{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:46:20Z","timestamp":1790451980204,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ijoms.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Oral and Maxillofacial Surgery"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ijom.2026.04.011","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:34:18Z","timestamp":1776944058000},"page":"1113-1122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of horizontal and extended platelet-rich fibrin on soft tissue healing and outcomes after impacted mandibular third molar extraction: a controlled trial"],"prefix":"10.1016","volume":"55","author":[{"given":"A.","family":"Haskic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hadziabdic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Miron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijom.2026.04.011_bib1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.coms.2006.11.013","article-title":"Complications of third molar surgery","volume":"19","author":"Bouloux","year":"2007","journal-title":"Oral Maxillofac Surg Clin N\u00a0Am"},{"key":"10.1016\/j.ijom.2026.04.011_bib2","article-title":"Antibiotics to prevent complications following tooth extractions","volume":"2","author":"Lodi","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ijom.2026.04.011_bib3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.adaj.2018.02.012","article-title":"Benefits and harms associated with analgesic medications used in the management of acute dental pain","volume":"149","author":"Moore","year":"2018","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ijom.2026.04.011_bib4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jormas.2020.02.004","article-title":"Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus following lower third molar removal: a randomized controlled clinical trial","volume":"121","author":"Torul","year":"2020","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00784-019-03156-9","article-title":"Effect of platelet-rich fibrin on cell proliferation, migration, differentiation, inflammation, and osteoclastogenesis: a systematic review of in vitro studies","volume":"24","author":"Strauss","year":"2020","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.ijom.2026.04.011_bib6","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00784-017-2133-z","article-title":"Use of platelet-rich fibrin in regenerative dentistry: a systematic review","volume":"21","author":"Miron","year":"2017","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.ijom.2026.04.011_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/prd.12521","article-title":"Optimization of platelet-rich fibrin","volume":"94","author":"Miron","year":"2024","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.ijom.2026.04.011_bib8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12903-020-01299-w","article-title":"Evaluation of 24 protocols for the production of platelet-rich fibrin","volume":"20","author":"Miron","year":"2020","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.ijom.2026.04.011_bib9","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/jbm.a.36734","article-title":"A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation","volume":"107","author":"Miron","year":"2019","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.ijom.2026.04.011_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/09537104.2020.1717455","article-title":"Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF)","volume":"32","author":"Fujioka-Kobayashi","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.ijom.2026.04.011_bib11","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/prd.12537","article-title":"Extended platelet-rich fibrin","volume":"94","author":"Miron","year":"2024","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.ijom.2026.04.011_bib12","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.3390\/app11041666","article-title":"Effects of leukocyte-platelet-rich fibrin (L\u2013PRF) on pain, soft tissue healing, growth factors, and cytokines after third molar extraction: a randomized, split-mouth, double-blinded clinical trial","volume":"11","author":"Da Silva","year":"2021","journal-title":"Appl Sci"},{"key":"10.1016\/j.ijom.2026.04.011_bib13","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.ijom.2019.01.020","article-title":"Randomized double-blind clinical trial evaluation of bone healing after third molar surgery with the use of leukocyte- and platelet-rich fibrin","volume":"48","author":"Ritto","year":"2019","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jormas.2020.04.008","article-title":"Advanced\u2013PRF: clinical evaluation in impacted mandibular third molar sockets","volume":"122","author":"Gupta","year":"2021","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib15","doi-asserted-by":"crossref","first-page":"e433","DOI":"10.4317\/medoral.25856","article-title":"Evaluation of bone repair with platelet-rich fibrin following the extraction of impacted third molars \u2013 randomized clinical trial","volume":"28","author":"Rodrigues","year":"2023","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.ijom.2026.04.011_bib16","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.joms.2014.11.013","article-title":"Evaluation of treatment outcome after impacted mandibular third molar surgery with the use of autologous platelet-rich fibrin: a randomized controlled clinical study","volume":"73","author":"Kumar","year":"2015","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib17","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/09537104.2020.1754382","article-title":"Histological comparison of platelet rich fibrin clots prepared by fixed-angle versus horizontal centrifugation","volume":"32","author":"Fujioka-Kobayashi","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.ijom.2026.04.011_bib18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/09537104.2020.1775188","article-title":"vivo evaluation of the biocompatibility and biodegradation of a new denatured plasma membrane combined with liquid PRF (Alb-PRF)","volume":"32","author":"Gheno","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.ijom.2026.04.011_bib19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1054\/bjom.2001.0684","article-title":"Classification of surgical difficulty in extracting impacted third molars","volume":"40","author":"Yuasa","year":"2002","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition","volume":"22","author":"Silness","year":"1964","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.ijom.2026.04.011_bib21","first-page":"105","article-title":"Effectiveness