{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:48:50Z","timestamp":1787161730900,"version":"build-2736575974"},"reference-count":59,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.ijom.2016.01.008","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T03:00:37Z","timestamp":1459047637000},"page":"1015-1022","source":"Crossref","is-referenced-by-count":19,"title":["Clinical effects of an avocado\u2013soybean unsaponifiable extract on arthralgia and osteoarthritis of the temporomandibular joint: preliminary study"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-7683","authenticated-orcid":false,"given":"I.S.","family":"Catunda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.C. do E.","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S. de S.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.F.N.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijom.2016.01.008_bib0300","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0304-3959(92)90212-T","article-title":"Effect of temporomandibular disorder pain duration on facial expressions and verbal report of pain","volume":"51","author":"LeResche","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0305","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/bmj.317.7152.190","article-title":"Temporomandibular disorders: a clinical update","volume":"317","author":"Dimitroulis","year":"1998","journal-title":"BMJ"},{"issue":"Suppl. 3","key":"10.1016\/j.ijom.2016.01.008_bib0310","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-0501.2007.01480.x","article-title":"Is there a superiority of multimodal as opposed to simple therapy in patients with temporomandibular disorders? A qualitative systematic review of the literature","volume":"18","author":"Turp","year":"2007","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.ijom.2016.01.008_bib0315","series-title":"Tratamento das desordens temporomandibulares Brazil","author":"Okeson","year":"2008"},{"key":"10.1016\/j.ijom.2016.01.008_bib0320","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin","year":"1992","journal-title":"J Craniomandib Disord"},{"key":"10.1016\/j.ijom.2016.01.008_bib0325","first-page":"9","article-title":"Longitudinal outcome of temporomandibular disorders: a 5-year epidemiologic study of muscle disorders defined by research diagnostic criteria for temporomandibular disorders","volume":"17","author":"Rammelsberg","year":"2003","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0330","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","article-title":"Diagnostic criteria for temporomandibular disorders (DC\/TMD) for clinical and research applications: recommendations of the International RDC\/TMD Consortium Network and Orofacial Pain Special Interest Group","volume":"28","author":"Schiffman","year":"2014","journal-title":"J Oral Facial Pain Headache"},{"key":"10.1016\/j.ijom.2016.01.008_bib0335","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/00016350310004089","article-title":"Temporomandibular joint related painless symptoms, orofacial pain, neck pain, headache, and psychosocial factors among non-patients","volume":"61","author":"Rantala","year":"2003","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.ijom.2016.01.008_bib0340","first-page":"21","article-title":"Prevalence of temporomandibular disorder subtypes, psychologic distress, and psychosocial dysfunction in Asian patients","volume":"17","author":"Yap","year":"2003","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0345","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.tripleo.2011.04.021","article-title":"Research diagnostic criteria for temporomandibular disorders: a systematic review of axis I epidemiologic findings","volume":"112","author":"Manfredini","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.ijom.2016.01.008_bib0350","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1297-319X(00)00216-5","article-title":"Pathophysiology of osteoarthritis","volume":"67","author":"van den Berg","year":"2000","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.ijom.2016.01.008_bib0355","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.ijom.2016.01.008_bib0360","first-page":"28","article-title":"Psychologic status in patients with temporomandibular disorders","volume":"19","author":"Celic","year":"2006","journal-title":"Int J Prosthodont"},{"key":"10.1016\/j.ijom.2016.01.008_bib0365","first-page":"407","article-title":"Factors related to oral health related quality of life in TMD patients","volume":"37","author":"Rener-Sitar","year":"2013","journal-title":"Coll Antropol"},{"key":"10.1016\/j.ijom.2016.01.008_bib0370","first-page":"28","article-title":"The impact of orofacial pain on the quality of life of patients with temporomandibular disorder","volume":"23","author":"Barros Vde","year":"2009","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0375","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0889-857X(05)70074-0","article-title":"Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate","volume":"25","author":"Deal","year":"1999","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.ijom.2016.01.008_bib0380","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10067-003-0731-4","article-title":"Avocado\u2013soybean unsaponifiables (ASU) for osteoarthritis\u2014a systematic review","volume":"22","author":"Ernst","year":"2003","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ijom.2016.01.008_bib0385","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/ecam\/nem132","article-title":"Metabolic effects of avocado\/soy unsaponifiables on articular chondrocytes","volume":"5","author":"Lippiello","year":"2008","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.ijom.2016.01.008_bib0390","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-9255-11-8","article-title":"Expression of pro-inflammatory mediators is inhibited by an avocado\/soybean unsaponifiables and epigallocatechin gallate combination","volume":"11","author":"Ownby","year":"2014","journal-title":"J Inflamm (Lond)"},{"key":"10.1016\/j.ijom.2016.01.008_bib0395","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1947603514554992","article-title":"Management of osteoarthritis with avocado\/soybean