{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:18:34Z","timestamp":1791166714240,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.ijpara.2006.02.005","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T08:45:47Z","timestamp":1142325947000},"page":"541-546","source":"Crossref","is-referenced-by-count":122,"title":["Cerebral malaria: role of microparticles and platelets in alterations of the blood\u2013brain barrier"],"prefix":"10.1016","volume":"36","author":[{"given":"Val\u00e9ry","family":"Combes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Coltel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Faille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Crocodile","family":"Wassmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges Emile","family":"Grau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ijpara.2006.02.005_bib1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S1471-4922(02)02353-X","article-title":"Breaking down the blood\u2013brain barrier: signaling a path to cerebral malaria?","volume":"18","author":"Adams","year":"2002","journal-title":"Trends Parasitol."},{"issue":"2","key":"10.1016\/j.ijpara.2006.02.005_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2249.2003.02174.x","article-title":"The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology","volume":"133","author":"Artavanis-Tsakonas","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ijpara.2006.02.005_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0169-4758(94)90238-0","article-title":"Cerebral malaria: the sequestration hypothesis","volume":"10","author":"Berendt","year":"1994","journal-title":"Parasitol. Today"},{"issue":"3\u20134","key":"10.1016\/j.ijpara.2006.02.005_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4269\/ajtmh.2001.64.207","article-title":"Blood\u2013brain barrier function in cerebral malaria in malawian children","volume":"64","author":"Brown","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpara.2006.02.005_bib5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0169-4758(94)90237-2","article-title":"The cytokine theory of human cerebral malaria","volume":"10","author":"Clark","year":"1994","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.ijpara.2006.02.005_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1567202043480116","article-title":"Cerebral malaria\u2014a neurovascular pathology with many riddles still to be solved","volume":"1","author":"Coltel","year":"2004","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.ijpara.2006.02.005_bib7","unstructured":"Coltel, N., Combes, V., Wassmer, S.C., Chimini, G., Grau, G.E. (in press). Cell vesiculation and immunopathology: implications in cerebral malaria. Microbes Infect."},{"issue":"1","key":"10.1016\/j.ijpara.2006.02.005_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI4985","article-title":"In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant","volume":"104","author":"Combes","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"21","key":"10.1016\/j.ijpara.2006.02.005_bib9","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1001\/jama.291.21.2542-b","article-title":"Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma","volume":"291","author":"Combes","year":"2004","journal-title":"J. Am. Med. Assoc."},{"issue":"1","key":"10.1016\/j.ijpara.2006.02.005_bib10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0002-9440(10)62253-5","article-title":"ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology","volume":"166","author":"Combes","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijpara.2006.02.005_bib11","first-page":"141","article-title":"Cerebral malaria: which model? which parasite?","volume":"2","author":"Combes","year":"2005","journal-title":"Drug Discov. Today"},{"issue":"3","key":"10.1016\/j.ijpara.2006.02.005_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1286-4579(02)01541-1","article-title":"Cerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis","volume":"4","author":"de Souza","year":"2002","journal-title":"Microbes Infect."},{"issue":"5","key":"10.1016\/j.ijpara.2006.02.005_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/cyto.2002.1042","article-title":"Synergistic induction of apoptosis in human endothelial cells by tumour necrosis factor-alpha and transforming growth factor-beta","volume":"18","author":"Emmanuel","year":"2002","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.ijpara.2006.02.005_bib14","doi-asserted-by":"crossref","first-page":"686","DOI":"10.4269\/ajtmh.2002.66.686","article-title":"Prognostic value of thrombocytopenia in African children with falciparum malaria","volume":"66","author":"Gerardin","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpara.2006.02.005_bib15","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0169-4758(94)90236-4","article-title":"Cerebral malaria: mediators, mechanical obstruction or more?","volume":"10","author":"Grau","year":"1994","journal-title":"Parasitol. Today"},{"issue":"24","key":"10.1016\/j.ijpara.2006.02.005_bib16","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1056\/NEJM198906153202404","article-title":"Tumor necrosis factor and disease severity in children with falciparum malaria","volume":"320","author":"Grau","year":"1989","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.ijpara.2006.02.005_bib17","first-page":"415","article-title":"TNF-induced microvascular pathology: active role for platelets and importance of the LFA-1\/ICAM-1 interaction","volume":"4","author":"Grau","year":"1993","journal-title":"Eur. Cytokine Netw."},{"issue":"3","key":"10.1016\/j.ijpara.2006.02.005_bib18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1086\/367960","article-title":"Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria","volume":"187","author":"Grau","year":"2003","journal-title":"J. Infect. Dis."},{"issue":"7","key":"10.1016\/j.ijpara.2006.02.005_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/35017029","article-title":"ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine","volume":"2","author":"Hamon","year":"2000","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.ijpara.2006.02.005_bib20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1084\/jem.174.4.785","article-title":"Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production","volume":"174","author":"Hawrylowicz","year":"1991","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.ijpara.2006.02.005_bib21","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/nm899","article-title":"Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A","volume":"9","author":"Hrachovinova","year":"2003","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.ijpara.2006.02.005_bib22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1471-4906(03)00229-1","article-title":"Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria","volume":"24","author":"Hunt","year":"2003","journal-title":"Trends Immunol."