{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:12:03Z","timestamp":1788797523438,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"vor","delay-in-days":826,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Diagnosis of tuberculous pleurisy is difficult and better diagnostic tools are needed. Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium TB infections. They cannot differentiate between latent and active infections. As IGRA tests have recently been approved for the differential diagnosis of active TB, the diagnostic accuracy of the latest generation of IGRA were assessed to detect tuberculous pleurisy in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The QuantiFERONTB\u00ae-Gold (QFT-G) test was used in pleural fluid from 100 immunocompetent patients (23 patients for the tuberculous group and 77 patients for the non-tuberculous group). Clinical data were recorded. Adenosine deaminase activity (ADA) analysis and TB culture were performed on pleural fluid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The QFT-G in pleural fluid was positive in 10 (43.5%) patients and indeterminate in 13(56.5%) patients in the tuberculous pleurisy group. There was not a single patient with a negative test result in the tuberculous pleurisy group. The ADA levels were detected as 46.2 \u00b1 12.6 in patients with tuberculous pleurisy and18.6 \u00b1 39.8 in patients with non-tuberculous pleurisy. The sensitivity, specificity, positive predictive value and negative predictive value of QFT-G in pleural fluid for tuberculous pleurisy were 43.5%, 54.5%, 30.3% and 100%; and of ADA in pleural fluid (&gt;40IU\/ml) for tuberculous pleurisy the results were 82.6%, 96.1%, 90.5% and 92.5% respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>While the value of the QFT-G test in exclusion of tuberculous pleurisy was found to be higher in this study, its other diagnostic efficiency values were detected to be low. It is recommended that a new cut-off value be established while diagnosing active TB in prospective clinical studies and that it is also essential to do the same for the studies in various regions with high and low prevalence of TB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijmyco.2012.09.005","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T03:00:31Z","timestamp":1352084431000},"page":"180-184","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["The diagnostic efficiency of QuantiFERONTB\u00ae -Gold test in the diagnosis of tuberculous pleurisy"],"prefix":"10.4103","volume":"1","author":[{"given":"Ali Kadri","family":"Cirak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Komurcuoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil","family":"Tekgul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semra","family":"Bilaceroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naime","family":"Tasdogen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayriz","family":"Gunduz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20260907","first-page":"435","article-title":"Extrapulmonarytuberculosis: clinical and epidemiologic spectrum of 636 cases","volume":"35","author":"Ilgazli","year":"2004","journal-title":"Arch. Med"},{"key":"R2-4-20260907","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1378\/chest.06-2063","article-title":"Diagnosis and treatment of tuberculous pleural effusion in","volume":"131","author":"Gopi","year":"2006","journal-title":"Chest"},{"key":"R3-4-20260907","first-page":"1","article-title":"The diagnostic value of interferon gamma in the diagnosis of pleural tuberculosis","volume":"21","author":"Cok","year":"2007","journal-title":"Turk. J. Infect"},{"key":"R4-4-20260907","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00063198-199907000-00012","article-title":"Useful tests on the pleural fluid in the management of patients with pleural effusions","volume":"5","author":"Light","year":"1999","journal-title":"Curr. Opin. Pulm. Med"},{"key":"R5-4-20260907","first-page":"1","article-title":"Updated guidelines for using interferon gamma release assays to detect Mycobacterium tuberculosis infection.United States 2010","volume":"59","author":"Mazurek","year":"2010","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"R6-4-20260907","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1001\/archinte.158.18.2017","article-title":"Tuberculous pleurisy: a study of 254 patients","volume":"158","author":"Valdes","year":"(1998)","journal-title":"Arch. Intern. Med"},{"key":"R7-4-20260907","first-page":"1355","article-title":"Evaluation of polymerase chain reaction","volume":"118","author":"Villegas","year":"2000","journal-title":"adenosine deaminase, and interferon-c in pleural fluid for the differential diagnosis of pleural tuberculosis, Ches"},{"key":"R8-4-20260907","first-page":"70","article-title":"The diagnostic markers of tuberculous pleural effusion","volume":"3","author":"Ciledag","year":"(2008)","journal-title":"Pleural Bull. Turk. Thorac. Soc"},{"key":"R9-4-20260907","first-page":"321","article-title":"Determination