unsaponifiables","volume":"6","author":"Christiansen","year":"2015","journal-title":"Cartilage"},{"key":"10.1016\/j.ijom.2016.01.008_bib0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joca.2010.10.017","article-title":"Nutraceuticals: do they represent a new era in the management of osteoarthritis? A narrative review from the lessons taken with five products","volume":"19","author":"Henrotin","year":"2011","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.ijom.2016.01.008_bib0405","first-page":"23","article-title":"Diagnosis of the craniomandibular dysfunction through anamnesis","volume":"42","author":"Fonseca","year":"1994","journal-title":"Rev Ga\u00facha Odontol"},{"key":"10.1016\/j.ijom.2016.01.008_bib0410","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jbmt.2014.08.001","article-title":"Accuracy of the Fonseca anamnestic index in the identification of myogenous temporomandibular disorder in female community cases","volume":"19","author":"Berni","year":"2015","journal-title":"J Bodyw Mov Ther"},{"key":"10.1016\/j.ijom.2016.01.008_bib0415","first-page":"46","article-title":"Oral health-related quality of life in patients with temporomandibular disorders","volume":"21","author":"John","year":"2007","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0420","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1472-6831-12-26","article-title":"Profiling the clinical presentation of diagnostic characteristics of a sample of symptomatic TMD patients","volume":"12","author":"Pimenta e Silva Machado","year":"2012","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.ijom.2016.01.008_bib0425","first-page":"168","article-title":"Degenerative disease of the temporomandibular joint","volume":"9","author":"Kamelchuk","year":"1995","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0430","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1177\/088307389000500408","article-title":"Myotonia congenita: Thomsen's, Bell's, or Leyden's disease","volume":"5","author":"Lanska","year":"1990","journal-title":"J Child Neurol"},{"key":"10.1016\/j.ijom.2016.01.008_bib0435","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0304-3959(94)90097-3","article-title":"A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales","volume":"56","author":"Price","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0440","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1046\/j.1365-2842.2001.00727.x","article-title":"Pain measurement in TMD patients: evaluation of precision and sensitivity of different scales","volume":"28","author":"Conti","year":"2001","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.ijom.2016.01.008_bib0445","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0304-3959(86)90228-9","article-title":"The measurement of clinical pain intensity: a comparison of six methods","volume":"27","author":"Jensen","year":"1986","journal-title":"Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0450","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-2842.1995.tb01048.x","article-title":"Self-assessment of pain and discomfort in patients with temporomandibular disorders: a comparison of five different scales with respect to their precision and sensitivity as well as their capacity to register memory of pain and discomfort","volume":"22","author":"Magnusson","year":"1995","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.ijom.2016.01.008_bib0455","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF00562315","article-title":"Comparison of fixed interval and visual analogue scales for rating chronic pain","volume":"8","author":"Joyce","year":"1975","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.ijom.2016.01.008_bib0460","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0304-3959(87)90089-3","article-title":"Pressure algometry over normal muscles. Standard values, validity and reproducibility of pressure threshold","volume":"30","author":"Fischer","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0465","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0304-3959(86)90235-6","article-title":"Pressure\u2013pain threshold in human temporal region. Evaluation of a new pressure algometer","volume":"25","author":"Jensen","year":"1986","journal-title":"Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0470","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0196-9781(90)90141-Q","article-title":"Pain and tenderness in human temporal muscle induced by bradykinin and 5-hydroxytryptamine","volume":"11","author":"Jensen","year":"1990","journal-title":"Peptides"},{"key":"10.1016\/j.ijom.2016.01.008_bib0475","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0304-3959(89)90189-9","article-title":"Pressure pain thresholds in normal muscles: reliability, measurement effects, and topographic differences","volume":"37","author":"Ohrbach","year":"1989","journal-title":"Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0480","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2842.2000.00526.x","article-title":"The diagnostic value of pressure algometry in myofascial pain of the jaw muscles","volume":"27","author":"Farella","year":"2000","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.ijom.2016.01.008_bib0485","first-page":"214","article-title":"Comparison of algometry and palpation in the recognition of temporomandibular disorder pain complaints","volume":"18","author":"Visscher","year":"2004","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0490","first-page":"207","article-title":"[Effects of unsaponifiable extracts of avocado\/soy beans (PIAS) on the production of collagen by cultures of synoviocytes, articular chondrocytes and skin fibroblasts]","volume":"56","author":"Mauviel","year":"1989","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"10.1016\/j.ijom.2016.01.008_bib0495","first-page":"241","article-title":"[Effect of unsaponifiable extracts of avocado and soybean (Piascledine) on the collagenolytic action of cultures of human rheumatoid synoviocytes and rabbit articular chondrocytes treated with interleukin-1]","volume":"58","author":"Mauviel","year":"1991","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"10.1016\/j.ijom.2016.01.008_bib0500","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.joca.2007.10.003","article-title":"Symptomatic