},{"issue":"11","key":"10.1016\/j.ijpara.2006.02.005_bib23","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nm1317","article-title":"Platelets mediate cytotoxic T lymphocyte-induced liver damage","volume":"11","author":"Iannacone","year":"2005","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.ijpara.2006.02.005_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0002-9343(89)80688-6","article-title":"Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria","volume":"87","author":"Kern","year":"1989","journal-title":"Am. J. Med."},{"issue":"3","key":"10.1016\/j.ijpara.2006.02.005_bib25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1055\/s-0037-1615227","article-title":"Platelet associated fibrinogen and ICAM-2 induce firm adhesion of neutrophils under flow conditions","volume":"80","author":"Kuijper","year":"1998","journal-title":"Thromb. Haemost."},{"issue":"8725","key":"10.1016\/j.ijpara.2006.02.005_bib26","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/0140-6736(90)92827-5","article-title":"TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria","volume":"336","author":"Kwiatkowski","year":"1990","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ijpara.2006.02.005_bib27","first-page":"1397","article-title":"Platelets play an important role in TNF-induced microvascular endothelial cell pathology","volume":"151","author":"Lou","year":"1997","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.ijpara.2006.02.005_bib28","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1128\/CMR.14.4.810-820.2001","article-title":"Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans","volume":"14","author":"Lou","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"issue":"4","key":"10.1016\/j.ijpara.2006.02.005_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/mp.50.4.175","article-title":"Role of platelet adhesion in homeostasis and immunopathology","volume":"50","author":"Mannel","year":"1997","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.ijpara.2006.02.005_bib30","first-page":"791","article-title":"Role of certain adhesive receptors mediating platelet or endothelial cell interactions with leukocytes","volume":"42","author":"McGregor","year":"1994","journal-title":"Pathol. Biol."},{"issue":"4","key":"10.1016\/j.ijpara.2006.02.005_bib31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/jnnp.69.4.433","article-title":"Cerebral malaria","volume":"69","author":"Newton","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"4","key":"10.1016\/j.ijpara.2006.02.005_bib32","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1073\/pnas.98.4.1805","article-title":"Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria","volume":"98","author":"Pain","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"32","key":"10.1016\/j.ijpara.2006.02.005_bib33","doi-asserted-by":"crossref","first-page":"7352","DOI":"10.1523\/JNEUROSCI.1002-05.2005","article-title":"Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema","volume":"25","author":"Penet","year":"2005","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ijpara.2006.02.005_bib34","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1164\/ajrccm\/147.2.435","article-title":"Effective treatment of the pulmonary fibrosis elicited in mice by bleomycin or silica with anti-CD-11 antibodies","volume":"147","author":"Piguet","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"issue":"7","key":"10.1016\/j.ijpara.2006.02.005_bib35","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1128\/IAI.68.7.3822-3829.2000","article-title":"Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice","volume":"68","author":"Piguet","year":"2000","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.ijpara.2006.02.005_bib36","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1086\/373992","article-title":"Plasmodium falciparum\u2014infected erythrocyte adhesion induces caspase activation and apoptosis in human endothelial cells","volume":"187","author":"Pino","year":"2003","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.ijpara.2006.02.005_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1086\/314552","article-title":"Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria?","volume":"179","author":"Sanni","year":"1999","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.ijpara.2006.02.005_bib38","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nm986","article-title":"Differentiating the pathologies of cerebral malaria by postmortem parasite counts","volume":"10","author":"Taylor","year":"2004","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.ijpara.2006.02.005_bib39","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1750-3639.1997.tb01075.x","article-title":"Cerebral malaria","volume":"7","author":"Turner","year":"1997","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ijpara.2006.02.005_bib40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1749-6632.2003.tb03135.x","article-title":"Pathophysiology of cerebral malaria: role of host cells in the modulation of cytoadhesion","volume":"992","author":"Wassmer","year":"2003","journal-title":"Ann. NY Acad. Sci."},{"issue":"2","key":"10.1016\/j.ijpara.2006.02.005_bib41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1086\/380761","article-title":"Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells","volume":"189","author":"Wassmer","year":"2004","journal-title":"J. Infect. Dis."},{"issue":"9","key":"10.1016\/j.ijpara.2006.02.005_bib42","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1371\/journal.pmed.0020245","article-title":"Inhibition of endothelial activation: a new way to treat cerebral malaria?","volume":"2","author":"Wassmer","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.ijpara.2006.02.005_bib43","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.4049\/jimmunol.176.2.1180","article-title":"TGF-beta 1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria","volume":"176","author":"Wassmer","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.02.005_bib44","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1128\/IAI.74.1.645-653.2006","article-title":"Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum","volume":"74","author":"Wassmer","year":"2006","journal-title":"Infect. Immun."},{"issue":"9","key":"10.1016\/j.ijpara.2006.02.005_bib45","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.it.2004.07.003","article-title":"Platelets: signaling cells in the immune continuum","volume":"25","author":"Weyrich","year":"2004","journal-title":"Trends Immunol."},{"issue":"6","key":"10.1016\/j.ijpara.2006.02.005_bib46","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1172\/JCI118575","article-title":"Activated platelets signal chemokine synthesis by human monocytes","volume":"97","author":"Weyrich","year":"1996","journal-title":"J. Clin. Invest."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751906000634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751906000634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T05:09:39Z","timestamp":1555477779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751906000634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0020751906000634"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2006.02.005","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}