{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:36:47Z","timestamp":1780601807275,"version":"3.54.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijoms.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.ijom.2020.02.002","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:56:54Z","timestamp":1585875414000},"page":"1464-1469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Unilateral condylar hyperplasia in hemifacial hyperplasia, is there genetic proof of overgrowth?"],"prefix":"10.1016","volume":"49","author":[{"given":"J.W.","family":"Nolte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.H.E.","family":"Karssemakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Becking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.M.","family":"Hennekam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijom.2020.02.002_bib0005","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4103\/0976-237X.86492","article-title":"Congenital hemifacial hyperplasia","volume":"2","author":"Deshingkar","year":"2011","journal-title":"Contemp Clin Dent"},{"key":"10.1016\/j.ijom.2020.02.002_bib0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0301-0503(86)80290-9","article-title":"Hemimandibular hyperplasia\u2013hemimandibular elongation","volume":"14","author":"Obwegeser","year":"1986","journal-title":"J Maxillofac Surg"},{"key":"10.1016\/j.ijom.2020.02.002_bib0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.joms.2009.07.033","article-title":"Unilateral condylar hyperactivity: a histopathologic analysis of 47 patients","volume":"68","author":"Saridin","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2020.02.002_bib0020","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.joms.2007.08.046","article-title":"The clinical characteristics of condylar hyperplasia: experience with 61 patients","volume":"66","author":"Nitzan","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2020.02.002_bib0025","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/bonekey.2015.21","article-title":"Missense mutation in the PTEN promoter of a patient with hemifacial hyperplasia","volume":"4","author":"Yamazaki","year":"2015","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.ijom.2020.02.002_bib0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJMoa1104017","article-title":"Mosaic activating mutation in AKT1 associated with the Proteus syndrome","volume":"365","author":"Lindhurst","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijom.2020.02.002_bib0035","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/ng.2332","article-title":"Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA","volume":"44","author":"Lindhurst","year":"2012","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.ijom.2020.02.002_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2014.12.069","article-title":"Lymphatic and other vascular malformative\/overgrowth disorders are caused by somatic mutations in PIK3CA","volume":"166","author":"Luks","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.ijom.2020.02.002_bib0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1834-7819.1969.tb03326.x","article-title":"Aetiology of condylar hyperplasia","author":"Egyedi","year":"1969","journal-title":"Aust Dent J"},{"key":"10.1016\/j.ijom.2020.02.002_bib0050","doi-asserted-by":"crossref","first-page":"160","DOI":"10.11622\/smedj.2013161","article-title":"A rare clinical case of true hemifacial hyperplasia","volume":"54","author":"Austin","year":"2013","journal-title":"Singap Med J"},{"key":"10.1016\/j.ijom.2020.02.002_bib0055","article-title":"Congenital hemifacial hyperplasia: clinical presentation and literature review","volume":"2016","author":"Shanmugasundaram","year":"2016","journal-title":"Case Rep Dent"},{"key":"10.1016\/j.ijom.2020.02.002_bib0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/cge.12832","article-title":"J. CLOVES syndrome: review of a PIK3CA-related overgrowth spectrum (PROS)","volume":"91","author":"Martinez-Lopez","year":"2017","journal-title":"Clin Genet"},{"key":"10.1016\/j.ijom.2020.02.002_bib0065","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/ajmg.c.31531","article-title":"Somatic overgrowth disorders of the PI3K\/AKT\/ mTOR pathway and therapeutic strategies","volume":"172C","author":"Keppler-Noreuil","year":"2016","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.ijom.2020.02.002_bib0070","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.87623","article-title":"PIK3CA-associated developmental disorders exhibit distinct classes of mutations with variable expression and tissue distribution","volume":"1","author":"Mirzaa","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.ijom.2020.02.002_bib0075","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1097\/00006534-199810000-00041","article-title":"Increased proliferative activity of osteoblasts in congenital hemifacial hypertrophy","volume":"102","author":"Yoshimoto","year":"1998","journal-title":"Plast Reconstr Surg"}],"container-title":["International Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502720300515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502720300515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:33:00Z","timestamp":1760272380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0901502720300515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0901502720300515"],"URL":"https:\/\/doi.org\/10.1016\/j.ijom.2020.02.002","relation":{},"ISSN":["0901-5027"],"issn-type":[{"value":"0901-5027","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unilateral condylar hyperplasia in hemifacial hyperplasia, is there genetic proof of overgrowth?","name":"articletitle","label":"Article Title"},{"value":"International Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijom.2020.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd on behalf of International Association of Oral and Maxillofacial Surgeons.","name":"copyright","label":"Copyright"}]}}