of benzydamine HCl in the treatment of periodontal post-surgical patients","volume":"10","author":"Landry","year":"1988","journal-title":"Res Clin Forums"},{"key":"10.1016\/j.ijom.2026.04.011_bib22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1079-2104(03)00464-5","article-title":"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery","volume":"96","author":"\u00dcst\u00fcn","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.ijom.2026.04.011_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1054\/ijom.2002.0263","article-title":"Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review","volume":"31","author":"Blum","year":"2002","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"4S","key":"10.1016\/j.ijom.2026.04.011_bib24","article-title":"Risk factors for post-extraction infection of mandibular third molar: a retrospective clinical study","volume":"125","author":"Mukainaka","year":"2024","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12903-019-0824-3","article-title":"Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis","volume":"19","author":"Xiang","year":"2019","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.ijom.2026.04.011_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bjoms.2015.10.015","article-title":"Platelet-rich fibrin: the benefits","volume":"54","author":"Kumar","year":"2016","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib27","first-page":"377","article-title":"Influence of leukocyte- and platelet-rich fibrin (L-PRF) on the outcomes of impacted mandibular third molar removal surgery: a split-mouth randomized clinical trial","volume":"49","author":"Daugela","year":"2018","journal-title":"Quintessence Int"},{"key":"10.1016\/j.ijom.2026.04.011_bib28","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.joms.2021.07.006","article-title":"Application of platelet-rich fibrin derivatives for mandibular third molar extraction related post-operative sequelae: a systematic review and network meta-analysis","author":"Bao","year":"2021","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib29","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ijom.2020.08.014","article-title":"Effect of platelet-rich fibrin on the control of alveolar osteitis, pain, trismus, soft tissue healing, and swelling following mandibular third molar surgery: an updated systematic review and meta-analysis","author":"Zhu","year":"2021","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/jbm.b.34680","article-title":"Effects of rotor angle and time after centrifugation on the biological in vitro properties of platelet rich fibrin membranes","volume":"109","author":"Louren\u00e7o","year":"2021","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.ijom.2026.04.011_bib31","first-page":"537","article-title":"Histological evaluation of gingival and intrabony periodontal defects treated with platelet-rich fibrin using different protocols: a canine study","volume":"19","author":"Shirakata","year":"2021","journal-title":"Oral Health Prev Dent"},{"key":"10.1016\/j.ijom.2026.04.011_bib32","doi-asserted-by":"crossref","DOI":"10.1080\/09537104.2023.2228417","article-title":"Effects of platelet-rich fibrin produced by three centrifugation protocols on bone neoformation in defects created in rat calvaria","volume":"34","author":"Ferreira S\u00e1vio","year":"2023","journal-title":"Platelets"},{"key":"10.1016\/j.ijom.2026.04.011_bib33","article-title":"Comparison between autologous albumin gel and liquid platelet-rich fibrin mixture versus connective tissue graft to modify the gingival phenotype: a randomized controlled trial","volume":"16","author":"Abdulhak","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.ijom.2026.04.011_bib34","article-title":"Horizontal platelet-rich fibrin in vestibuloplasty: a case report","volume":"16","author":"Dal Pont","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.ijom.2026.04.011_bib35","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joms.2024.02.003","article-title":"Effect of advanced platelet-rich fibrin (A-PRF) on postoperative level of pain and swelling following third molar surgery","volume":"82","author":"Praganta","year":"2024","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib36","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.ijom.2021.11.014","article-title":"The use of advanced platelet-rich fibrin after surgical removal of mandibular third molars: a systematic review and meta-analysis","volume":"51","author":"Vitenson","year":"2022","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3390\/jfb14100505","article-title":"Clinical and biochemical evaluation of the use of Alb-PRF versus L-PRF in mandibular third molar extractions: a split-mouth randomized clinical trial","volume":"14","author":"Javid","year":"2023","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.ijom.2026.04.011_bib38","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.ijom.2017.04.006","article-title":"Evaluation of postoperative complications after mandibular third molar surgery with the use of platelet-rich fibrin: a systematic review and meta-analysis","volume":"46","author":"Canellas","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijom.2026.04.011_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12903-021-01497-0","article-title":"A technical note on contamination from PRF tubes containing silica and silicone","volume":"21","author":"Miron","year":"2021","journal-title":"BMC Oral Health"}],"container-title":["International Journal of Oral and Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502726001529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0901502726001529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:42:57Z","timestamp":1785253377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0901502726001529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0901502726001529"],"URL":"https:\/\/doi.org\/10.1016\/j.ijom.2026.04.011","relation":{},"ISSN":["0901-5027"],"issn-type":[{"value":"0901-5027","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of horizontal and extended platelet-rich fibrin on soft tissue healing and outcomes after impacted mandibular third molar extraction: a controlled trial","name":"articletitle","label":"Article Title"},{"value":"International Journal of Oral and Maxillofacial Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijom.2026.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}