{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:58:32Z","timestamp":1773280712952,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Obstetric Anesthesia"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.ijoa.2008.08.001","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T20:10:08Z","timestamp":1232568608000},"page":"262-267","source":"Crossref","is-referenced-by-count":33,"title":["Cesarean section and primary pulmonary hypertension: the role of intravenous dexmedetomidine"],"prefix":"10.1016","volume":"18","author":[{"given":"H.","family":"Toyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Wagatsuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ejima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijoa.2008.08.001_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJM199701093360207","article-title":"Primary pulmonary hypertension","volume":"336","author":"Rubin","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijoa.2008.08.001_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","article-title":"Survival in patients with primary pulmonary hypertension: results from a national prospective registry","volume":"115","author":"D\u2019Alonzo","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijoa.2008.08.001_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00006254-196408000-00001","article-title":"Primary pulmonary hypertension in pregnancy","volume":"19","author":"McCaffrey","year":"1964","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.ijoa.2008.08.001_bib4","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/S0735-1097(98)00162-4","article-title":"Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996","volume":"31","author":"Weiss","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijoa.2008.08.001_bib5","series-title":"Cardiac Problems in Pregnancy","author":"Elkayam","year":"1998"},{"key":"10.1016\/j.ijoa.2008.08.001_bib6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1017\/S0265021506000378","article-title":"Perioperative use of alpha2-adrenoceptor agonists and the cardiac patient","volume":"23","author":"Aantaa","year":"2006","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.ijoa.2008.08.001_bib7","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1172\/JCI115146","article-title":"Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide","volume":"87","author":"Mukoyama","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijoa.2008.08.001_bib8","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jacc.2003.09.051","article-title":"Clinical significance of brain natriuretic peptide in primary pulmonary hypertension","volume":"43","author":"Leuchte","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijoa.2008.08.001_bib9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/01.CIR.102.8.865","article-title":"Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension","volume":"102","author":"Nagaya","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijoa.2008.08.001_bib10","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S0735-1097(01)01490-5","article-title":"Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation","volume":"38","author":"Wiedemann","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijoa.2008.08.001_bib11","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1378\/chest.128.4.2368","article-title":"Characterization of brain natriuretic peptide in long-term follow-up of pulmonary arterial hypertension","volume":"128","author":"Leuchte","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.ijoa.2008.08.001_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/bja\/63.1.116","article-title":"Extradural analgesia in the intrapartum management of a patient with pulmonary hypertension","volume":"63","author":"Power","year":"1989","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ijoa.2008.08.001_bib13","series-title":"Anesthetic and Obstetric Management of High-Risk Pregnancy","first-page":"245","article-title":"Cardiac disease","author":"Johnsson","year":"1991"},{"key":"10.1016\/j.ijoa.2008.08.001_bib14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0959-289X(96)80072-0","article-title":"Anesthetic considerations for parturients with primary pulmonary hypertension: review of the literature and clinical presentation","volume":"5","author":"Khan","year":"1996","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2008.08.001_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1183\/09031936.98.12020265","article-title":"Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension","volume":"12","author":"Sitbon","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijoa.2008.08.001_bib16","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/j.1399-6576.2006.01136.x","article-title":"The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery","volume":"50","author":"But","year":"2006","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.ijoa.2008.08.001_bib17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/vr.159.19.624","article-title":"Cardiopulmonary effects of dexmedetomidine in goats and sheep anaesthetised with sevoflurane","volume":"159","author":"Kutter","year":"2006","journal-title":"Vet Rec"},{"key":"10.1016\/j.ijoa.2008.08.001_bib18","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.2460\/ajvr.2005.66.1496","article-title":"Cardiopulmonary effects of dexmedetomidine in sevoflurane-anesthetized sheep with and without nitric oxide inhalation","volume":"66","author":"Kastner","year":"2005","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.ijoa.2008.08.001_bib19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/00000542-200008000-00016","article-title":"The effects of increasing plasma concentrations of dexmedetomidine in humans","volume":"93","author":"Ebert","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2008.08.001_bib20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF03007461","article-title":"Systemic and pulmonary blood pressure during caesarean section in parturients with gestational hypertension","volume":"27","author":"Hodgkinson","year":"1980","journal-title":"Can Anaesth Soc J"},{"key":"10.1016\/j.ijoa.2008.08.001_bib21","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1399-6576.2005.00780.x","article-title":"Single-dose dexmedetomidine attenuates airway and circulatory reflexes during extubation","volume":"49","author":"Guler","year":"2005","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.ijoa.2008.08.001_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijoa.2004.11.004","article-title":"The in vitro effects of clonidine and dexmedetomidine on human myometrium","volume":"14","author":"Sia","year":"2005","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2008.08.001_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1399-6576.1997.tb04685.x","article-title":"Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta","volume":"41","author":"Ala-Kokko","year":"1997","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.ijoa.2008.08.001_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijoa.2004.01.005","article-title":"General anaesthesia with target controlled infusion of propofol for planned caesarean section: maternal and neonatal effects of a remifentanil-based technique","volume":"13","author":"Van de Velde","year":"2004","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2008.08.001_bib25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1054\/ijoa.2001.0910","article-title":"The use of remifentanil during general anaesthesia for caesarean delivery in two patients with severe heart dysfunction","volume":"11","author":"Wadsworth","year":"2002","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2008.08.001_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijoa.2003.12.008","article-title":"General anaesthesia using remifentanil for caesarean section in parturients with critical aortic stenosis: a series of four cases","volume":"13","author":"Orme","year":"2004","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2008.08.001_bib27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijoa.2006.07.009","article-title":"Caesarean section using total intravenous anaesthesia in a patient with Ebstein\u2019s anomaly complicated by supraventricular tachycardia","volume":"16","author":"Macfarlane","year":"2007","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2008.08.001_bib28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijoa.2008.01.002","article-title":"Remifentanil for cesarean section under general anesthesia: effects on maternal stress hormone secretion and neonatal well-being: a randomized trial","volume":"17","author":"Draisci","year":"2008","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2008.08.001_bib29","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ajog.2004.12.006","article-title":"Evaluation of B-type natriuretic peptide (BNP) levels in normal and preeclamptic women","volume":"193","author":"Resnik","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ijoa.2008.08.001_bib30","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/molehr\/4.6.609","article-title":"Nitric oxide metabolite concentrations in maternal plasma decrease during parturition: possible transient down-regulation of nitric oxide synthesis","volume":"4","author":"Nanno","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ijoa.2008.08.001_bib31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1677\/joe.0.1400393","article-title":"Plasma concentration of atrial natriuretic peptide and brain natriuretic peptide during normal human pregnancy and the postpartum period","volume":"140","author":"Yoshimura","year":"1994","journal-title":"J Endocrinol"},{"key":"10.1016\/j.ijoa.2008.08.001_bib32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0002-9378(95)90208-2","article-title":"Effect of corticosteroids for fetal maturation on perinatal outcomes","volume":"173","author":"National Institutes of Health (NIH) Consensus Development Panel","year":"1995","journal-title":"Am J Obstet Gynecol"}],"container-title":["International Journal of Obstetric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959289X08001398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959289X08001398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T10:54:00Z","timestamp":1545476040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959289X08001398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0959289X08001398"],"URL":"https:\/\/doi.org\/10.1016\/j.ijoa.2008.08.001","relation":{},"ISSN":["0959-289X"],"issn-type":[{"value":"0959-289X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}