{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:15:39Z","timestamp":1784110539914,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijoms.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.ijom.2019.10.015","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T00:40:52Z","timestamp":1573864852000},"page":"558-563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The prognostic significance of the lymph node ratio in oral cancer differs for anatomical subsites"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-7228","authenticated-orcid":false,"given":"J.","family":"Moratin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-1362","authenticated-orcid":false,"given":"Karl","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kansy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ristow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-0457","authenticated-orcid":false,"given":"C.","family":"Flechtenmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Freier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Freudlsperger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijom.2019.10.015_bib0005","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijom.2019.10.015_bib0010","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJMoa1506007","article-title":"Elective versus therapeutic neck dissection in node-negative oral cancer","volume":"373","author":"D\u2019Cruz","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijom.2019.10.015_bib0015","first-page":"305","article-title":"Neck involvement in early carcinoma of tongue. Is elective neck dissection warranted?","volume":"57","author":"Akhtar","year":"2007","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.ijom.2019.10.015_bib0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2019.10.015_bib0025","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijom.2019.10.015_bib0030","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1177\/0194599817750354","article-title":"Is perineural invasion of head and neck squamous cell carcinomas linked to tobacco consumption?","volume":"158","author":"Baumeister","year":"2018","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0035","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/jamaoto.2018.2974","article-title":"Association between lymph node ratio and recurrence and survival outcomes in patients with oral cavity cancer","volume":"145","author":"Ding","year":"2019","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0040","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/cncr.11202","article-title":"Extent of extracapsular spread: a critical prognosticator in oral tongue cancer","volume":"97","author":"Greenberg","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.ijom.2019.10.015_bib0045","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.athoracsur.2013.04.031","article-title":"Lymph node ratio predicts recurrence and survival after R0 resection for non-small cell lung cancer","volume":"96","author":"Taylor","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1748-717X-8-119","article-title":"Using the lymph nodal ratio to predict the risk of locoregional recurrence in lymph node-positive breast cancer patients treated with mastectomy without radiation therapy","volume":"8","author":"Wu","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijom.2019.10.015_bib0055","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s11605-008-0762-x","article-title":"Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: effect of number of metastatic lymph nodes and lymph node ratio","volume":"13","author":"Asiyanbola","year":"2009","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0060","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00428-016-2015-9","article-title":"A critical evaluation of lymph node ratio in head and neck cancer","volume":"469","author":"de Ridder","year":"2016","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ijom.2019.10.015_bib0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/jrms.JRMS_948_17","article-title":"The prognostic value of lymph node ratio in survival of head-and-neck squamous cell carcinoma","volume":"23","author":"Eshraghi Samani","year":"2018","journal-title":"J Res Med Sci"},{"key":"10.1016\/j.ijom.2019.10.015_bib0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.radonc.2017.06.018","article-title":"Lymph node ratio relationship to regional failure and distant metastases in oral cavity cancer","volume":"124","author":"Hosni","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2019.10.015_bib0075","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/jso.23387","article-title":"Can metastatic lymph node ratio (LNR) predict survival in oral cavity cancer patients?","volume":"108","author":"Sayed","year":"2013","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.ijom.2019.10.015_bib0080","doi-asserted-by":"crossref","first-page":"6708","DOI":"10.1038\/s41598-017-07134-7","article-title":"Lymph node ratio is associated with adverse clinicopathological features and is a crucial nodal parameter for oral and oropharyngeal cancer","volume":"7","author":"Feng","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijom.2019.10.015_bib0085","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.radonc.2012.09.022","article-title":"Lymph node ratio predicts the benefit of post-operative radiotherapy in oral cavity cancer","volume":"106","author":"Urban","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2019.10.015_bib0090","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jcms.2018.03.021","article-title":"The importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma","volume":"46","author":"Safi","year":"2018","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0095","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/bjc.2013.570","article-title":"Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research","volume":"109","author":"Patel","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijom.2019.10.015_bib0100","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.jcms.2018.05.053","article-title":"The prognostic relevance of lymph node ratio in patients with oral squamous cell carcinoma treated with neoadjuvant therapy regimen and radical surgery","volume":"46","author":"Rempel","year":"2018","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jcms.2017.11.021","article-title":"Lymph node ratio as prognosticator in floor of mouth squamous cell carcinoma patients","volume":"46","author":"Zirk","year":"2018","journal-title":"J Craniomaxillofac Surg"},{"issue":"Suppl 1","key":"10.1016\/j.ijom.2019.10.015_bib0110","article-title":"Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review","volume":"6","author":"Isayeva","year":"2012","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.ijom.2019.10.015_bib0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10006-012-0383-0","article-title":"The role of human papillomavirus in oral squamous cell carcinoma: myth and reality","volume":"18","author":"Kansy","year":"2014","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0120","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jcms.2018.01.002","article-title":"Squamous cell carcinoma of the maxilla: analysis of clinicopathological predictors for disease recurrence and metastatic behavior","volume":"46","author":"Moratin","year":"2018","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0125","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijsu.2018.03.073","article-title":"Lymphovascular invasion as a predictor for lymph node metastasis and a prognostic factor in gastric cancer patients under 70 years of age: a retrospective analysis","volume":"53","author":"Zhang","year":"2018","journal-title":"Int J Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0130","article-title":"The impact of lymphovascular invasion on risk of upstaging and lymph node metastasis at the time of radical cystectomy","author":"Werntz","year":"2018","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.ijom.2019.10.015_bib0135","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s10120-017-0785-7","article-title":"Lymphovascular invasion and lymph node metastasis rates in papillary adenocarcinoma of the stomach: implications for endoscopic resection","volume":"21","author":"Min","year":"2018","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.ijom.2019.10.015_bib0140","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1002\/hed.24922","article-title":"Importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the buccal mucosa","volume":"39","author":"Safi","year":"2017","journal-title":"Head Neck"},{"key":"10.1016\/j.ijom.2019.10.015_bib0145","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.jcms.2017.04.008","article-title":"The importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the tongue","volume":"45","author":"Safi","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.ijom.2019.10.015_bib0150","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jcms.2019.03.003","article-title":"The occurrence of cervical metastases in squamous cell carcinoma of the tongue: is there a rationale for bilateral neck dissection in early-stage tumors?","volume":"47","author":"Moratin","year":"2019","journal-title":"J Craniomaxillofac Surg"}],"container-title":["International Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S090150271931389X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S090150271931389X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:32:29Z","timestamp":1760272349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S090150271931389X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S090150271931389X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijom.2019.10.015","relation":{},"ISSN":["0901-5027"],"issn-type":[{"value":"0901-5027","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The prognostic significance of the lymph node ratio in oral cancer differs for anatomical subsites","name":"articletitle","label":"Article Title"},{"value":"International Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijom.2019.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}