{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T20:27:11Z","timestamp":1775161631465,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","obstetanesthesia.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Obstetric Anesthesia"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.ijoa.2015.05.002","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T20:35:15Z","timestamp":1435437315000},"page":"237-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["A systematic review of the effects of adding neostigmine to local anesthetics for neuraxial administration in obstetric anesthesia and analgesia"],"prefix":"10.1016","volume":"24","author":[{"given":"A.P.","family":"Cossu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.","family":"De Giudici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Piras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Scanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cossu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Saba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Finco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Brazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijoa.2015.05.002_b0005","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1213\/ANE.0000000000000077","article-title":"A comparison of remifentanil parturient-controlled intravenous analgesia with epidural analgesia: a meta-analysis of randomized controlled trials","volume":"118","author":"Liu","year":"2014","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0010","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ijoa.2010.08.004","article-title":"Labour analgesia and the baby: good news is no news","volume":"20","author":"Reynolds","year":"2011","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2015.05.002_b0015","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/01.anes.0000264744.63275.10","article-title":"Practice guidelines for obstetric anesthesia: an updated report by the American Society of Anesthesiologists Task Force on Obstetric Anesthesia","volume":"106","author":"American Society of Anesthesiologists Task Force on Obstetric Anesthesia","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijoa.2008.05.005","article-title":"Impact of the addition of sufentanil 5microg or clonidine 75microg on the minimum local analgesic concentration of ropivacaine for epidural analgesia in labor: a randomized comparison","volume":"17","author":"Dewandre","year":"2008","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2015.05.002_b0025","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/bja\/aem101","article-title":"Effects of intrathecal and i.v. small-dose sufentanil on the median effective dose of intrathecal bupivacaine for Caesarean section","volume":"98","author":"Wang","year":"2007","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ijoa.2015.05.002_b0030","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1213\/00000539-200102000-00025","article-title":"Levobupivacaine for epidural analgesia in labor: the sparing effect of epidural fentanyl","volume":"92","author":"Robinson","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0035","first-page":"96","article-title":"The effects of intrathecal and systemic adjuvants on subarachnoid block","volume":"80","author":"Staikou","year":"2014","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.ijoa.2015.05.002_b0040","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/01.aco.0000192812.56161.f8","article-title":"The use of neuraxial adjuvant drugs (neostigmine, clonidine) in obstetrics","volume":"19","author":"Roelants","year":"2006","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.ijoa.2015.05.002_b0045","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1213\/00000539-199706000-00018","article-title":"Intrathecal neostigmine for post-cesarean section analgesia: dose response","volume":"84","author":"Krukowski","year":"1997","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0050","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1053\/j.jvca.2012.01.038","article-title":"Fenoldopam and acute renal failure in cardiac surgery: a meta-analysis of randomized placebo-controlled trials","volume":"26","author":"Zangrillo","year":"2012","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.ijoa.2015.05.002_b0055","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analysis","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.ijoa.2015.05.002_b0060","unstructured":"Higgins JP, Green S (editors). Cochrane handbook for systematic reviews of interventions Version 5.1.0 [updated March 2011]. The cochrane collaboration, 2011. www.cochrane-handbook.org."},{"key":"10.1016\/j.ijoa.2015.05.002_b0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2044.1999.00634.x","article-title":"Analgesic and adverse effects of a low dose of intrathecally administered hyperbaric neostigmine alone or combined with morphine in patients submitted to spinal anesthesia: pilot studies","volume":"54","author":"Klamt","year":"1999","journal-title":"Anaesthesia"},{"key":"10.1016\/j.ijoa.2015.05.002_b0070","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1213\/01.ane.0000244595.03322.52","article-title":"The effect of a lidocaine test dose on analgesia and mobility after an epidural combination of neostigmine and sufentanil in early labor","volume":"103","author":"Roelants","year":"2006","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/EJA.0b013e32836249e9","article-title":"Epidural neostigmine and clonidine improves the quality of combined spinal epidural analgesia in labor: a randomized, double-blind controlled trial","volume":"31","author":"Boogmans","year":"2014","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.ijoa.2015.05.002_b0080","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ijoa.2009.01.003","article-title":"Effects of epidural clonidine and neostigmine following intrathecal labor analgesia: a randomized, double-blind, placebo-controlled trial","volume":"18","author":"Van de Velde","year":"2009","journal-title":"Int J Obstet Anesth"},{"key":"10.1016\/j.ijoa.2015.05.002_b0085","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1213\/ane.0b013e31819518e4","article-title":"Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study","volume":"109","author":"Ross","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0090","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/00000542-200506000-00021","article-title":"Epidural administration of neostigmine and clonidine to induce labor analgesia: evaluation of efficacy and local anesthetic-sparing effect","volume":"102","author":"Roelants","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0095","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00000542-200408000-00025","article-title":"Epidural neostigmine combined with sufentanil provides balanced and selective analgesia in early