{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:18:39Z","timestamp":1788542319119,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,8]],"date-time":"2015-11-08T00:00:00Z","timestamp":1446940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective\/Background:<\/jats:title>\n                    <jats:p>The diagnostics of latent tuberculosis infection in Poland using the tuberculin skin test is challenging due to the obligatory Bacillus Calmette\u2013Gu\u00e9rin vaccinations. Interferon-gamma release assays are still very rarely used for diagnostics. We compared the tuberculin skin test and the QuantiFERON-TB Gold In-Tube test to evaluate the degree of latent tuberculosis infection in at-risk groups for tuberculosis (homeless, close contacts, periodic contacts, nursing-home attendees) and in healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>QuantiFERON-TB Gold In-Tube tests were carried out on 785 individuals from the homeless (n=150), close contacts (n=171), periodic contacts (n=163), nursing-home attendees (n=152), and healthy individuals (n=149). The tuberculin skin test was performed on 129, 156, 147, 148, and 121 participants, respectively. We evaluated the (a) correlation between serum concentrations of interferon gamma and the tuberculin-skin-test induration diameter; (b) between the number of QuantiFERON-TB Gold In-Tube-positive results and the tuberculin-skin-test diameter in the studied groups; and (c) agreement between both tests and the kappa coefficient using the tuberculin-skin-test diameters of 5, 10, and 15 mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Larger tuberculin-skin-test induration diameters were associated with elevated serum concentrations of interferon gamma. We found a positive correlation between the number of positive QuantiFERON-TB Gold In-Tube screening results and the tuberculin-skin-test induration diameter. The agreement between QuantiFERON-TB Gold In-Tube and tuberculin-skin-test screening results improved with increasing tuberculin-skin-test induration diameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Based on measures of tuberculin-skin-test induration diameter alone, it is difficult to diagnose latent tuberculosis infection with certainty. The agreement of the QuantiFERON-TB Gold In-Tube test increases with the tuberculin-skin-test diameter. Tuberculin-skin-test diameters larger than 15 mm are more likely to be associated with active infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijmyco.2015.10.004","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T03:48:59Z","timestamp":1447732139000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Interferon-gamma release assays and tuberculin skin testing for diagnosing latent Mycobacterium tuberculosis infection in at-risk groups in Poland"],"prefix":"10.4103","volume":"5","author":[{"given":"Katarzyna","family":"Kruczak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucyna","family":"Mastalerz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"S\u0142adek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20260904","first-page":"446","article-title":"Comment to the article: Nowe moz_ liwo\u015b ci diagnostyki utajonego zaka_zenia pra\u00f4tkiem gru\u017a licy (New possibilities of diagnosing mycobacteria tuberculosis infections)","volume":"76","author":"Demkow","year":"2008","journal-title":"Pneumonol. Alergol. Pol"},{"key":"R3-5-20260904","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1586\/14737159.6.3.413","article-title":"New tools and emerging technologies for the diagnosis of tuberculosis. Part I. Latent tuberculosis","volume":"6","author":"Pai","year":"2006","journal-title":"Expert Rev. Mol. Diagn"},{"key":"R5-5-20260904","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1183\/18106838.0504.302","article-title":"Diagnosis of tuberculosis: principles and practice of using interferon-gamma release assays (IGRAs)","volume":"5","author":"Lalvani","year":"2009","journal-title":"Breathe"},{"key":"R6-5-20260904","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1172\/JCI31810","article-title":"Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis","volume":"117","author":"Ernst","year":"2007","journal-title":"J. Clin. Invest"},{"key":"R7-5-20260904","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1183\/09031936.00028507","article-title":"Quantitative scoring of an interferon gamma assay for differentiating active from latent tuberculosis","volume":"30","author":"Janssens","year":"2007","journal-title":"Eur. Respir. J"},{"key":"R8-5-20260904","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thx.2009.116376","article-title":"Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis","volume":"64","author":"Dheda","year":"2009","journal-title":"Thorax"},{"key":"R9-5-20260904","first-page":"269","article-title":"Accuracy of an interferon-gamma release assay to detect active pulmonary and extra-pulmonary tuberculosis","volume":"12","author":"Nishimura","year":"2008","journal-title":"Int. J. Tuberc. Lung Dis"},{"key":"R10-5-20260904","doi-asserted-by":"crossref","first-page":"e2665","DOI":"10.1371\/journal.pone.0002665","article-title":"Interferon-gamma release assay for the diagnosis of latent TB infection\u2014analysis of discordant results, when compared to the tuberculin skin test","volume":"3","author":"Nienhaus","year":"2008","journal-title":"PLoS One"},{"key":"R11-5-20260904","first-page":"942","article-title":"Correspondence, discordance between