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The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science 318, 245\u2013250.","DOI":"10.1126\/science.1143609"},{"key":"10.1016\/j.ijpara.2008.03.003_bib58","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/cm.10142","article-title":"Orientation of the central pair complex during flagellar bend formation in Chlamydomonas","volume":"56","author":"Mitchell","year":"2003","journal-title":"Cell Motil. 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Parasitol."},{"key":"10.1016\/j.ijpara.2008.03.003_bib61","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1096\/fj.06-6818com","article-title":"The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence","volume":"21","author":"Oberholzer","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.ijpara.2008.03.003_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1091\/mbc.10.1.1","article-title":"Rotation of the central pair microtubules in eukaryotic flagella","volume":"10","author":"Omoto","year":"1999","journal-title":"Mol. Biol. 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