{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:43:04Z","timestamp":1783618984585,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Indian Journal of Medical Microbiology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ijmmb.2025.100896","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T19:56:21Z","timestamp":1750276581000},"page":"100896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Advancing beyond conventional vaccines: The potential of next-generation vaccines in combatting antibiotic-resistant bacteria"],"prefix":"10.1016","volume":"56","author":[{"given":"A.R.","family":"Heamchandsaravanan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damodharan","family":"Perumal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragala Venkata","family":"Nandha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabu","family":"Dhandapani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijmmb.2025.100896_bib1","first-page":"135","article-title":"Penicillin's discovery and antibiotic resistance: lessons for the future?","volume":"90","author":"Lobanovska","year":"2017","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.ijmmb.2025.100896_bib2","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1016\/j.sjbs.2021.08.054","article-title":"The role of vaccines in combating antimicrobial resistance (AMR) bacteria","volume":"28","author":"Alghamdi","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.ijmmb.2025.100896_bib3","first-page":"277","article-title":"The antibiotic resistance crisis: part 1: causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"P T"},{"key":"10.1016\/j.ijmmb.2025.100896_bib4","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.glmedi.2024.100081","article-title":"Antimicrobial resistance: impacts, challenges, and future prospects","volume":"2","author":"Ahmed","year":"2024","journal-title":"J Med Surg Public Health"},{"key":"10.1016\/j.ijmmb.2025.100896_bib5","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.3389\/fimmu.2020.01755","article-title":"Challenges for clinical development of vaccines for prevention of hospital-acquired bacterial infections","volume":"11","author":"Bekeredjian-Ding","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijmmb.2025.100896_bib6","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.3390\/antibiotics12101504","article-title":"Empowering low- and middle-income countries to combat AMR by minimal use of antibiotics: a way forward","volume":"12","author":"Kanan","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.ijmmb.2025.100896_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrmicro1614","article-title":"The antibiotic resistome: the nexus of chemical and genetic diversity","volume":"5","author":"Wright","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ijmmb.2025.100896_bib8","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3390\/vaccines11071264","article-title":"The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria","volume":"11","author":"Khalid","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.ijmmb.2025.100896_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S2666-5247(22)00303-2","article-title":"The role of bacterial vaccines in the fight against antimicrobial resistance: an analysis of the preclinical and clinical development pipeline","volume":"4","author":"Frost","year":"2023","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.ijmmb.2025.100896_bib10","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1080\/21645515.2023.2228669","article-title":"Challenges in development of vaccines directed toward antimicrobial resistant bacterial species","volume":"19","author":"Brazzoli","year":"2023","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.ijmmb.2025.100896_bib11","first-page":"21","article-title":"Edward Jenner and the history of smallpox and vaccination","volume":"18","author":"Riedel","year":"2005","journal-title":"SAVE Proc"},{"key":"10.1016\/j.ijmmb.2025.100896_bib12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jinf.2012.03.012","article-title":"Bacillus Calmette-Gu\u00e9rin (BCG) complications associated with primary immunodeficiency diseases","volume":"64","author":"Norouzi","year":"2012","journal-title":"J Infect"},{"key":"10.1016\/j.ijmmb.2025.100896_bib13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/vaccines10040572","article-title":"Benefits of inactivated vaccine and viral vector vaccine immunization on COVID-19 infection in kidney transplant recipients","volume":"10","author":"Sutharattanapong","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.ijmmb.2025.100896_bib14","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3390\/vaccines11030695","article-title":"The integrated consideration of vaccine platforms, adjuvants, and delivery routes for successful vaccine development","volume":"11","author":"Kozak","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.ijmmb.2025.100896_bib15","first-page":"1332","article-title":"The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects","volume":"15","author":"Lu","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijmmb.2025.100896_bib16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41392-023-01579-1","article-title":"mRNA vaccines in disease prevention and treatment","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.ijmmb.2025.100896_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jama.1982.03320260024022","article-title":"Adverse reactions to tetanus toxoid","volume":"247","author":"Jacobs","year":"1982","journal-title":"JAMA"},{"key":"10.1016\/j.ijmmb.2025.100896_bib18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/14760584.2021.1903879","article-title":"Effects of SARS-CoV-2 variants on vaccine efficacy and response strategies","volume":"20","author":"Bian","year":"2021","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.ijmmb.2025.100896_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/vaccines7020037","article-title":"A comparison of plasmid DNA and mRNA as vaccine technologies","volume":"7","author":"Liu","year":"2019","journal-title":"Vaccines"},{"key":"10.1016\/j.ijmmb.2025.100896_bib20","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1371\/journal.pone.0164692","article-title":"Development of a freeze-dried, heat-stable influenza subunit vaccine formulation","volume":"11","author":"Flood","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ijmmb.2025.100896_bib21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1586\/14760584.2014.905746","article-title":"The BCG replacement vaccine VPM1002: from drawing board to clinical trial","volume":"13","author":"Kaufmann","year":"2014","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.ijmmb.2025.100896_bib22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/CVI.00439-16","article-title":"Safety and immunogenicity of the recombinant Mycobacterium bovis BCG vaccine VPM1002 in HIV-unexposed newborn infants in South Africa","volume":"24","author":"Loxton","year":"2017","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.ijmmb.2025.100896_bib23","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S1473-3099(16)30132-3","article-title":"Global burden of drug-resistant tuberculosis in children: a mathematical modelling study","volume":"16","author":"Dodd","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijmmb.2025.100896_bib24","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/S0140-6736(20)32137-1","article-title":"SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates","volume":"396","author":"Poland","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ijmmb.2025.100896_bib25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11033-018-4167-y","article-title":"Cloning and expression of nlpA gene as DNA vaccine candidate against Acinetobacter baumannii","volume":"45","author":"Hashemzehi","year":"2018","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.ijmmb.2025.100896_bib26","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41587-022-01294-2","article-title":"The clinical progress of mRNA vaccines and immunotherapies","volume":"40","author":"Barbier","year":"2022","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ijmmb.2025.100896_bib27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijmmb.2025.100896_bib28","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41467-022-33721-y","article-title":"Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes","volume":"13","author":"Mayer","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijmmb.2025.100896_bib29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1126\/sciadv.adg1036","article-title":"A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium","volume":"9","author":"Kon","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.ijmmb.2025.100896_bib30","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ymthe.2021.01.030","article-title":"Allergic reactions and anaphylaxis to LNP-based COVID-19 vaccines","volume":"29","author":"Moghimi","year":"2021","journal-title":"Mol Ther"},{"key":"10.1016\/j.ijmmb.2025.100896_bib31","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1080\/07391102.2018.1519460","article-title":"Vaccinomics approach for developing multi-epitope peptide pneumococcal vaccine","volume":"37","author":"Dorosti","year":"2019","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.ijmmb.2025.100896_bib32","first-page":"887","article-title":"Immunoinformatics approach toward the introduction of a novel multi-epitope vaccine against Clostridium difficile","volume":"13","author":"Tan","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijmmb.2025.100896_bib33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41598-022-18610-0","article-title":"Identification and construction of a multi-epitopes vaccine design against Klebsiella aerogenes: molecular modeling study","volume":"12","author":"Alzarea","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijmmb.2025.100896_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/vaccines10050665","article-title":"Designing of a novel multi-antigenic epitope-based vaccine against E. hormaechei: an intergraded reverse vaccinology and immunoinformatics approach","volume":"10","author":"Albekairi","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.ijmmb.2025.100896_bib35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.humimm.2019.02.008","article-title":"A multiepitopic theoretical fusion construct based on in-silico epitope screening of known vaccine candidates for protection against wide range of enterobacterial pathogens","volume":"80","author":"Kumar","year":"2019","journal-title":"Hum Immunol"},{"key":"10.1016\/j.ijmmb.2025.100896_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12859-019-2713-9","article-title":"PanRV: pangenome-reverse vaccinology approach for identifications of potential vaccine candidates in microbial pangenome","volume":"20","author":"Naz","year":"2019","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.ijmmb.2025.100896_bib37","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4269\/ajtmh.19-0479","article-title":"Associations among water, sanitation, and hygiene, and food exposures and typhoid fever in case-control studies: a systematic review and meta-analysis","volume":"103","author":"Brockett","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijmmb.2025.100896_bib38","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s12272-017-0933-y","article-title":"Pneumonia and Streptococcus pneumoniae vaccine","volume":"40","author":"Kim","year":"2017","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.ijmmb.2025.100896_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/vaccines10020199","article-title":"The candidate antigens to achieving an effective vaccine against Staphylococcus aureus","volume":"10","author":"Jahantigh","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.ijmmb.2025.100896_bib40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/infdis\/jiv429","article-title":"Extraintestinal pathogenic Escherichia coli, a common human pathogen: challenges for vaccine development and progress in the field","volume":"213","author":"Poolman","year":"2016","journal-title":"J Infect Dis"}],"container-title":["Indian Journal of Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0255085725001094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0255085725001094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T20:17:55Z","timestamp":1756153075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0255085725001094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":40,"alternative-id":["S0255085725001094"],"URL":"https:\/\/doi.org\/10.1016\/j.ijmmb.2025.100896","relation":{},"ISSN":["0255-0857"],"issn-type":[{"value":"0255-0857","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing beyond conventional vaccines: The potential of next-generation vaccines in combatting antibiotic-resistant bacteria","name":"articletitle","label":"Article Title"},{"value":"Indian Journal of Medical Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijmmb.2025.100896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100896"}}