{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:23:16Z","timestamp":1785576196042,"version":"3.56.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ijom.2018.09.006","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T10:47:41Z","timestamp":1539082061000},"page":"373-381","source":"Crossref","is-referenced-by-count":32,"title":["Impact of bisphosphonate therapy on dental implant outcomes: An overview of systematic review evidence"],"prefix":"10.1016","volume":"48","author":[{"given":"V.","family":"Mendes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.O.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Calasans-Maia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Granjeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5739-394X","authenticated-orcid":false,"given":"V.","family":"Moraschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijom.2018.09.006_bib0005","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1592\/phco.26.5.655","article-title":"Ibandronate, an experimental intravenous bisphosphonate for osteoporosis, bone metastases, and hypercalcemia of malignancy","volume":"26","author":"Guay","year":"2006","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ijom.2018.09.006_bib0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/8756-3282(95)00445-9","article-title":"Bisphosphonates: a review of their pharmacokinetic properties","volume":"18","author":"Lin","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.ijom.2018.09.006_bib0015","first-page":"34","article-title":"A systematic review assessing the effectiveness of alendronate in reducing periprosthetic bone loss after cementless primary THA","author":"Zeng","year":"2011","journal-title":"Orthopedics"},{"key":"10.1016\/j.ijom.2018.09.006_bib0020","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.ijom.2015.02.018","article-title":"Raloxifene enhances peri-implant bone healing in osteoporotic rats","volume":"44","author":"Ramalho-Ferreira","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0025","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1902\/jop.1999.70.10.1228","article-title":"Qualitative analysis of peripheral peri-implant bone and influence of alendronate sodium on early bone regeneration","volume":"70","author":"Meraw","year":"1999","journal-title":"J Periodontol"},{"key":"10.1016\/j.ijom.2018.09.006_bib0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2474-13-42","article-title":"Effect of local zoledronate on implant osseointegration in a rat model","volume":"22","author":"Back","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.ijom.2018.09.006_bib0035","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.ijom.2015.05.013","article-title":"Influence of the local application of sodium alendronate gel on osseointegration of titanium implants","volume":"44","author":"Guimar\u00e3es","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0040","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.bone.2012.02.001","article-title":"A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants","volume":"50","author":"Abtahi","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.ijom.2018.09.006_bib0045","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/0022034512472335","article-title":"Effect of local vs. systemic bisphosphonate delivery on dental implant fixation in a model of osteonecrosis of the jaw","volume":"92","author":"Abtahi","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.ijom.2018.09.006_bib0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ijom.2018.09.006_bib0055","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1111\/clr.12526","article-title":"What is the impact of bisphosphonate therapy upon dental implant survival? A systematic review and meta-analysis","volume":"27","author":"Ata-Ali","year":"2016","journal-title":"Clin Oral Implant Res"},{"key":"10.1016\/j.ijom.2018.09.006_bib0060","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1563\/AAID-JOI-D-11-00234","article-title":"Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: a systematic review","volume":"39","author":"Chadha","year":"2013","journal-title":"J Oral Implantol"},{"key":"10.1016\/j.ijom.2018.09.006_bib0065","first-page":"329","article-title":"Bisphosphonates and dental implants: a meta-analysis","volume":"47","author":"Chrcanovic","year":"2016","journal-title":"Quintessence Int"},{"key":"10.1016\/j.ijom.2018.09.006_bib0070","first-page":"e644","article-title":"Bisphosphonate treatment and dental implants: a systematic review","volume":"21","author":"de Freitas","year":"2016","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.ijom.2018.09.006_bib0075","series-title":"Cochrane handbook for systematic reviews of interventions version 4.2.6 [updated September 2006]","author":"Higgins","year":"2006"},{"key":"10.1016\/j.ijom.2018.09.006_bib0080","first-page":"7","article-title":"Utilization of the PICO framework to improve searching PubMed for clinical questions","volume":"15","author":"Schardt","year":"2007","journal-title":"BMC Med Inform Decis Mak"},{"key":"10.1016\/j.ijom.2018.09.006_bib0085","unstructured":"Grey Literature Report. The New York Academy of Medicine. http:\/\/www.greylit.org [Accessibility verified December 15, 2017]."