{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:37:26Z","timestamp":1787773046469,"version":"build-2784847793"},"reference-count":53,"publisher":"Elsevier BV","issue":"10-11","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.ijpara.2006.05.005","type":"journal-article","created":{"date-parts":[[2006,6,3]],"date-time":"2006-06-03T11:18:41Z","timestamp":1149333521000},"page":"1185-1195","source":"Crossref","is-referenced-by-count":29,"title":["Expression of IL-4 receptor on non-bone marrow-derived cells is necessary for the timely elimination of Strongyloides venezuelensis in mice, but not for intestinal IL-4 production"],"prefix":"10.1016","volume":"36","author":[{"given":"Deborah","family":"Negr\u00e3o-Corr\u00eaa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle G.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Terezinha M.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Scheuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano L.S.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro M.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2006.05.005_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0022149X00000894","article-title":"Analysis of T cell populations and IL-3 mRNA expression in mesenteric lymph node cells and intestinal intraepithelial lymphocytes in Strongyloides ratti-infected mice","volume":"72","author":"Abe","year":"1998","journal-title":"J. Helminthol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib2","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1086\/425017","article-title":"Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma","volume":"190","author":"Araujo","year":"2004","journal-title":"J. Infect. Dis."},{"issue":"5, Suppl. 1","key":"10.1016\/j.ijpara.2006.05.005_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1590\/S0074-02762004000900005","article-title":"Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases","volume":"99","author":"Araujo","year":"2004","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"10.1016\/j.ijpara.2006.05.005_bib4","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.4049\/jimmunol.160.7.3453","article-title":"A critical role for IL-13 in resistance to intestinal nematode infection","volume":"160","author":"Bancroft","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib5","first-page":"447","article-title":"Isolamento e manuten\u00e7\u00e3o do Strongyloides ratti (Sandground, 1925) em condi\u00e7\u00f5es de laborat\u00f3rio","volume":"20","author":"Brener","year":"1960","journal-title":"Rev. Brasil Biol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0167-5699(96)80600-1","article-title":"IL-4 and IL-13 receptors: are they one and the same","volume":"17","author":"Callard","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1016\/j.ijpara.2006.05.005_bib7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0169-4758(97)01144-7","article-title":"The global burden of intestinal nematode infections \u2013 fifty years on","volume":"13","author":"Chan","year":"1997","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.ijpara.2006.05.005_bib8","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.4049\/jimmunol.172.4.2059","article-title":"IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils","volume":"172","author":"Chen","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib9","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.4049\/jimmunol.162.10.6178","article-title":"Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils","volume":"162","author":"Cohn","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2307\/3285768","article-title":"How much human helminthiasis is there in the world?","volume":"85","author":"Crompton","year":"1999","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1383-5769(02)00086-7","article-title":"Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in mice","volume":"52","author":"El-Malky","year":"2003","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.ijpara.2006.05.005_bib12","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.4049\/jimmunol.164.5.2303","article-title":"Stat6 regulation of in vivo IL-4 responses","volume":"164","author":"Finkelman","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev.immunol.15.1.505","article-title":"Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models","volume":"15","author":"Finkelman","year":"1997","journal-title":"Ann. Rev. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","article-title":"Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites","volume":"201","author":"Finkelman","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijpara.2006.05.005_bib15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/clinids\/11.5.755","article-title":"Global prevalence of strongyloidiasis: critical review with epidemiologic insights into the prevention of disseminated disease","volume":"11","author":"Genta","year":"1989","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.ijpara.2006.05.005_bib16","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1086\/425014","article-title":"T helper cell type 2 responsiveness predicts future susceptibility to gastrointestinal nematodes in humans","volume":"190","author":"Jackson","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijpara.2006.05.005_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4049\/jimmunol.163.1.337","article-title":"Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile","volume":"163","author":"Jankovic","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1365-3024.1998.00148.x","article-title":"Immune responses to third stage larvae of Onchocerca volvulus in interferon-gamma and interleukin-4 knockout mice","volume":"20","author":"Johnson","year":"1998","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80439-2","article-title":"Stat6 is required for mediating responses to IL-4 and for development of Th2 cells","volume":"4","author":"Kaplan","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2006.05.005_bib20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0020-7519(93)90159-V","article-title":"Mucosal mast cells and the expulsive mechanisms of mice against Strongyloides venezuelensis","volume":"23","author":"Khan","year":"1993","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/32190","article-title":"Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites","volume":"392","author":"Lantz","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ijpara.2006.05.005_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-3024.2003.00630.x","article-title":"Is there a common mechanism of gastrointestinal nematode expulsion?","volume":"25","author":"Lawrence","year":"2003","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib23","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/(SICI)1521-4141(199809)28:09<2672::AID-IMMU2672>3.0.CO;2-F","article-title":"IL-4-regulated enteropathy in an intestinal nematode infection","volume":"28","author":"Lawrence","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1074-7613(00)80413-6","article-title":"IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses","volume":"4","author":"Magram","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2006.05.005_bib25","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.164.7.3749","article-title":"A role of mast cell glycosaminoglycans for the immunological expulsion of intestinal nematode, Strongyloides venezuelensis","volume":"164","author":"Maruyama","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1084\/jem.20030096","article-title":"Decoy receptors in the regulation of T helper cell type 2 responses","volume":"197","author":"McKenzie","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2006.05.005_bib27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1074-7613(00)80625-1","article-title":"Impaired