labor","volume":"101","author":"Roelants","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0100","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00000542-200402000-00030","article-title":"Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery","volume":"100","author":"Kaya","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0105","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1213\/01.ANE.0000050480.73209.9C","article-title":"The effect of epidural neostigmine combined with ropivacaine and sufentanil on neuraxial analgesia during labor","volume":"96","author":"Roelants","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0110","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1097\/00000539-200112000-00048","article-title":"Neostigmine combined with bupivacaine, clonidine, and sufentanil for spinal labor analgesia","volume":"93","author":"D\u2019Angelo","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0115","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/00000542-200002000-00016","article-title":"Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia","volume":"92","author":"Owen","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0120","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1097\/00000542-199911000-00020","article-title":"Intrathecal neostigmine and sufentanil for early labor analgesia","volume":"91","author":"Nelson","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0125","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1213\/00000539-199808000-00020","article-title":"The efficacy of intrathecal neostigmine, intrathecal morphine, and their combination for post-cesarean section analgesia","volume":"87","author":"Chung","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0130","first-page":"49","article-title":"Enhancement of analgesic effect of intrathecal neostigmine and clonidine on bupivacaine spinal anesthesia","volume":"23","author":"Pan","year":"1998","journal-title":"Reg Anesth Pain Med"},{"issue":"Suppl. 34","key":"10.1016\/j.ijoa.2015.05.002_b0135","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00003643-200505001-00544","article-title":"Epidural continuous infusion of sufentanil and neostigmine for labor analgesia","volume":"22","author":"Renier","year":"2005","journal-title":"Eur J Anaesthesiol"},{"issue":"suppl 37","key":"10.1016\/j.ijoa.2015.05.002_b0140","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00003643-200606001-00661","article-title":"Combined epidural clonidine and neostigmine safely and effectively prolong initial spinal labor analgesia: a randomized, double-blind, placebo controlled trial","volume":"23","author":"Van Dam","year":"2006","journal-title":"Eur J Anaesthesiol"},{"issue":"suppl 37","key":"10.1016\/j.ijoa.2015.05.002_b0145","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00003643-200606001-00664","article-title":"Continuous infusion of epidural sufentanil, neostigmine and clonidine for labor analgesia","volume":"23","author":"Versyck","year":"2006","journal-title":"Eur J Anaesthesiol"},{"issue":"suppl 44","key":"10.1016\/j.ijoa.2015.05.002_b0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00003643-200805001-00507","article-title":"Effects of epidural clonidine and neostigmine on the quality of epidural labor analgesia using a local anesthetic\/opioid mixture: a placebo-controlled, double-blind trial","volume":"25","author":"Geelen","year":"2008","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.ijoa.2015.05.002_b0155","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00000542-199802000-00027","article-title":"Effects of intrathecal neostigmine, bupivacaine, and their combination on sympathetic nerve activity in rats","volume":"88","author":"Pan","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0160","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/00000542-200110000-00033","article-title":"Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain","volume":"95","author":"Chen","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0165","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1097\/00000542-199906000-00006","article-title":"Study of three different doses of epidural neostigmine coadministered with lidocaine for post-operative analgesia","volume":"90","author":"Lauretti","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0170","first-page":"617","article-title":"The effects of intrathecal neostigmine on somatic and visceral pain: Improvement by association with a peripheral anticholinergic","volume":"86","author":"Lauretti","year":"1996","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0175","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0304-3959(02)00046-5","article-title":"Biological basis of visceral pain: recent developments","volume":"96","author":"Al-Chaer","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.ijoa.2015.05.002_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000542-199608000-00013","article-title":"Interaction between intrathecal neostigmine and epidural clonidine in human volunteers","volume":"85","author":"Hood","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0185","first-page":"1140","article-title":"Postoperative analgesia from intrathecal neostigmine in sheep","volume":"80","author":"Bouaziz","year":"1995","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0190","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1213\/00000539-199611000-00024","article-title":"Spinal neostigmine diminishes, but does not abolish, hypotension from spinal bupivacaine in sheep","volume":"83","author":"Rose","year":"1996","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ijoa.2015.05.002_b0195","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1097\/00000542-199805000-00017","article-title":"Acetylcholinesterase and butyrylcholinesterase are expressed in the spinal meninges of monkeys and pigs","volume":"88","author":"Ummenhoffer","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijoa.2015.05.002_b0200","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1213\/00000539-199603000-00034","article-title":"Cerebrospinal fluid norepinephrine and acetylcholine concentrations during acute pain","volume":"82","author":"Eisenach","year":"1996","journal-title":"Anesth Analg"}],"container-title":["International Journal of Obstetric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959289X15000783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959289X15000783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T19:10:09Z","timestamp":1652641809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959289X15000783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0959289X15000783"],"URL":"https:\/\/doi.org\/10.1016\/j.ijoa.2015.05.002","relation":{},"ISSN":["0959-289X"],"issn-type":[{"value":"0959-289X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A systematic review of the effects of adding neostigmine to local anesthetics for neuraxial administration in obstetric anesthesia and analgesia","name":"articletitle","label":"Article Title"},{"value":"International Journal of Obstetric Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijoa.2015.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}