},{"key":"10.1016\/j.ijom.2018.09.006_bib0090","unstructured":"OpenGrey. System for Information on Grey Literature in Europe. http:\/\/www.opengrey.eu [Accessibility verified December 15, 2017]."},{"key":"10.1016\/j.ijom.2018.09.006_bib0095","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"21","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.ijom.2018.09.006_bib0100","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/clr.12556","article-title":"Denosumab and osteonecrosis of the jaw. A systematic analysis of events reported in clinical trials","volume":"27","author":"Boquete-Castro","year":"2016","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.ijom.2018.09.006_bib0105","doi-asserted-by":"crossref","first-page":"878","DOI":"10.12968\/denu.2015.42.9.878","article-title":"Periodontal disease, dental implants, extractions and medications related to osteonecrosis of the jaws","volume":"42","author":"Shah","year":"2015","journal-title":"Dent Update"},{"key":"10.1016\/j.ijom.2018.09.006_bib0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1308\/205016815815944650","article-title":"Bisphosphonate and implant dentistry\u2014is it safe?","volume":"4","author":"Thirunavukarasu","year":"2015","journal-title":"Prim Dent J"},{"key":"10.1016\/j.ijom.2018.09.006_bib0115","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1902\/jop.2009.090587","article-title":"Osseointegration of dental implants in patients undergoing bisphosphonate treatment: a literature review","volume":"81","author":"Javed","year":"2010","journal-title":"J Periodontol"},{"key":"10.1016\/j.ijom.2018.09.006_bib0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40729-016-0041-7","article-title":"Dental implants in patients treated with antiresorptive medication\u00f6a systematic literature review","volume":"2","author":"Walter","year":"2016","journal-title":"Int J Implant Dent"},{"key":"10.1016\/j.ijom.2018.09.006_bib0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1563\/aaid-joi-16-00057","article-title":"Medication-related osteonecrosis of the jaw and dental implants failures: a systematic review","volume":"43","author":"Guazzo","year":"2017","journal-title":"J Oral Implantol"},{"key":"10.1016\/j.ijom.2018.09.006_bib0130","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.ijom.2017.04.014","article-title":"Does local delivery of bisphosphonates influence the osseointegration of titanium implants? A systematic review","volume":"46","author":"Guimar\u00e3es","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"Suppl 4","key":"10.1016\/j.ijom.2018.09.006_bib0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0501.2009.01772.x","article-title":"What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review","volume":"20","author":"Madrid","year":"2009","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.ijom.2018.09.006_bib0140","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijom.2018.09.006_bib0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/ebmed-2016-110401","article-title":"New evidence pyramid","volume":"21","author":"Murad","year":"2016","journal-title":"Evid Based Med"},{"key":"10.1016\/j.ijom.2018.09.006_bib0150","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","article-title":"Bisphosphonates: mechanism of action and role in clinical practice","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ijom.2018.09.006_bib0155","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2174\/1566524023362104","article-title":"Bisphosphonate mechanism action","volume":"2","author":"Rodan","year":"2002","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.ijom.2018.09.006_bib0160","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00198-007-0384-2","article-title":"Osteonecrosis of the jaw induced by orally administered bisphosphonates: incidence, clinical features, predisposing factors and treatment outcome","volume":"18","author":"Yarom","year":"2007","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ijom.2018.09.006_bib0165","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.tripleo.2006.10.010","article-title":"Osteonecrosis of the jaws associated with use of risedronate: report of 2 new cases","volume":"103","author":"Brooks","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.ijom.2018.09.006_bib0170","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1902\/jop.2007.060239","article-title":"Effect of long-term oral bisphosphonates on implant wound healing: literature review and a case report","volume":"78","author":"Wang","year":"2007","journal-title":"J Periodontol"},{"key":"10.1016\/j.ijom.2018.09.006_bib0175","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.joms.2010.02.037","article-title":"Oral bisphosphonate-associated osteonecrosis of the jaw after implant surgery: a case report and literature review","volume":"68","author":"Bedogni","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0180","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00198-009-0973-3","article-title":"Osteonecrosis of the jaw induced by oral administration of bisphosphonates in Asian population: five