosa","volume":"13","author":"Grudniak","year":"2018","journal-title":"Future Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib17","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1128\/JB.00963-15","article-title":"The Pseudomonas aeruginosa PAO1 two-component regulator CarSR regulates calcium homeostasis and calcium-induced virulence factor production through its regulatory targets CarO and CarP","volume":"198","author":"Guragain","year":"2016","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2026.151727_bib18","doi-asserted-by":"crossref","first-page":"ftx017","DOI":"10.1093\/femspd\/ftx017","article-title":"The surface-displayed chaperones GroEL and DnaK of Mycoplasma pneumoniae interact with human plasminogen and components of the extracellular matrix","volume":"75","author":"Hagemann","year":"2017","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.ijmm.2026.151727_bib19","article-title":"DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks","author":"Hallgren","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.ijmm.2026.151727_bib20","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1038\/s41596-021-00515-3","article-title":"Microtiter plate assays to assess antibiofilm activity against bacteria","volume":"16","author":"Haney","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijmm.2026.151727_bib21","doi-asserted-by":"crossref","first-page":"8717","DOI":"10.1038\/s41467-024-52732-5","article-title":"PlzR regulates type IV pili assembly in Pseudomonas aeruginosa via PilZ binding","volume":"15","author":"Hendrix","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijmm.2026.151727_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fcimb.2019.00313","article-title":"Maintaining integrity under stress: envelope stress response regulation of pathogenesis in Gram-negative bacteria","volume":"9","author":"Hews","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib23","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/nprot.2015.115","article-title":"Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange","volume":"10","author":"Hmelo","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijmm.2026.151727_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2021.126719","article-title":"Type 3 secretion system of Pseudomonas aeruginosa","volume":"246","author":"Horna","year":"2021","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.ijmm.2026.151727_bib25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1574-6968.2011.02436.x","article-title":"Signal integration by the Cpx-envelope stress system","volume":"326","author":"Hunke","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijmm.2026.151727_bib26","doi-asserted-by":"crossref","first-page":"20440","DOI":"10.1073\/pnas.0908760106","article-title":"Molecular basis of pyoverdine siderophore recycling in Pseudomonas aeruginosa","volume":"106","author":"Imperi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2026.151727_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.fm.2023.104393","article-title":"CpxAR two-component system contributes to virulence properties of Cronobacter sakazakii","volume":"117","author":"Jin","year":"2024","journal-title":"Food Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib28","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1128\/AEM.01098-08","article-title":"Broad-host-range expression vectors with tightly regulated promoters and their use to examine the influence of TraR and TraM expression on Ti plasmid quorum sensing","volume":"74","author":"Khan","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib29","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1128\/JB.01966-06","article-title":"Cytosolic proteins contribute to surface plasminogen recruitment of Neisseria meningitidis","volume":"189","author":"Knaust","year":"2007","journal-title":"J. Bacteriol."},{"issue":"2","key":"10.1016\/j.ijmm.2026.151727_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02549-14","article-title":"The ferrous iron-responsive BqsRS two-component system activates genes that promote cationic stress tolerance","volume":"6","author":"Kreamer","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.ijmm.2026.151727_bib31","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ijmm.2026.151727_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01031-19","article-title":"Indole signaling at the host-microbiota-pathogen interface","volume":"10","author":"Kumar","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.ijmm.2026.151727_bib33","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/pro.2120","article-title":"The crystal structure of the periplasmic domain of Vibrio parahaemolyticus CpxA","volume":"21","author":"Kwon","year":"2012","journal-title":"Protein Sci."},{"key":"10.1016\/j.ijmm.2026.151727_bib34","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and Clustal X version 2.0","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ijmm.2026.151727_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104429","article-title":"Pathogen-associated gene discovery workflows for novel antivirulence therapeutic development","volume":"88","author":"Lau","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ijmm.2026.151727_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02710-22","article-title":"The two-component system CpxRA represses Salmonella pathogenicity island 2 by directly acting on the ssrab regulatory operon","volume":"10","author":"Le\u00f3n-Montes","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.ijmm.2026.151727_bib37","doi-asserted-by":"crossref","first-page":"e00126","DOI":"10.1128\/JB.00126-18","article-title":"CpxR\/CpxA controls scsABCD transcription to counteract copper and oxidative stress in Salmonella enterica serovar Typhimurium","volume":"200","author":"L\u00f3pez","year":"2018","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2026.151727_bib38","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1128\/IAI.05679-11","article-title":"DegP is involved in Cpx-mediated posttranscriptional regulation of the type III secretion apparatus in enteropathogenic Escherichia coli","volume":"80","author":"MacRitchie","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2026.151727_bib39","doi-asserted-by":"crossref","first-page":"W521","DOI":"10.1093\/nar\/gkae241","article-title":"The EMBL-EBI Job Dispatcher sequence analysis tools framework in 2024","volume":"52","author":"Madeira","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2026.151727_bib40","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1111\/1462-2920.14368","article-title":"The CpxRA stress response system regulates virulence features of avian pathogenic Escherichia coli","volume":"20","author":"Matter","year":"2018","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001776","article-title":"Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation","volume":"12","author":"Mechaly","year":"2014","journal-title":"PLoS. Biol."