{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:43:46Z","timestamp":1768351426748,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijoms.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ijom.2022.01.014","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T07:53:39Z","timestamp":1643874819000},"page":"1264-1272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment outcomes of proton beam therapy combined with retrograde intra-arterial infusion chemotherapy for locally advanced oral cancer in the elderly"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1204-5807","authenticated-orcid":false,"given":"T.","family":"Kitabatake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-0337","authenticated-orcid":false,"given":"M.","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mitsudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijom.2022.01.014_bib0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11864-009-0105-5","article-title":"Combined modality therapy in the elderly population","volume":"10","author":"Lin","year":"2009","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0010","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1200\/jco.2004.22.90140.5505","article-title":"Update of MACH-NC (Meta-Analysis of Chemotherapy in Head & Neck Cancer) database focused on concomitant chemoradiotherapy","volume":"22","author":"Bourhis","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0015","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.critrevonc.2005.04.010","article-title":"Adjuvant chemo- and radiotherapy for poor prognosis head and neck squamous cell carcinomas","volume":"56","author":"Bernier","year":"2005","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomized trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0025","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.radonc.2014.03.005","article-title":"Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: analysis of therapeutic results in 112 cases","volume":"111","author":"Mitsudo","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0030","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/archotol.132.11.1242","article-title":"Proton beam radiation therapy for skull base adenoid cystic carcinoma","volume":"132","author":"Pommier","year":"2006","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijom.2022.01.014_bib0035","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/hed.21092","article-title":"Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors","volume":"31","author":"Truong","year":"2009","journal-title":"Head Neck"},{"key":"10.1016\/j.ijom.2022.01.014_bib0040","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00432-015-2069-0","article-title":"Treatment results of alternating chemoradiotherapy followed by proton beam therapy boost combined with intra-arterial infusion chemotherapy for stage III\u2013IVB tongue cancer","volume":"142","author":"Takayama","year":"2016","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0045","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3390\/cancers11101413","article-title":"Proton beam therapy combined with intra-arterial infusion chemotherapy for stage IV adenoid cystic carcinoma of the base of the tongue","volume":"11","author":"Takayama","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijom.2022.01.014_bib0050","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.tripleo.2007.07.031","article-title":"A new method of selective intra-arterial infusion therapy via the superficial temporal artery for head and neck cancer","volume":"105","author":"Fuwa","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.ijom.2022.01.014_bib0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/jjco\/hyv160","article-title":"Preliminary results of proton beam therapy combined with weekly cisplatin intra-arterial infusion via a superficial temporal artery for treatment of maxillary sinus carcinoma","volume":"46","author":"Nakamura","year":"2016","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0060","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.radonc.2012.10.006","article-title":"Bioeffect modeling and equieffective dose concepts in radiation oncology\u2014terminology, quantities and units","volume":"105","author":"Bentzen","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fonc.2016.00199","article-title":"Treatment of elderly patients with squamous cell carcinoma of the head and neck","volume":"6","author":"Szturz","year":"2016","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0070","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2794","article-title":"Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD","volume":"4","author":"Tsai","year":"2016","journal-title":"Peer J"},{"key":"10.1016\/j.ijom.2022.01.014_bib0075","article-title":"Nomograms to predict survival of stage IV tongue squamous cell carcinoma after surgery","volume":"98","author":"Sun","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ijom.2022.01.014_bib0080","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/hed.21891","article-title":"Multi-agent concurrent chemoradiotherapy for locally advanced head and neck squamous cell cancer in the elderly","volume":"34","author":"Michal","year":"2012","journal-title":"Head Neck"},{"key":"10.1016\/j.ijom.2022.01.014_bib0085","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jgo.2013.05.003","article-title":"Survival and selected outcomes of older adults with locally advanced head\/neck cancer treated with chemoradiation therapy","volume":"4","author":"Maggiore","year":"2013","journal-title":"J Geriatr Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0090","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4103\/ijc.IJC_725_18","article-title":"Concurrent chemotherapy for head and neck cancer in older patient: Outcomes and their determinants","volume":"56","author":"Srinivasalu","year":"2019","journal-title":"Indian J Cancer"},{"key":"10.1016\/j.ijom.2022.01.014_bib0095","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s00405-011-1489-y","article-title":"Functional organ preservation after chemoradiotherapy in elderly patients with loco- regionally advanced head and neck squamous cell carcinoma","volume":"268","author":"Boscolo-Rizzo","year":"2011","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0100","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00066-012-0125-0","article-title":"Impact of intensity-modulated and image-guided radiotherapy on elderly patients undergoing chemoradiation for locally advanced head and neck cancer","volume":"188","author":"Nguyen","year":"2012","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0105","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.amjoto.2013.07.010","article-title":"Feasibility and toxicity of concurrent chemoradiation for elderly patients with head and neck cancer","volume":"34","author":"Daly","year":"2013","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13014-020-1481-z","article-title":"Radiotherapy for geriatric head-and-neck cancer patients: what is the value of standard treatment in the elderly?","volume":"15","author":"Haehl","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0115","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13014-017-0847-3","article-title":"Clinical outcomes of retrograde intra-arterial chemotherapy concurrent with radiotherapy for elderly oral squamous cell carcinoma patients aged over 80 years old","volume":"12","author":"Hayashi","year":"2017","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0120","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1200\/JCO.1994.12.10.2113","article-title":"Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer","volume":"12","author":"Robbins","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0125","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.radonc.2015.12.008","article-title":"Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation","volume":"118","author":"Romesser","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0130","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","article-title":"Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis","volume":"26","author":"Machtay","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0135","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/BF02493488","article-title":"Case report: aspiration from delayed fibrosis of the neck","volume":"6","author":"Eisele","year":"1990","journal-title":"Dysphagia"},{"key":"10.1016\/j.ijom.2022.01.014_bib0140","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ijrobp.2004.05.050","article-title":"Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: which anatomic structures are affected and can they be spared by IMRT?","volume":"60","author":"Eisbruch","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijom.2022.01.014_bib0145","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ctrv.2017.07.003","article-title":"Treatment of late sequelae after radiotherapy for head and neck cancer","volume":"59","author":"Strojan","year":"2017","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ijom.2022.01.014_bib0150","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.radonc.2020.08.013","article-title":"Non-operative management for oral cavity carcinoma: definitive radiation therapy as a potential alternative treatment approach","volume":"154","author":"Hosni","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0155","first-page":"18","article-title":"Surgery vs. primary radiotherapy in early-stage oropharyngeal cancer","volume":"9","author":"Pedro","year":"2018","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ijom.2022.01.014_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3508795","article-title":"Chemoradiotherapy as definitive treatment for elderly patients with head and neck cancer","volume":"2018","author":"M\u00fcller von der Gr\u00fcn","year":"2018","journal-title":"Biomed Res Int"}],"container-title":["International Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502722000297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502722000297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:36:48Z","timestamp":1760272608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0901502722000297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0901502722000297"],"URL":"https:\/\/doi.org\/10.1016\/j.ijom.2022.01.014","relation":{},"ISSN":["0901-5027"],"issn-type":[{"value":"0901-5027","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment outcomes of proton beam therapy combined with retrograde intra-arterial infusion chemotherapy for locally advanced oral cancer in the elderly","name":"articletitle","label":"Article Title"},{"value":"International Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijom.2022.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}