tuberculin skin test and interferon-gamma assays","volume":"10","author":"Pai","year":"2006","journal-title":"Int. J. Tuberc. Lung Dis"},{"key":"R12-5-20260904","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1001\/jama.293.22.2756","article-title":"Discrepancy between the tuberculin skin test and the whole-blood interferon-gamma assay infection in an intermediate tuberculosis-burden country","volume":"293","author":"Kang","year":"2005","journal-title":"JAMA"},{"key":"R13-5-20260904","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/CVI.00132-07","article-title":"Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation","volume":"14","author":"Leyten","year":"2007","journal-title":"Clin. Vaccine Immunol"},{"key":"R14-5-20260904","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/CVI.00093-07","article-title":"Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection","volume":"14","author":"Cehovin","year":"2007","journal-title":"Clin. Vaccine Immunol"},{"key":"R15-5-20260904","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1183\/09031936.00201609","article-title":"Tuberculosis contact investigation in low prevalence countries: a European consensus","volume":"36","author":"Erkens","year":"2010","journal-title":"Eur. Respir. J"},{"key":"R16-5-20260904","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/thorax.57.9.804","article-title":"A meta-analysis of the effect of Bacille Calmette Gue\u00e9rin vaccination on tuberculin skin test measurements","volume":"57","author":"Wang","year":"2002","journal-title":"Thorax"},{"key":"R17-5-20260904","first-page":"1021","article-title":"Waning of the specific interferon-gamma response after years of tuberculosis infection","volume":"11","author":"Mori","year":"2007","journal-title":"Int. J. Tuberc. Lung Dis"},{"key":"R18-5-20260904","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1183\/09031936.00115110","article-title":"Interferon-c release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systemic review and meta-analysis","volume":"37","author":"Diel","year":"2011","journal-title":"Eur. Respir. J"},{"key":"R19-5-20260904","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1183\/09031936.00120908","article-title":"LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement","volume":"33","author":"Mack","year":"2009","journal-title":"Eur. Respir. J"},{"key":"R20-5-20260904","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1164\/rccm.200711-1613OC","article-title":"Predictive value of a whole blood IFN-c assay for the development of active tuberculosis disease after recent infection with Mycobacterium tuberculosis","volume":"177","author":"Diel","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"R21-5-20260904","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1164\/rccm.200502-196OC","article-title":"Routine hospital use of a new commercial whole blood interferon-gamma assay for the diagnosis of tuberculosis infection","volume":"172","author":"Ferrara","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"R22-5-20260904","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1164\/rccm.200608-1099OC","article-title":"Comparison of two interferon-gamma assays and tuberculin skin test for tracing tuberculosis contacts","volume":"175","author":"Arend","year":"2007","journal-title":"Am. J. Crit. Care Med"},{"key":"R23-5-20260904","first-page":"37","article-title":"Ocena stopnia zakaz_ enia pra\u00f4tkiem gru\u017a licy (utajonej infekcji gru\u017a liczej) przy pomocy testu Quantiferon-GIT (QFT-GIT) w wybranych grupach ryzyka w populacji Krakowa (Assessment of the degree of mycobacteria tuberculosis infection (latent tuberculosis infection) using the Quantiferon-GIT (QFT-GIT) test in selected risk groups among the population of Krak\u00f3w)","volume":"1","author":"Kruczak","year":"2009","journal-title":"Nowa medycyna (New Med"},{"key":"R24-5-20260904","first-page":"407","article-title":"Ocena cze\u00f4sto\u015bci wyste\u00f4powania zakaz_ enia pra\u00f4tkiem gru\u017a licy w populacji wojew\u00f3dztwa mazowieckiego na podstawie wyniku testu mierza\u00f4cego uwalnianie interferonu gamma po stymulacji swoistymi antygenami ESAT-6 i CFP-10 (Prevalence of latent infection with Mycobacterium tuberculosis in Mazovia Region using interferon gamma release assay after stimulation with specific antigens ESAT-6 and CFP-10)","volume":"79","author":"Ku\u015b","year":"2011","journal-title":"Pneumonol. Alergol. Pol"},{"key":"R25-5-20260904","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3109\/00365548.2014.927955","article-title":"Comparison of IGRA tests and TST in the diagnosis of latent tuberculosis infection and predicting tuberculosis in risk groups in Krak\u00f3w, Poland","volume":"46","author":"Kruczak","year":"2014","journal-title":"Scand. J. Infect. Dis"}],"container-title":["The International Journal of Mycobacteriology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2212553115001582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2212553115001582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/01929415-201605010-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:01:45Z","timestamp":1788541305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01929415-201605010-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijmyco.2015.10.004","relation":{},"ISSN":["2212-5531","2212-554X"],"issn-type":[{"value":"2212-5531","type":"print"},{"value":"2212-554X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}