development of Th2 cells in IL-13-deficient mice","volume":"9","author":"McKenzie","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2006.05.005_bib28","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1084\/jem.20040590","article-title":"Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite","volume":"200","author":"Min","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2006.05.005_bib29","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.4049\/jimmunol.172.4.2439","article-title":"Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections","volume":"172","author":"Mitre","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib30","doi-asserted-by":"crossref","first-page":"7302","DOI":"10.4049\/jimmunol.162.12.7302","article-title":"Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling","volume":"162","author":"Mohrs","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib31","first-page":"13","article-title":"Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system","volume":"69","author":"Murata","year":"1999","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-3024.1994.tb00358.x","article-title":"Selective effector mechanisms for the expulsion of intestinal helminths","volume":"16","author":"Nawa","year":"1994","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib33","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1128\/IAI.71.5.2607-2614.2003","article-title":"Changes in pulmonary function and parasite burden in rats infected with Strongyloides venezuelensis concomitant with induction of allergic airway inflammation","volume":"71","author":"Negr\u00e3o-Corr\u00eaa","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2006.05.005_bib34","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1128\/IAI.72.2.1135-1142.2004","article-title":"Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice","volume":"72","author":"Negr\u00e3o-Corr\u00eaa","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2006.05.005_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000088878","article-title":"The mutual influence of nematode infection and allergy","volume":"90","author":"Negr\u00e3o-Corr\u00eaa","year":"2006","journal-title":"Chem. Immunol. Allergy"},{"key":"10.1016\/j.ijpara.2006.05.005_bib36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0002-9343(92)90113-P","article-title":"Strongyloides stercoralis hyperinfection in a carrier of HTLV-I virus with evidence of selective immunosuppression","volume":"92","author":"Newton","year":"1992","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ijpara.2006.05.005_bib37","doi-asserted-by":"crossref","first-page":"10838","DOI":"10.1073\/pnas.94.20.10838","article-title":"An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice","volume":"94","author":"Noben-Trauth","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2006.05.005_bib38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3347\/kjp.2000.38.4.209","article-title":"Mucosal immunity against parasitic gastrointestinal nematodes","volume":"38","author":"Onah","year":"2000","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib39","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1365-3083.2001.00917.x","article-title":"IL-12: keeping cell-mediated immunity alive","volume":"53","author":"Park","year":"2001","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1189\/jlb.0702356","article-title":"Basophils express a type 2 cytokine profile on exposure to proteases from helminths and house dust mites","volume":"73","author":"Phillips","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib41","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1365-3024.2001.00407.x","article-title":"HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis","volume":"23","author":"Porto","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-3024.1997.d01-142.x","article-title":"IL-12 eliminates the Th-2 dependent protective immune response of mice to larval Strongyloides stercoralis","volume":"19","author":"Rotman","year":"1997","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib43","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1084\/jem.20042202","article-title":"IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity","volume":"202","author":"Sasaki","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2006.05.005_bib44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0035-9203(94)90499-5","article-title":"Reduced efficacy of chemotherapy might accumulate concurrent HTLV-1 infection among strongyloidiasis patients in Okinawa, Japan","volume":"88","author":"Sato","year":"1994","journal-title":"Trans. Royal Soc. Trop. Med. Hygiene"},{"key":"10.1016\/j.ijpara.2006.05.005_bib45","first-page":"283","article-title":"Strongyloidiasis","volume":"5","author":"Siddiqui","year":"2003","journal-title":"Curr. Treatment Option"},{"key":"10.1016\/j.ijpara.2006.05.005_bib46","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.1128\/IAI.70.11.6263-6272.2002","article-title":"Infection with Strongyloides venezuelensis induces transient airway eosinophilic inflammation, an increase in immunoglobulin E, and hyperresponsiveness in rats","volume":"70","author":"Silveira","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2006.05.005_bib47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-065X.1999.tb01329.x","article-title":"Regulation of the IL-12\/IL-12R axis: a critical step in T-helper cell differentiation and effector function","volume":"170","author":"Sinigaglia","year":"1999","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijpara.2006.05.005_bib48","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1128\/IAI.69.12.7743-7752.2001","article-title":"Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite","volume":"69","author":"Spencer","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2006.05.005_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0022-1759(85)90242-X","article-title":"Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors","volume":"83","author":"Strath","year":"1985","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ijpara.2006.05.005_bib50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1074-7613(00)80477-X","article-title":"IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis","volume":"8","author":"Urban","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2006.05.005_bib51","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.4049\/jimmunol.167.11.6078","article-title":"Cutting edge: IL-4 receptor expression by non-bone marrow-derived cells is required to expel gastrointestinal nematode parasites","volume":"167","author":"Urban","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/clim.1998.4628","article-title":"Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived","volume":"90","author":"Wang","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ijpara.2006.05.005_bib53","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1079\/JOH2003187","article-title":"Strongyloides ratti: the role of interleukin-5 in protection against tissue migrating larvae and intestinal adult worms","volume":"77","author":"Watanabe","year":"2003","journal-title":"J. Helminthol."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751906001603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751906001603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T16:20:02Z","timestamp":1683476402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751906001603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":53,"journal-issue":{"issue":"10-11","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0020751906001603"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2006.05.005","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}