{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:32Z","timestamp":1791229472705,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.ijpara.2005.01.008","type":"journal-article","created":{"date-parts":[[2005,3,12]],"date-time":"2005-03-12T15:56:18Z","timestamp":1110642978000},"page":"637-646","source":"Crossref","is-referenced-by-count":36,"title":["Differential effects of polyamine derivative compounds against Leishmania infantum promastigotes and axenic amastigotes"],"prefix":"10.1016","volume":"35","author":[{"given":"J.","family":"Tavares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ouaissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.K.T.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tom\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cordeiro-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2005.01.008_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.cdd.4400950","article-title":"On the origin, evolution, and nature of programmed cell death: a timeline of four billion years","volume":"9","author":"Ameisen","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ijpara.2005.01.008_bib2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/sj.cdd.4400951","article-title":"On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization","volume":"9","author":"Arnoult","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ijpara.2005.01.008_bib3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0966-842X(98)01433-4","article-title":"Recent advances in identifying and validating drug targets in trypanosomes and leishmanias","volume":"7","author":"Barrett","year":"1999","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ijpara.2005.01.008_bib4","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1097\/00002030-199910010-00015","article-title":"HIV viral load and response to antileishmanial chemotherapy in co-infected patients","volume":"13","author":"Berhe","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.ijpara.2005.01.008_bib5","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0968-0896(97)00070-9","article-title":"New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase","volume":"5","author":"Bonnet","year":"1997","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ijpara.2005.01.008_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0968-0896(99)00268-0","article-title":"Trypanothione reductase inhibition\/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series","volume":"8","author":"Bonnet","year":"2000","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijpara.2005.01.008_bib7","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0891-5849(02)01089-4","article-title":"Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum","volume":"33","author":"Castro","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijpara.2005.01.008_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0165-2478(03)00020-8","article-title":"Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) protein homologue during canine natural infections: pathological implications","volume":"86","author":"Cordeiro-da-Silva","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ijpara.2005.01.008_bib9","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.pt.2003.09.008","article-title":"Leishmaniasis\u2014current chemotherapy and recent advances in the search for novel drugs","volume":"19","author":"Croft","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2005.01.008_bib10","first-page":"4944","article-title":"The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects","volume":"59","author":"Dai","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijpara.2005.01.008_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1677\/erc.0.0060069","article-title":"Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment","volume":"6","author":"Davidson","year":"2000","journal-title":"Endocrinol. Related Cancer"},{"key":"10.1016\/j.ijpara.2005.01.008_bib12","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0006-3495(88)83158-8","article-title":"Membrane potential can be determined in individual cells from the nernstian distribution of cationic dyes","volume":"53","author":"Ehrenberg","year":"1988","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijpara.2005.01.008_bib13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1146\/annurev.mi.46.100192.003403","article-title":"Metabolism and functions of trypanothione in the kinetoplastida","volume":"46","author":"Fairlamb","year":"1992","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ijpara.2005.01.008_bib14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/14756369709029312","article-title":"Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine","volume":"12","author":"Garforth","year":"1997","journal-title":"J. Enzyme Inhib."},{"key":"10.1016\/j.ijpara.2005.01.008_bib15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0014-5793(01)03091-5","article-title":"Spermidine is essential for normal proliferation of trypanosomatid protozoa","volume":"508","author":"Gonzalez","year":"2001","journal-title":"Fed. Eur. Biol. Soc. Lett."},{"key":"10.1016\/j.ijpara.2005.01.008_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0304-3835(99)00208-6","article-title":"Strain-specific differences in formation of apoptotic DNA leaders in MCF-7 breast cancer cells","volume":"144","author":"Gooch","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijpara.2005.01.008_bib17","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1073\/pnas.94.21.11557","article-title":"The role of polyamine catabolism in polyamine-induced programmed cell death","volume":"94","author":"Ha","year":"1997","journal-title":"Proc. Natl Acad. Sci."},{"key":"10.1016\/j.ijpara.2005.01.008_bib18","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0169-4758(99)01516-1","article-title":"Enzymes of parasite thiol metabolism as drug targets","volume":"15","author":"Krauth-Siegel","year":"1999","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.ijpara.2005.01.008_bib19","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/S0960-894X(00)00293-6","article-title":"The synthesis and in vitro cytotoxic studies of novel bis-naphthalimidopropyl polyamine derivatives","volume":"10","author":"Lin","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ijpara.2005.01.008_bib20","first-page":"2071","article-title":"Induction of programmed cell death in human breast cancer cells by an unsymetrically alkylated polyamine analogue","volume":"53","author":"McCloskey","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijpara.2005.01.008_bib21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S1471-4922(01)01908-0","article-title":"Targeting polyamines of parasitic protozoa in chemotherapy","volume":"17","author":"Muller","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2005.01.008_bib22","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1128\/AAC.45.8.2185-2197.2001","article-title":"Clinical and experimental advances in treatment of visceral Leishmaniasis","volume":"45","author":"Murry","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpara.2005.01.008_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(91)90198-O","article-title":"A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry","volume":"139","author":"Nicoletti","year":"1991","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ijpara.2005.01.008_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-9292-2-5","article-title":"Apoptosis-like death in trypanosomatids: Search for putative pathways and genes involved","volume":"2","author":"Ouaissi","year":"2003","journal-title":"Kinetoplastid Biol. Dis."},{"key":"10.1016\/j.ijpara.2005.01.008_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0009-2797(01)00165-X","article-title":"Cytotoxicity, DNA binding and localisation of novel bis-naphthalimidopropyl polyamine derivatives","volume":"137","author":"Pavlov","year":"2000","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ijpara.2005.01.008_bib26","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0024-3205(02)01832-5","article-title":"Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells","volume":"71","author":"Pavlov","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.ijpara.2005.01.008_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0166-6851(01)00293-6","article-title":"Genetic analysis of spermidine synthase from Leishmania donovani","volume":"115","author":"Roberts","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2005.01.008_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0006-3495(99)77214-0","article-title":"Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives","volume":"76","author":"Scaduto","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijpara.2005.01.008_bib29","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1128\/AAC.41.5.972","article-title":"Axenically cultured amastigote forms as an in vitro model for investigation of antileishmanial agents","volume":"41","author":"Sereno","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpara.2005.01.008_bib30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/PL00000852","article-title":"Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications","volume":"58","author":"Thomas","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijpara.2005.01.008_bib31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-2958.1998.00968.x","article-title":"Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tyrA gene locus","volume":"29","author":"Tovar","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijpara.2005.01.008_bib32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","article-title":"A novel assay for apoptosis. Flow cytometry detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V","volume":"184","author":"Vernes","year":"1995","journal-title":"J. Immunol. Mehods"},{"key":"10.1016\/j.ijpara.2005.01.008_bib33","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pt.2003.09.010","article-title":"Drugs for the control of parasitic diseases: current status and development","volume":"19","author":"Watkins","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2005.01.008_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0091-679X(01)65009-X","article-title":"Measurement of membrane permeability and permeability transition of mitochondria","volume":"65","author":"Zamzami","year":"2001","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.ijpara.2005.01.008_bib35","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/sj.cdd.4401071","article-title":"Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?","volume":"9","author":"Zangger","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ijpara.2005.01.008_bib36","volume":"vol. 1","author":"Zuckeman","year":"1977"}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751905000391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751905000391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T17:11:43Z","timestamp":1549213903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751905000391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0020751905000391"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2005.01.008","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}