of adenosine deaminase activity and its isoenzymes for diagnosis of pleural effusions","volume":"5","author":"Gorguner","year":"(2000)","journal-title":"Respirology"},{"key":"R10-4-20260907","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1258\/000456303766477011","article-title":"Diagnostic value of adenosine deaminase in tuberculous pleural effusion: a meta-analysis","volume":"40","author":"Goto","year":"(2003)","journal-title":"Ann. Clin. Biochem"},{"key":"R11-4-20260907","first-page":"747","article-title":"Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role","volume":"9","author":"Valdes","year":"(1996)","journal-title":"and relevance to the origin of increased ADA in tuberculous pleurisy, Eur. Respir. J"},{"key":"R12-4-20260907","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1378\/chest.93.2.308","article-title":"High level of interferon gamma in tuberculous pleural effusion","volume":"93","author":"Ribera","year":"1988","journal-title":"Ches"},{"key":"R13-4-20260907","first-page":"211","article-title":"Diagnostic significance of gamma-interferon in tuberculous pleurisy","volume":"52","author":"Poyraz","year":"(2004)","journal-title":"TuN berk. Toraks Derg"},{"key":"R14-4-20260907","first-page":"30","article-title":"TuN berkuN loz ploN rezilerinde plevra s.v.s.-serum gamma interferon oran.n.n tan.sal deg. eri","volume":"1","author":"KoN ktuN rk","year":"(2000)","journal-title":"Toraks Derg"},{"key":"R15-4-20260907","first-page":"777","article-title":"Adenosine deaminase and interferon-c measurements for the diagnosis of tuberculous pleurisy: a meta-analysis","volume":"7","author":"Greco","year":"(2003)","journal-title":"Int. J. Tuberc. Lung Dis"},{"key":"R16-4-20260907","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/INF.0b013e31819abf6b","article-title":"Interferon-gamma release assay improves the diagnosis of tuberculosis in children","volume":"28","author":"Bianchi","year":"(2009)","journal-title":"Pediatr. Infect. Dis. J"},{"key":"R17-4-20260907","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/147323000803600307","article-title":"QuantiFERON-TB Gold in the diagnosis of active tuberculosis","volume":"36","author":"Bartu","year":"(2008)","journal-title":"J. Int. Med. Res"},{"key":"R18-4-20260907","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1469-0691.2011.03555.x","article-title":"Guidelines on interferon-c release assays for tuberculosis infection: concordance","volume":"17","author":"Denkinger","year":"(2011)","journal-title":"discordance or confusion?, Clin Microbiol. Infect"},{"key":"R19-4-20260907","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1183\/09031936.00114810","article-title":"Interferon-c release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis","volume":"37","author":"Sester","year":"(2011)","journal-title":"Eur. Respir. J"},{"key":"R20-4-20260907","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1378\/chest.09-2350","article-title":"Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a meta-analysis","volume":"137","author":"Diel","year":"(2010)","journal-title":"Ches"},{"key":"R21-4-20260907","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7326\/0003-4819-149-3-200808050-00241","article-title":"Systematic review: T-cellbased assays for the diagnosis of latent tuberculosis infection: an update","volume":"149","author":"Pai","year":"(2008)","journal-title":"Ann. Intern. Med"},{"key":"R23-4-20260907","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2334-8-35","article-title":"Evaluation of immune responses in HIV infected patients with pleural tuberculosis by the QuantiFERON\u00ae TB-Gold interferon-gamma assay","volume":"8","author":"Baba","year":"(2008)","journal-title":"BMC Infect. Dis"},{"key":"R24-4-20260907","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/MCP.0b013e32832bcc4e","article-title":"Interferon-gamma release assays for the diagnosis of TB pleural effusions: hype or real hope?","volume":"15","author":"Hooper","year":"(2009)","journal-title":"Curr Opin. Pulm. Med"},{"key":"R25-4-20260907","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1183\/09031936.00147507","article-title":"Novel tests for diagnosing tuberculous pleural effusion: what works and what does not?","volume":"31","author":"Trajman","year":"(2008)","journal-title":"Eur Respir. J"}],"container-title":["The International Journal of Mycobacteriology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2212553112000945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2212553112000945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/01929415-201201040-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:00:56Z","timestamp":1788796856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01929415-201201040-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijmyco.2012.09.005","relation":{},"ISSN":["2212-5531","2212-554X"],"issn-type":[{"value":"2212-5531","type":"print"},{"value":"2212-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}