{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:58:27Z","timestamp":1791212307275,"version":"4.1.0"},"reference-count":6,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","obstetanesthesia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Obstetric Anesthesia"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ijoa.2026.104889","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T15:01:12Z","timestamp":1772377272000},"page":"104889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Stability of the pH of local anesthetics after bicarbonation: an electrochemical assay of clinical mixtures"],"prefix":"10.1016","volume":"66","author":[{"given":"Samantha L.","family":"Armstrong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-1994","authenticated-orcid":false,"given":"Erin J.","family":"Ciampa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5179","key":"10.1016\/j.ijoa.2026.104889_b0005","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1126\/science.8085162","article-title":"Molecular determinants of state-dependent block of Na+ channels by local anesthetics","volume":"265","author":"Ragsdale","year":"1994","journal-title":"Science"},{"issue":"51","key":"10.1016\/j.ijoa.2026.104889_b0010","doi-asserted-by":"crossref","first-page":"13111","DOI":"10.1073\/pnas.1814928115","article-title":"Fenestrations control resting-state block of a voltage-gated sodium channel","volume":"115","author":"Gamal El-Din","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.ijoa.2026.104889_b0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1213\/00000539-199301000-00023","article-title":"On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: drug structure-activity studies on isolated peripheral nerve","volume":"76","author":"Wong","year":"1993","journal-title":"Anesth Analg"},{"issue":"7","key":"10.1016\/j.ijoa.2026.104889_b0020","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1213\/00000539-198607000-00010","article-title":"Comparison of pH-adjusted lidocaine solutions for epidural anesthesia","volume":"65","author":"DiFazio","year":"1986","journal-title":"Anesth Analg"},{"issue":"2","key":"10.1016\/j.ijoa.2026.104889_b0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/229255031202000207","article-title":"How acidic is the lidocaine we are injecting, and how much bicarbonate should we add?","volume":"20","author":"Frank","year":"2012","journal-title":"Can J Plast Surg"},{"issue":"1","key":"10.1016\/j.ijoa.2026.104889_b0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1136\/rapm-2023-105229","article-title":"Crystallization of mixtures of local anesthetics with and without select adjuvants: a semiquantitative light microscopy analysis","volume":"50","author":"Hoerner","year":"2025","journal-title":"Reg Anesth Pain Med"}],"container-title":["International Journal of Obstetric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959289X26000464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959289X26000464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:49:44Z","timestamp":1791211784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959289X26000464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":6,"alternative-id":["S0959289X26000464"],"URL":"https:\/\/doi.org\/10.1016\/j.ijoa.2026.104889","relation":{},"ISSN":["0959-289X"],"issn-type":[{"value":"0959-289X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stability of the pH of local anesthetics after bicarbonation: an electrochemical assay of clinical mixtures","name":"articletitle","label":"Article Title"},{"value":"International Journal of Obstetric Anesthesia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijoa.2026.104889","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104889"}}