efficacy of avocado\u2013soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials","volume":"16","author":"Christensen","year":"2008","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.ijom.2016.01.008_bib0505","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01450955","article-title":"Effects of three avocado\/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes","volume":"17","author":"Henrotin","year":"1998","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.ijom.2016.01.008_bib0510","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.joca.2009.08.015","article-title":"Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate","volume":"18","author":"Heinecke","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.ijom.2016.01.008_bib0515","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/1529-0131(199901)42:1<148::AID-ANR18>3.0.CO;2-U","article-title":"Avocado\/soya unsaponifiables enhance the expression of transforming growth factor beta1 and beta2 in cultured articular chondrocytes","volume":"42","author":"Boumediene","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ijom.2016.01.008_bib0520","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1053\/joca.1999.0315","article-title":"Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU)","volume":"8","author":"Cake","year":"2000","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.ijom.2016.01.008_bib0525","first-page":"41","article-title":"The possible chondroprotective effect of the unsaponifiable constituents of avocado and soya in vivo","volume":"24","author":"Khayyal","year":"1998","journal-title":"Drugs Exp Clin Res"},{"key":"10.1016\/j.ijom.2016.01.008_bib0530","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0022-3913(90)90079-R","article-title":"Assessing clinical signs of temporomandibular disorders: reliability of clinical examiners","volume":"63","author":"Dworkin","year":"1990","journal-title":"J Prosthet Dent"},{"key":"10.1016\/j.ijom.2016.01.008_bib0535","first-page":"17","article-title":"The reproducibility of muscle and joint tenderness detection methods and maximum mandibular movement measurement for the temporomandibular system","volume":"12","author":"Goulet","year":"1998","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.ijom.2016.01.008_bib0540","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/0975-5950.79210","article-title":"Outcomes of management of early temporomandibular joint disorders: how effective is nonsurgical therapy in the long-term","volume":"1","author":"Mortazavi","year":"2010","journal-title":"Natl J Maxillofac Surg"},{"key":"10.1016\/j.ijom.2016.01.008_bib0545","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.tripleo.2011.06.012","article-title":"No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints\u2014a randomized, controlled, short-term study","volume":"112","author":"Cahlin","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.ijom.2016.01.008_bib0550","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/08869634.2001.11746162","article-title":"A randomized double-blind clinical trial of the effect of chondroitin sulfate and glucosamine hydrochloride on temporomandibular joint disorders: a pilot study","volume":"19","author":"Nguyen","year":"2001","journal-title":"Cranio"},{"key":"10.1016\/j.ijom.2016.01.008_bib0555","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/030097401316909602","article-title":"Symptoms modifying effect of avocado\/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study","volume":"30","author":"Appelboom","year":"2001","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.ijom.2016.01.008_bib0560","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/1529-0131(199801)41:1<81::AID-ART11>3.0.CO;2-9","volume":"41","author":"Maheu","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ijom.2016.01.008_bib0565","first-page":"CD007261","article-title":"Interventions for the management of temporomandibular joint osteoarthritis","volume":"4","author":"de Souza","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ijom.2016.01.008_bib0570","first-page":"1347","article-title":"Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial","volume":"28","author":"Thie","year":"2001","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ijom.2016.01.008_bib0575","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/sj.ebd.6400909","article-title":"Two commentaries on interventions for the management of temporomandibular joint osteoarthritis","volume":"14","author":"Patel","year":"2013","journal-title":"Evid Based Dent"},{"key":"10.1016\/j.ijom.2016.01.008_bib0580","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.4317\/medoral.19061","article-title":"Application of an oral health-related quality of life questionnaire in primary care patients with orofacial pain and temporomandibular disorders","volume":"19","author":"Blanco-Aguilera","year":"2014","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.ijom.2016.01.008_bib0585","first-page":"437","article-title":"TMJ lubrication system: its effect on the joint function, dysfunction, and treatment approach","volume":"25","author":"Nitzan","year":"2004","journal-title":"Compend Contin Educ Dent"},{"key":"10.1016\/j.ijom.2016.01.008_bib0590","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000070570","article-title":"\u2018Friction and adhesive forces\u2019\u2014possible underlying causes for temporomandibular joint internal derangement","volume":"174","author":"Nitzan","year":"2003","journal-title":"Cells Tissues Organs"}],"container-title":["International Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502716000291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502716000291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T22:20:02Z","timestamp":1536877202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0901502716000291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0901502716000291"],"URL":"https:\/\/doi.org\/10.1016\/j.ijom.2016.01.008","relation":{},"ISSN":["0901-5027"],"issn-type":[{"value":"0901-5027","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}