{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:57:47Z","timestamp":1760101067217},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.ijom.2018.06.001","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T10:09:51Z","timestamp":1530353391000},"page":"1381-1388","source":"Crossref","is-referenced-by-count":5,"title":["Common polymorphism in the glycine N-methyltransferase gene as a novel risk factor for cleft lip with or without cleft palate"],"prefix":"10.1016","volume":"47","author":[{"given":"N.","family":"Karas Ku\u017eeli\u010dki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"\u0160mid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Eberlinc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ger\u0161ak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Mlinari\u010d-Ra\u0161\u010dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijom.2018.06.001_bib0005","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"Mossey","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ijom.2018.06.001_bib0010","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007950.pub2","article-title":"Effects and safety of periconceptional folate supplementation for preventing birth defects","volume":"10","author":"De-Regil","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ijom.2018.06.001_bib0015","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00394-015-1076-x","article-title":"The impact of MTHFR 677C\/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies","volume":"56","author":"Colson","year":"2017","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.ijom.2018.06.001_bib0020","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1399-0004.2006.00618.x","article-title":"Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population","volume":"69","author":"Mostowska","year":"2006","journal-title":"Clin Genet"},{"key":"10.1016\/j.ijom.2018.06.001_bib0025","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1002\/ajmg.a.35503","article-title":"Infants\u2019 MTHFR polymorphisms and nonsyndromic orofacial clefts susceptibility: a meta-analysis based on 17 case\u2013control studies","volume":"158A","author":"Pan","year":"2012","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ijom.2018.06.001_bib0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oxfordjournals.aje.a114086","article-title":"Reproducibility and validity of a semiquantitative food frequency questionnaire","volume":"122","author":"Willett","year":"1985","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ijom.2018.06.001_bib0035","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijom.2018.06.001_bib0040","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1073\/pnas.91.1.210","article-title":"Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver","volume":"91","author":"Yeo","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijom.2018.06.001_bib0045","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1158\/1078-0432.CCR-06-1551","article-title":"Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer","volume":"13","author":"Huang","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijom.2018.06.001_bib0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ymgme.2014.07.016","article-title":"Hyperhomocysteinemia: related genetic diseases and congenital defects, abnormal DNA methylation and newborn screening issues","volume":"113","author":"Iacobazzi","year":"2014","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.ijom.2018.06.001_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004214","article-title":"Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke","volume":"10","author":"Williams","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ijom.2018.06.001_bib0060","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1530\/REP-09-0517","article-title":"Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo","volume":"139","author":"Kwong","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.ijom.2018.06.001_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070062","article-title":"A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization","volume":"8","author":"DebRoy","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijom.2018.06.001_bib0070","first-page":"337","article-title":"Nonsyndromic cleft lip and palate: evidence of linkage to a microsatellite marker on 6p23","volume":"56","author":"Carinci","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ijom.2018.06.001_bib0075","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/0973-029X.92976","article-title":"A comprehensive review of the genetic basis of cleft lip and palate","volume":"16","author":"Kohli","year":"2012","journal-title":"J Oral Maxillofac Pathol"},{"key":"10.1016\/j.ijom.2018.06.001_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmg.2013.12.002","article-title":"Evidence of the involvement of the DHFR gene in nonsyndromic cleft lip with or without cleft palate","volume":"57","author":"Martinelli","year":"2014","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.ijom.2018.06.001_bib0085","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkp215","article-title":"Human Splicing Finder: an online bioinformatics tool to predict splicing signals","volume":"37","author":"Desmet","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijom.2018.06.001_bib0090","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/01.ede.0000254430.61294.c0","article-title":"Maternal smoking and environmental tobacco smoke exposure and the risk of orofacial clefts","volume":"18","author":"Honein","year":"2007","journal-title":"Epidemiology"},{"key":"10.1016\/j.ijom.2018.06.001_bib0095","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/ije\/dyn098","article-title":"Folate intake, markers of folate status and oral clefts: is the evidence converging?","volume":"37","author":"Johnson","year":"2008","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ijom.2018.06.001_bib0100","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1093\/jn\/134.11.3106","article-title":"Maternal nutritional status and the risk for orofacial cleft offspring in humans","volume":"134","author":"Krapels","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.ijom.2018.06.001_bib0105","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1177\/0022034513507452","article-title":"Micronutrients and oral clefts: a case\u2013control study","volume":"92","author":"McKinney","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.ijom.2018.06.001_bib0110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/01.ede.0000208348.30012.35","article-title":"Maternal nutrient intakes and risk of orofacial clefts","volume":"17","author":"Shaw","year":"2006","journal-title":"Epidemiology"},{"key":"10.1016\/j.ijom.2018.06.001_bib0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/bdra.20315","article-title":"Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysis","volume":"79","author":"Badovinac","year":"2007","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ijom.2018.06.001_bib0120","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/bdra.23133","article-title":"Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: an individual participant data pooled-analysis","volume":"97","author":"Butali","year":"2013","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ijom.2018.06.001_bib0125","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ijporl.2014.01.002","article-title":"A case\u2013control study of environmental exposures for nonsyndromic cleft of the lip and\/or palate in eastern Guangdong, China","volume":"78","author":"Lin","year":"2014","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.ijom.2018.06.001_bib0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijom.2012.10.008","article-title":"Current concepts on the effect of environmental factors on cleft lip and palate","volume":"42","author":"Molina-Solana","year":"2013","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.06.001_bib0135","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10654-013-9849-0","article-title":"Periconceptional folic acid associated with an increased risk of oral clefts relative to non-folate related malformations in the Northern Netherlands: a population based case\u2013control study","volume":"28","author":"Rozendaal","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ijom.2018.06.001_bib0140","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s10654-013-9862-3","article-title":"Is folic acid a risk factor for oral clefts?","volume":"28","author":"Czeizel","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ijom.2018.06.001_bib0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/bies.950180111","article-title":"Transcriptional regulation of the dihydrofolate reductase gene","volume":"18","author":"Slansky","year":"1996","journal-title":"Bioessays"},{"key":"10.1016\/j.ijom.2018.06.001_bib0150","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20130030","article-title":"Androgen response element of the glycine N-methyltransferase gene is located in the coding region of its first exon","volume":"33","author":"Lee","year":"2013","journal-title":"Biosci Rep"},{"key":"10.1016\/j.ijom.2018.06.001_bib0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139990","article-title":"An Sp1 modulated regulatory region unique to higher primates regulates human androgen receptor promoter activity in prostate cancer cells","volume":"10","author":"Hay","year":"2015","journal-title":"PLoS One"}],"container-title":["International Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502718302145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502718302145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T10:41:51Z","timestamp":1554288111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0901502718302145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0901502718302145"],"URL":"https:\/\/doi.org\/10.1016\/j.ijom.2018.06.001","relation":{},"ISSN":["0901-5027"],"issn-type":[{"value":"0901-5027","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}