},{"key":"10.1016\/j.ijmm.2026.151727_bib42","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.70096","article-title":"Multiple chaperone DnaK-FliC flagellin interactions are required for Pseudomonas aeruginosa flagellum assembly and indicate a new function for DnaK","volume":"18","author":"Molinari","year":"2025","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.ijmm.2026.151727_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41392-022-01056-1","article-title":"Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics","volume":"7","author":"Qin","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.ijmm.2026.151727_bib44","article-title":"The response regulator BqsR\/CarR controls ferrous iron (Fe\u00b2\u207a) acquisition in Pseudomonas aeruginosa","author":"Paredes","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.ijmm.2026.151727_bib45","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.bbamcr.2013.10.018","article-title":"Everything old is new again: an update on current research on the Cpx envelope stress response","volume":"1843","author":"Raivio","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijmm.2026.151727_bib46","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1128\/JB.00105-13","article-title":"The Escherichia coli Cpx envelope stress response regulates genes of diverse function that impact antibiotic resistance and membrane integrity","volume":"195","author":"Raivio","year":"2013","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2026.151727_bib47","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1128\/jb.179.24.7724-7733.1997","article-title":"Transduction of envelope stress in Escherichia coli by the Cpx two-component system","volume":"179","author":"Raivio","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijmm.2026.151727_bib48","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1073\/pnas.060030097","article-title":"Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa","volume":"97","author":"Rashid","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijmm.2026.151727_bib49","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00764-16","article-title":"The Pseudomonas aeruginosa PrrF small rnas regulate iron homeostasis during acute murine lung infection","volume":"85","author":"Reinhart","year":"2017","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijmm.2026.151727_bib50","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1007\/s40265-021-01635-6","article-title":"The epidemiology and pathogenesis and treatment of Pseudomonas aeruginosa Infections: an update","volume":"81","author":"Reynolds","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.ijmm.2026.151727_bib51","doi-asserted-by":"crossref","first-page":"W320","DOI":"10.1093\/nar\/gku316","article-title":"Deciphering key features in protein structures with the new ENDscript server","volume":"42","author":"Robert","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2026.151727_bib52","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.biochi.2018.05.001","article-title":"Biological and regulatory roles of acid-induced small RNA RyeC in Salmonella Typhimurium","volume":"150","author":"Ryan","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.ijmm.2026.151727_bib53","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1002\/pmic.200400928","article-title":"The cell wall subproteome of Listeria monocytogenes","volume":"4","author":"Schaumburg","year":"2004","journal-title":"Proteomics"},{"key":"10.1016\/j.ijmm.2026.151727_bib54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jbiotec.2019.11.004","article-title":"Rapid and solitary production of mono-rhamnolipid biosurfactant and biofilm inhibiting pyocyanin by a taxonomic outlier Pseudomonas aeruginosa strain CR1","volume":"307","author":"Sood","year":"2020","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ijmm.2026.151727_bib55","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.hlife.2023.11.005","article-title":"Phenazines: Natural products for microbial growth control","volume":"2","author":"Sousa","year":"2024","journal-title":"hLife"},{"key":"10.1016\/j.ijmm.2026.151727_bib56","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/mmi.13365","article-title":"The CpxRA two-component system contributes to Legionella pneumophila virulence","volume":"100","author":"Tanner","year":"2016","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib57","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/21505594.2018.1556151","article-title":"The Yersinia pseudotuberculosis Cpx envelope stress system contributes to transcriptional activation of rovM","volume":"10","author":"Thanikkal","year":"2019","journal-title":"Virulence"},{"key":"10.1016\/j.ijmm.2026.151727_bib58","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00921-23","article-title":"Identification of cpxS mutational resistome in Pseudomonas aeruginosa","volume":"67","author":"Tian","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijmm.2026.151727_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005932","article-title":"CpxR Activates MexAB-OprM efflux pump expression and enhances antibiotic resistance in both laboratory and clinical nalB-type isolates of Pseudomonas aeruginosa","volume":"12","author":"Tian","year":"2016","journal-title":"PLoS. Pathog."