cases","volume":"21","author":"Park","year":"2010","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ijom.2018.09.006_bib0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1754-4505.2009.00128.x","article-title":"Bisphosphonate-associated osteonecrosis of the jaw, with healing after teriparatide: a review of the literature and a case report","volume":"30","author":"Narongroeknawin","year":"2010","journal-title":"Spec Care Dentist"},{"key":"10.1016\/j.ijom.2018.09.006_bib0190","first-page":"349","article-title":"Safety of oral bisphosphonates: controlled studies on alveolar bone","volume":"21","author":"Jeffcoat","year":"2006","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.ijom.2018.09.006_bib0195","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.joms.2007.12.040","article-title":"Oral bisphosphonates and dental implants: a retrospective study","volume":"66","author":"Bell","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0200","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.joms.2007.09.019","article-title":"Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases","volume":"66","author":"Grant","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0205","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijom.2014.10.023","article-title":"Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review","volume":"44","author":"Moraschini","year":"2015","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0210","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jcms.2011.05.003","article-title":"Bisphosphonate-related osteonecrosis of the jaws\u00fccharacteristics, risk factors, clinical features, localization and impact on oncological treatment","volume":"40","author":"Otto","year":"2012","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0215","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1601-0825.2010.01778.x","article-title":"Msx-1 is suppressed in bisphosphonate-exposed jaw bone analysis of bone turnover-related cell signalling after bisphosphonate treatment","volume":"17","author":"Wehrhan","year":"2011","journal-title":"Oral Dis"},{"key":"10.1016\/j.ijom.2018.09.006_bib0220","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00784-009-0312-2","article-title":"Expression profile and synthesis of different collagen types I, II, III, and V of human gingival fibroblasts, osteoblasts, and SaOS-2 cells after bisphosphonate treatment","volume":"14","author":"Simon","year":"2010","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.ijom.2018.09.006_bib0225","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2008.09.012","article-title":"Osteonecrosis of the jaw: who gets it, and why?","volume":"44","author":"Reid","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.ijom.2018.09.006_bib0230","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.1016\/j.jcms.2011.10.024","article-title":"The cytotoxic effects of three different bisphosphonates in-vitro on human gingival fibroblasts, osteoblasts and osteogenic sarcoma cells","volume":"40","author":"A\u00e7il","year":"2011","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0235","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jcms.2012.10.018","article-title":"Major histocompatibility complex class II polymorphisms are associated with the development of anti-resorptive agent-induced osteonecrosis of the jaw","volume":"41","author":"Stockmann","year":"2013","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0240","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.joms.2007.08.003","article-title":"Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment","volume":"65","author":"Marx","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0245","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.joms.2009.07.088","article-title":"CTX and its role in managing patients exposed to oral bisphosphonates","volume":"68","author":"Dodson","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0250","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1016\/j.joms.2009.04.067","article-title":"Correlation between serum C-terminal cross-linking telopeptide of type I collagen and staging of oral bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Kwon","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2018.09.006_bib0255","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ijom.2016.10.009","article-title":"Efficacy of the C-terminal telopeptide test in predicting the development of bisphosphonate-related osteonecrosis of the jaw: a systematic review","volume":"46","author":"Dal Pr\u00e1","year":"2017","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["International Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S090150271830376X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S090150271830376X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T17:51:49Z","timestamp":1549907509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S090150271830376X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S090150271830376X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijom.2018.09.006","relation":{},"ISSN":["0901-5027"],"issn-type":[{"value":"0901-5027","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}