{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:17:53Z","timestamp":1788351473448,"version":"build-2803163510"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,8,10]],"date-time":"2027-08-10T00:00:00Z","timestamp":1817856000000},"content-version":"am","delay-in-days":313,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM157351"],"award-info":[{"award-number":["R01GM157351"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000086","name":"National Science Foundation Directorate for Mathematical and Physical Sciences","doi-asserted-by":"publisher","award":["2108729"],"award-info":[{"award-number":["2108729"]}],"id":[{"id":"10.13039\/100000086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Mass Spectrometry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ijms.2026.117672","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:46:52Z","timestamp":1785944812000},"page":"117672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fabrication of thermoplastic microfluidic probes for nanospray desorption electrospray ionization mass spectrometry"],"prefix":"10.1016","volume":"528","author":[{"given":"Renkai","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangtang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Xue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-9644","authenticated-orcid":false,"given":"Julia","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijms.2026.117672_bib1","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1039\/c0an00312c","article-title":"Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry","volume":"135","author":"Roach","year":"2010","journal-title":"Analyst"},{"key":"10.1016\/j.ijms.2026.117672_bib2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1021\/acsmeasuresciau.4c00028","article-title":"Nanospray desorption electrospray ionization Mass spectrometry imaging (nano-DESI MSI): a tutorial review","volume":"4","author":"Iqfath","year":"2024","journal-title":"ACS Meas. Sci. Au"},{"key":"10.1016\/j.ijms.2026.117672_bib3","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1203689109","article-title":"Mass spectral molecular networking of living microbial colonies","volume":"109","author":"Watrous","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.ijms.2026.117672_bib4","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/ac202801g","article-title":"Chemical characterization of crude petroleum using nanospray desorption electrospray ionization coupled with high-resolution mass spectrometry","volume":"84","author":"Eckert","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib5","doi-asserted-by":"crossref","first-page":"11171","DOI":"10.1021\/acs.analchem.5b03389","article-title":"Imaging of proteins in tissue samples using nanospray desorption electrospray Ionization Mass spectrometry","volume":"87","author":"Hsu","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib6","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1021\/ac300916k","article-title":"Study of electrochemical reactions using nanospray desorption electrospray ionization mass spectrometry","volume":"84","author":"Liu","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib7","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s00216-014-8174-0","article-title":"Three-dimensional imaging of lipids and metabolites in tissues by nanospray desorption electrospray ionization mass spectrometry","volume":"407","author":"Lanekoff","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib8","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1021\/acs.analchem.0c05277","article-title":"Native mass spectrometry imaging of proteins and protein complexes by nano-desi","volume":"93","author":"Cooper","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib9","doi-asserted-by":"crossref","first-page":"28343","DOI":"10.1021\/acs.analchem.5c05767","article-title":"Imaging of protein assemblies up to 231 kDa in tissues with Nano-DESI mass spectrometry","volume":"97","author":"Hale","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib10","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1039\/C7AN00901A","article-title":"A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue","volume":"142","author":"Duncan","year":"2017","journal-title":"Analyst"},{"key":"10.1016\/j.ijms.2026.117672_bib11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/ac302308p","article-title":"Imaging nicotine in rat brain tissue by use of nanospray desorption electrospray ionization mass spectrometry","volume":"85","author":"Lanekoff","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib12","author":"Yang"},{"key":"10.1016\/j.ijms.2026.117672_bib13","author":"Li"},{"key":"10.1016\/j.ijms.2026.117672_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341830","article-title":"High-resolution integrated microfluidic probe for mass spectrometry imaging of biological tissues","volume":"1279","author":"Li","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ijms.2026.117672_bib15","doi-asserted-by":"crossref","first-page":"9690","DOI":"10.1021\/acs.analchem.2c01093","article-title":"High-Throughput Nano-DESI mass spectrometry imaging of biological tissues using an integrated microfluidic probe","volume":"94","author":"Li","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib16","article-title":"High-spatial-resolution mass spectrometry imaging of biological tissues using a microfluidic probe","author":"Jiang","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijms.2026.117672_bib17","article-title":"A Low-Cost, high-resolution thermoplastic microfluidic probe for mass spectrometry imaging of biological tissue samples","author":"Li","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijms.2026.117672_bib18","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1039\/D3LC00637A","article-title":"A monolithic microfluidic probe for ambient mass spectrometry imaging of biological tissues","volume":"23","author":"Jiang","year":"2023","journal-title":"Lab Chip"},{"key":"10.1016\/j.ijms.2026.117672_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10404-010-0605-4","article-title":"Cyclic olefin polymers: emerging materials for lab-on-a-chip applications","volume":"9","author":"Nunes","year":"2010","journal-title":"Microfluid. Nanofluidics"},{"key":"10.1016\/j.ijms.2026.117672_bib20","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1038\/s41596-019-0237-4","article-title":"High spatial resolution imaging of biological tissues using nanospray desorption electrospray ionization mass spectrometry","volume":"14","author":"Yin","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijms.2026.117672_bib21","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1021\/jasms.5c00011","article-title":"Pneumatically assisted microfluidic probe for enhanced mass spectrometry imaging performance","volume":"36","author":"Jiang","year":"2025","journal-title":"J. Am. Soc. Mass Spectrom."}],"container-title":["International Journal of Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138738062600103X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138738062600103X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:38:45Z","timestamp":1788349125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138738062600103X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":21,"alternative-id":["S138738062600103X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijms.2026.117672","relation":{},"ISSN":["1387-3806"],"issn-type":[{"value":"1387-3806","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fabrication of thermoplastic microfluidic probes for nanospray desorption electrospray ionization mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"International Journal of Mass Spectrometry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijms.2026.117672","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117672"}}