},{"key":"10.1016\/j.ijmm.2026.151727_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107383","article-title":"Dynamic interaction between the CpxA sensor kinase and the periplasmic accessory protein CpxP mediates signal recognition in E. coli","volume":"9","author":"Tschauner","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.ijmm.2026.151727_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1279826","article-title":"Key players in the regulation of iron homeostasis at the host-pathogen interface","volume":"14","author":"Ullah","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijmm.2026.151727_bib62","article-title":"Bronchoalveolar lavage of murine lungs to analyze inflammatory cell infiltration","volume":"123","author":"Van Hoecke","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ijmm.2026.151727_bib63","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1128\/AAC.00236-15","article-title":"Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system","volume":"59","author":"van Rensburg","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijmm.2026.151727_bib64","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1007\/s00216-020-02696-4","article-title":"Phenazines as potential biomarkers of Pseudomonas aeruginosa infections: synthesis regulation, pathogenesis and analytical methods for their detection","volume":"412","author":"Vilaplana","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ijmm.2026.151727_bib65","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1365-2958.2010.07145.x","article-title":"The Cpx envelope stress response both facilitates and inhibits elaboration of the enteropathogenic Escherichia coli bundle-forming pilus","volume":"76","author":"Vogt","year":"2010","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib66","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2024.2404951","article-title":"Regulatory role of the Cpx ESR in bacterial behaviours","volume":"15","author":"Wan","year":"2024","journal-title":"Virulence"},{"key":"10.1016\/j.ijmm.2026.151727_bib67","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.03089-20","article-title":"Two-component signaling systems regulate diverse virulence-associated traits in Pseudomonas aeruginosa","volume":"87","author":"Wang","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib68","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijmm.2026.151727_bib69","first-page":"467","article-title":"The cpx proteins of Escherichia coli K12","volume":"203","author":"Weber","year":"1988","journal-title":"Struct. cpxA Polypept. Inn. Membr. Compon. J. Mol. Biol."},{"key":"10.1016\/j.ijmm.2026.151727_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/science.adi0908","article-title":"Evolution and host-specific adaptation of Pseudomonas aeruginosa","volume":"385","author":"Weimann","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.ijmm.2026.151727_bib71","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s00253-017-8702-x","article-title":"Heterologous production of long-chain rhamnolipids from Burkholderia glumae in Pseudomonas putida\u2014a step forward to tailor-made rhamnolipids","volume":"102","author":"Wittgens","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ijmm.2026.151727_bib72","unstructured":"World Health Organization, 2017. Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. World Health Organization, Geneva, pp. 5\u20136."},{"key":"10.1016\/j.ijmm.2026.151727_bib73","unstructured":"World Health Organization, 2024. WHO Bacterial Priority Pathogens List, 2024: bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance. World Health Organization, Geneva, pp. 7\u20138."},{"issue":"7","key":"10.1016\/j.ijmm.2026.151727_bib74","first-page":"2022","article-title":"Mutation of the envelope stress-responsive protein CpxA capable of regulating the antimicrobial resistance and virulence of bacteria","volume":"40","author":"Xie","year":"2024","journal-title":"Chin. J. Biotechnol."},{"key":"10.1016\/j.ijmm.2026.151727_bib75","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/mmi.13077","article-title":"The cell wall amidase AmiB is essential for Pseudomonas aeruginosa cell division, drug resistance and viability","volume":"97","author":"Yakhnina","year":"2015","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib76","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/microorganisms8030395","article-title":"Heat shock protein DnaJ in Pseudomonas aeruginosa affects biofilm formation via pyocyanin production","volume":"8","author":"Zeng","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.ijmm.2026.151727_bib77","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00419-22","article-title":"Systematic identification of CpxRA-regulated genes and their roles in Escherichia coli stress response","volume":"7","author":"Zhao","year":"2022","journal-title":"mSystems"},{"key":"10.1016\/j.ijmm.2026.151727_bib78","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/jobm.201900267","article-title":"Functional roles of norCB in Pseudomonas aeruginosa ATCC 9027 under aerobic conditions","volume":"59","author":"Zhou","year":"2019","journal-title":"J. Basic. Microbiol."},{"key":"10.1016\/j.ijmm.2026.151727_bib79","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.1074\/jbc.M110.194092","article-title":"Structural basis for two-component system inhibition and pilus sensing by the auxiliary CpxP protein","volume":"286","author":"Zhou","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijmm.2026.151727_bib80","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/AAC.01152-09","article-title":"Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase","volume":"54","author":"Zhu","year":"2010","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["International Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422126000299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1438422126000299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:05:56Z","timestamp":1793937956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1438422126000299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":80,"alternative-id":["S1438422126000299"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmm.2026.151727","relation":{},"ISSN":["1438-4221"],"issn-type":[{"value":"1438-4221","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gain-of-function mutation in the sensor kinase CpxS modulates the antimicrobial resistance and virulence of Pseudomonas aeruginosa","name":"articletitle","label":"Article Title"},{"value":"International Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmm.2026.151727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"151727"}}