{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:55:13Z","timestamp":1772614513300,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijoms.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ijom.2022.01.003","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T22:19:55Z","timestamp":1643149195000},"page":"1251-1256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of adjuvant radiotherapy in locally advanced T4 mandible squamous cell carcinoma in the N0 patient: a single centre experience"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6552-337X","authenticated-orcid":false,"given":"C.W.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.W.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lee-Warder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"S2","key":"10.1016\/j.ijom.2022.01.003_bib0005","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1017\/S0022215116000499","article-title":"Oral cavity and lip cancer: United Kingdom National Multidisciplinary Guidelines","volume":"130","author":"Kerawala","year":"2016","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.ijom.2022.01.003_bib0010","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.4317\/medoral.18772","article-title":"Oral cancer: current role of radiotherapy and chemotherapy","volume":"18","author":"Huang","year":"2013","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.ijom.2022.01.003_bib0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-8140(01)00358-9","article-title":"Radiotherapy-related early morbidity in head and neck cancer: quantitative clinical radiobiology as deduced from the CHART trial","volume":"60","author":"Bentzen","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2022.01.003_bib0020","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/hed.24780","article-title":"Postoperative radiotherapy for patients with oral squamous cell carcinoma with intermediate risk of recurrence: a case match study","volume":"39","author":"Barry","year":"2017","journal-title":"Head Neck"},{"key":"10.1016\/j.ijom.2022.01.003_bib0025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bjoms.2011.08.014","article-title":"Systematic review of the current evidence in the use of postoperative radiotherapy for oral squamous cell carcinoma","volume":"50","author":"Brown","year":"2012","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2022.01.003_bib0030","series-title":"AJCC cancer staging manual","article-title":"Springer International Publishing","author":"American Joint Committee on Cancer","year":"2009"},{"key":"10.1016\/j.ijom.2022.01.003_bib0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijom.2016.09.014","article-title":"Prognostic factors in mandibular gingival squamous cell carcinoma: a 10-year retrospective study","volume":"46","author":"Niu","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2022.01.003_bib0040","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/lary.26211","article-title":"Impact of mandibular invasion on prognosis in oral squamous cell carcinoma four centimeters or less in size","volume":"127","author":"Fives","year":"2017","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijom.2022.01.003_bib0045","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/MLG.0b013e31816422bb","article-title":"The prognostic impact of extent of bone invasion and extent of bone resection in oral carcinoma","volume":"118","author":"Patel","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijom.2022.01.003_bib0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000048242","article-title":"Squamous cell carcinomas of the mandibular alveolus: analysis of prognostic factors","volume":"62","author":"Shingaki","year":"2002","journal-title":"Oncology"},{"key":"10.1016\/j.ijom.2022.01.003_bib0055","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.joms.2003.05.014","article-title":"Treatment of head and neck cancer with bone or cartilage invasion by surgery and postoperative radiotherapy","volume":"62","author":"Ampil","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2022.01.003_bib0060","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/COC.0b013e31819380a8","article-title":"Treatment outcomes of T4 locally advanced head and neck cancers with soft tissue invasion or bone and cartilage invasion","volume":"32","author":"Do","year":"2009","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijom.2022.01.003_bib0065","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/COC.0b013e3181bead63","article-title":"Prognostic significance of bone or cartilage invasion of locally advanced head and neck cancers","volume":"33","author":"Do","year":"2010","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijom.2022.01.003_bib0070","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1001\/jama.291.20.2441","article-title":"Prognostic importance of comorbidity in a hospital-based cancer registry","volume":"291","author":"Piccirillo","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ijom.2022.01.003_bib0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijom.2020.06.006","article-title":"The utility of postoperative radiotherapy in intermediate-risk oral squamous cell carcinoma","volume":"50","author":"Liu","year":"2021","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2022.01.003_bib0080","series-title":"Standards and datasets for reporting cancers. Dataset for histopathology reporting of mucosal malignancies of the oral cavity","first-page":"9","author":"Helliwell","year":"2013"},{"key":"10.1016\/j.ijom.2022.01.003_bib0085","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/jamaoto.2016.4238","article-title":"A proposal to redefine close surgical margins in squamous cell carcinoma of the oral tongue","volume":"143","author":"Zanoni","year":"2017","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijom.2022.01.003_bib0090","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1001\/jamaoto.2017.0548","article-title":"Definition of \u201cclose margin\u201d in oral cancer surgery and association of margin distance with local recurrence rate","volume":"143","author":"Tasche","year":"2017","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijom.2022.01.003_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104913","article-title":"The relevance of surgical margins in clinically early oral squamous cell carcinoma","volume":"110","author":"Bajwa","year":"2020","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijom.2022.01.003_bib0100","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3389\/fonc.2019.01125","article-title":"A review of controversial issues in the management of head and neck cancer: a Swiss multidisciplinary and multi-institutional patterns of care study\u2014part 1 (head and neck surgery)","volume":"9","author":"Dulguerov","year":"2019","journal-title":"Front Oncol"}],"container-title":["International Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502722000054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502722000054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:36:14Z","timestamp":1760272574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0901502722000054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0901502722000054"],"URL":"https:\/\/doi.org\/10.1016\/j.ijom.2022.01.003","relation":{},"ISSN":["0901-5027"],"issn-type":[{"value":"0901-5027","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of adjuvant radiotherapy in locally advanced T4 mandible squamous cell carcinoma in the N0 patient: a single centre experience","name":"articletitle","label":"Article Title"},{"value":"International Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijom.2022.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}